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Stem cell research & therapy2019; 10(1); 181; doi: 10.1186/s13287-019-1291-0

Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges.

Abstract: Tendon injuries, as one of the most common orthopedic disorders, are the major cause of early retirement or wastage among sport horses which mainly affect the superficial digital flexor tendon (SDFT). Tendon repair is a slow process, and tendon tissue is often replaced by scar tissue. The current treatment options are often followed by an incomplete recovery that increases the susceptibility to re-injury. Recently, cell therapy has been used in veterinary medicine to treat tendon injuries, although the risk of ectopic bone formation after cell injection is possible in some cases. In vitro tenogenic induction may overcome the mentioned risk in clinical application. Moreover, a better understanding of treatment strategies for musculoskeletal injuries in horse may have future applications for human and vice versa. This comprehensive review outlines the current strategies of stem cell therapy in equine tendon injury and in vitro tenogenic induction of equine stem cell.
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Publication Date: 2019-06-18 PubMed ID: 31215490PubMed Central: PMC6582602DOI: 10.1186/s13287-019-1291-0Google Scholar: Lookup
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Summary

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The research article discusses current strategies and challenges of using stem cell therapy for tendon repair in horses, focusing on enhancing the healing process and reducing the risk of re-injury.

Overview of Tendon Injuries in Horses

  • Tendon injuries are major causes of early retirements or wastage in sport horses, specifically affecting the superficial digital flexor tendon (SDFT).
  • Recovery from these injuries is generally slow and often results in incomplete healing, with scar tissue replacing the tendon tissue. This subsequently increases susceptibility to future injuries.

Current Treatment Options and Limitations

  • The existing treatment measures often lead to incomplete recovery, making horses prone to re-injuries.
  • The use of cell therapy in veterinary medicine has shown promising results in the treatment of tendon injuries. However, this method carries the risk of ectopic bone formation or the growth of bone in unwanted areas following cell injection.

In Vitro Tenogenic Induction: A Potential Solution

  • One way to mitigate the risk of ectopic bone formation is through in vitro tenogenic induction. This process involves treating the cells in a controlled environment before injecting them into the injured tendon, to ensure that they acquire the necessary properties for tendon repair.
  • Tenogenic induction may make the clinical application of cell therapy safer and more effective for treating tendon injuries.

Significance of Research on Equine Tendon Injuries

  • A comprehensive understanding of treatment strategies for musculoskeletal injuries in horses may have future implications for humans, and vice versa.
  • Therefore, studies on equine tendon injuries not only improve veterinary treatments but may also contribute to advances in human medicine.

In conclusion, this article highlights the potential of stem cell therapy for treating equine tendon injuries. It sheds light on the existing limitations within traditional methods of treatment and projects in vitro tenogenic induction as a potential solution to those challenges.

Cite This Article

APA
Shojaee A, Parham A. (2019). Strategies of tenogenic differentiation of equine stem cells for tendon repair: current status and challenges. Stem Cell Res Ther, 10(1), 181. https://doi.org/10.1186/s13287-019-1291-0

Publication

Stem cell research & therapy
ISSN: 1757-6512
NlmUniqueID: 101527581
Country: England
Language: English
Volume: 10
Issue: 1
Pages: 181

Researcher Affiliations

Shojaee, Asiyeh
  • Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Parham, Abbas
  • Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Parham@um.ac.ir.
  • Stem Cell Biology and Regenerative Medicine Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran. Parham@um.ac.ir.

MeSH Terms

  • Animals
  • Cell Differentiation / physiology
  • Cell- and Tissue-Based Therapy / methods
  • Fetal Blood / cytology
  • Horses
  • Stem Cells / cytology
  • Stem Cells / physiology
  • Tendon Injuries / therapy
  • Tissue Engineering / methods

Conflict of Interest Statement

The authors declare that they have no competing interests.

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