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Lancet (London, England)1997; 349(9045); 93-95; doi: 10.1016/s0140-6736(96)06162-4

Fatal encephalitis due to novel paramyxovirus transmitted from horses.

Abstract: In September, 1994, an outbreak of severe respiratory disease affected 18 horses, their trainer, and a stablehand in Queensland, Australia. Fourteen horses and one human being died. A novel virus was isolated from those affected and named equine morbillivirus (EMV). We report a case of encephalitis caused by this virus. Results: A 35-year-old man from Queensland had a brief aseptic meningitic illness in August, 1994, shortly after caring for two horses that died from EMV infection and then assisting at their necropsies. He then suffered severe encephalitis 13 months later, characterised by uncontrolled focal and generalised epileptic activity. Rising titres of neutralising antibodies to EMV in the patient's serum at the time of the second illness suggested an anamnestic response. Distinctive cortical changes were shown on magnetic resonance neuroimaging and histopathological examination of the brain at necropsy. Immunohistochemistry and electronmicroscopy of brain tissue revealed pathology characteristic of the earlier cases of EMV infection. PCR on cerebrospinal fluid taken during the second illness, brain tissue, and serum retained from the original illness resulted in an amplified product identical to that previously described from EMV. Conclusions: The results of serology, PCR, electronmicroscopy, and immunohistochemistry strongly suggest that EMV was the cause of this patient's encephalitis, and that exposure to the virus occurred 3 months before the fatal illness.
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Publication Date: 1997-01-11 PubMed ID: 8996421DOI: 10.1016/s0140-6736(96)06162-4Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates a novel virus, named equine morbillivirus (EMV), that caused severe respiratory disease in horses and was later found to result in fatal encephalitis in a human who had cared for these horses. The study suggests that the human’s exposure to the virus and subsequent death was due to encephalitis resulting from the EMV infection.

Background and Case Presentation

  • Emerging in September 1994, an outbreak of severe respiratory disease affected 18 horses, their trainer, and a stablehand in Queensland, Australia. Fourteen horses and one human died as a result of the disease which was caused by a newly discovered virus, named equine morbillivirus (EMV).
  • A 35-year-old man who had previously cared for two horses who died of the EMV infection and assisted at their autopsy had an aseptic meningitic illness. He then developed severe encephalitis 13 months later, characterized by uncontrolled focal and generalised epileptic activity. Rising antibody titres against EMV in his serum during the second illness suggested an anamnestic response, indicating a rapid immune response to a previously encountered antigen.

Findings and Interpretation

  • Cortical changes were shown on Magnetic Resonance Imaging (MRI) scans and a histopathological examination of his brain at post-mortem confirmed these changes. Immunohistochemistry and electron microscopies of the brain tissue revealed damage similar to that observed in the earlier cases of EMV infection.>
  • Further examination using Polymerase Chain Reaction (PCR) on cerebrospinal fluid from the second illness, brain tissue, and serum retained from the original illness resulted in amplified products identical to those previously described from EMV, linking the patient’s illness to EMV.

Conclusion

  • The research concludes that the combination of serology, PCR, electron microscopy, and immunohistochemistry results strongly suggest that EMV was indeed the cause of this patient’s encephalitis. Furthermore, it is suggested that exposure to the virus occurred three months before the fatal encephallitis presented itself.

This study highlights the potential zoonotic risks of EMV and underlines the importance of disease surveillance in animals due to their potential to spill over into human populations.

Cite This Article

APA
O'Sullivan JD, Allworth AM, Paterson DL, Snow TM, Boots R, Gleeson LJ, Gould AR, Hyatt AD, Bradfield J. (1997). Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet, 349(9045), 93-95. https://doi.org/10.1016/s0140-6736(96)06162-4

Publication

Lancet (London, England)
ISSN: 0140-6736
NlmUniqueID: 2985213R
Country: England
Language: English
Volume: 349
Issue: 9045
Pages: 93-95

Researcher Affiliations

O'Sullivan, J D
  • Department of Neurology, Royal Brisbane Hospital, Herston, Queensland, Australia.
Allworth, A M
    Paterson, D L
      Snow, T M
        Boots, R
          Gleeson, L J
            Gould, A R
              Hyatt, A D
                Bradfield, J

                  MeSH Terms

                  • Adult
                  • Animals
                  • Brain / pathology
                  • Disease Outbreaks / veterinary
                  • Fatal Outcome
                  • Horse Diseases / transmission
                  • Horses
                  • Humans
                  • Male
                  • Meningoencephalitis / pathology
                  • Meningoencephalitis / virology
                  • Morbillivirus Infections / pathology
                  • Morbillivirus Infections / transmission
                  • Morbillivirus Infections / veterinary
                  • Occupational Exposure / adverse effects
                  • Zoonoses

