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Journal of veterinary internal medicine2009; 23(3); 450-461; doi: 10.1111/j.1939-1676.2009.0304.x

Equine herpesvirus-1 consensus statement.

Abstract: Equine herpesvirus-1 is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). In recent years, there has been an apparent increase in the incidence of EHM in North America, with serious consequences for horses and the horse industry. This consensus statement draws together current knowledge in the areas of pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment.
Publication Date: 2009-08-04 PubMed ID: 19645832DOI: 10.1111/j.1939-1676.2009.0304.xGoogle Scholar: Lookup
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  • Consensus Development Conference
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article centers around the highly common and often harmful infection in horses – Equine herpesvirus-1. The focus is majorly on its severe clinical outcomes, namely abortion and equine herpesvirus myeloencephalopathy (EHM). The researchers consolidate the latest knowledge on its causes, variations, spread, diagnostic testing, vaccination, as well as prevention, control, and treatment of outbreaks.

Pathogenesis

  • Equine herpesvirus-1 is a widespread viral infection affecting horses. It’s key concern centers around it leading to severe clinical outcomes, such as abortion and equine herpesvirus myeloencephalopathy (EHM), a neurological disease in horses.
  • The virus primarily affects the respiratory system but can also cause severe damage to the reproductive and nervous systems. It can lead to an array of diseases including respiratory disease, especially in young foals, abortion in pregnant mares, and EHM.

Strain Variation

  • The researchers delve into the different variations of Equine herpesvirus-1. The focus is to determine any unique characteristics that might influence the severity of the infection and the associated clinical outcomes.

Epidemiology

  • In the study of epidemiology, the researchers ascertain how the Equine herpesvirus-1 infection spreads among horse populations. They take into account the potential risk factors leading to increased infection rates such as environmental conditions and horse breeding practices.

Diagnostic Testing

  • The study recognizes the importance of accurate diagnostic testing in identifying cases of Equine herpesvirus-1 infections and, consequently, controlling its spread. It takes into account the numerous testing procedures available and their effectiveness.

Vaccination

  • Creating a successful vaccination against the virus is also a critical part of the consensus statement. The vaccine’s performance, recommendations for its use, and its influence on the prevalence of the virus, are all key areas of interest.

Outbreak Prevention and Control

  • The consensus statement discusses the practices and guidelines for preventing and managing outbreaks of the virus. It subjects the effectiveness of these prevention and management strategies to a thorough examination.

Treatment

  • The paper provides an informative guide on available treatments for horses that have contracted the virus. It presents a detailed evaluation of their effectiveness and practicality.

Cite This Article

APA
Lunn DP, Davis-Poynter N, Flaminio MJ, Horohov DW, Osterrieder K, Pusterla N, Townsend HG. (2009). Equine herpesvirus-1 consensus statement. J Vet Intern Med, 23(3), 450-461. https://doi.org/10.1111/j.1939-1676.2009.0304.x

Publication

ISSN: 0891-6640
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 23
Issue: 3
Pages: 450-461

Researcher Affiliations

Lunn, D P
  • Department of Clinical Sciences, James L Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1620, USA. lunnp@colostate.edu
Davis-Poynter, N
    Flaminio, M J B F
      Horohov, D W
        Osterrieder, K
          Pusterla, N
            Townsend, H G G

              MeSH Terms

              • Animals
              • Central Nervous System Diseases / veterinary
              • Central Nervous System Diseases / virology
              • Disease Outbreaks / prevention & control
              • Disease Outbreaks / veterinary
              • Female
              • Herpesviridae Infections / epidemiology
              • Herpesviridae Infections / prevention & control
              • Herpesviridae Infections / veterinary
              • Herpesvirus 1, Equid / classification
              • Herpesvirus 1, Equid / physiology
              • Horse Diseases / epidemiology
              • Horse Diseases / virology
              • Horses
              • Pregnancy
              • Pregnancy Complications, Infectious / veterinary
              • Pregnancy Complications, Infectious / virology
              • Risk Factors
              • Viral Vaccines / immunology

