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Home / Equine Research Bank / Vet Rec / Serum amyloid A does not predict non-survival in hospitalise...
The Veterinary record2023; 192(7); e2644; doi: 10.1002/vetr.2644

Serum amyloid A does not predict non-survival in hospitalised adult horses with acute colitis.

Abstract: Predicting non-survival in horses with acute colitis improves early decision making. Therefore, this study aimed to determine the prognostic value of serum amyloid A (SAA) and other clinicopathological and clinical variables in adult horses with acute colitis. Clinical variables, SAA and other blood biomarkers, including plasma L-lactate (lactate), were assessed in 176 horses with acute colitis. A multivariate model for the prediction of non-survival was constructed. Icelandic horses were analysed separately. Admission SAA was similar in survivors (median 548 mg/L; range 0-5453 mg/L) and non-survivors (396 mg/L; 0-5294) (p = 0.43). A model for non-survival included year of admission, lactate, heart rate, age and colic duration of more than 24 hours. Icelandic horses had a relative risk of 2.9 (95% confidence interval = 2.2-3.8) for acute colitis compared to other breeds. Lactate in Icelandic horses was higher than that in other breeds in both survivors (4.0 mmol/L, range 1.0-12.7 vs. 2.0, 0.7-12.5) and non-survivors (10.0, 1.5-26 vs. 5.4, 0.8-22) (p < 0.001). The prognostic value of repeated measurements of SAA could not be assessed in this study, as 71% of the non-surviving horses died within a day of admission. Admission SAA did not predict non-survival. Breed needs consideration when lactate is evaluated as a predictor for non-survival in horses with colitis.
© 2023 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.
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Publication Date: 2023-02-13 PubMed ID: 36780213DOI: 10.1002/vetr.2644Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research aimed to understand if a particular biological marker, serum amyloid A (SAA), could predict non-survival in horses suffering from acute colitis. The study concluded that SAA levels could not be used as a predictor, and further factors such as year of admission, lactate levels, heart rate, age, the duration of colic, and breed must be taken into account.

Research Purpose and Methodology

  • The primary aim of this study was to determine whether serum amyloid A (SAA), a protein produced by the liver in response to inflammation, could be used as a prognostic indicator in horses with acute colitis. Acute colitis is a severe inflammation of the large intestine in horses, causing pain and often leading to life-threatening complications if not promptly treated.
  • The researchers measured admission SAA levels, various blood biomarkers, and clinical variables in a group of 176 hospitalized adult horses diagnosed with acute colitis. Other considered factors included plasma L-lactate, year of admission, heart rate, age, and duration of colic more than 24 hours.
  • To build a predictive model for non-survival, a multivariate analysis was conducted. The study also analyzed Icelandic horses separately due to their unique genetic characteristics and susceptibility to certain conditions.

Research Findings

  • The study found no significant difference in admission SAA levels between surviving and non-surviving horses, showing that SAA cannot be used as a predictor for non-survival in horses with acute colitis.
  • However, certain factors shown to be valuable in the predictive model included the year of admission, lactate levels, heart rate, age, and colic duration of more than 24 hours.
  • Interestingly, the study also found that Icelandic horses had a higher relative risk (2.9 times increase in risk) of developing acute colitis compared to other breeds, making breed an important consideration in evaluation and treatment.
  • Additionally, lactate levels in Icelandic horses were found to be higher compared to other breeds, suggesting that this could be a significant factor in evaluating the risk of non-survival in horses with colitis.

Research Limitations and Conclusions

  • The research had certain limitations, as 71% of non-surviving horses in the sample died within a day of admission, making it impossible to assess the prognostic value of repeated measurements of SAA.
  • The study concluded that SAA levels upon admission do not predict non-survival in horses with acute colitis. Other factors, including breed, must be considered when evaluating lactate as a predictor for non-survival.

Cite This Article

APA
Runge KE, Bak M, Vestergaard A, Staerk-Østergaard J, Jacobsen S, Pihl TH. (2023). Serum amyloid A does not predict non-survival in hospitalised adult horses with acute colitis. Vet Rec, 192(7), e2644. https://doi.org/10.1002/vetr.2644

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 192
Issue: 7
Pages: e2644

Researcher Affiliations

Runge, Kira Elisabeth
  • Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, Denmark.
Bak, Maj
  • Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, Denmark.
Vestergaard, Amalie
  • Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, Denmark.
Staerk-Østergaard, Jacob
  • Department of Veterinary and Animal Sciences, Animal Welfare and Disease Control, University of Copenhagen, Copenhagen, Denmark.
Jacobsen, Stine
  • Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, Denmark.
Pihl, Tina Holberg
  • Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, Denmark.

MeSH Terms

  • Horses
  • Animals
  • Serum Amyloid A Protein
  • Colitis / veterinary
  • Lactic Acid
  • Prognosis
  • Biomarkers
  • Horse Diseases

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