Gene therapy: future therapies in osteoarthritis.
Abstract: The field of equine veterinary practice is in an ever-evolving state, requiring current technologies to be constantly evaluated for new applications. The specific use of gene therapy in the horse is a novel application. The authors want to help familiarize the equine practitioner with the concept of gene therapy, and introduce its use and potential future benefits for the equine industry in the treatment of osteoarthritis.
Publication Date: 2005-01-22 PubMed ID: 15658173DOI: 10.1016/s0749-0739(17)30059-7Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article explores the concept of gene therapy and details its potential use and benefits in treating osteoarthritis in horses in the field of equine veterinary practice.
Overview of Gene Therapy
- Gene therapy is a cutting-edge medical procedure that involves altering or manipulating the genes inside the body’s cells to prevent or treat diseases at their source. It is considered a massive advancement in modern medical technology and it is heralded as a way forward in the treatment of various diseases, including osteoarthritis.
Gene Therapy in Equine Veterinary Practice
- In this research, the application of gene therapy is viewed in the context of equine veterinary practice. Equine medicine traditionally has been more conservative in its treatment methodologies.
- However, this paper suggests a potential paradigm shift in how diseases such as osteoarthritis in horses can be treated. It introduces the concept of gene therapeutics into the discipline and details how it can be applied in equine medical practice.
Gene Therapy for Osteoarthritis
- Osteoarthritis is a degenerative joint disease; it remains one of the most challenging diseases to treat in horses because it involves the progressive deterioration of cartilage in the horse’s joints, leading to pain, stiffness, and reduced mobility.
- The research highlights the potential of gene therapy in treating this disease. It describes how this therapy could potentially modify or alter the genes affecting the production and maintenance of joint cartilage, thereby tackling the disease at its core.
- The application of gene therapy could not only bring about profound improvements in the health and quality of life of the affected horses, but it could also revolutionize the field of equine veterinary medicine by bringing in an advanced, proactive approach to disease treatment.
Future Implication
- While promising, the application of gene therapy in the equine industry is still very much in its infancy. This research is essentially introductory and it hopes to familiarize equine practitioners with the concept of gene therapy and inspire further research and eventual integration of this promising technology into everyday equine veterinary practice.
Cite This Article
APA
Frisbie DD, McIlwraith CW.
(2005).
Gene therapy: future therapies in osteoarthritis.
Vet Clin North Am Equine Pract, 17(2), 233-vi.
https://doi.org/10.1016/s0749-0739(17)30059-7 Publication
Researcher Affiliations
- Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado 80524, USA. dfrisbie@lamar.colostate.edu
MeSH Terms
- Animals
- Gene Transfer Techniques / veterinary
- Genetic Therapy / methods
- Genetic Therapy / veterinary
- Horse Diseases / therapy
- Horses
- Osteoarthritis / therapy
- Osteoarthritis / veterinary
References
This article includes 41 references
Citations
This article has been cited 6 times.- Wang D, Liu W, Venkatesan JK, Madry H, Cucchiarini M. Therapeutic Controlled Release Strategies for Human Osteoarthritis. Adv Healthc Mater 2025 Jan;14(2):e2402737.
- Chen H, Li Z, Li X, Lu J, Chen B, Wang Q, Wu G. Biomaterial-Based Gene Delivery: Advanced Tools for Enhanced Cartilage Regeneration. Drug Des Devel Ther 2023;17:3605-3624.
- Thampi P, Samulski RJ, Grieger JC, Phillips JN, McIlwraith CW, Goodrich LR. Gene therapy approaches for equine osteoarthritis. Front Vet Sci 2022;9:962898.
- Mobasheri A, Choi H, Martín-Vasallo P. Over-Production of Therapeutic Growth Factors for Articular Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines. Biology (Basel) 2020 Oct 9;9(10).
- McIlwraith CW, Frisbie DD, Kawcak CE. The horse as a model of naturally occurring osteoarthritis. Bone Joint Res 2012 Nov;1(11):297-309.
- Koch TG, Berg LC, Betts DH. Current and future regenerative medicine - principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine. Can Vet J 2009 Feb;50(2):155-65.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists