FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Vet Clin North Am Equine Pract / Regenerative medicine for tendinous and ligamentous injuries...
The Veterinary clinics of North America. Equine practice2008; 24(1); 191-201; doi: 10.1016/j.cveq.2007.11.002

Regenerative medicine for tendinous and ligamentous injuries of sport horses.

Abstract: After tendon injury, the scar tissue that replaces the damaged tendon results in a substantial risk for reinjury. The goal of regenerative therapies is to restore normal structural architecture and biomechanical function to an injured tissue. Successful restoration processes for any tissue are thought to recapitulate those of development, in which there are spatial and temporal interactions between scaffold, growth factors, and cell populations.
Get Full Text
Publication Date: 2008-03-04 PubMed ID: 18314043DOI: 10.1016/j.cveq.2007.11.002Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research examines the use of regenerative therapies for the treatment of tendon and ligament injuries in sport horses, with the goal of achieving full functional recovery by replicating normal tissue development processes.

Research Aim

  • The primary aim of the study is to investigate the use of regenerative medicine to treat sport horses that have suffered tendon or ligament injuries. The focus is to reduce the reinjury risk, associated with scar tissue formed in damaged tendons, by recreating the normal tissue dynamics.

Significance of Regenerative Treatments

  • Regenerative treatments have the potential to drastically impact the prognosis for tendon and ligament injuries by aiming not merely to treat the symptoms, but to restore the tissue to its pre-injury state.
  • Instead of just curing the symptoms, the process aims to recover the original strength and elasticity of the tendon, thereby reducing the risk of reinjury.

Underlying Mechanism

  • The underlying mechanism focuses on replicating the processes of normal tissue development in the injured tissue.
  • Restoration of normal tissue is based on the interaction between three components: scaffold, growth factors, and cell populations. These elements are manipulated to stimulate biological processes similar to those occurring in tissue development.

Implications

  • These findings could significantly influence the approach to treating sport horses, providing an improvement in recovery time, reducing the risk of reinjury, and potentially extending the horses’ athletic performance lifespan.

Cite This Article

APA
Fortier LA, Smith RK. (2008). Regenerative medicine for tendinous and ligamentous injuries of sport horses. Vet Clin North Am Equine Pract, 24(1), 191-201. https://doi.org/10.1016/j.cveq.2007.11.002

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 24
Issue: 1
Pages: 191-201

Researcher Affiliations

Fortier, Lisa A
  • Department of Clinical Sciences, VMC C3-181, Cornell University, Ithaca, NY 14853, USA. laf4@cornell.edu
Smith, Roger K W

    MeSH Terms

    • Animals
    • Athletic Injuries / prevention & control
    • Athletic Injuries / therapy
    • Athletic Injuries / veterinary
    • Cicatrix / prevention & control
    • Cicatrix / veterinary
    • Horses / injuries
    • Ligaments / injuries
    • Physical Conditioning, Animal
    • Risk Factors
    • Safety
    • Secondary Prevention
    • Sports
    • Tendon Injuries / therapy
    • Tendon Injuries / veterinary
    • Wound Healing / physiology

