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Home / Equine Research Bank / Can Vet J / Prognostic indicators of poor outcome in horses with laminit...
The Canadian veterinary journal = La revue veterinaire canadienne2010; 51(6); 623-628;

Prognostic indicators of poor outcome in horses with laminitis at a tertiary care hospital.

Abstract: This retrospective study investigated the factors associated with a poor outcome (death by euthanasia or from other causes) in horses treated for laminitis at a tertiary care hospital. Cases (n = 247) were defined as patients with laminitis that were euthanized or that died of other causes during hospitalization. Controls (n = 344) were patients with laminitis that survived to be discharged from the hospital. In the final multivariate analysis, the factors significantly associated with an increased risk for death and their respective odds ratios (OR) were as follows: Thoroughbred (OR = 1.57); racehorse (OR = 1.76); treatment with flunixin meglumine (OR = 1.76); vascular pathology (OR = 2.12); distal displacement of the third phalanx (OR = 2.68); pneumonia (OR = 2.87); and lameness of Obel grade II (OR = 2.99), grade III (OR = 9.63), or grade IV (OR = 20.48). The use of glue-on shoes significantly reduced the risk for death (OR = 0.36). Indicateurs d’un pronostic de mauvais résultats chez les chevaux atteints de laminite dans une clinique de soins tertiaires. Cette étude rétrospective a examiné les facteurs associés à de mauvais résultats (mort par euthanasie ou pour d’autres causes) chez les chevaux traités pour la laminite dans une clinique de soins tertiaires. Les cas (n = 247) étaient définis comme des patients atteints de la laminite qui ont été euthanasiés ou qui sont morts d’autres causes durant l’hospitalisation. Les témoins (n = 344) étaient des patients atteints de laminite qui avaient survécu au congé de la clinique. Dans l’analyse finale multicritères, les facteurs présentant une association significative avec le risque accru de mort et leurs ratios respectifs d’incidence (RI) étaient les suivants : Thoroughbred (RI = 1,57); cheval de course (RI = 1,76); traitement à la flunixin méglumine (RI = 1,76); pathologie vasculaire (RI = 2,12); déplacement distal de la troisième phalange (RI = 2,68); pneumonie (RI = 2,87); et boiterie de grade Obel II (RI = 2,99), de grade III (RI = 9,63) ou de grade IV (RI = 20,48). L’usage de fers collés réduisait significativement le risque de mort (RI = 0,36). (Traduit par Isabelle Vallières)
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Publication Date: 2010-09-03 PubMed ID: 20808574PubMed Central: PMC2871359
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study retrospectively analyzed factors that could predict poor outcomes (e.g., death or euthanasia) in horses treated for laminitis in a tertiary care hospital.

Study Overview

  • The researchers classified a total of 591 horses into either cases (n= 247) or controls (n= 344). Cases were horses with laminitis that were euthanized or died due to other causes. On the other hand, controls were horses with laminitis that survived and were discharged from the hospital.

Findings and Analysis

  • Upon conducting a final multivariate analysis, the researchers identified several factors that significantly increased the risk of death in these horses. They presented these factors along with their respective odds ratios (OR) to quantify the increased risk.
  • The factors identified were: being a Thoroughbred (OR = 1.57); being a racehorse (OR = 1.76); undergoing treatment with flunixin meglumine (OR = 1.76); having vascular pathology (OR = 2.12); having a distal displacement of the third phalanx (OR = 2.68); suffering from pneumonia (OR = 2.87); and exhibiting lameness of Obel grade II (OR = 2.99), grade III (OR = 9.63), or grade IV (OR = 20.48).
  • The researchers also identified that the use of glue-on shoes significantly reduced the risk of death (OR = 0.36).

Implications of the Study

  • Understanding these risk factors can help in better managing cases of laminitis in tertiary care settings and potentially reduce the mortality rate.
  • Additionally, this data could support developing specific care protocols for horses suffering from laminitis, particularly ones presenting the risk factors identified.
  • The findings also shed light on the potential benefit of using glue-on shoes in this type of treatment, which could be further investigated.