              Citations

              This article has been cited 85 times.
              1. Anderson C, Baha H, Boghdeh N, Barrera M, Alem F, Narayanan A. Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease.. Viruses 2023 May 13;15(5).
                doi: 10.3390/v15051163pubmed: 37243249google scholar: lookup
              2. Barbosa JD, Lins AMC, Bomjardim HDA, Silveira NDSES, Barbosa CC, Beuttemmuller EA, Brito MF, Salvarani FM. Equine Herpesvirus Type 1 Myeloencephalitis in the Brazilian Amazon.. Animals (Basel) 2022 Dec 23;13(1).
                doi: 10.3390/ani13010059pubmed: 36611668google scholar: lookup
              3. Harvey AM, Ramp D, Mellor DJ. Review of the Foundational Knowledge Required for Assessing Horse Welfare.. Animals (Basel) 2022 Dec 1;12(23).
                doi: 10.3390/ani12233385pubmed: 36496906google scholar: lookup
              4. Klouth E, Zablotski Y, Petersen JL, de Bruijn M, Gröndahl G, Müller S, Goehring LS. Epidemiological Aspects of Equid Herpesvirus-Associated Myeloencephalopathy (EHM) Outbreaks.. Viruses 2022 Nov 21;14(11).
                doi: 10.3390/v14112576pubmed: 36423188google scholar: lookup
              5. Roach J, Arango Sabogal JC, Smith K, Foote A, Verheyen K, de Mestre AM. Multivariable analysis to determine risk factors associated with abortion in mares.. Reprod Fertil 2022 Nov 1;3(4):301-12.
                doi: 10.1530/RAF-22-0087pubmed: 36374277google scholar: lookup
              6. Tsai MS, François S, Newman C, Macdonald DW, Buesching CD. Infection with a Recently Discovered Gammaherpesvirus Variant in European Badgers, Meles meles, is Associated with Higher Relative Viral Loads in Blood.. Pathogens 2022 Oct 6;11(10).
                doi: 10.3390/pathogens11101154pubmed: 36297210google scholar: lookup
              7. Badr C, Souiai O, Arbi M, El Behi I, Essaied MS, Khosrof I, Benkahla A, Chabchoub A, Ghram A. Epidemiological and Phylogeographic Study of Equid Herpesviruses in Tunisia.. Pathogens 2022 Sep 5;11(9).
                doi: 10.3390/pathogens11091016pubmed: 36145448google scholar: lookup
              8. Thieulent CJ, Sutton G, Toquet MP, Fremaux S, Hue E, Fortier C, Pléau A, Deslis A, Abrioux S, Guitton E, Pronost S, Paillot R. Oral Administration of Valganciclovir Reduces Clinical Signs, Virus Shedding and Cell-Associated Viremia in Ponies Experimentally Infected with the Equid Herpesvirus-1 C(2254) Variant.. Pathogens 2022 May 4;11(5).
                doi: 10.3390/pathogens11050539pubmed: 35631060google scholar: lookup
              9. Hu Y, Jia Q, Liu J, Sun W, Bao Z, Che C, Wu G, Fan B, Jarhen, Ran D. Molecular characteristics and pathogenicity of an equid alphaherpesvirus 1 strain isolated in China.. Virus Genes 2022 Aug;58(4):284-293.
                doi: 10.1007/s11262-022-01910-ypubmed: 35567668google scholar: lookup
              10. Carvelli A, Nielsen SS, Paillot R, Broglia A, Kohnle L. Clinical impact, diagnosis and control of Equine Herpesvirus-1 infection in Europe.. EFSA J 2022 Apr;20(4):e07230.
                doi: 10.2903/j.efsa.2022.7230pubmed: 35414834google scholar: lookup
              11. Mureşan A, Mureşan C, Siteavu M, Avram E, Bochynska D, Taulescu M. An Outbreak of Equine Herpesvirus-4 in an Ecological Donkey Milk Farm in Romania.. Vaccines (Basel) 2022 Mar 18;10(3).
                doi: 10.3390/vaccines10030468pubmed: 35335100google scholar: lookup
              12. Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Roberts HC, Padalino B, Pasquali P, Spoolder H, Ståhl K, Calvo AV, Viltrop A, Winckler C, Carvelli A, Paillot R, Broglia A, Kohnle L, Baldinelli F, Van der Stede Y. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infection with Equine Herpesvirus-1.. EFSA J 2022 Jan;20(1):e07036.
                doi: 10.2903/j.efsa.2022.7036pubmed: 35035581google scholar: lookup
              13. Temesgen T, Getachew Y, Negussie H. Molecular Identification of Equine Herpesvirus 1, 2, and 5 in Equids with Signs of Respiratory Disease in Central Ethiopia.. Vet Med (Auckl) 2021;12:337-345.
                doi: 10.2147/VMRR.S339042pubmed: 34956854google scholar: lookup
              14. El Brini Z, Fassi Fihri O, Paillot R, Lotfi C, Amraoui F, El Ouadi H, Dehhaoui M, Colitti B, Alyakine H, Piro M. Seroprevalence of Equine Herpesvirus 1 (EHV-1) and Equine Herpesvirus 4 (EHV-4) in the Northern Moroccan Horse Populations.. Animals (Basel) 2021 Sep 29;11(10).
                doi: 10.3390/ani11102851pubmed: 34679874google scholar: lookup
              15. Vandenberghe E, Boshuizen B, Delesalle CJG, Goehring LS, Groome KA, van Maanen K, de Bruijn CM. New Insights into the Management of an EHV-1 (Equine Hospital) Outbreak.. Viruses 2021 Jul 22;13(8).
                doi: 10.3390/v13081429pubmed: 34452295google scholar: lookup
              16. Knox A, Beddoe T. Isothermal Nucleic Acid Amplification Technologies for the Detection of Equine Viral Pathogens.. Animals (Basel) 2021 Jul 20;11(7).
                doi: 10.3390/ani11072150pubmed: 34359278google scholar: lookup
              17. Hales EN, Aleman M, Marquardt SA, Katzman SA, Woolard KD, Miller AD, Finno CJ. Postmortem diagnoses of spinal ataxia in 316 horses in California.. J Am Vet Med Assoc 2021 Jun 15;258(12):1386-1393.
                doi: 10.2460/javma.258.12.1386pubmed: 34061609google scholar: lookup
              18. Dayaram A, Seeber PA, Greenwood AD. Environmental Detection and Potential Transmission of Equine Herpesviruses.. Pathogens 2021 Apr 1;10(4).
                doi: 10.3390/pathogens10040423pubmed: 33916280google scholar: lookup
              19. Laval K, Poelaert KCK, Van Cleemput J, Zhao J, Vandekerckhove AP, Gryspeerdt AC, Garré B, van der Meulen K, Baghi HB, Dubale HN, Zarak I, Van Crombrugge E, Nauwynck HJ. The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1.. Front Microbiol 2021;12:662686.
                doi: 10.3389/fmicb.2021.662686pubmed: 33746936google scholar: lookup
              20. Zarski LM, Giessler KS, Jacob SI, Weber PSD, McCauley AG, Lee Y, Soboll Hussey G. Identification of Host Factors Associated with the Development of Equine Herpesvirus Myeloencephalopathy by Transcriptomic Analysis of Peripheral Blood Mononuclear Cells from Horses.. Viruses 2021 Feb 24;13(3).
                doi: 10.3390/v13030356pubmed: 33668216google scholar: lookup
              21. Zarski LM, Weber PSD, Lee Y, Soboll Hussey G. Transcriptomic Profiling of Equine and Viral Genes in Peripheral Blood Mononuclear Cells in Horses during Equine Herpesvirus 1 Infection.. Pathogens 2021 Jan 7;10(1).
                doi: 10.3390/pathogens10010043pubmed: 33430330google scholar: lookup
              22. Giessler KS, Samoilowa S, Soboll Hussey G, Kiupel M, Matiasek K, Sledge DG, Liesche F, Schlegel J, Fux R, Goehring LS. Viral Load and Cell Tropism During Early Latent Equid Herpesvirus 1 Infection Differ Over Time in Lymphoid and Neural Tissue Samples From Experimentally Infected Horses.. Front Vet Sci 2020;7:621.
                doi: 10.3389/fvets.2020.00621pubmed: 33102556google scholar: lookup
              23. Sutton G, Thieulent C, Fortier C, Hue ES, Marcillaud-Pitel C, Pléau A, Deslis A, Guitton E, Paillot R, Pronost S. Identification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C(2254)/H(752) Strain in French Horses Showing no Major Impact on the Strain Behaviour.. Viruses 2020 Oct 13;12(10).
                doi: 10.3390/v12101160pubmed: 33066315google scholar: lookup
              24. Stasiak K, Dunowska M, Rola J. Outbreak of equid herpesvirus 1 abortions at the Arabian stud in Poland.. BMC Vet Res 2020 Oct 6;16(1):374.
                doi: 10.1186/s12917-020-02586-ypubmed: 33023592google scholar: lookup
              25. Goodrich EL, McLean A, Guarino C. A Pilot Serosurvey for Selected Pathogens in Feral Donkeys (Equus asinus).. Animals (Basel) 2020 Oct 2;10(10).
                doi: 10.3390/ani10101796pubmed: 33023217google scholar: lookup
              26. Aleman M, Berryhill E, Woolard K, Easton-Jones CA, Kozikowski-Nicholas T, Dyson S, Kilcoyne I. Sidewinder gait in horses.. J Vet Intern Med 2020 Sep;34(5):2122-2131.
                doi: 10.1111/jvim.15870pubmed: 32820825google scholar: lookup
              27. Attili AR, Colognato R, Preziuso S, Moriconi M, Valentini S, Petrini S, De Mia GM, Cuteri V. Evaluation of Three Different Vaccination Protocols against EHV1/EHV4 Infection in Mares: Double Blind, Randomized Clinical Trial.. Vaccines (Basel) 2020 Jun 1;8(2).
                doi: 10.3390/vaccines8020268pubmed: 32492841google scholar: lookup
              28. Day MJ, Carey S, Clercx C, Kohn B, MarsilIo F, Thiry E, Freyburger L, Schulz B, Walker DJ. Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe.. J Comp Pathol 2020 Apr;176:86-108.
                doi: 10.1016/j.jcpa.2020.02.005pubmed: 32359641google scholar: lookup
              29. Seo MG, Ouh IO, Lee SK, Lee JS, Kwon OD, Kwak D. Molecular Detection and Genetic Characteristics of Equine Herpesvirus in Korea.. Pathogens 2020 Feb 11;9(2).
                doi: 10.3390/pathogens9020110pubmed: 32053974google scholar: lookup
              30. Stokol T, Soboll Hussey G. Editorial: Current Research in Equid Herpesvirus Type-1 (EHV-1).. Front Vet Sci 2019;6:492.
                doi: 10.3389/fvets.2019.00492pubmed: 31998768google scholar: lookup
              31. Lecollinet S, Pronost S, Coulpier M, Beck C, Gonzalez G, Leblond A, Tritz P. Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?. Viruses 2019 Dec 24;12(1).
                doi: 10.3390/v12010023pubmed: 31878129google scholar: lookup
              32. Oladunni FS, Horohov DW, Chambers TM. EHV-1: A Constant Threat to the Horse Industry.. Front Microbiol 2019;10:2668.
                doi: 10.3389/fmicb.2019.02668pubmed: 31849857google scholar: lookup
              33. Sutton G, Garvey M, Cullinane A, Jourdan M, Fortier C, Moreau P, Foursin M, Gryspeerdt A, Maisonnier V, Marcillaud-Pitel C, Legrand L, Paillot R, Pronost S. Molecular Surveillance of EHV-1 Strains Circulating in France during and after the Major 2009 Outbreak in Normandy Involving Respiratory Infection, Neurological Disorder, and Abortion.. Viruses 2019 Oct 4;11(10).
                doi: 10.3390/v11100916pubmed: 31590336google scholar: lookup
              34. Oladunni FS, Sarkar S, Reedy S, Balasuriya UBR, Horohov DW, Chambers TM. Equid Herpesvirus 1 Targets the Sensitization and Induction Steps To Inhibit the Type I Interferon Response in Equine Endothelial Cells.. J Virol 2019 Dec 1;93(23).
                doi: 10.1128/JVI.01342-19pubmed: 31511388google scholar: lookup
              35. Schnabel CL, Babasyan S, Rollins A, Freer H, Wimer CL, Perkins GA, Raza F, Osterrieder N, Wagner B. An Equine Herpesvirus Type 1 (EHV-1) Ab4 Open Reading Frame 2 Deletion Mutant Provides Immunity and Protection from EHV-1 Infection and Disease.. J Virol 2019 Nov 15;93(22).
                doi: 10.1128/JVI.01011-19pubmed: 31462575google scholar: lookup
              36. Tsujimura K, Bannai H, Nemoto M, Kokado H. Loop-mediated isothermal amplification-fluorescent loop primer assay for the genotyping of a single nucleotide polymorphism at position 2254 in the viral DNA polymerase gene of equid alphaherpesvirus 1.. J Vet Diagn Invest 2019 Jul;31(4):640-644.
                doi: 10.1177/1040638719856404pubmed: 31170890google scholar: lookup
              37. Brown LJ, Brown G, Kydd J, Stout TAE, Schulman ML. Failure to detect equid herpesvirus types 1 and 4 DNA in placentae and healthy new-born Thoroughbred foals.. J S Afr Vet Assoc 2019 May 30;90(0):e1-e5.
                doi: 10.4102/jsava.v90i0.1736pubmed: 31170779google scholar: lookup
              38. Poelaert KCK, Van Cleemput J, Laval K, Descamps S, Favoreel HW, Nauwynck HJ. Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moderate the Pathogenesis of Alphaherpesviruses.. Front Microbiol 2019;10:723.
                doi: 10.3389/fmicb.2019.00723pubmed: 31024501google scholar: lookup
              39. Rossi TM, Moore A, O'Sullivan TL, Greer AL. Equine Rhinitis A Virus Infection at a Standardbred Training Facility: Incidence, Clinical Signs, and Risk Factors for Clinical Disease.. Front Vet Sci 2019;6:71.
                doi: 10.3389/fvets.2019.00071pubmed: 30918893google scholar: lookup
              40. Holz CL, Sledge DG, Kiupel M, Nelli RK, Goehring LS, Soboll Hussey G. Histopathologic Findings Following Experimental Equine Herpesvirus 1 Infection of Horses.. Front Vet Sci 2019;6:59.
                doi: 10.3389/fvets.2019.00059pubmed: 30886853google scholar: lookup
              41. Tan L, Yuan X, Liu Y, Cai X, Guo S, Wang A. Non-muscle Myosin II: Role in Microbial Infection and Its Potential as a Therapeutic Target.. Front Microbiol 2019;10:401.
                doi: 10.3389/fmicb.2019.00401pubmed: 30886609google scholar: lookup
              42. Poelaert KCK, Van Cleemput J, Laval K, Favoreel HW, Couck L, Van den Broeck W, Azab W, Nauwynck HJ. Equine Herpesvirus 1 Bridles T Lymphocytes To Reach Its Target Organs.. J Virol 2019 Apr 1;93(7).
                doi: 10.1128/JVI.02098-18pubmed: 30651370google scholar: lookup
              43. Garvey M, Lyons R, Hector RD, Walsh C, Arkins S, Cullinane A. Molecular Characterisation of Equine Herpesvirus 1 Isolates from Cases of Abortion, Respiratory and Neurological Disease in Ireland between 1990 and 2017.. Pathogens 2019 Jan 15;8(1).
                doi: 10.3390/pathogens8010007pubmed: 30650561google scholar: lookup
              44. Serpa PBS, Brooks MB, Divers T, Ness S, Birschmann I, Papich MG, Stokol T. Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration.. Front Vet Sci 2018;5:304.
                doi: 10.3389/fvets.2018.00304pubmed: 30564584google scholar: lookup
              45. Matczuk AK, Skarbek M, Jackulak NA, Bażanów BA. Molecular characterisation of equid alphaherpesvirus 1 strains isolated from aborted fetuses in Poland.. Virol J 2018 Dec 3;15(1):186.
                doi: 10.1186/s12985-018-1093-5pubmed: 30509297google scholar: lookup
              46. Seeber PA, Dayaram A, Sicks F, Osterrieder N, Franz M, Greenwood AD. Noninvasive Detection of Equid Herpesviruses in Fecal Samples.. Appl Environ Microbiol 2019 Feb 1;85(3).
                doi: 10.1128/AEM.02234-18pubmed: 30446563google scholar: lookup
              47. Wimer CL, Schnabel CL, Perkins G, Babasyan S, Freer H, Stout AE, Rollins A, Osterrieder N, Goodman LB, Glaser A, Wagner B. The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses.. PLoS One 2018;13(11):e0206679.
                doi: 10.1371/journal.pone.0206679pubmed: 30440016google scholar: lookup
              48. Poelaert KCK, Van Cleemput J, Laval K, Favoreel HW, Soboll Hussey G, Maes RK, Nauwynck HJ. Abortigenic but Not Neurotropic Equine Herpes Virus 1 Modulates the Interferon Antiviral Defense.. Front Cell Infect Microbiol 2018;8:312.
