Modelling the spread of a viral infection in equine populations managed in Thoroughbred racehorse training yards.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research developed a computer simulation to model the spread of equine influenza (EI) in racehorse training yards. The model showed various factors can influence the spread of EI, including vaccination timing and the arrival of new horses.
Research Goals and Methodology
In this research, the scientists aimed to construct a mathematical model that realistically represents the management life cycle of a population of horses in a Thoroughbred flat racing yard. To achieve this, they used the Monte Carlo technique, a computational algorithm often used in statistical physics and mathematical finance for its ability to incorporate complex probabilistic models.
- The model involved numerous state variables to represent each horse.
- Events affecting the horses were triggered stochastically, meaning randomly with probabilities given by the input assumptions, to consider both the unpredictable nature of these factors and the heterogeneity of the horse population.
Leveraging the Model for EI Spread
The newly developed model was then used to simulate the spread of equine influenza (EI) within a typical yard, assuming that one or several infectious horses were introduced to the premises.
- The goal was to produce a variety of scenarios that could provide insights into the most effective strategies for preventing EI outbreaks.
- As per the model, under typical UK management conditions and usual vaccination protocols, the spread of EI would occur.
- The timing of the vaccination in connection with the racing season and the introduction of new horses proved a critical factor in controlling the contagion.
Validation and Insights
The researchers validated the predictive outcomes of their model by comparing them with the characteristics of an existing EI vaccine.
- According to their findings, vaccination in mid-December with additional boosters in June and September emerged as a viable strategy for preventing the spread of EI in training establishments.
- The study overall provides useful computational tools for evaluating and designing EI prevention strategies tailored to the specific conditions of particular training yards.
Cite This Article
Publication
Researcher Affiliations
- Department of Veterinary Clinical Studies, Veterinary Informatics and Epidemiology, University of Glasgow, Glasgow G61 1QH, UK. domenech@vfs.maff.gsi.gov.uk
MeSH Terms
- Animals
- Breeding
- Computer Simulation
- Disease Outbreaks / veterinary
- Horse Diseases / epidemiology
- Horse Diseases / prevention & control
- Horses
- Housing, Animal
- Models, Biological
- Monte Carlo Method
- Orthomyxoviridae Infections / epidemiology
- Orthomyxoviridae Infections / prevention & control
- Orthomyxoviridae Infections / veterinary
- Physical Conditioning, Animal
- United Kingdom / epidemiology
Citations
This article has been cited 6 times.- Shnaiderman-Torban A, Navon-Venezia S, Paitan Y, Archer H, Abu Ahmad W, Bonder D, Hanael E, Nissan I, Zizelski Valenci G, Weese SJ, Steinman A. Extended spectrum β lactamase-producing Enterobacteriaceae shedding by race horses in Ontario, Canada. BMC Vet Res 2020 Dec 9;16(1):479.
- Entenfellner J, Gahan J, Garvey M, Walsh C, Venner M, Cullinane A. Response of Sport Horses to Different Formulations of Equine Influenza Vaccine. Vaccines (Basel) 2020 Jul 10;8(3).
- Milwid RM, O'Sullivan TL, Poljak Z, Laskowski M, Greer AL. Comparing the effects of non-homogenous mixing patterns on epidemiological outcomes in equine populations: A mathematical modelling study. Sci Rep 2019 Mar 1;9(1):3227.
- Spence KL, O'Sullivan TL, Poljak Z, Greer AL. Using a computer simulation model to examine the impact of biosecurity measures during a facility-level outbreak of equine influenza. Can J Vet Res 2018 Apr;82(2):89-96.
- Daly JM, Newton JR, Wood JL, Park AW. What can mathematical models bring to the control of equine influenza?. Equine Vet J 2013 Nov;45(6):784-8.
- Gardner CL, Yin J, Burke CW, Klimstra WB, Ryman KD. Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice. Virology 2009 Aug 1;390(2):338-47.