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Bone & joint research2012; 1(11); 297-309; doi: 10.1302/2046-3758.111.2000132

The horse as a model of naturally occurring osteoarthritis.

Abstract: Osteoarthritis (OA) is an important cause of pain, disability and economic loss in humans, and is similarly important in the horse. Recent knowledge on post-traumatic OA has suggested opportunities for early intervention, but it is difficult to identify the appropriate time of these interventions. The horse provides two useful mechanisms to answer these questions: 1) extensive experience with clinical OA in horses; and 2) use of a consistently predictable model of OA that can help study early pathobiological events, define targets for therapeutic intervention and then test these putative therapies. This paper summarises the syndromes of clinical OA in horses including pathogenesis, diagnosis and treatment, and details controlled studies of various treatment options using an equine model of clinical OA.
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Publication Date: 2012-11-01 PubMed ID: 23610661PubMed Central: PMC3626203DOI: 10.1302/2046-3758.111.2000132Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper discusses how horses serve as a practical model for studying osteoarthritis (OA), which is a significant cause of pain and disability in people. It provides a dual approach: analyzing clinical OA cases in horses and using a predictable OA model in horses to devise potential treatment solutions.

Understanding Osteoarthritis in Horses

Osteoarthritis (OA) is a condition that causes not only discomfort but also disability, both in humans and horses. The study pivots on the premise that understanding the progression, diagnosis, and treatment of OA in horses can provide crucial insights into addressing the condition in both species:

  • The paper examines the syndromes related to clinical osteoarthritis in horses. This includes the strategies for diagnosing the condition as well as the root causes or pathogenesis of the disease in equines.
  • The researchers also analyze the treatments currently deployed for managing OA in horses. This review provides a firm foundation for exploring potential interventions and curative strategies.

The Dual Approach to OA Research

The article discusses a dual approach in studying osteoarthritis in horses. This method helps in defining the right time for therapeutic intervention and provides a reliable platform for testing potential therapies:

  • One arm of the approach involves studying clinical OA in horses. This implies analyzing the practical experiences and real-world cases of equine OA. Leveraging these experiences enables the researchers to gain a more profound and practical understanding of the disease progression and treatment effects.
  • The second element utilizes a predictive, controlled model of OA in horses. This model allows the research team to scrutinize the early stages of the disease or “pathobiological” events, identifying areas where therapeutic intervention could potentially slow or halt the progression of OA.
  • The dual methodology not only studies the disease from a theoretical lens but also tests putative or proposed therapies in a controlled environment. Hence, it provides a well-rounded research base for the disorder.

Testing Potential Therapies

In this study, controlled experiments are carried out to test various treatment options for osteoarthritis. These tests are conducted using the horse model of clinical OA, offering a more nuanced understanding of therapeutic efficiency:

  • The consistent and predictable nature of the OA model used in horses helps in designing and assessing potential therapies, defining an avenue for early interventions.
  • By testing the likely therapies in real-world conditions, the researchers can conduct an extensive investigation of the possible treatments and identify the most effective ones.

Cite This Article

APA
McIlwraith CW, Frisbie DD, Kawcak CE. (2012). The horse as a model of naturally occurring osteoarthritis. Bone Joint Res, 1(11), 297-309. https://doi.org/10.1302/2046-3758.111.2000132

Publication

Bone & joint research
ISSN: 2046-3758
NlmUniqueID: 101586057
Country: England
Language: English
Volume: 1
Issue: 11
Pages: 297-309

Researcher Affiliations

McIlwraith, C W
  • Orthopaedic Research Center, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA.
Frisbie, D D
    Kawcak, C E

      Conflict of Interest Statement

      None declared

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