                doi: 10.3389/fcimb.2018.00312pubmed: 30258819google scholar: lookup
              49. Burns EN, Finno CJ. Equine degenerative myeloencephalopathy: prevalence, impact, and management.. Vet Med (Auckl) 2018;9:63-67.
                doi: 10.2147/VMRR.S148542pubmed: 30234005google scholar: lookup
              50. Seeber PA, Quintard B, Sicks F, Dehnhard M, Greenwood AD, Franz M. Environmental stressors may cause equine herpesvirus reactivation in captive Grévy's zebras (Equus grevyi).. PeerJ 2018;6:e5422.
                doi: 10.7717/peerj.5422pubmed: 30155350google scholar: lookup
              51. Schnabel CL, Wimer CL, Perkins G, Babasyan S, Freer H, Watts C, Rollins A, Osterrieder N, Wagner B. Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity.. BMC Vet Res 2018 Aug 22;14(1):245.
                doi: 10.1186/s12917-018-1563-4pubmed: 30134896google scholar: lookup
              52. Stokol T, Serpa PBS, Brooks MB, Divers T, Ness S. Subcutaneous Administration of Low-Molecular-Weight Heparin to Horses Inhibits Ex Vivo Equine Herpesvirus Type 1-Induced Platelet Activation.. Front Vet Sci 2018;5:106.
                doi: 10.3389/fvets.2018.00106pubmed: 29892605google scholar: lookup
              53. Tallmadge RL, Žygelytė E, Van de Walle GR, Kristie TM, Felippe MJB. Effect of a Histone Demethylase Inhibitor on Equine Herpesvirus-1 Activity In Vitro.. Front Vet Sci 2018;5:34.
                doi: 10.3389/fvets.2018.00034pubmed: 29594155google scholar: lookup
              54. Bryant NA, Wilkie GS, Russell CA, Compston L, Grafham D, Clissold L, McLay K, Medcalf L, Newton R, Davison AJ, Elton DM. Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks.. Transbound Emerg Dis 2018 Jun;65(3):817-832.
                doi: 10.1111/tbed.12809pubmed: 29423949google scholar: lookup
              55. Garvey M, Suárez NM, Kerr K, Hector R, Moloney-Quinn L, Arkins S, Davison AJ, Cullinane A. Equid herpesvirus 8: Complete genome sequence and association with abortion in mares.. PLoS One 2018;13(2):e0192301.
                doi: 10.1371/journal.pone.0192301pubmed: 29414990google scholar: lookup
              56. Dehghanpir SD, Birkenheuer CH, Yang K, Murelli RP, Morrison LA, Le Grice SFJ, Baines JD. Broad anti-herpesviral activity of α-hydroxytropolones.. Vet Microbiol 2018 Feb;214:125-131.
                doi: 10.1016/j.vetmic.2017.12.016pubmed: 29408023google scholar: lookup
              57. Kumar R, Patil RD. Cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases.. Vet World 2017 Dec;10(12):1427-1438.
              58. Okada A, Suganuma S, Badr Y, Omatsu T, Mizutani T, Ohya K, Fukushi H. Decreased expression of the immediate early protein, ICP4, by deletion of the tegument protein VP22 of equine herpesvirus type 1.. J Vet Med Sci 2018 Feb 20;80(2):311-315.
                doi: 10.1292/jvms.17-0380pubmed: 29279464google scholar: lookup
              59. Paillot R, Marcillaud Pitel C, D'Ablon X, Pronost S. Equine Vaccines: How, When and Why? Report of the Vaccinology Session, French Equine Veterinarians Association, 2016, Reims.. Vaccines (Basel) 2017 Dec 4;5(4).
                doi: 10.3390/vaccines5040046pubmed: 29207516google scholar: lookup
              60. Van Cleemput J, Poelaert KCK, Laval K, Maes R, Hussey GS, Van den Broeck W, Nauwynck HJ. Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions.. Sci Rep 2017 Nov 30;7(1):16656.
                doi: 10.1038/s41598-017-16804-5pubmed: 29192251google scholar: lookup
              61. Pennington MR, Ledbetter EC, Van de Walle GR. New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems.. Viruses 2017 Nov 18;9(11).
                doi: 10.3390/v9110349pubmed: 29156583google scholar: lookup
