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The Veterinary clinics of North America. Equine practice2018; 34(1); 113-125; doi: 10.1016/j.cveq.2017.11.010

Equine Dysautonomia.

Abstract: Equine dysautonomia (ED; also known as equine grass sickness) is a neurological disease of unknown cause, which primarily affects grazing adult horses. The clinical signs reflect degeneration of specific neuronal populations, predominantly within the autonomic and enteric nervous systems, with disease severity and prognosis determined by the extent of neuronal loss. This review is primarily focused on the major clinical decision-making processes in relation to ED, namely, (1) clinical diagnosis, (2) selection of appropriate ancillary diagnostic tests, (3) obtaining diagnostic confirmation, (4) selection of treatment candidates, and (5) identifying appropriate criteria for euthanasia.
Publication Date: 2018-02-03 PubMed ID: 29398183DOI: 10.1016/j.cveq.2017.11.010Google Scholar: Lookup
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  • Journal Article
  • Review

Summary

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This research article provides a review on equine dysautonomia (or equine grass sickness), a neurological disorder affecting horses with unknown origins, and discusses the key decision-making processes related to the disease, including diagnosis, treatment, and euthanasia.

Understanding Equine Dysautonomia

  • The paper presents a review on equine dysautonomia (ED), also referred to as equine grass sickness, which is a neurological disease. However, the root cause of this disease remains unknown.
  • The disease mainly affects horses that graze and is characterized by the degeneration of specific neuronal populations. The most affected are the autonomic and enteric nervous systems.
  • The severity of the disease and the prognosis are majorly determined by the extent of neuronal loss.

Clinical Decision-making Processes

  • The researchers focus on the various clinical decision-making processes that are critical in relation to ED.
  • These processes include clinical diagnosis, selection of suitable ancillary diagnostic tests, obtaining diagnostic confirmation, selecting treatment candidates, and identifying relevant criteria for euthanasia.

ED Clinical Diagnosis and Diagnostic Tests

  • The article emphasizes the need for an arms-on clinical diagnosis given the lack of definitive diagnostic tests for ED.
  • The selection of appropriate ancillary diagnostic tests is critical in supporting the presumptive diagnosis, thereby contributing to ED knowledge and potential treatments.

Diagnostic Confirmation and Treatment

  • The importance of obtaining diagnostic confirmation is also highlighted in the paper. This is crucial in ensuring the correct interpretation of ancillary test results and initiating appropriate treatment.
  • Further, the researchers discuss the significance of choosing candidates for treatment. This involves considering several factors, including severity of the disease, duration of clinical signs, and the individual horse’s response to early medical management.

Euthanasia Criteria

  • Last but not least, the authors underline the importance of identifying suitable criteria for euthanasia. Due to the serious nature of ED, euthanasia is sometimes the most humane and viable option, and having clear criteria helps make the difficult decision more straightforward for vets and horse owners.

Cite This Article

APA
McGorum BC, Pirie RS. (2018). Equine Dysautonomia. Vet Clin North Am Equine Pract, 34(1), 113-125. https://doi.org/10.1016/j.cveq.2017.11.010

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 34
Issue: 1
Pages: 113-125
PII: S0749-0739(17)30923-9

Researcher Affiliations

McGorum, Bruce C
  • The Dick Vet Equine Hospital, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Easter Bush, Roslin, Midlothian EH25 9RG, GBR. Electronic address: bruce.mcgorum@ed.ac.uk.
Pirie, R Scott
  • The Dick Vet Equine Hospital, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Easter Bush, Roslin, Midlothian EH25 9RG, GBR.

MeSH Terms

  • Animals
  • Horse Diseases / diagnosis
  • Horse Diseases / microbiology
  • Horse Diseases / pathology
  • Horses
  • Primary Dysautonomias / diagnosis
  • Primary Dysautonomias / microbiology
  • Primary Dysautonomias / pathology
  • Primary Dysautonomias / veterinary

Citations

This article has been cited 5 times.
  1. Laus F, Corsalini J, Mandara MT, Bazzano M, Bertoletti A, Gialletti R. Equine grass sickness in italy: a case series study. BMC Vet Res 2021 Aug 6;17(1):264.
    doi: 10.1186/s12917-021-02966-ypubmed: 34362361google scholar: lookup
  2. Unterköfler MS, McGorum BC, Milne EM, Licka TF. Establishment of a model for equine small intestinal disease: effects of extracorporeal blood perfusion of equine ileum on metabolic variables and histological morphology - an experimental ex vivo study. BMC Vet Res 2019 Nov 8;15(1):400.
    doi: 10.1186/s12917-019-2145-9pubmed: 31703590google scholar: lookup
  3. Atkins CN, Hahn CN, McGorum BC. Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities. J Vet Intern Med 2025 Jul-Aug;39(4):e70140.
    doi: 10.1111/jvim.70140pubmed: 40525668google scholar: lookup
  4. Harte T, Smith D, Moore J, Wells B. Review of published research on primary dysautonomia of domestic animals. Vet Rec 2026 Jan 3;198(1):e30-e40.
    doi: 10.1002/vetr.5499pubmed: 40482055google scholar: lookup
  5. Tan Yi Shean L, Milne EM, Shaw DJ, Maxwell S, Del-Pozo J. Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia. J Vet Diagn Invest 2024 Nov;36(6):864-869.
    doi: 10.1177/10406387241265715pubmed: 39113499google scholar: lookup