FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Methods Mol Biol / Ferret Models for Henipavirus Infection.
Methods in molecular biology (Clifton, N.J.)2023; 2682; 205-217; doi: 10.1007/978-1-0716-3283-3_15

Ferret Models for Henipavirus Infection.

Abstract: Henipaviruses are emerging zoonotic viruses that can cause outbreaks of severe respiratory and neurological disease in humans and animals such as horses. The mechanism by which these viruses can cause disease remain largely unknown and to date there are no therapeutics or vaccines approved for use in humans. Nipah virus is listed on the World Health Organization R & D Blueprint list of epidemic threats. In order to advance the availability of effective therapeutics and vaccines and medicines that can be used to save lives and avert large scale crises, animal models are required which recapitulate the disease progression in humans. Ferrets are highly susceptible to infection with henipaviruses and develop both severe respiratory and neurological disease. Therefore, the ferret model is highly suitable for studies into both the pathogenesis of henipaviruses, as well as pre-clinical evaluation of intervention strategies.
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.
Get Full Text
Publication Date: 2023-08-23 PubMed ID: 37610584PubMed Central: 3291367DOI: 10.1007/978-1-0716-3283-3_15Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on henipaviruses, notably the Nipah virus, which are capable of causing serious respiratory and neurological diseases in humans and animals such as horses. The mechanisms for this are largely unknown and there are currently no approved treatments. The study suggests that ferrets, who exhibit severe reactions to these viruses, could be used as models for understanding the disease progression and testing potential therapeutic strategies.

Understanding Henipaviruses

  • Henipaviruses are a group of viruses that are transmitted to humans and other animals from fruit bats and can cause severe respiratory and neurological diseases.
  • The mechanisms through which these viruses cause disease are largely not understood, resulting in a lack of effective therapeutics or vaccines approved for use in humans.
  • The Nipah virus, a type of henipavirus, is considered an epidemic threat by the World Health Organization due to its potential for causing widespread disease outbreaks.

The Use of Ferrets in the Study

  • Ferrets, being highly susceptible to henipavirus infection, are considered a suitable model for studying the pathogenesis of these diseases.
  • When infected, ferrets develop both severe respiratory and neurological symptoms similar to humans, making them an appropriate species for such investigative works.
  • By studying the disease progression in ferrets, researchers hope to gain insight into how the virus behaves in humans, with the ultimate aim of developing effective treatments and/or vaccines.

Advancements in Therapeutics and Vaccines

  • The use of ferret models can aid in the pre-clinical evaluation of potential intervention strategies, offering a valuable resource in the path to developing treatments and vaccines.
  • Through these studies, researchers aim to produce medicines capable of saving lives and averting large-scale crises caused by outbreaks of henipaviruses in the future.

Cite This Article

APA
Rockx B, Mire CE. (2023). Ferret Models for Henipavirus Infection. Methods Mol Biol, 2682, 205-217. https://doi.org/10.1007/978-1-0716-3283-3_15

Publication

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
NlmUniqueID: 9214969
Country: United States
Language: English
Volume: 2682
Pages: 205-217

Researcher Affiliations

Rockx, Barry
  • Wageningen Bioveterinary Institute, Lelystad and Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands. Barry.rockx@wur.nl.
Mire, Chad E
  • Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
  • Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

MeSH Terms

  • Humans
  • Animals
  • Horses
  • Henipavirus Infections
  • Ferrets
  • Disease Outbreaks
  • Disease Progression
  • Epidemics