              62. Hue ES, Richard EA, Fortier CI, Fortier GD, Paillot R, Raue R, Pronost SL. Equine PBMC Cytokines Profile after In Vitro α- and γ-EHV Infection: Efficacy of a Parapoxvirus Ovis Based-Immunomodulator Treatment.. Vaccines (Basel) 2017 Sep 19;5(3).
                doi: 10.3390/vaccines5030028pubmed: 28925977google scholar: lookup
              63. Platiša L, Brantegem LV, Kumcu A, Ducatelle R, Philips W. Influence of study design on digital pathology image quality evaluation: the need to define a clinical task.. J Med Imaging (Bellingham) 2017 Apr;4(2):021108.
                doi: 10.1117/1.JMI.4.2.021108pubmed: 28653011google scholar: lookup
              64. Stasiak K, Dunowska M, Hills SF, Rola J. Genetic characterization of equid herpesvirus type 1 from cases of abortion in Poland.. Arch Virol 2017 Aug;162(8):2329-2335.
                doi: 10.1007/s00705-017-3376-3pubmed: 28451902google scholar: lookup
              65. Dayaram A, Franz M, Schattschneider A, Damiani AM, Bischofberger S, Osterrieder N, Greenwood AD. Long term stability and infectivity of herpesviruses in water.. Sci Rep 2017 Apr 21;7:46559.
                doi: 10.1038/srep46559pubmed: 28429732google scholar: lookup
              66. Zhao J, Poelaert KCK, Van Cleemput J, Nauwynck HJ. CCL2 and CCL5 driven attraction of CD172a(+) monocytic cells during an equine herpesvirus type 1 (EHV-1) infection in equine nasal mucosa and the impact of two migration inhibitors, rosiglitazone (RSG) and quinacrine (QC).. Vet Res 2017 Feb 27;48(1):14.
                doi: 10.1186/s13567-017-0419-4pubmed: 28241864google scholar: lookup
              67. Franz M, Goodman LB, Van de Walle GR, Osterrieder N, Greenwood AD. A Point Mutation in a Herpesvirus Co-Determines Neuropathogenicity and Viral Shedding.. Viruses 2017 Jan 10;9(1).
                doi: 10.3390/v9010006pubmed: 28075374google scholar: lookup
              68. Wagner B, Perkins G, Babasyan S, Freer H, Keggan A, Goodman LB, Glaser A, Torsteinsdóttir S, Svansson V, Björnsdóttir S. Neonatal Immunization with a Single IL-4/Antigen Dose Induces Increased Antibody Responses after Challenge Infection with Equine Herpesvirus Type 1 (EHV-1) at Weanling Age.. PLoS One 2017;12(1):e0169072.
                doi: 10.1371/journal.pone.0169072pubmed: 28045974google scholar: lookup
              69. Faverjon C, Vial F, Andersson MG, Lecollinet S, Leblond A. Early detection of West Nile virus in France: quantitative assessment of syndromic surveillance system using nervous signs in horses.. Epidemiol Infect 2017 Apr;145(5):1044-1057.
                doi: 10.1017/S0950268816002946pubmed: 27938434google scholar: lookup
              70. Stokol T, Serpa PBS, Zahid MN, Brooks MB. Unfractionated and Low-Molecular-Weight Heparin and the Phosphodiesterase Inhibitors, IBMX and Cilostazol, Block Ex Vivo Equid Herpesvirus Type-1-Induced Platelet Activation.. Front Vet Sci 2016;3:99.
                doi: 10.3389/fvets.2016.00099pubmed: 27909693google scholar: lookup
              71. Perez-Ecija A, Mendoza FJ, Estepa JC, Bautista MJ, Pérez J. Equid herpesvirus 1 and rhodococcus equi coinfection in a foal with bronchointerstitial pneumonia.. J Vet Med Sci 2016 Oct 1;78(9):1511-1513.
                doi: 10.1292/jvms.16-0024pubmed: 27264610google scholar: lookup
              72. Houtsma A, Bedenice D, Pusterla N, Pugliese B, Mapes S, Hoffman AM, Paxson J, Rozanski E, Mukherjee J, Wigley M, Mazan MR. Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study.. Multidiscip Respir Med 2015;10:33.
                doi: 10.1186/s40248-015-0030-3pubmed: 26535117google scholar: lookup
              73. Taktaz Hafshejani T, Nekoei S, Vazirian B, Doosti A, Khamesipour F, Anyanwu MU. Molecular Detection of Equine Herpesvirus Types 1 and 4 Infection in Healthy Horses in Isfahan Central and Shahrekord Southwest Regions, Iran.. Biomed Res Int 2015;2015:917854.
                doi: 10.1155/2015/917854pubmed: 26421307google scholar: lookup
              74. Badenhorst M, Page P, Ganswindt A, Laver P, Guthrie A, Schulman M. Detection of equine herpesvirus-4 and physiological stress patterns in young Thoroughbreds consigned to a South African auction sale.. BMC Vet Res 2015 Jun 2;11:126.
                doi: 10.1186/s12917-015-0443-4pubmed: 26033323google scholar: lookup
              75. Okada A, Izume S, Ohya K, Fukushi H. Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells.. J Vet Med Sci 2015 Oct;77(10):1293-7.
                doi: 10.1292/jvms.14-0648pubmed: 25948053google scholar: lookup
              76. Stokol T, Yeo WM, Burnett D, DeAngelis N, Huang T, Osterrieder N, Catalfamo J. Equid herpesvirus type 1 activates platelets.. PLoS One 2015;10(4):e0122640.
                doi: 10.1371/journal.pone.0122640pubmed: 25905776google scholar: lookup
              77. Ohta M, Nemoto M, Tsujimura K, Kondo T, Matsumura T. Evaluation of the usefulness of a PCR assay performed at a clinical laboratory for the diagnosis of respiratory disease induced by equine herpesvirus type 1 in the field.. J Equine Sci 2011;22(3):53-6.
                doi: 10.1294/jes.22.53pubmed: 24833987google scholar: lookup
              78. Schulman M, Becker A, Ganswindt S, Guthrie A, Stout T, Ganswindt A. The effect of consignment to broodmare sales on physiological stress measured by faecal glucocorticoid metabolites in pregnant Thoroughbred mares.. BMC Vet Res 2014 Jan 17;10:25.
                doi: 10.1186/1746-6148-10-25pubmed: 24433380google scholar: lookup
              79. Hussey GS, Goehring LS, Lunn DP, Hussey SB, Huang T, Osterrieder N, Powell C, Hand J, Holz C, Slater J. Experimental infection with equine herpesvirus type 1 (EHV-1) induces chorioretinal lesions.. Vet Res 2013 Dec 5;44(1):118.
                doi: 10.1186/1297-9716-44-118pubmed: 24308772google scholar: lookup
              80. Walter J, Seeh C, Fey K, Bleul U, Osterrieder N. Clinical observations and management of a severe equine herpesvirus type 1 outbreak with abortion and encephalomyelitis.. Acta Vet Scand 2013 Mar 5;55(1):19.
                doi: 10.1186/1751-0147-55-19pubmed: 23497661google scholar: lookup
              81. Yeo WM, Osterrieder N, Stokol T. Equine herpesvirus type 1 infection induces procoagulant activity in equine monocytes.. Vet Res 2013 Mar 11;44(1):16.
                doi: 10.1186/1297-9716-44-16pubmed: 23497076google scholar: lookup
              82. Carmichael RJ, Whitfield C, Maxwell LK. Pharmacokinetics of ganciclovir and valganciclovir in the adult horse.. J Vet Pharmacol Ther 2013 Oct;36(5):441-9.
                doi: 10.1111/jvp.12029pubmed: 23301502google scholar: lookup
              83. Fukushi H, Yamaguchi T, Yamada S. Complete genome sequence of equine herpesvirus type 9.. J Virol 2012 Dec;86(24):13822.
                doi: 10.1128/JVI.02607-12pubmed: 23166237google scholar: lookup
              84. Azab W, Zajic L, Osterrieder N. The role of glycoprotein H of equine herpesviruses 1 and 4 (EHV-1 and EHV-4) in cellular host range and integrin binding.. Vet Res 2012 Aug 21;43(1):61.
                doi: 10.1186/1297-9716-43-61pubmed: 22909178google scholar: lookup
              85. Goodman LB, Wimer C, Dubovi EJ, Gold C, Wagner B. Immunological correlates of vaccination and infection for equine herpesvirus 1.. Clin Vaccine Immunol 2012 Feb;19(2):235-41.
                doi: 10.1128/CVI.05522-11pubmed: 22205656google scholar: lookup