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The Veterinary clinics of North America. Equine practice2014; 30(3); 543-560; doi: 10.1016/j.cveq.2014.08.011

Equine viral arteritis.

Abstract: Equine arteritis virus (EAV), the causative agent of equine viral arteritis (EVA), is a respiratory and reproductive disease that occurs throughout the world. EAV infection is highly species-specific and exclusively limited to members of the family Equidae, which includes horses, donkeys, mules, and zebras. EVA is an economically important disease and outbreaks could cause significant losses to the equine industry. The primary objective of this article is to summarize current understanding of EVA, specifically the disease, pathogenesis, epidemiology, host immune response, vaccination and treatment strategies, prevention and control measures, and future directions.
Publication Date: 2014-11-06 PubMed ID: 25441113DOI: 10.1016/j.cveq.2014.08.011Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Equine Viral Arteritis (EVA) is a significant yet infrequent disease in horses that can lead to both direct and indirect financial losses. Through strategies like serological and virological screening, effective quarantine, and strategic vaccination, EAV infection and EVA can be effectively prevented.

Understanding Equine Viral Arteritis (EVA)

  • Equine Viral Arteritis (EVA) is a disease that primarily affects horses. Although it’s not a common disease, when it does strike it can yield severe repercussions.
  • The disease can lead to a variety of directly harmful effects on the horses, including causing abortions, sparking pneumonia in newborn horses, and initiating febrile (fever-based) disease in performance horses. Thus, it can cause considerable health damage to horses and disrupt breeding and performance activities.

Economic Consequences of EVA

  • The harm EVA can cause to horses translates into potential economic costs. This includes direct costs resulting from the health impacts on horses, for example, loss of potential income from aborted foals and decrease in performance of infected horses.
  • Beyond these direct costs, EVA can also bring about indirect financial losses. These mostly come in the form of restrictions on the movement of horses, especially carrier stallions who are persistently infected and their semen, due to national and international trades and animal movement regulations. Restrictions can inhibit the selling or breeding potential of stallions and might necessitate expensive testing or treatments.

Preventing EAV Infection and EVA

  • The paper highlights that there are effective strategies available to prevent Equine Arteritis Virus (EAV) infection and consequently, EVA. These strategies are primarily preventive and revolve around the principles of good herd management.
  • Serological and virological screenings are suggested, which are tests that can detect markers in the horse’s blood that indicate an EAV infection. By identifying infected horses, they can be treated or isolated appropriately to prevent the spread of the virus.
  • Implementing appropriate quarantine procedures for newly acquired or infected horses helps to control the spread of EAV within a herd. By separating these horses, they can’t infect others and can be treated without risk to the rest of the population.
  • Strategic vaccination is another primary prevention method. Vaccinations help to “train” the horse’s immune system to fight off the virus if exposure occurs, thus preventing the development of EVA.

These combined strategies can not only prevent EVA, but also help manage the disease if outbreaks do occur, limiting the negative health effects and economic impacts.

Cite This Article

APA
Balasuriya UB. (2014). Equine viral arteritis. Vet Clin North Am Equine Pract, 30(3), 543-560. https://doi.org/10.1016/j.cveq.2014.08.011

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 30
Issue: 3
Pages: 543-560

Researcher Affiliations

Balasuriya, Udeni B R
  • Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY 40546-0099, USA. Electronic address: ubalasuriya@uky.edu.

MeSH Terms

  • Abortion, Veterinary / virology
  • Animals
  • Arteritis / physiopathology
  • Arteritis / veterinary
  • Arteritis / virology
  • Arterivirus Infections / physiopathology
  • Arterivirus Infections / veterinary
  • Arterivirus Infections / virology
  • Equartevirus / isolation & purification
  • Equidae
  • Female
  • Horse Diseases / physiopathology
  • Horse Diseases / virology
  • Horses
  • Pregnancy