Cite This Article

APA
Orsini JA, Parsons CS, Capewell L, Smith G. (2010). Prognostic indicators of poor outcome in horses with laminitis at a tertiary care hospital. Can Vet J, 51(6), 623-628.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 51
Issue: 6
Pages: 623-628

Researcher Affiliations

Orsini, James A
  • The New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, 19348, USA. orsini@vet.upenn.edu
Parsons, Corrina Snook
    Capewell, Linda
      Smith, Gary

        MeSH Terms

        • Animals
        • Female
        • Follow-Up Studies
        • Foot Diseases / mortality
        • Foot Diseases / therapy
        • Foot Diseases / veterinary
        • Hoof and Claw / pathology
        • Horse Diseases / mortality
        • Horse Diseases / therapy
        • Horses
        • Inflammation / mortality
        • Inflammation / therapy
        • Inflammation / veterinary
        • Lameness, Animal / mortality
        • Lameness, Animal / therapy
        • Male
        • Odds Ratio
        • Prognosis
        • Retrospective Studies
        • Risk Factors
        • Shoes
        • Treatment Outcome

        References

        This article includes 11 references
        1. Stick JA, Jann HW, Scott EA. Pedal bone rotation as a prognostic sign in laminitis of horses.. J Am Vet Med Assoc 1982;180:251–253.
          pubmed: 7056672
        2. Baxter GM. Equine laminitis caused by distal displacement of the distal phalanx: 12 cases (1976–1985). J Am Vet Med Assoc 1986;189:326–329.
          pubmed: 3744996
        3. Hunt RJ. A retrospective evaluation of laminitis in horses.. Equine Vet J 1993;25:61–64.
          pubmed: 8422888
        4. Cripps PJ, Eustace RA. Factors involved in the prognosis of equine laminitis in the UK.. Equine Vet J 1999;31:433–442.
          pubmed: 10505961
        5. Obel N. Studies on the histopathology of acute laminitis.. .
        6. Hosmer DW, Lemeshow S. Applied Logistic Regression.. .
        7. Hosmer DW, Lemeshow S. Applied Logistic Regression.. .
        8. Reeves MJ, Salman MD, Smith G. Risk factors for equine acute abdominal disease (colic): Results from a multi-center case-control study.. Prev Vet Med 1996;26:285–301.
        9. Colles CM, Jeffcott LB. Laminitis in the horse.. Vet Rec 1977;100:262–264.
          pubmed: 871051
        10. Swanson TD. Clinical presentation, diagnosis, and prognosis of acute laminitis.. Vet Clin North Am Equine Pract 1999;15:311–319.
          pubmed: 10472114
        11. O’Grady S. How to restore alignment of P3 in horses with chronic laminitis.. Proc Am Assoc Equine Pract 2003;49:328–336.

        Citations

        This article has been cited 6 times.
        1. Hargitaiova K, Maleas G. High-metacarpal deep digital flexor tenotomy and Steward clog shoeing for managing chronic refractory laminitis: A retrospective clinical study. Vet Surg 2026 Jan;55(1):236-247.
          doi: 10.1111/vsu.70068pubmed: 41392305google scholar: lookup
        2. Aoun R, Charles I, DeRouen A, Takawira C, Lopez MJ. Shoe configuration effects on third phalanx and capsule motion of unaffected and laminitic equine hooves in-situ. PLoS One 2023;18(5):e0285475.
          doi: 10.1371/journal.pone.0285475pubmed: 37155654google scholar: lookup
        3. Meier A, McGree J, Klee R, Preuß J, Reiche D, de Laat M, Sillence M. The application of a new laminitis scoring method to model the rate and pattern of improvement from equine endocrinopathic laminitis in a clinical setting. BMC Vet Res 2021 Jan 7;17(1):16.
          doi: 10.1186/s12917-020-02715-7pubmed: 33413384google scholar: lookup
        4. Bauquier J, Tudor E, Bailey S. Effect of the p38 MAPK inhibitor doramapimod on the systemic inflammatory response to intravenous lipopolysaccharide in horses. J Vet Intern Med 2020 Sep;34(5):2109-2116.
          doi: 10.1111/jvim.15847pubmed: 32700419google scholar: lookup
        5. Norton E, Schultz N, Geor R, McFarlane D, Mickelson J, McCue M. Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. Genes (Basel) 2019 Nov 6;10(11).
          doi: 10.3390/genes10110893pubmed: 31698676google scholar: lookup
        6. Pollard D, Wylie CE, Verheyen KLP, Newton JR. Identification of modifiable factors associated with owner-reported equine laminitis in Britain using a web-based cohort study approach. BMC Vet Res 2019 Feb 12;15(1):59.
          doi: 10.1186/s12917-019-1798-8pubmed: 30755193google scholar: lookup
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