                  Citations

                  This article has been cited 107 times.
                  1. Rockx B, Mire CE. Ferret Models for Henipavirus Infection. Methods Mol Biol 2023;2682:205-217.
                    doi: 10.1007/978-1-0716-3283-3_15pubmed: 37610584google scholar: lookup
                  2. Gazal S, Sharma N, Gazal S, Tikoo M, Shikha D, Badroo GA, Rashid M, Lee SJ. Nipah and Hendra Viruses: Deadly Zoonotic Paramyxoviruses with the Potential to Cause the Next Pandemic. Pathogens 2022 Nov 25;11(12).
                    doi: 10.3390/pathogens11121419pubmed: 36558753google scholar: lookup
                  3. Van Brussel K, Holmes EC. Zoonotic disease and virome diversity in bats. Curr Opin Virol 2022 Feb;52:192-202.
                    doi: 10.1016/j.coviro.2021.12.008pubmed: 34954661google scholar: lookup
                  4. Lewis CE, Pickering B. Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment. ILAR J 2022 Jan 7;61(1):86-102.
                    doi: 10.1093/ilar/ilab029pubmed: 34864994google scholar: lookup
                  5. Contreras EM, Monreal IA, Ruvalcaba M, Ortega V, Aguilar HC. Antivirals targeting paramyxovirus membrane fusion. Curr Opin Virol 2021 Dec;51:34-47.
                    doi: 10.1016/j.coviro.2021.09.003pubmed: 34592709google scholar: lookup
                  6. Yuen KY, Fraser NS, Henning J, Halpin K, Gibson JS, Betzien L, Stewart AJ. Hendra virus: Epidemiology dynamics in relation to climate change, diagnostic tests and control measures. One Health 2021 Jun;12:100207.
                    doi: 10.1016/j.onehlt.2020.100207pubmed: 33363250google scholar: lookup
                  7. Amaya M, Broder CC. Vaccines to Emerging Viruses: Nipah and Hendra. Annu Rev Virol 2020 Sep 29;7(1):447-473.
                    doi: 10.1146/annurev-virology-021920-113833pubmed: 32991264google scholar: lookup
                  8. Goh GX, Tan K, Ang BSP, Wang LF, Tchoyoson Lim CC. Neuroimaging in Zoonotic Outbreaks Affecting the Central Nervous System: Are We Fighting the Last War?. AJNR Am J Neuroradiol 2020 Oct;41(10):1760-1767.
                    doi: 10.3174/ajnr.A6727pubmed: 32819907google scholar: lookup
                  9. Åsjö B, Kruse H. Zoonoses in the Emergence of Human Viral Diseases. Perspect Med Virol 2006;16:15-41.
                    doi: 10.1016/S0168-7069(06)16003-6pubmed: 32287585google scholar: lookup
                  10. Breed AC, Field HE, Epstein JH, Daszak P. Emerging henipaviruses and flying foxes - Conservation and management perspectives. Biol Conserv 2006 Aug;131(2):211-220.
                    doi: 10.1016/j.biocon.2006.04.007pubmed: 32226079google scholar: lookup
                  11. Voigt K, Hoffmann M, Drexler JF, Müller MA, Drosten C, Herrler G, Krüger N. Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein. Viruses 2019 Aug 29;11(9).
                    doi: 10.3390/v11090800pubmed: 31470664google scholar: lookup
                  12. Slaughter KB, Dutch RE. Transmembrane Domain Dissociation Is Required for Hendra Virus F Protein Fusogenic Activity. J Virol 2019 Nov 15;93(22).
                    doi: 10.1128/JVI.01069-19pubmed: 31462574google scholar: lookup
                  13. Dawes BE, Freiberg AN. Henipavirus infection of the central nervous system. Pathog Dis 2019 Mar 1;77(2).
                    doi: 10.1093/femspd/ftz023pubmed: 30985897google scholar: lookup
                  14. Dawes BE, Kalveram B, Ikegami T, Juelich T, Smith JK, Zhang L, Park A, Lee B, Komeno T, Furuta Y, Freiberg AN. Favipiravir (T-705) protects against Nipah virus infection in the hamster model. Sci Rep 2018 May 15;8(1):7604.
                    doi: 10.1038/s41598-018-25780-3pubmed: 29765101google scholar: lookup
                  15. Greninger AL. A decade of RNA virus metagenomics is (not) enough. Virus Res 2018 Jan 15;244:218-229.
                    doi: 10.1016/j.virusres.2017.10.014pubmed: 29055712google scholar: lookup
                  16. Black P, Douglas I, Field H. This could be the start of something big-20 years since the identification of bats as the natural host of Hendra virus. One Health 2015 Dec;1:14-16.
                    doi: 10.1016/j.onehlt.2015.07.001pubmed: 28616459google scholar: lookup