References

This article includes 26 references
  1. Escaffre O, Borisevich V, Rockx B. Pathogenesis of Hendra and Nipah virus infection in humans.. J Infect Dev Ctries 2013 Apr 17;7(4):308-11.
    doi: 10.3855/jidc.3648pubmed: 23592639google scholar: lookup
  2. Chew MH, Arguin PM, Shay DK, Goh KT, Rollin PE, Shieh WJ, Zaki SR, Rota PA, Ling AE, Ksiazek TG, Chew SK, Anderson LJ. Risk factors for Nipah virus infection among abattoir workers in Singapore.. J Infect Dis 2000 May;181(5):1760-3.
    doi: 10.1086/315443pubmed: 10823780google scholar: lookup
  3. Luby SP, Gurley ES, Hossain MJ. Transmission of human infection with Nipah virus.. Clin Infect Dis 2009 Dec 1;49(11):1743-8.
    doi: 10.1086/647951pubmed: 19886791google scholar: lookup
  4. Luby SP, Rahman M, Hossain MJ, Blum LS, Husain MM, Gurley E, Khan R, Ahmed BN, Rahman S, Nahar N, Kenah E, Comer JA, Ksiazek TG. Foodborne transmission of Nipah virus, Bangladesh.. Emerg Infect Dis 2006 Dec;12(12):1888-94.
    doi: 10.3201/eid1212.060732pubmed: 17326940pmc: 3291367google scholar: lookup
  5. O'Sullivan JD, Allworth AM, Paterson DL, Snow TM, Boots R, Gleeson LJ, Gould AR, Hyatt AD, Bradfield J. Fatal encephalitis due to novel paramyxovirus transmitted from horses.. Lancet 1997 Jan 11;349(9045):93-5.
    doi: 10.1016/S0140-6736(96)06162-4pubmed: 8996421google scholar: lookup
  6. Bossart KN, Zhu Z, Middleton D, Klippel J, Crameri G, Bingham J, McEachern JA, Green D, Hancock TJ, Chan YP, Hickey AC, Dimitrov DS, Wang LF, Broder CC. A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection.. PLoS Pathog 2009 Oct;5(10):e1000642.
    doi: 10.1371/journal.ppat.1000642pubmed: 19888339pmc: 2765826google scholar: lookup
  7. Kurup D, Wirblich C, Feldmann H, Marzi A, Schnell MJ. Rhabdovirus-based vaccine platforms against henipaviruses.. J Virol 2015 Jan;89(1):144-54.
    doi: 10.1128/JVI.02308-14pubmed: 25320306google scholar: lookup
  8. Lo MK, Bird BH, Chattopadhyay A, Drew CP, Martin BE, Coleman JD, Rose JK, Nichol ST, Spiropoulou CF. Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.. Antiviral Res 2014 Jan;101:26-9.
    doi: 10.1016/j.antiviral.2013.10.012pubmed: 24184127google scholar: lookup
  9. McEachern JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, Feng YR, Broder CC, Wang LF, Bossart KN. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats.. Vaccine 2008 Jul 23;26(31):3842-52.
    doi: 10.1016/j.vaccine.2008.05.016pubmed: 18556094pmc: 6186147google scholar: lookup
  10. van Doremalen N, Lambe T, Sebastian S, Bushmaker T, Fischer R, Feldmann F, Haddock E, Letko M, Avanzato VA, Rissanen I, LaCasse R, Scott D, Bowden TA, Gilbert S, Munster V. A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters.. PLoS Negl Trop Dis 2019 Jun;13(6):e0007462.
    doi: 10.1371/journal.pntd.0007462pubmed: 31170144pmc: 6581282google scholar: lookup
  11. Food Drug Administration HHS. New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Final rule.. Fed Regist 67:37988–37998.
  12. Rockx B. Recent developments in experimental animal models of Henipavirus infection.. Pathog Dis .
    doi: 10.1111/2049-632x.12149google scholar: lookup
  13. Middleton DJ, Westbury HA, Morrissy CJ, van der Heide BM, Russell GM, Braun MA, Hyatt AD. Experimental Nipah virus infection in pigs and cats.. J Comp Pathol 2002 Feb-Apr;126(2-3):124-36.
    doi: 10.1053/jcpa.2001.0532pubmed: 11945001google scholar: lookup
  14. Dhondt KP, Mathieu C, Chalons M, Reynaud JM, Vallve A, Raoul H, Horvat B. Type I interferon signaling protects mice from lethal henipavirus infection.. J Infect Dis 2013 Jan 1;207(1):142-51.
    doi: 10.1093/infdis/jis653pubmed: 23089589google scholar: lookup
