Overview of current laminitis research.
Abstract: All cases of laminitis are characterized by failure of the attachment of the epidermal cells of the epidermal laminae to the underlying basement membrane of the dermal laminae despite the diversity of diseases that underlie the syndrome. The preponderance of evidence supports roles for inflammation, metabolic derangement, endothelial and venous dysfunction, and matrix degradation as causes of laminitis. Inflammation, oxidant stress, and matrix degradation may be factors common to each of these mechanisms that lead to the laminar damage of laminitis. The understanding of the pathophysiology and progression of the disease is incomplete, and this limits efforts to prevent and treat this devastating disease successfully. However, scientific investigations are occurring at a phenomenal rate and shedding light on the pathophysiologic events involved with laminitis.
Copyright 2010 Elsevier Inc. All rights reserved.
Publication Date: 2010-04-13 PubMed ID: 20381735DOI: 10.1016/j.cveq.2010.01.001Google Scholar: Lookup
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Summary
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This research article focuses on the study of laminitis, a disease prevalent in horses. The scientists explored the causative factors involved, such as inflammation, metabolic disorders, endothelial and venous dysfunction, and matrix degradation, and how these contribute to the pathophysiology of the disease. Moreover, it acknowledges that current understanding of laminitis remains incomplete, limiting effective prevention and treatment efforts, yet highlights the rapid pace of scientific investigations as a beacon of hope.
Disease Focus: Laminitis
- The article centers around laminitis, a disease primarily affecting horses. It presents an overview of the various factors that lead to the onset of this disease, adding to the failures in the attachment of epidermal cells to the underlying basement membrane of the dermal laminae.
Key Causative Factors
- The authors highlight inflammation, metabolic derangement, endothelial and venous dysfunction, and matrix degradation as significant factors leading to laminitis. These conditions are believed to disrupt the usual workings of the epidermal cells, resulting in the symptoms of laminitis.
- Of the identified causes, inflammation, oxidant stress, and matrix degradation appear to be common contributing influences to each mechanism leading to laminar damage, the main symptom of laminitis.
Current Understanding of Laminitis
- The authors admit the current understanding of the pathophysiology and progression of laminitis is incomplete. This limitation hinders the development of effective preventive measures and treatments.
Future Investigations and Hope
- Despite the existing limitations in understanding laminitis, the article concludes on a positive note by acknowledging the rapid pace of scientific investigations into the disease. Such research efforts are providing an increasing amount of light on the pathophysiological events associated with laminitis, making it possible to improve prevention and treatment methodologies in the future.
Cite This Article
APA
Eades SC.
(2010).
Overview of current laminitis research.
Vet Clin North Am Equine Pract, 26(1), 51-63.
https://doi.org/10.1016/j.cveq.2010.01.001 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Equine Health Studies Program, Louisiana State University, Baton Rouge, LA 70803, USA. seades1@lsu.edu
MeSH Terms
- Animals
- Foot Diseases / etiology
- Foot Diseases / prevention & control
- Foot Diseases / veterinary
- Hoof and Claw / pathology
- Horse Diseases / etiology
- Horse Diseases / prevention & control
- Horses
- Inflammation / etiology
- Inflammation / prevention & control
- Inflammation / veterinary
- Research
Citations
This article has been cited 8 times.- Aoun R, Charles I, DeRouen A, Takawira C, Lopez MJ. Shoe configuration effects on third phalanx and capsule motion of unaffected and laminitic equine hooves in-situ.. PLoS One 2023;18(5):e0285475.
- Seidel SRT, de Souza AF, Fülber J, Bogossian PM, Rodrigues NNP, Baccarin RYA. Evaluation of platelet-rich plasma applied in the coronary band of healthy equine hooves.. Can Vet J 2021 Jul;62(7):729-735.
- Angelone M, Conti V, Biacca C, Battaglia B, Pecorari L, Piana F, Gnudi G, Leonardi F, Ramoni R, Basini G, Dotti S, Renzi S, Ferrari M, Grolli S. The Contribution of Adipose Tissue-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma to the Treatment of Chronic Equine Laminitis: A Proof of Concept.. Int J Mol Sci 2017 Oct 11;18(10).
- Faramarzi B, Lee D, May K, Dong F. Response to acupuncture treatment in horses with chronic laminitis.. Can Vet J 2017 Aug;58(8):823-827.
- Lancaster LS, Bowker RM. Acupuncture Points of the Horse's Distal Thoracic Limb: A Neuroanatomic Approach to the Transposition of Traditional Points.. Animals (Basel) 2012 Sep 17;2(3):455-71.
- Holl HM, Gao S, Fei Z, Andrews C, Brooks SA. Generation of a de novo transcriptome from equine lamellar tissue.. BMC Genomics 2015 Oct 3;16:739.
- Wang L, Pawlak EA, Johnson PJ, Belknap JK, Alfandari D, Black SJ. Expression and activity of collagenases in the digital laminae of horses with carbohydrate overload-induced acute laminitis.. J Vet Intern Med 2014 Jan-Feb;28(1):215-22.
- Wang L, Pawlak EA, Johnson PJ, Belknap JK, Eades S, Stack S, Cousin H, Black SJ. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae.. PLoS One 2013;8(2):e56025.
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