                  17. Plowright RK, Peel AJ, Streicker DG, Gilbert AT, McCallum H, Wood J, Baker ML, Restif O. Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir-Host Populations. PLoS Negl Trop Dis 2016 Aug;10(8):e0004796.
                    doi: 10.1371/journal.pntd.0004796pubmed: 27489944google scholar: lookup
                  18. Broder CC, Weir DL, Reid PA. Hendra virus and Nipah virus animal vaccines. Vaccine 2016 Jun 24;34(30):3525-34.
                    doi: 10.1016/j.vaccine.2016.03.075pubmed: 27154393google scholar: lookup
                  19. Peel AJ, Field HE, Reid PA, Plowright RK, Broder CC, Skerratt LF, Hayman DT, Restif O, Taylor M, Martin G, Crameri G, Smith I, Baker M, Marsh GA, Barr J, Breed AC, Wood JL, Dhand N, Toribio JA, Cunningham AA, Fulton I, Bryden WL, Secombe C, Wang LF. The equine Hendra virus vaccine remains a highly effective preventative measure against infection in horses and humans: 'The imperative to develop a human vaccine for the Hendra virus in Australia'. Infect Ecol Epidemiol 2016;6:31658.
                    doi: 10.3402/iee.v6.31658pubmed: 27151273google scholar: lookup
                  20. Field HE, Smith CS, de Jong CE, Melville D, Broos A, Kung N, Thompson J, Dechmann DK. Landscape Utilisation, Animal Behaviour and Hendra Virus Risk. Ecohealth 2016 Mar;13(1):26-38.
                    doi: 10.1007/s10393-015-1066-8pubmed: 26403793google scholar: lookup
                  21. Ong KC, Wong KT. Henipavirus Encephalitis: Recent Developments and Advances. Brain Pathol 2015 Sep;25(5):605-13.
                    doi: 10.1111/bpa.12278pubmed: 26276024google scholar: lookup
                  22. Edson D, Field H, McMichael L, Jordan D, Kung N, Mayer D, Smith C. Flying-fox roost disturbance and Hendra virus spillover risk. PLoS One 2015;10(5):e0125881.
                    doi: 10.1371/journal.pone.0125881pubmed: 26016629google scholar: lookup
                  23. Enkirch T, von Messling V. Ferret models of viral pathogenesis. Virology 2015 May;479-480:259-70.
                    doi: 10.1016/j.virol.2015.03.017pubmed: 25816764google scholar: lookup
                  24. Wynne JW, Shiell BJ, Marsh GA, Boyd V, Harper JA, Heesom K, Monaghan P, Zhou P, Payne J, Klein R, Todd S, Mok L, Green D, Bingham J, Tachedjian M, Baker ML, Matthews D, Wang LF. Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL-mediated apoptosis. Genome Biol 2014;15(11):532.
                    doi: 10.1186/PREACCEPT-1718798964145132pubmed: 25398248google scholar: lookup
                  25. Middleton D. Hendra virus. Vet Clin North Am Equine Pract 2014 Dec;30(3):579-89.
                    doi: 10.1016/j.cveq.2014.08.004pubmed: 25281398google scholar: lookup
                  26. Mendez DH, Kelly J, Buttner P, Nowak M, Speare R. Management of the slowly emerging zoonosis, Hendra virus, by private veterinarians in Queensland, Australia: a qualitative study. BMC Vet Res 2014 Sep 17;10:215.
                    doi: 10.1186/s12917-014-0215-6pubmed: 25224910google scholar: lookup
                  27. Sun W, McCrory TS, Khaw WY, Petzing S, Myers T, Schmitt AP. Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes. J Virol 2014 Nov;88(22):13099-110.
                    doi: 10.1128/JVI.02103-14pubmed: 25210190google scholar: lookup
                  28. Mendez D, Buttner P, Speare R. Hendra virus in Queensland, Australia, during the winter of 2011: veterinarians on the path to better management strategies. Prev Vet Med 2014 Nov 1;117(1):40-51.
                    doi: 10.1016/j.prevetmed.2014.08.002pubmed: 25175674google scholar: lookup
                  29. Mancini DA, Pereira AS, Mendonça RM, Kawamoto AH, Alves RC, Pinto JR, Mori E, Richtzenhain LJ, Mancini-Filho J. Presence of respiratory viruses in equines in Brazil. Rev Inst Med Trop Sao Paulo 2014 May-Jun;56(3):191-5.
                    doi: 10.1590/s0036-46652014000300002pubmed: 24878995google scholar: lookup
                  30. Wynne JW, Wang LF. Bats and viruses: friend or foe?. PLoS Pathog 2013 Oct;9(10):e1003651.
                    doi: 10.1371/journal.ppat.1003651pubmed: 24204253google scholar: lookup
                  31. Pallister JA, Klein R, Arkinstall R, Haining J, Long F, White JR, Payne J, Feng YR, Wang LF, Broder CC, Middleton D. Vaccination of ferrets with a recombinant G glycoprotein subunit vaccine provides protection against Nipah virus disease for over 12 months. Virol J 2013 Jul 16;10:237.
