Equine Gastric Ulcer Syndrome affects fitness parameters in poorly performing Standardbred racehorses.
Abstract: Equine Gastric Ulcer Syndrome (EGUS) is a highly prevalent disorder in horses, which can be classified, based on the localization of the lesions, as Equine Squamous Gastric Disease (ESGD) or Equine Glandular Gastric Disease (EGGD). Although EGUS is recognized as a common cause of poor performance in racehorses, objective investigations about its relation with athletic capacity are lacking. Therefore, the present retrospective study aims to evaluate the associations between EGUS severity and some fitness parameters measured during an incremental treadmill test in Standardbred racehorses in training. Unassigned: With this aim, data from 87 Standard bred racehorses which underwent a complete diagnostic evaluation for poor performance was reviewed. During gastroscopic examination, a 0-4 score was assigned to ESGD, while EGGD was evaluated for absence/presence; a total EGUS score was obtained by adding 1 point to ESGD score in horses showing concomitant EGGD. Fitness parameters obtained during incremental treadmill test included speed at a heart rate of 200 bpm (V200), speed and heart rate at a blood lactate of 4 mmol/L (VLa4, HRLa4), peak lactate, lactate and heart rate at 30 minutes post-exercise, maximum speed, minimum pH and maximum hematocrit. The associations between fitness parameters and EGUS and ESGD scores were evaluated by Spearman correlation, while Mann-Whitney test was used to compare them between horses with or without EGGD. Statistical significance was set at p<0.05. Unassigned: EGUS grade was inversely correlated with V200 (p = 0.0025) and minimum pH (p = 0.0469); ESGD grade was inversely correlated with V200 (p = 0.0025) and VLa4 (p = 0.0363). Although a trend was observed, no significant differences in V200 were observed between horses with or without EGGD (p = 0.073); horses with EGGD reached a lower minimum pH (p = 0.0087). Unassigned: These results show a negative association between aerobic capacity and EGUS, in particular ESGD. Although different hypotheses have been proposed, including abdominal pain and decreased appetite due to lactate accumulation, the underlying mechanisms are still unknown, and it is not clear whether EGUS represents a cause or a consequence of an early lactate accumulation and post-exercise acidosis.
Copyright © 2022 Lo Feudo, Stucchi, Conturba, Stancari, Zucca and Ferrucci.
Publication Date: 2022-11-25 PubMed ID: 36504861PubMed Central: PMC9732101DOI: 10.3389/fvets.2022.1014619Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Aerobic Capacity
- Athletic Performance
- Clinical Study
- Correlation Analysis
- Equine Diseases
- Equine Health
- Exercise Physiology
- Fitness
- Gastrointestinal Health
- Horse Racing
- Horse Training
- Lactate
- Physiology
- Retrospective Study
- Standardbred Horses
- Treadmill Exercise
- Ulcers
- Veterinary Care
- Veterinary Medicine
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research investigated the relationship between Equine Gastric Ulcer Syndrome (EGUS) and fitness parameters in poorly performing Standardbred racehorses.
Study Overview
- The researchers performed a retrospective study to assess any correlations between the severity of EGUS, further classified into Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD), and certain fitness indices measured during an incremental treadmill test undertaken by racehorses in training.
- The data was sourced from historical performance evaluations of 87 Standardbred racehorses, all of which had previously undergone comprehensive diagnostic evaluations due to underperformance.
- The researchers assigned a score (from 0-4) to gauge the extent of ESGD, whereas EGGD was evaluated as being either present or absent. The cumulative EGUS score was calculated by adding 1 point to the ESGD score in horses exhibiting concurrent EGGD.
Fitness Parameters Evaluated
- Fitness characteristics including speed at a heart rate of 200 bpm (V200), speed and heart rate at a blood lactate level of 4 mmol/L (VLa4, HRLa4), peak lactate, lactate and heart rate 30 minutes post-exercise, maximum speed, minimum blood pH, and maximum hematocrit level were measured.
Data Analysis
- The relationships between EGUS and ESGD scores and the measured fitness factors were probed using Spearman correlation.
- A Mann-Whitney test was used to identify any differences between the fitness parameters of horses with EGGD and those without it.
- A value of p<0.05 was considered statistically significant.
Key Findings
- The study identified an inverse correlation between EGUS severity and V200 and minimum pH. Similarly, the severity of ESGD was inversely related to V200 and VLa4.
- There appeared to be a trend suggesting an effect of EGGD on V200, however, this effect did not reach statistical significance. Nevertheless, horses with EGGD consistently exhibited a lower minimum blood pH.