    Citations

    This article has been cited 29 times.
    1. Duddy HR, Schoonover MJ, Hague BA. Outcome following local injection of a liquid amnion allograft for treatment of equine tendonitis or desmitis - 100 cases. BMC Vet Res 2022 Nov 7;18(1):391.
      doi: 10.1186/s12917-022-03480-5pubmed: 36345002google scholar: lookup
    2. Mukherjee P, Roy S, Ghosh D, Nandi SK. Role of animal models in biomedical research: a review. Lab Anim Res 2022 Jul 1;38(1):18.
      doi: 10.1186/s42826-022-00128-1pubmed: 35778730google scholar: lookup
    3. Melotti L, Carolo A, Elshazly N, Boesso F, Da Dalt L, Gabai G, Perazzi A, Iacopetti I, Patruno M. Case Report: Repeated Intralesional Injections of Autologous Mesenchymal Stem Cells Combined With Platelet-Rich Plasma for Superficial Digital Flexor Tendon Healing in a Show Jumping Horse. Front Vet Sci 2022;9:843131.
      doi: 10.3389/fvets.2022.843131pubmed: 35252428google scholar: lookup
    4. Fülber J, Agreste FR, Seidel SRT, Sotelo EDP, Barbosa ÂP, Michelacci YM, Baccarin RYA. Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system. World J Stem Cells 2021 Jun 26;13(6):645-658.
      doi: 10.4252/wjsc.v13.i6.645pubmed: 34249233google scholar: lookup
    5. Secchi V, Masala G, Corda A, Corda F, Potop E, Barbero Fernandez A, Pinna Parpaglia ML, Sanna Passino E. Strain Elastography of Injured Equine Superficial Digital Flexor Tendons: A Reliability Study of Manual Measurements. Animals (Basel) 2021 Mar 12;11(3).
      doi: 10.3390/ani11030795pubmed: 33809249google scholar: lookup
    6. Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, Pasolini MP. The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data. Animals (Basel) 2021 Mar 12;11(3).
      doi: 10.3390/ani11030793pubmed: 33809227google scholar: lookup
    7. Osborn ML, Cornille JL, Blas-Machado U, Uhl EW. The equine navicular apparatus as a premier enthesis organ: Functional implications. Vet Surg 2021 May;50(4):713-728.
      doi: 10.1111/vsu.13620pubmed: 33710628google scholar: lookup
    8. Ribitsch I, Baptista PM, Lange-Consiglio A, Melotti L, Patruno M, Jenner F, Schnabl-Feichter E, Dutton LC, Connolly DJ, van Steenbeek FG, Dudhia J, Penning LC. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do. Front Bioeng Biotechnol 2020;8:972.
      doi: 10.3389/fbioe.2020.00972pubmed: 32903631google scholar: lookup
    9. Shojaee A, Parham A. Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges. Stem Cell Res Ther 2019 Jun 18;10(1):181.
      doi: 10.1186/s13287-019-1291-0pubmed: 31215490google scholar: lookup
    10. Chicharro-Alcántara D, Rubio-Zaragoza M, Damiá-Giménez E, Carrillo-Poveda JM, Cuervo-Serrato B, Peláez-Gorrea P, Sopena-Juncosa JJ. Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management. J Funct Biomater 2018 Jan 18;9(1).
      doi: 10.3390/jfb9010010pubmed: 29346333google scholar: lookup
    11. Eydt C, Geburek F, Schröck C, Hambruch N, Rohn K, Pfarrer C, Staszyk C. Sternal bone marrow derived equine multipotent mesenchymal stromal cells (MSCs): investigations considering the sampling site and the use of different culture media. Vet Med Sci 2016 Aug;2(3):200-210.
      doi: 10.1002/vms3.36pubmed: 29067195google scholar: lookup
    12. Lang HM, Schnabel LV, Cassano JM, Fortier LA. Effect of needle diameter on the viability of equine bone marrow derived mesenchymal stem cells. Vet Surg 2017 Jul;46(5):731-737.
      doi: 10.1111/vsu.12639pubmed: 28328147google scholar: lookup
    13. White NA 2nd, Barrett JG. Magnetic Resonance Imaging-Guided Treatment of Equine Distal Interphalangeal Joint Collateral Ligaments: 2009-2014. Front Vet Sci 2016;3:73.
      doi: 10.3389/fvets.2016.00073pubmed: 27656645google scholar: lookup
    14. Sasao T, Fukuda Y, Yoshida S, Miyabara S, Kasashima Y, Kuwano A, Arai K. Population doubling level-dependent change of secreted glycosaminoglycan in equine bone marrow-derived mesenchymal stem cells. J Equine Sci 2015;26(3):73-80.
      doi: 10.1294/jes.26.73pubmed: 26435680google scholar: lookup