                    doi: 10.1186/1743-422X-10-237pubmed: 23867060google scholar: lookup
                  32. Broder CC, Xu K, Nikolov DB, Zhu Z, Dimitrov DS, Middleton D, Pallister J, Geisbert TW, Bossart KN, Wang LF. A treatment for and vaccine against the deadly Hendra and Nipah viruses. Antiviral Res 2013 Oct;100(1):8-13.
                    doi: 10.1016/j.antiviral.2013.06.012pubmed: 23838047google scholar: lookup
                  33. McCaskill JL, Marsh GA, Monaghan P, Wang LF, Doran T, McMillan NA. Potent inhibition of Hendra virus infection via RNA interference and poly I:C immune activation. PLoS One 2013;8(5):e64360.
                    doi: 10.1371/journal.pone.0064360pubmed: 23691205google scholar: lookup
                  34. Escaffre O, Borisevich V, Carmical JR, Prusak D, Prescott J, Feldmann H, Rockx B. Henipavirus pathogenesis in human respiratory epithelial cells. J Virol 2013 Mar;87(6):3284-94.
                    doi: 10.1128/JVI.02576-12pubmed: 23302882google scholar: lookup
                  35. Taylor C, Playford EG, McBride WJ, McMahon J, Warrilow D. No evidence of prolonged Hendra virus shedding by 2 patients, Australia. Emerg Infect Dis 2012 Dec;18(12):2025-7.
                    doi: 10.3201/eid1812.120722pubmed: 23171522google scholar: lookup
                  36. Dups J, Middleton D, Yamada M, Monaghan P, Long F, Robinson R, Marsh GA, Wang LF. A new model for Hendra virus encephalitis in the mouse. PLoS One 2012;7(7):e40308.
                    doi: 10.1371/journal.pone.0040308pubmed: 22808132google scholar: lookup
                  37. Smith EC, Gregory SM, Tamm LK, Creamer TP, Dutch RE. Role of sequence and structure of the Hendra fusion protein fusion peptide in membrane fusion. J Biol Chem 2012 Aug 24;287(35):30035-48.
                    doi: 10.1074/jbc.M112.367862pubmed: 22761418google scholar: lookup
                  38. Broder CC. Henipavirus outbreaks to antivirals: the current status of potential therapeutics. Curr Opin Virol 2012 Apr;2(2):176-87.
                    doi: 10.1016/j.coviro.2012.02.016pubmed: 22482714google scholar: lookup
                  39. Broder CC, Geisbert TW, Xu K, Nikolov DB, Wang LF, Middleton D, Pallister J, Bossart KN. Immunization strategies against henipaviruses. Curr Top Microbiol Immunol 2012;359:197-223.
                    doi: 10.1007/82_2012_213pubmed: 22481140google scholar: lookup
                  40. Geisbert TW, Feldmann H, Broder CC. Animal challenge models of henipavirus infection and pathogenesis. Curr Top Microbiol Immunol 2012;359:153-77.
                    doi: 10.1007/82_2012_208pubmed: 22476556google scholar: lookup
                  41. Mendez DH, Judd J, Speare R. Unexpected result of Hendra virus outbreaks for veterinarians, Queensland, Australia. Emerg Infect Dis 2012 Jan;18(1):83-5.
                    doi: 10.3201/eid1801.111006pubmed: 22261152google scholar: lookup
                  42. Peel AJ, Baker KS, Crameri G, Barr JA, Hayman DT, Wright E, Broder CC, Fernández-Loras A, Fooks AR, Wang LF, Cunningham AA, Wood JL. Henipavirus neutralising antibodies in an isolated island population of African fruit bats. PLoS One 2012;7(1):e30346.
                    doi: 10.1371/journal.pone.0030346pubmed: 22253928google scholar: lookup
                  43. Breed AC, Breed MF, Meers J, Field HE. Evidence of endemic Hendra virus infection in flying-foxes (Pteropus conspicillatus)--implications for disease risk management. PLoS One 2011;6(12):e28816.
                    doi: 10.1371/journal.pone.0028816pubmed: 22194920google scholar: lookup
                  44. Marsh GA, Haining J, Hancock TJ, Robinson R, Foord AJ, Barr JA, Riddell S, Heine HG, White JR, Crameri G, Field HE, Wang LF, Middleton D. Experimental infection of horses with Hendra virus/Australia/horse/2008/Redlands. Emerg Infect Dis 2011 Dec;17(12):2232-8.
                    doi: 10.3201/eid1712.111162pubmed: 22172152google scholar: lookup
                  45. Wong KT, Ong KC. Pathology of acute henipavirus infection in humans and animals. Patholog Res Int 2011;2011:567248.
                    doi: 10.4061/2011/567248pubmed: 21961078google scholar: lookup
                  46. Virtue ER, Marsh GA, Baker ML, Wang LF. Interferon production and signaling pathways are antagonized during henipavirus infection of fruit bat cell lines. PLoS One 2011;6(7):e22488.