Citations

This article has been cited 12 times.
  1. Thieulent CJ, Sarkar S, Carossino M, Bhowmik M, Zhu H, Balasuriya UBR. Cell Surface Vimentin Is an Attachment Factor That Facilitates Equine Arteritis Virus Infection In Vitro. Viruses 2026 Jan 15;18(1).
    doi: 10.3390/v18010113pubmed: 41600875google scholar: lookup
  2. Thieulent CJ, Carossino M, Balasuriya UBR, Graves K, Bailey E, Eberth J, Canisso IF, Andrews FM, Keowen ML, Go YY. Development of a TaqMan(®) Allelic Discrimination qPCR Assay for Rapid Detection of Equine CXCL16 Allelic Variants Associated With the Establishment of Long-Term Equine Arteritis Virus Carrier State in Stallions. Front Genet 2022;13:871875.
    doi: 10.3389/fgene.2022.871875pubmed: 35495124google scholar: lookup
  3. Chaudhari J, Liew CS, Workman AM, Riethoven JM, Steffen D, Sillman S, Vu HLX. Host Transcriptional Response to Persistent Infection with a Live-Attenuated Porcine Reproductive and Respiratory Syndrome Virus Strain. Viruses 2020 Jul 28;12(8).
    doi: 10.3390/v12080817pubmed: 32731586google scholar: lookup
  4. Satué K, Gardon JC, Muñoz A. Clinical and laboratorial description of the differential diagnoses of hemostatic disorders in the horse. Iran J Vet Res 2020 Winter;21(1):1-8.
    pubmed: 32368218
  5. Carossino M, Dini P, Kalbfleisch TS, Loynachan AT, Canisso IF, Cook RF, Timoney PJ, Balasuriya UBR. Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis. PLoS Pathog 2019 Jul;15(7):e1007950.
    doi: 10.1371/journal.ppat.1007950pubmed: 31356622google scholar: lookup
  6. Nam B, Mekuria Z, Carossino M, Li G, Zheng Y, Zhang J, Cook RF, Shuck KM, Campos JR, Squires EL, Troedsson MHT, Timoney PJ, Balasuriya UBR. Intrahost Selection Pressure Drives Equine Arteritis Virus Evolution during Persistent Infection in the Stallion Reproductive Tract. J Virol 2019 Jun 15;93(12).
    doi: 10.1128/JVI.00045-19pubmed: 30918077google scholar: lookup
  7. Bannai H, Nemoto M, Tsujimura K, Yamanaka T, Kokado H, Kondo T. Evaluation of two enzyme-linked immunosorbent assays for the detection of antibodies against equine arteritis virus. J Equine Sci 2018 Dec;29(4):111-115.
    doi: 10.1294/jes.29.111pubmed: 30607135google scholar: lookup
  8. Carossino M, Dini P, Kalbfleisch TS, Loynachan AT, Canisso IF, Shuck KM, Timoney PJ, Cook RF, Balasuriya UBR. Downregulation of MicroRNA eca-mir-128 in Seminal Exosomes and Enhanced Expression of CXCL16 in the Stallion Reproductive Tract Are Associated with Long-Term Persistence of Equine Arteritis Virus. J Virol 2018 May 1;92(9).
    doi: 10.1128/JVI.00015-18pubmed: 29444949google scholar: lookup
  9. Carossino M, Wagner B, Loynachan AT, Cook RF, Canisso IF, Chelvarajan L, Edwards CL, Nam B, Timoney JF, Timoney PJ, Balasuriya UBR. Equine Arteritis Virus Elicits a Mucosal Antibody Response in the Reproductive Tract of Persistently Infected Stallions. Clin Vaccine Immunol 2017 Oct;24(10).
    doi: 10.1128/CVI.00215-17pubmed: 28814389google scholar: lookup
  10. Carossino M, Loynachan AT, Canisso IF, Cook RF, Campos JR, Nam B, Go YY, Squires EL, Troedsson MHT, Swerczek T, Del Piero F, Bailey E, Timoney PJ, Balasuriya UBR. Equine Arteritis Virus Has Specific Tropism for Stromal Cells and CD8(+) T and CD21(+) B Lymphocytes but Not for Glandular Epithelium at the Primary Site of Persistent Infection in the Stallion Reproductive Tract. J Virol 2017 Jul 1;91(13).
    doi: 10.1128/JVI.00418-17pubmed: 28424285google scholar: lookup
  11. Sarkar S, Bailey E, Go YY, Cook RF, Kalbfleisch T, Eberth J, Chelvarajan RL, Shuck KM, Artiushin S, Timoney PJ, Balasuriya UB. Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion. PLoS Genet 2016 Dec;12(12):e1006467.
    doi: 10.1371/journal.pgen.1006467pubmed: 27930647google scholar: lookup
  12. Sarkar S, Chelvarajan L, Go YY, Cook F, Artiushin S, Mondal S, Anderson K, Eberth J, Timoney PJ, Kalbfleisch TS, Bailey E, Balasuriya UB. Equine Arteritis Virus Uses Equine CXCL16 as an Entry Receptor. J Virol 2016 Jan 13;90(7):3366-84.
    doi: 10.1128/JVI.02455-15pubmed: 26764004google scholar: lookup