    15. Miyabara S, Yuda Y, Kasashima Y, Kuwano A, Arai K. Regulation of Tenomodulin Expression Via Wnt/β-catenin Signaling in Equine Bone Marrow-derived Mesenchymal Stem Cells. J Equine Sci 2014;25(1):7-13.
      doi: 10.1294/jes.25.7pubmed: 24834008google scholar: lookup
    16. Carrade DD, Lame MW, Kent MS, Clark KC, Walker NJ, Borjesson DL. Comparative Analysis of the Immunomodulatory Properties of Equine Adult-Derived Mesenchymal Stem Cells(). Cell Med 2012;4(1):1-11.
      doi: 10.3727/215517912X647217pubmed: 23152950google scholar: lookup
    17. Spaas JH, Guest DJ, Van de Walle GR. Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?. Sports Med 2012 Oct 1;42(10):871-90.
      doi: 10.1007/BF03262300pubmed: 22963225google scholar: lookup
    18. Mensing N, Gasse H, Hambruch N, Haeger JD, Pfarrer C, Staszyk C. Isolation and characterization of multipotent mesenchymal stromal cells from the gingiva and the periodontal ligament of the horse. BMC Vet Res 2011 Aug 2;7:42.
      doi: 10.1186/1746-6148-7-42pubmed: 21810270google scholar: lookup
    19. Torricelli P, Fini M, Filardo G, Tschon M, Pischedda M, Pacorini A, Kon E, Giardino R. Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses. Int Orthop 2011 Oct;35(10):1569-76.
      doi: 10.1007/s00264-011-1237-3pubmed: 21394594google scholar: lookup
    20. Lovati AB, Corradetti B, Lange Consiglio A, Recordati C, Bonacina E, Bizzaro D, Cremonesi F. Comparison of equine bone marrow-, umbilical cord matrix and amniotic fluid-derived progenitor cells. Vet Res Commun 2011 Feb;35(2):103-21.
      doi: 10.1007/s11259-010-9457-3pubmed: 21193959google scholar: lookup
    21. Georg R, Maria C, Gisela A, Bianca C. Autologous conditioned plasma as therapy of tendon and ligament lesions in seven horses. J Vet Sci 2010 Jun;11(2):173-5.
      doi: 10.4142/jvs.2010.11.2.173pubmed: 20458161google scholar: lookup
    22. Murray SJ, Santangelo KS, Bertone AL. Evaluation of early cellular influences of bone morphogenetic proteins 12 and 2 on equine superficial digital flexor tenocytes and bone marrow-derived mesenchymal stem cells in vitro. Am J Vet Res 2010 Jan;71(1):103-14.
      doi: 10.2460/ajvr.71.1.103pubmed: 20043789google scholar: lookup
    23. Zhao C, Chieh HF, Bakri K, Ikeda J, Sun YL, Moran SL, An KN, Amadio PC. The effects of bone marrow stromal cell transplants on tendon healing in vitro. Med Eng Phys 2009 Dec;31(10):1271-5.
      doi: 10.1016/j.medengphy.2009.08.004pubmed: 19736035google scholar: lookup
    24. Koch TG, Berg LC, Betts DH. Current and future regenerative medicine - principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine. Can Vet J 2009 Feb;50(2):155-65.
      pubmed: 19412395
    25. Koch TG, Berg LC, Betts DH. Concepts for the clinical use of stem cells in equine medicine. Can Vet J 2008 Oct;49(10):1009-17.
      pubmed: 19119371
    26. Debnath A, Bhattacharya M, Chakraborty C, Das A. Potential role of different animal models for the evaluation of bioactive compounds. Ann Med Surg (Lond) 2025 Nov;87(11):7288-7305.
      doi: 10.1097/MS9.0000000000003860pubmed: 41180662google scholar: lookup
    27. Carmona JU, Carmona-Ramírez LH, López C. Platelet-Rich Plasma and Related Orthobiologics for the Treatment of Equine Musculoskeletal Disorders-A Bibliometric Analysis from 2000 to 2024. Vet Sci 2024 Aug 21;11(8).
      doi: 10.3390/vetsci11080385pubmed: 39195839google scholar: lookup
    28. Reis IL, Lopes B, Sousa P, Sousa AC, Caseiro AR, Mendonça CM, Santos JM, Atayde LM, Alvites RD, Maurício AC. Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives-A Review. Vet Sci 2024 Apr 26;11(5).
      doi: 10.3390/vetsci11050190pubmed: 38787162google scholar: lookup
    29. Zhang Z, Zhang Y, Wang H, Li B, Cao R, Li Y, Cui S, Zhang W. Curcumin Improves Functional Recovery of Ruptured Tendon by Promoting Tenogenesis via PI3K/Akt Signaling. Stem Cells Transl Med 2024 May 14;13(5):477-489.
      doi: 10.1093/stcltm/szae007pubmed: 38387017google scholar: lookup
    Subscribe to our newsletter
    Join 99,030 horse owners like you who receive our email updates on horse health and nutrition.