                    doi: 10.1371/journal.pone.0022488pubmed: 21811620google scholar: lookup
                  47. Pallister J, Middleton D, Wang LF, Klein R, Haining J, Robinson R, Yamada M, White J, Payne J, Feng YR, Chan YP, Broder CC. A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge. Vaccine 2011 Aug 5;29(34):5623-30.
                    doi: 10.1016/j.vaccine.2011.06.015pubmed: 21689706google scholar: lookup
                  48. Rockx B, Brining D, Kramer J, Callison J, Ebihara H, Mansfield K, Feldmann H. Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection. J Virol 2011 Aug;85(15):7658-71.
                    doi: 10.1128/JVI.00473-11pubmed: 21593160google scholar: lookup
                  49. Plowright RK, Foley P, Field HE, Dobson AP, Foley JE, Eby P, Daszak P. Urban habituation, ecological connectivity and epidemic dampening: the emergence of Hendra virus from flying foxes (Pteropus spp.). Proc Biol Sci 2011 Dec 22;278(1725):3703-12.
                    doi: 10.1098/rspb.2011.0522pubmed: 21561971google scholar: lookup
                  50. Sohayati AR, Hassan L, Sharifah SH, Lazarus K, Zaini CM, Epstein JH, Shamsyul Naim N, Field HE, Arshad SS, Abdul Aziz J, Daszak P. Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus. Epidemiol Infect 2011 Oct;139(10):1570-9.
                    doi: 10.1017/S0950268811000550pubmed: 21524339google scholar: lookup
                  51. Vigant F, Lee B. Hendra and nipah infection: pathology, models and potential therapies. Infect Disord Drug Targets 2011 Jun;11(3):315-36.
                    doi: 10.2174/187152611795768097pubmed: 21488828google scholar: lookup
                  52. Porotto M, Yi F, Moscona A, LaVan DA. Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. PLoS One 2011 Mar 1;6(3):e16874.
                    doi: 10.1371/journal.pone.0016874pubmed: 21390296google scholar: lookup
                  53. Tulsiani SM, Graham GC, Moore PR, Jansen CC, Van Den Hurk AF, Moore FA, Simmons RJ, Craig SB. Emerging tropical diseases in Australia. Part 5. Hendra virus. Ann Trop Med Parasitol 2011 Jan;105(1):1-11.
                    doi: 10.1179/136485911X12899838413547pubmed: 21294944google scholar: lookup
                  54. Porotto M, Rockx B, Yokoyama CC, Talekar A, Devito I, Palermo LM, Liu J, Cortese R, Lu M, Feldmann H, Pessi A, Moscona A. Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry. PLoS Pathog 2010 Oct 28;6(10):e1001168.
                    doi: 10.1371/journal.ppat.1001168pubmed: 21060819google scholar: lookup
                  55. Smith EC, Dutch RE. Side chain packing below the fusion peptide strongly modulates triggering of the Hendra virus F protein. J Virol 2010 Oct;84(20):10928-32.
                    doi: 10.1128/JVI.01108-10pubmed: 20702638google scholar: lookup
                  56. Aljofan M, Lo MK, Rota PA, Michalski WP, Mungall BA. Off Label Antiviral Therapeutics for Henipaviruses: New Light Through Old Windows. J Antivir Antiretrovir 2010 Jan 1;2(1):1-10.
                    doi: 10.4172/jaa.1000014pubmed: 20668647google scholar: lookup
                  57. Rockx B, Bossart KN, Feldmann F, Geisbert JB, Hickey AC, Brining D, Callison J, Safronetz D, Marzi A, Kercher L, Long D, Broder CC, Feldmann H, Geisbert TW. A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment. J Virol 2010 Oct;84(19):9831-9.
                    doi: 10.1128/JVI.01163-10pubmed: 20660198google scholar: lookup
                  58. Wong KT. Emerging epidemic viral encephalitides with a special focus on henipaviruses. Acta Neuropathol 2010 Sep;120(3):317-25.
                    doi: 10.1007/s00401-010-0720-zpubmed: 20652579google scholar: lookup
                  59. Rihtaric D, Hostnik P, Steyer A, Grom J, Toplak I. Identification of SARS-like coronaviruses in horseshoe bats (Rhinolophus hipposideros) in Slovenia. Arch Virol 2010 Apr;155(4):507-14.
                    doi: 10.1007/s00705-010-0612-5pubmed: 20217155google scholar: lookup
                  60. Playford EG, McCall B, Smith G, Slinko V, Allen G, Smith I, Moore F, Taylor C, Kung YH, Field H. Human Hendra virus encephalitis associated with equine outbreak, Australia, 2008. Emerg Infect Dis 2010 Feb;16(2):219-23.
                    doi: 10.3201/eid1602.090552pubmed: 20113550google scholar: lookup