  15. Geisbert TW, Daddario-DiCaprio KM, Hickey AC, Smith MA, Chan YP, Wang LF, Mattapallil JJ, Geisbert JB, Bossart KN, Broder CC. Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection.. PLoS One 2010 May 18;5(5):e10690.
    doi: 10.1371/journal.pone.0010690pubmed: 20502528pmc: 2872660google scholar: lookup
  16. Pallister J, Middleton D, Wang LF, Klein R, Haining J, Robinson R, Yamada M, White J, Payne J, Feng YR, Chan YP, Broder CC. A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge.. Vaccine 2011 Aug 5;29(34):5623-30.
    doi: 10.1016/j.vaccine.2011.06.015pubmed: 21689706pmc: 3153950google scholar: lookup
  17. Rockx B, Bossart KN, Feldmann F, Geisbert JB, Hickey AC, Brining D, Callison J, Safronetz D, Marzi A, Kercher L, Long D, Broder CC, Feldmann H, Geisbert TW. A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment.. J Virol 2010 Oct;84(19):9831-9.
    doi: 10.1128/JVI.01163-10pubmed: 20660198pmc: 2937751google scholar: lookup
  18. Williamson MM, Hooper PT, Selleck PW, Westbury HA, Slocombe RF. Experimental hendra virus infectionin pregnant guinea-pigs and fruit Bats (Pteropus poliocephalus).. J Comp Pathol 2000 Feb-Apr;122(2-3):201-7.
    doi: 10.1053/jcpa.1999.0364pubmed: 10684689google scholar: lookup
  19. Wong KT, Grosjean I, Brisson C, Blanquier B, Fevre-Montange M, Bernard A, Loth P, Georges-Courbot MC, Chevallier M, Akaoka H, Marianneau P, Lam SK, Wild TF, Deubel V. A golden hamster model for human acute Nipah virus infection.. Am J Pathol 2003 Nov;163(5):2127-37.
    doi: 10.1016/S0002-9440(10)63569-9pubmed: 14578210pmc: 1892425google scholar: lookup
  20. Smith H, Sweet C. Lessons for human influenza from pathogenicity studies with ferrets.. Rev Infect Dis 1988 Jan-Feb;10(1):56-75.
    doi: 10.1093/clinids/10.1.56pubmed: 3281223google scholar: lookup
  21. Clayton BA, Middleton D, Bergfeld J, Haining J, Arkinstall R, Wang L, Marsh GA. Transmission routes for nipah virus from Malaysia and Bangladesh.. Emerg Infect Dis 2012 Dec;18(12):1983-93.
    doi: 10.3201/eid1812.120875pubmed: 23171621pmc: 3557903google scholar: lookup
  22. Mire CE, Versteeg KM, Cross RW, Agans KN, Fenton KA, Whitt MA, Geisbert TW. Single injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease.. Virol J 2013 Dec 13;10:353.
    doi: 10.1186/1743-422X-10-353pubmed: 24330654pmc: 3878732google scholar: lookup
  23. Pallister JA, Klein R, Arkinstall R, Haining J, Long F, White JR, Payne J, Feng YR, Wang LF, Broder CC, Middleton D. Vaccination of ferrets with a recombinant G glycoprotein subunit vaccine provides protection against Nipah virus disease for over 12 months.. Virol J 2013 Jul 16;10:237.
    doi: 10.1186/1743-422X-10-237pubmed: 23867060pmc: 3718761google scholar: lookup
  24. León AJ, Banner D, Xu L, Ran L, Peng Z, Yi K, Chen C, Xu F, Huang J, Zhao Z, Lin Z, Huang SH, Fang Y, Kelvin AA, Ross TM, Farooqui A, Kelvin DJ. Sequencing, annotation, and characterization of the influenza ferret infectome.. J Virol 2013 Feb;87(4):1957-66.
    doi: 10.1128/JVI.02476-12pubmed: 23236062pmc: 3571481google scholar: lookup
  25. Leon AJ, Borisevich V, Boroumand N, Seymour R, Nusbaum R, Escaffre O, Xu L, Kelvin DJ, Rockx B. Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains.. PLoS Negl Trop Dis 2018 Mar;12(3):e0006343.
    doi: 10.1371/journal.pntd.0006343pubmed: 29538374pmc: 5868854google scholar: lookup
  26. Barthold SW, Bayne KA, Davis MA. Guide for the care and use of laboratory animals.. National Academy Press, Washington.

Citations

This article has been cited 0 times.
Subscribe to our newsletter
Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.