- The findings indicate that aerobic capacity (fitness) is negatively impacted by EGUS, specifically ESGD.
Future Directions
- The mechanisms through which EGUS influences fitness are not well understood. The authors suggest possible causes may include abdominal discomfort and reduced appetite as a result of lactic acid build up, but further study is needed to provide clarity.
- The authors also highlight the need for additional research to determine if EGUS is a cause or a consequent reaction to early lactic acid accumulation and post-exercise acidosis in racehorses.
Cite This Article
APA
Lo Feudo CM, Stucchi L, Conturba B, Stancari G, Zucca E, Ferrucci F.
(2022).
Equine Gastric Ulcer Syndrome affects fitness parameters in poorly performing Standardbred racehorses.
Front Vet Sci, 9, 1014619.
https://doi.org/10.3389/fvets.2022.1014619 Publication
Researcher Affiliations
- Equine Sports Medicine Laboratory "Franco Tradati", Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
- Veterinary Teaching Hospital, Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
- Veterinary Teaching Hospital, Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
- Veterinary Teaching Hospital, Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
- Equine Sports Medicine Laboratory "Franco Tradati", Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
- Equine Sports Medicine Laboratory "Franco Tradati", Department of Veterinary Medicine and Animal Sciences, Università Degli Studi di Milano, Lodi, Italy.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
This article includes 63 references
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European college of equine internal medicine consensus statement—Equine Gastric Ulcer Syndrome in adult horses. J Vet Intern Med (2015) 29:1288–99.
- Andrews FM, Bernard W, Byars D, Cohen N, Divers T, MacAllister C. Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (EGUS). Equine Vet Educ (1999) 11:262–72.
- Bell RJW, Kingston JK, Mogg TD, Perkins NR. The prevalence of gastric ulceration in racehorses in New Zealand. N Z Vet J (2007) 55:13–8.
- Dionne RM, Vrins A, Doucet MY, Parè J. Gastric ulcers in Standardbred racehorses: prevalence, lesion description, and risk factors. J Vet Intern Med (2003) 17:218–22.
- Rabuffo TS, Orsini JA, Sullivan E, Engiles J, Norman T, Boston R. Associations between age or sex and prevalence of gastric ulceration in Standardbred racehorses in training. J Am Vet Med Assoc (2002) 221:1156–9.
- Roy MA, Vrins A, Beauchamp G, Doucet MY. Prevalence of ulcers of the squamous gastric mucosa in Standardbred horses. J Vet Intern Med (2005) 19:744–50.
- Ferrucci F, Zucca E, Di Fabio V, Croci C, Tradati F. Gastroscopic findings in 63 Standardbred racehorses in training. Vet Res Commun (2003) 27:759–62.
- Sandin A, Skidell J, Häggström J, Girma K, Nilsson G. Post-mortem findings of gastric ulcers in Swedish horses up to 1 year of age: a retrospective study 1924–1996. Acta Vet Scand (1999) 40:109–20.
- Orsini J. Gastric ulceration in the mature horse: a review. Equine Vet Educ (2000) 12:24–7.
- Sykes BW, Bowen M, Habershon-Butcher JL, Green M, Hallowell GD. Management factors and clinical implications of glandular and squamous gastric disease in horse. J Vet Intern Med (2019) 33:233–40.
- Banse HE, Andrews FM. Equine glandular gastric disease: prevalence, impact and management strategies. Vet Med (2019) 10:69–76.
- De Brujin CM, Schutrups AH, Seesing EHAL. Prevalence of equine gastric ulceration syndrome in Standardbreds. Vet Rec (2009) 164:814–5.
- Orsini JA, Hackett ES, Grenager N. The effect of exercise on equine gastric ulcer syndrome in the thoroughbred and Standardbred athlete. J Equine Vet Sci (2009) 29:167–71.
- Andrews FM, Larson C, Harris P. Nutritional management of gastric ulceration. Equine Vet Edu (2017) 29:45–55.
- Reese RE, Andrews FM. Nutrition and dietary management of equine gastric ulcer syndrome. Vet Clin North Am Equine Pract (2009) 25:79–92.
- Pedersen S, Cribb A, Windeyer M, Read E, French D, Banse H. Risk factors for equine glandular and squamous gastric disease in show jumping Warmbloods. Equine Vet J (2018) 50:747–51.
- Lorenzo-Figueras M, Merritt A. Effects of exercise on gastric volume and pH in the proximal portion of the stomach of horses. Am J Vet Res (2002) 63:1481–7.