                  61. Graham RL, Baric RS. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. J Virol 2010 Apr;84(7):3134-46.
                    doi: 10.1128/JVI.01394-09pubmed: 19906932google scholar: lookup
                  62. Freiberg AN, Worthy MN, Lee B, Holbrook MR. Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection. J Gen Virol 2010 Mar;91(Pt 3):765-72.
                    doi: 10.1099/vir.0.017269-0pubmed: 19889926google scholar: lookup
                  63. Aljofan M, Sganga ML, Lo MK, Rootes CL, Porotto M, Meyer AG, Saubern S, Moscona A, Mungall BA. Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro. Virol J 2009 Nov 4;6:187.
                    doi: 10.1186/1743-422X-6-187pubmed: 19889218google scholar: lookup
                  64. Tyler KL. Emerging viral infections of the central nervous system: part 2. Arch Neurol 2009 Sep;66(9):1065-74.
                    doi: 10.1001/archneurol.2009.189pubmed: 19752295google scholar: lookup
                  65. Wolf MC, Wang Y, Freiberg AN, Aguilar HC, Holbrook MR, Lee B. A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics. Virol J 2009 Jul 31;6:119.
                    doi: 10.1186/1743-422X-6-119pubmed: 19646266google scholar: lookup
                  66. Whitman SD, Smith EC, Dutch RE. Differential rates of protein folding and cellular trafficking for the Hendra virus F and G proteins: implications for F-G complex formation. J Virol 2009 Sep;83(17):8998-9001.
                    doi: 10.1128/JVI.00414-09pubmed: 19553334google scholar: lookup
                  67. Brüssow H. Europe, the bull and the Minotaur: the biological legacy of a Neolithic love story. Environ Microbiol 2009 Nov;11(11):2778-88.
                    doi: 10.1111/j.1462-2920.2009.01962.xpubmed: 19508344google scholar: lookup
                  68. Porotto M, Orefice G, Yokoyama CC, Mungall BA, Realubit R, Sganga ML, Aljofan M, Whitt M, Glickman F, Moscona A. Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. J Virol 2009 May;83(10):5148-55.
                    doi: 10.1128/JVI.00164-09pubmed: 19264786google scholar: lookup
                  69. Tan CT, Chua KB. Nipah virus encephalitis. Curr Infect Dis Rep 2008 Jul;10(4):315-20.
                    doi: 10.1007/s11908-008-0051-6pubmed: 18765105google scholar: lookup
                  70. Mungall BA, Schopman NC, Lambeth LS, Doran TJ. Inhibition of Henipavirus infection by RNA interference. Antiviral Res 2008 Dec;80(3):324-31.
                    doi: 10.1016/j.antiviral.2008.07.004pubmed: 18687361google scholar: lookup
                  71. Dominguez SR, O'Shea TJ, Oko LM, Holmes KV. Detection of group 1 coronaviruses in bats in North America. Emerg Infect Dis 2007 Sep;13(9):1295-300.
                    doi: 10.3201/eid1309.070491pubmed: 18252098google scholar: lookup
                  72. Porotto M, Carta P, Deng Y, Kellogg GE, Whitt M, Lu M, Mungall BA, Moscona A. Molecular determinants of antiviral potency of paramyxovirus entry inhibitors. J Virol 2007 Oct;81(19):10567-74.
                    doi: 10.1128/JVI.01181-07pubmed: 17652384google scholar: lookup
                  73. Gardner AE, Dutch RE. A conserved region in the F(2) subunit of paramyxovirus fusion proteins is involved in fusion regulation. J Virol 2007 Aug;81(15):8303-14.
                    doi: 10.1128/JVI.00366-07pubmed: 17507474google scholar: lookup
                  74. Gardner AE, Martin KL, Dutch RE. A conserved region between the heptad repeats of paramyxovirus fusion proteins is critical for proper F protein folding. Biochemistry 2007 May 1;46(17):5094-105.
                    doi: 10.1021/bi6025648pubmed: 17417875google scholar: lookup
                  75. Hanna JN, McBride WJ, Brookes DL, Shield J, Taylor CT, Smith IL, Craig SB, Smith GA. Hendra virus infection in a veterinarian. Med J Aust 2006 Nov 20;185(10):562-4.
                    doi: 10.5694/j.1326-5377.2006.tb00692.xpubmed: 17115969google scholar: lookup
                  76. Hagmaier K, Stock N, Goodbourn S, Wang LF, Randall R. A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species. J Gen Virol 2006 Dec;87(Pt 12):3649-3653.
                    doi: 10.1099/vir.0.82261-0pubmed: 17098981google scholar: lookup
                  77. Wong S, Lau S, Woo P, Yuen KY. Bats as a continuing source of emerging infections in humans. Rev Med Virol 2007 Mar-Apr;17(2):67-91.
                    doi: 10.1002/rmv.520pubmed: 17042030google scholar: lookup
                  78. Schowalter RM, Smith SE, Dutch RE. Characterization of human metapneumovirus F protein-promoted membrane fusion: critical roles for proteolytic processing and low pH. J Virol 2006 Nov;80(22):10931-41.
                    doi: 10.1128/JVI.01287-06pubmed: 16971452google scholar: lookup
                  79. Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev 2006 Jul;19(3):531-45.
                    doi: 10.1128/CMR.00017-06pubmed: 16847084google scholar: lookup
                  80. Eaton BT, Broder CC, Middleton D, Wang LF. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol 2006 Jan;4(1):23-35.
                    doi: 10.1038/nrmicro1323pubmed: 16357858google scholar: lookup
                  81. Mackenzie JS. Emerging zoonotic encephalitis viruses: lessons from Southeast Asia and Oceania. J Neurovirol 2005 Oct;11(5):434-40.
                    doi: 10.1080/13550280591002487pubmed: 16287684google scholar: lookup
                  82. Schierup MH, Mordhorst CH, Muller CP, Christensen LS. Evidence of recombination among early-vaccination era measles virus strains. BMC Evol Biol 2005 Oct 6;5:52.
                    doi: 10.1186/1471-2148-5-52pubmed: 16209713google scholar: lookup
                  83. Reynes JM, Counor D, Ong S, Faure C, Seng V, Molia S, Walston J, Georges-Courbot MC, Deubel V, Sarthou JL. Nipah virus in Lyle's flying foxes, Cambodia. Emerg Infect Dis 2005 Jul;11(7):1042-7.
                    doi: 10.3201/eid1107.041350pubmed: 16022778google scholar: lookup
                  84. Bender JB, Tsukayama DT. Horses and the risk of zoonotic infections. Vet Clin North Am Equine Pract 2004 Dec;20(3):643-53.
                    doi: 10.1016/j.cveq.2004.07.003pubmed: 15519824google scholar: lookup
                  85. Su JR. Emerging viral infections. Clin Lab Med 2004 Sep;24(3):773-95, vii.
                    doi: 10.1016/j.cll.2004.05.002pubmed: 15325064google scholar: lookup
                  86. Pager CT, Wurth MA, Dutch RE. Subcellular localization and calcium and pH requirements for proteolytic processing of the Hendra virus fusion protein. J Virol 2004 Sep;78(17):9154-63.
                    doi: 10.1128/JVI.78.17.9154-9163.2004pubmed: 15308711google scholar: lookup
                  87. Johnson RT. Emerging viral infections of the nervous system. J Neurovirol 2003 Apr;9(2):140-7.
                    doi: 10.1080/13550280390194091pubmed: 12707845google scholar: lookup
                  88. Cinque P, Bossolasco S, Lundkvist A. Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system. J Clin Virol 2003 Jan;26(1):1-28.
                    doi: 10.1016/s1386-6532(02)00173-7pubmed: 12589831google scholar: lookup
                  89. Wong KT, Shieh WJ, Kumar S, Norain K, Abdullah W, Guarner J, Goldsmith CS, Chua KB, Lam SK, Tan CT, Goh KJ, Chong HT, Jusoh R, Rollin PE, Ksiazek TG, Zaki SR. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002 Dec;161(6):2153-67.
                    doi: 10.1016/S0002-9440(10)64493-8pubmed: 12466131google scholar: lookup
                  90. Olson JG, Rupprecht C, Rollin PE, An US, Niezgoda M, Clemins T, Walston J, Ksiazek TG. Antibodies to Nipah-like virus in bats (Pteropus lylei), Cambodia. Emerg Infect Dis 2002 Sep;8(9):987-8.
                    doi: 10.3201/eid0809.010515pubmed: 12194780google scholar: lookup
                  91. Mackenzie JS, Chua KB, Daniels PW, Eaton BT, Field HE, Hall RA, Halpin K, Johansen CA, Kirkland PD, Lam SK, McMinn P, Nisbet DJ, Paru R, Pyke AT, Ritchie SA, Siba P, Smith DW, Smith GA, van den Hurk AF, Wang LF, Williams DT. Emerging viral diseases of Southeast Asia and the Western Pacific. Emerg Infect Dis 2001;7(3 Suppl):497-504.
                    doi: 10.3201/eid0707.017703pubmed: 11485641google scholar: lookup
                  92. Wang LF, Yu M, Hansson E, Pritchard LI, Shiell B, Michalski WP, Eaton BT. The exceptionally large genome of Hendra virus: support for creation of a new genus within the family Paramyxoviridae. J Virol 2000 Nov;74(21):9972-9.
                    doi: 10.1128/jvi.74.21.9972-9979.2000pubmed: 11024125google scholar: lookup
