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Preventive veterinary medicine2000; 47(1-2); 61-77; doi: 10.1016/s0167-5877(00)00161-6

Modelling the spread of a viral infection in equine populations managed in Thoroughbred racehorse training yards.

Abstract: A Monte Carlo model that simulates the management life cycle of a horse population in training on a Thoroughbred flat racing yard (i.e. stable) was developed for computer implementation. Each horse was characterised by several state variables. Discrete events at the horse level were triggered stochastically to reflect uncertainty about some input assumptions and heterogeneity of the horse population in a particular yard. This mathematical model was subsequently used to mimic the spread of equine influenza (EI) within a typical yard following the introduction of one or several infectious horses. Different scenarios were simulated to demonstrate the value of strategies for preventing outbreaks of EI. Under typical UK management conditions and vaccination protocols, the model showed that EI would propagate and that the timing of vaccination in connection with the racing season and the arrival of new horses was a critical factor. The predicted outcomes (based on published characteristics of one EI vaccine) suggested that vaccination in mid-December with boosters in June and September was a viable and successful strategy in preventing the spread of EI in a training establishment.
Publication Date: 2000-10-06 PubMed ID: 11018735DOI: 10.1016/s0167-5877(00)00161-6Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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This research developed a computer simulation to model the spread of equine influenza (EI) in racehorse training yards. The model showed various factors can influence the spread of EI, including vaccination timing and the arrival of new horses.

Research Goals and Methodology

In this research, the scientists aimed to construct a mathematical model that realistically represents the management life cycle of a population of horses in a Thoroughbred flat racing yard. To achieve this, they used the Monte Carlo technique, a computational algorithm often used in statistical physics and mathematical finance for its ability to incorporate complex probabilistic models.

  • The model involved numerous state variables to represent each horse.
  • Events affecting the horses were triggered stochastically, meaning randomly with probabilities given by the input assumptions, to consider both the unpredictable nature of these factors and the heterogeneity of the horse population.

Leveraging the Model for EI Spread

The newly developed model was then used to simulate the spread of equine influenza (EI) within a typical yard, assuming that one or several infectious horses were introduced to the premises.

  • The goal was to produce a variety of scenarios that could provide insights into the most effective strategies for preventing EI outbreaks.
  • As per the model, under typical UK management conditions and usual vaccination protocols, the spread of EI would occur.
  • The timing of the vaccination in connection with the racing season and the introduction of new horses proved a critical factor in controlling the contagion.

Validation and Insights

The researchers validated the predictive outcomes of their model by comparing them with the characteristics of an existing EI vaccine.

  • According to their findings, vaccination in mid-December with additional boosters in June and September emerged as a viable strategy for preventing the spread of EI in training establishments.
  • The study overall provides useful computational tools for evaluating and designing EI prevention strategies tailored to the specific conditions of particular training yards.

Cite This Article

APA
de la Rua-Domenech R, Reid SW, González-Zariquiey AE, Wood JL, Gettinby G. (2000). Modelling the spread of a viral infection in equine populations managed in Thoroughbred racehorse training yards. Prev Vet Med, 47(1-2), 61-77. https://doi.org/10.1016/s0167-5877(00)00161-6

Publication

ISSN: 0167-5877
NlmUniqueID: 8217463
Country: Netherlands
Language: English
Volume: 47
Issue: 1-2
Pages: 61-77

Researcher Affiliations

de la Rua-Domenech, R
  • Department of Veterinary Clinical Studies, Veterinary Informatics and Epidemiology, University of Glasgow, Glasgow G61 1QH, UK. domenech@vfs.maff.gsi.gov.uk
Reid, S W
    González-Zariquiey, A E
      Wood, J L
        Gettinby, G

          MeSH Terms

          • Animals
          • Breeding
          • Computer Simulation
          • Disease Outbreaks / veterinary
          • Horse Diseases / epidemiology
          • Horse Diseases / prevention & control
          • Horses
          • Housing, Animal
          • Models, Biological
          • Monte Carlo Method
          • Orthomyxoviridae Infections / epidemiology
          • Orthomyxoviridae Infections / prevention & control
          • Orthomyxoviridae Infections / veterinary
          • Physical Conditioning, Animal
          • United Kingdom / epidemiology

          Citations

          This article has been cited 6 times.
          1. Shnaiderman-Torban A, Navon-Venezia S, Paitan Y, Archer H, Abu Ahmad W, Bonder D, Hanael E, Nissan I, Zizelski Valenci G, Weese SJ, Steinman A. Extended spectrum β lactamase-producing Enterobacteriaceae shedding by race horses in Ontario, Canada. BMC Vet Res 2020 Dec 9;16(1):479.
            doi: 10.1186/s12917-020-02701-zpubmed: 33298039google scholar: lookup
          2. Entenfellner J, Gahan J, Garvey M, Walsh C, Venner M, Cullinane A. Response of Sport Horses to Different Formulations of Equine Influenza Vaccine. Vaccines (Basel) 2020 Jul 10;8(3).
            doi: 10.3390/vaccines8030372pubmed: 32664411google scholar: lookup
          3. Milwid RM, O'Sullivan TL, Poljak Z, Laskowski M, Greer AL. Comparing the effects of non-homogenous mixing patterns on epidemiological outcomes in equine populations: A mathematical modelling study. Sci Rep 2019 Mar 1;9(1):3227.
            doi: 10.1038/s41598-019-40151-2pubmed: 30824806google scholar: lookup
          4. Spence KL, O'Sullivan TL, Poljak Z, Greer AL. Using a computer simulation model to examine the impact of biosecurity measures during a facility-level outbreak of equine influenza. Can J Vet Res 2018 Apr;82(2):89-96.
            pubmed: 29755187
          5. Daly JM, Newton JR, Wood JL, Park AW. What can mathematical models bring to the control of equine influenza?. Equine Vet J 2013 Nov;45(6):784-8.
            doi: 10.1111/evj.12104pubmed: 23679041google scholar: lookup
          6. Gardner CL, Yin J, Burke CW, Klimstra WB, Ryman KD. Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice. Virology 2009 Aug 1;390(2):338-47.
            doi: 10.1016/j.virol.2009.05.030pubmed: 19539968google scholar: lookup