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Frontiers in veterinary science2018; 5; 225; doi: 10.3389/fvets.2018.00225

Microbiome and Blood Analyte Differences Point to Community and Metabolic Signatures in Lean and Obese Horses.

Abstract: Due to modern management practices and the availability of energy dense feeds, obesity is a serious and increasingly common health problem for horses. Equine obesity is linked to insulin resistance and exacerbation of inflammatory issues such as osteoarthritis and laminitis. While the gut microbiome is thought to play a part in metabolic status in horses, bacterial communities associated with obesity have yet to be described. Here we report differences in metabolic factors in the blood of obese, normal and lean horses correlated with differences in gut microbiome composition. We report that obese horses had higher levels of leptin, triglycerides, glucose, and cortisol in their blood, and more diverse gut microbiome communities with higher relative abundance of Firmicutes, and lower numbers of Bacteroidetes and Actinobacteria. Network analyses of correlations between body condition, blood analytes, and microbial composition at the genus level revealed a more nuanced picture of microbe-host interactions, pointing to specific bacterial species and assemblages that may be signatures of obesity and leanness in the horse gut. In particular, bacteria groups positively associated with two blood analytes and obesity included spp., Prevotellaceae, spp., two members of Erysipelotrichaceae, and a Lachnospiraceae taxa. These results are an important first step in unraveling the metabolic differences between obese and lean horse gut communities, and designing targeted strategies for microbial intervention.
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Publication Date: 2018-09-20 PubMed ID: 30294603PubMed Central: PMC6158370DOI: 10.3389/fvets.2018.00225Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the link between obesity in horses and differences in their gut microbiome and blood metabolic factors. It highlights key bacteria that may be promoting obesity and suggests that understanding these connections may aid in developing targeted strategies for microbial intervention.

Objective of the Study

  • This study was designed to explore the connection between equine obesity and the gut microbiome. Modern methods of horse management and the availability of energy-dense feeds have led to an increased incidence of obesity in horses. This is a health concern as equine obesity is associated with insulin resistance and exacerbation of inflammatory issues.
  • The researchers aimed to describe the bacterial communities associated with obesity and to report on the differences in metabolic factors in the blood of obese, normal, and lean horses correlated with variations in gut microbiome composition.

Methodology and Findings

  • The study found that obese horses had higher levels of leptin, triglycerides, glucose, and cortisol in their blood, indicating a differing metabolic state. Additionally, these horses had more diverse gut microbiome communities with an increased relative abundance of Firmicutes and decreased numbers of Bacteroidetes and Actinobacteria.
  • Using network analyses, the researchers explored the correlations between body condition, blood analytes, and microbial composition at the genus level. This provided a more in-depth understanding of the microbe-host interactions occurring in obese horses and provided insights into specific bacterial species and assemblages that may serve as obesity and leanness signatures.
  • The research identified certain bacteria groups that showed a positive association with certain blood analytes and obesity. This includes Prevotellaceae, two members of Erysipelotrichaceae, and a Lachnospiraceae taxa.

Implications of the Study

  • This study represents an important step forward in understanding the metabolic differences between the gut communities of obese and lean horses. By identifying specific bacterial groups associated with obesity, there’s potential for the development of targeted strategies for microbial intervention to address equine obesity.

Cite This Article

APA
Biddle AS, Tomb JF, Fan Z. (2018). Microbiome and Blood Analyte Differences Point to Community and Metabolic Signatures in Lean and Obese Horses. Front Vet Sci, 5, 225. https://doi.org/10.3389/fvets.2018.00225

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 5
Pages: 225
PII: 225

Researcher Affiliations

Biddle, Amy S
  • Department of Animal and Food Science, University of Delaware, Newark, DE, United States.
Tomb, Jean-Francois
  • Department of Computer and Information Sciences, University of Delaware, Newark, DE, United States.
Fan, Zirui
  • Department of Computer and Information Sciences, University of Delaware, Newark, DE, United States.

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