                  93. Lim CC, Sitoh YY, Hui F, Lee KE, Ang BS, Lim E, Lim WE, Oh HM, Tambyah PA, Wong JS, Tan CB, Chee TS. Nipah viral encephalitis or Japanese encephalitis? MR findings in a new zoonotic disease. AJNR Am J Neuroradiol 2000 Mar;21(3):455-61.
                    pubmed: 10730635
                  94. Mackenzie JS. Emerging viral diseases: an Australian perspective. Emerg Infect Dis 1999 Jan-Feb;5(1):1-8.
                    doi: 10.3201/eid0501.990101pubmed: 10081666google scholar: lookup
                  95. Weiss RA. Xenotransplantation. BMJ 1998 Oct 3;317(7163):931-4.
                    doi: 10.1136/bmj.317.7163.931pubmed: 9756815google scholar: lookup
                  96. Chant K, Chan R, Smith M, Dwyer DE, Kirkland P. Probable human infection with a newly described virus in the family Paramyxoviridae. The NSW Expert Group. Emerg Infect Dis 1998 Apr-Jun;4(2):273-5.
                    doi: 10.3201/eid0402.980215pubmed: 9621198google scholar: lookup
                  97. Pigeaud DD, Fenton KA, Turcinovic J, Borisevich V, Agans KN, Deer DJ, Harrison MB, Fears AC, Dobias NS, Prasad AN, Smith IL, Williams DT, Woolsey CB, Broder CC, Cross RW, Geisbert TW. Experimental challenge of African green monkeys with contemporary Hendra virus isolates produces divergent clinical disease. Emerg Microbes Infect 2025 Dec;14(1):2544735.
                    doi: 10.1080/22221751.2025.2544735pubmed: 40768740google scholar: lookup
                  98. van den Hurk S, Yondo A, Velayudhan BT. Laboratory Diagnosis of Hendra and Nipah: Two Emerging Zoonotic Diseases with One Health Significance. Viruses 2025 Jul 17;17(7).
                    doi: 10.3390/v17071003pubmed: 40733619google scholar: lookup
                  99. Arshad A, Reif AH, Cavalleri JV, Desvars-Larrive A. Zoonotic pathogens in equids in Central Europe: a systematic review. BMC Vet Res 2025 Jul 8;21(1):451.
                    doi: 10.1186/s12917-025-04915-5pubmed: 40629389google scholar: lookup
                  100. Lenhard L, Müller M, Diederich S, Loerzer L, Friedrichs V, Köllner B, Finke S, Dorhoi A, Pei G. Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells. Viruses 2025 Apr 16;17(4).
                    doi: 10.3390/v17040573pubmed: 40285015google scholar: lookup
                  101. Spengler JR, Lo MK, Welch SR, Spiropoulou CF. Henipaviruses: epidemiology, ecology, disease, and the development of vaccines and therapeutics. Clin Microbiol Rev 2025 Mar 13;38(1):e0012823.
                    doi: 10.1128/cmr.00128-23pubmed: 39714175google scholar: lookup
                  102. Meier K, Olejnik J, Hume AJ, Mühlberger E. A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses. Pathogens 2024 Jul 16;13(7).
                    doi: 10.3390/pathogens13070587pubmed: 39057814google scholar: lookup
                  103. Passchier TC, White JBR, Maskell DP, Byrne MJ, Ranson NA, Edwards TA, Barr JN. The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures. Sci Rep 2024 Jun 18;14(1):14099.
                    doi: 10.1038/s41598-024-58243-zpubmed: 38890308google scholar: lookup
                  104. Caruso S, Edwards SJ. Recently Emerged Novel Henipa-like Viruses: Shining a Spotlight on the Shrew. Viruses 2023 Dec 11;15(12).
                    doi: 10.3390/v15122407pubmed: 38140648google scholar: lookup
                  105. Dhivahar J, Parthasarathy A, Krishnan K, Kovi BS, Pandian GN. Bat-associated microbes: Opportunities and perils, an overview. Heliyon 2023 Dec;9(12):e22351.
                    doi: 10.1016/j.heliyon.2023.e22351pubmed: 38125540google scholar: lookup
                  106. Zhang D, Yang Y, Li M, Lu Y, Liu Y, Jiang J, Liu R, Liu J, Huang X, Li G, Qu J. Ecological Barrier Deterioration Driven by Human Activities Poses Fatal Threats to Public Health due to Emerging Infectious Diseases. Engineering (Beijing) 2022 Mar;10:155-166.
                    doi: 10.1016/j.eng.2020.11.002pubmed: 33903827google scholar: lookup
                  107. Wang LF, Michalski WP, Yu M, Pritchard LI, Crameri G, Shiell B, Eaton BT. A novel P/V/C gene in a new member of the Paramyxoviridae family, which causes lethal infection in humans, horses, and other animals. J Virol 1998 Feb;72(2):1482-90.
                    doi: 10.1128/JVI.72.2.1482-1490.1998pubmed: 9445051google scholar: lookup
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