- Murray MJ. Equine model of inducing ulceration in alimentary squamous epithelial mucosa. Dig Dis Sci (1994) 39:2530–5.
- Furr M, Taylor L, Kronfeld D. The effects of exercise training on serum gastrin responses in the horse. Cornell Vet (1994) 84:41–5.
- Scheidegger MD, Gerber V, Bruckmaier R, Van Der Kolk JH, Burger D, Ramseyer A. Increased adrenocortical response to adrenocorticotropic hormone (ACTH) in sport horses with equine glandular gastric disease (EGGD). Vet J (2017) 228:7–12.
- Bell RJW, Mogg TD, Kingston JK. Equine gastric ulcer syndrome in adult horses: a review. N Z Vet J (2007) 55:1–12.
- Bezdekova B, Jahn P, Vyskocil M. Gastric ulceration, appetite and feeding practices in Standardbred racehorses in the Czech Republic. Acta Vet Brno (2008) 77:603–7.
- Vatistas NJ, Snyder JR, Carlson G, Johnson B, Arthur RM, Thurmond M. Cross-sectional study of gastric ulcers of the squamous mucosa in thoroughbred racehorses. Equine Vet J Suppl (1999) 29:34–9.
- Murray MJ, Grodinsky C, Anderson CW, Radue PF, Schmidt GR. Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs. Equine Vet J Suppl (1989) 21:68–72.
- Andrews FM, Nadeau J. Clinical syndromes of gastric ulceration in foals and mature horses. Equine Vet J (1999) 31:30–3.
- Dukti S, Perkins S, Murphy J, Barr B, Boston R, Southwood LL. Prevalence of gastric squamous ulceration in horses with abdominal pain. Equine Vet J (2006) 38:347–9.
- Videla R, Andrews FM. New perspectives in equine gastric ulcer syndrome. Vet Clin North Am Equine Pract (2009) 25:283–301.
- Murray MJ. Gastric ulceration in horses: 91 cases (1987–1990). J Am Vet Med Assoc (1992) 201:117–20.
- Jonnson H, Egenvall A. Prevalence of gastric ulceration in Swedish Standardbreds in race training. Equine Vet J (2006) 38:209–13.
- Franklin SH, Brazil TJ, Allen KJ. Poor performance associated with equine gastric ulceration syndrome in four Thoroughbred racehorses. Equine Vet Educ (2008) 20:119–24.
- Kollias-Baker C, Cox K, Jones J. Evaluation of the effects of omeprazole on physiological indices of performance of horses during incremental treadmill exercise. Vet Ther (2001) 2:361–9.
- Johnson JH, Vatistas N, Castro L, Fischer T, Pipers FS, Maye D. Field survey of the prevalence of gastric ulcers in thoroughbred racehorses and on response to treatment of affected horses with omeprazole paste. Equine Vet Educ (2001) 13:221–4.
- Nieto JE, Snyder JR, Vatistas NJ, Jones JH. Effect of gastric ulceration on physiologic responses to exercise in horses. Am J Vet Res (2009) 70:787–95.
- Murray MJ, Schusser GF, Pipers FS, Gross SJ. Factors associated with gastric lesions in thoroughbred racehorses. Equine Vet J (1996) 28:368–74.
- Andrews FM. Poor performance: Can heartburn slow a horse?. Equine Vet Educ (2008) 20:125–6.
- Collier DSJ, Stoneham SJ. Gastro-oesophageal ulcers in man and horse: semblance and dissemblance. Equine Vet J (1997) 29:410–2.
- Rodriguez-Stanley S, Bemben D, Zubaidi S, Redinger N, Miner PBJ. Effect of esophageal acid and prophylactic rabeprazole on performance in runners. Med Sci Sports Exerc (2006) 38:1659–65.
- Lo Feudo CM, Stucchi L, Stancari G, Alberti E, Conturba B, Zucca E. Associations between exercise-induced pulmonary hemorrhage (EIPH) and fitness parameters measured by incremental treadmill test in Standardbred racehorses. Animals (2022) 12:449.
- Stucchi L, Alberti E, Stancari G, Conturba B, Zucca E, Ferrucci F. The Relationship between lung inflammation and aerobic threshold in Standardbred racehorses with mild-moderate equine asthma. Animals (2020) 10:1278.
- Alberti E, Stucchi L, Lo Feudo CM, Stancari G, Conturba B, Ferrucci F. Evaluation of cardiac arrhythmias before, during, and after treadmill exercise testing in poorly performing Standardbred racehorses. Animals (2021) 11:2413.
- Stucchi L, Valli C, Stancari G, Zucca E, Ferrucci F. Creatine-kinase reference intervals at rest and after maximal exercise in Standardbred racehorses. Comp Exerc Physiol (2019) 15:319–25.
- Newell J, Higgins D, Madden N, Cruickshank J, Einbeck J, McMillan K. Software for calculating blood lactate endurance markers. J Sports Sci (2007) 25:1403–9.
- Lo Feudo CM, Stucchi L, Cavicchioli P, Stancari G, Conturba B, Zucca E. Association between dynamic upper airway obstructions and fitness parameters in Standardbred racehorses during high-speed treadmill exercise. J Am Vet Med Assoc (2022) 1:1–8.
- Sykes BW, Sykes KM, Hallowell GD. Efficacy of a combination of apolectol, live yeast (Saccharomyces cerevisiae [CNCM I-1077]), and magnesium hydroxide in the management of equine gastric ulcer syndrome in Thoroughbred racehorses: a blinded, randomized, placebo-controlled clinical trial. J Equine Vet Sci (2014) 34:1274–8.
- Hellings IR, Larsen S. ImproWin in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand (2014) 56:13.
- Lo Feudo CM, Stucchi L, Conturba B, Alberti E, Zucca E, Ferrucci F. Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses. Vet Rec (2021) 189:e942.
- Couetil LL, Cardwell JM, Gerber V, Lavoie JP, Leguillette R, Richard EA. Inflammatory airway disease of horses: revised consensus statement. J Vet Intern Med (2016) 30:503–15.
- Begg LM, O'Sullivan CB. The prevalence and distribution of gastric ulceration in 345 racehorses. Aust Vet J (2003) 81:199–201.
- McCarthy SF, Islam H, Hazell TJ. The emerging role of lactate as a mediator of exercise-induced appetite suppression. Am J Physiol Endocrinol Metab (2020) 319:E814–9.
- Paul LJ, Ericsson AC, Andrews FM, Keowen ML, Morales Yniguez F, Garza FJ. Gastric microbiome in horses with and without equine glandular gastric disease. J Vet Intern Med (2021) 35:2458–64.
- Clauss M, Gerard P, Mosca A, Leclerc M. Interplay between exercise and gut microbiome in the context of human health and performance. Front Nutr (2021) 8:637010.
- Worobetz LJ, Gerrard DF. Gastrointestinal symptoms during exercise in Enduro athletes: prevalence and speculations on the aetiology. N Z Med J (1985) 98:644–6.
- Alexander JA, Hunt LW, Patel AM. Prevalence, pathophysiology and treatment of patients with asthma and gastroesophageal reflux disease. Mayo Clin Proc (2000) 75:1055–63.
- Harding SM. Gastroesophageal reflux, asthma, and mechanisms of interaction. Am J Med (2001) 111:8S−12S.
- Patterson PE, Harding SM. Gastroesophageal reflux disorders and asthma. Curr Opin Pulm Med (1999) 5:63–7.
- Richter JE. Gastroesophageal reflux disease and asthma: the two are directly related. Am J Med (2000) 108:153S−8S.
- Herve PA, Denjean A, Jian R, Simonneau G, Duroux P. Intraesophageal perfusion of acid increases the bronchomotor response to methacholine and to iscapnic hyperventilation in asthmatic subjects. Am Rev Respir Dis (1986) 134:986–9.
- Perpina M, Pellicer C, Marco V, Maldonado J, Ponce J. The significance of the reflex bronchoconstriction provoked by gastroesophageal reflux in bronchial asthma. Eur J Respir Dis (1985) 66:91–7.
- Field SK. A critical review of the studies of the effects of simulated or real gastroesophageal reflux on pulmonary function in asthmatic adults. Chest (1999) 115:848–56.
- Schan CA, Harding SM, Haile JM, Bradley LA, Richter JE. Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology. Chest (1994) 106:731–7.
- Chakrabarti S, Singh K, Singh V, Nain CK, Jindal SK. Airway response to acid instillation in esophagus in bronchial asthma. Indian J Gastroenterol (1995) 14:22–7.
- Ricciardolo FL. Mechanism of citric acid-induced bronchoconstriction. Am J Med (2001) 111:18S−24S.
- Ivester KM, Couetil LL, Moore GE. An observational study of environmental exposures, airway cytology, and performance in racing thoroughbreds. J Vet Intern Med (2018) 32:1754–62.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists