The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses.

1. Network GA. The global asthma report 2018. 2018.
2. Hotchkiss JW, Reid SW, Christley RM. A survey of horse owners in Great Britain regarding horses in their care. Part 2: Risk factors for recurrent airway obstruction.. Equine Vet J 2007 Jul;39(4):301-8.
   pubmed: 17722720doi: 10.2746/042516407x180129google scholar: lookup
3. Kuruvilla ME, Lee FE, Lee GB. Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease.. Clin Rev Allergy Immunol 2019 Apr;56(2):219-233.
   pubmed: 30206782doi: 10.1007/s12016-018-8712-1google scholar: lookup
4. Couëtil LL, Cardwell JM, Gerber V, Lavoie JP, Léguillette R, Richard EA. Inflammatory Airway Disease of Horses--Revised Consensus Statement.. J Vet Intern Med 2016 Mar-Apr;30(2):503-15.
   pubmed: 26806374pmc: 4913592doi: 10.1111/jvim.13824google scholar: lookup
5. Sheats MK, Davis KU, Poole JA. Comparative Review of Asthma in Farmers and Horses.. Curr Allergy Asthma Rep 2019 Oct 10;19(11):50.
   pubmed: 31599358doi: 10.1007/s11882-019-0882-2google scholar: lookup
6. Bond S, Léguillette R, Richard EA, Couetil L, Lavoie JP, Martin JG, Pirie RS. Equine asthma: Integrative biologic relevance of a recently proposed nomenclature.. J Vet Intern Med 2018 Nov;32(6):2088-2098.
   pubmed: 30294851pmc: 6271326doi: 10.1111/jvim.15302google scholar: lookup
7. Loza MJ, Djukanovic R, Chung KF, Horowitz D, Ma K, Branigan P, Barnathan ES, Susulic VS, Silkoff PE, Sterk PJ, Baribaud F. Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.. Respir Res 2016 Dec 15;17(1):165.
   pubmed: 27978840pmc: 5159977doi: 10.1186/s12931-016-0482-9google scholar: lookup
8. Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.. J Allergy Clin Immunol 2017 Jun;139(6):1797-1807.
   pubmed: 27773852doi: 10.1016/j.jaci.2016.08.048google scholar: lookup
9. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.. Eur Respir J 2014 Feb;43(2):343-73.
   pubmed: 24337046doi: 10.1183/09031936.00202013google scholar: lookup
10. Svenningsen S, Nair P. Asthma endotypes and an overview of targeted therapy for asthma. Frontiers of Medicine (Lausanne) 2017;4:158.
11. McBrien CN, Menzies-Gow A. The biology of eosinophils and their role in asthma. Frontiers of Medicine (Lausanne) 2017;4:93.
12. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma.. Science 1998 Dec 18;282(5397):2261-3.
    pubmed: 9856950pmc: 3897229doi: 10.1126/science.282.5397.2261google scholar: lookup
13. Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma.. J Allergy Clin Immunol 1986 Apr;77(4):527-37.
    pubmed: 3514730doi: 10.1016/0091-6749(86)90341-6google scholar: lookup
14. van Dalen CJ, Kettle AJ. Substrates and products of eosinophil peroxidase.. Biochem J 2001 Aug 15;358(Pt 1):233-9.
    pubmed: 11485572pmc: 1222052doi: 10.1042/0264-6021:3580233google scholar: lookup
15. Ohno I, Nitta Y, Yamauchi K, Hoshi H, Honma M, Woolley K, O'Byrne P, Tamura G, Jordana M, Shirato K. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation.. Am J Respir Cell Mol Biol 1996 Sep;15(3):404-9.
    pubmed: 8810646doi: 10.1165/ajrcmb.15.3.8810646google scholar: lookup
16. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms.. Thorax 2002 Jul;57(7):643-8.
    pubmed: 12096210pmc: 1746367doi: 10.1136/thorax.57.7.643google scholar: lookup
17. Carr TF, Zeki AA, Kraft M. Eosinophilic and Noneosinophilic Asthma.. Am J Respir Crit Care Med 2018 Jan 1;197(1):22-37.
    pubmed: 28910134pmc: 5765385doi: 10.1164/rccm.201611-2232ppgoogle scholar: lookup
18. Telenga ED, Tideman SW, Kerstjens HAM, Hacken NHT, Timens W, Postma DS, van den Berge M. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy 2012;67(8):1060–1068.
19. Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8.. Chest 2001 May;119(5):1329-36.
    pubmed: 11348936doi: 10.1378/chest.119.5.1329google scholar: lookup
20. Mahmutovic Persson I, Menzel M, Ramu S, Cerps S, Akbarshahi H, Uller L. IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation.. Respir Res 2018 Jan 24;19(1):16.
    pubmed: 29361942pmc: 5781288doi: 10.1186/s12931-018-0725-zgoogle scholar: lookup
21. Ricciardolo FLM, Sorbello V, Folino A, Gallo F, Massaglia GM, Favatà G, Conticello S, Vallese D, Gani F, Malerba M, Folkerts G, Rolla G, Profita M, Mauad T, Di Stefano A, Ciprandi G. Identification of IL-17F/frequent exacerbator endotype in asthma.. J Allergy Clin Immunol 2017 Aug;140(2):395-406.
    pubmed: 27931975doi: 10.1016/j.jaci.2016.10.034google scholar: lookup
22. Magnan A, Bourdin A, Prazma CM, Albers FC, Price RG, Yancey SW, Ortega H. Treatment response with mepolizumab in severe eosinophilic asthma patients with previous omalizumab treatment.. Allergy 2016 Sep;71(9):1335-44.
    pubmed: 27087007pmc: 5089585doi: 10.1111/all.12914google scholar: lookup
23. Busse W. Anti-IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison. Journal of Allergy and Clinical Immunology 2019;143(1):190–200.e20.
24. Kubes P. The enigmatic neutrophil: what we do not know.. Cell Tissue Res 2018 Mar;371(3):399-406.
    pubmed: 29404726doi: 10.1007/s00441-018-2790-5google scholar: lookup
25. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation.. Nat Rev Immunol 2013 Mar;13(3):159-75.
    pubmed: 23435331doi: 10.1038/nri3399google scholar: lookup
26. Phillipson M, Kubes P. The neutrophil in vascular inflammation.. Nat Med 2011 Nov 7;17(11):1381-90.
    pubmed: 22064428pmc: 7095830doi: 10.1038/nm.2514google scholar: lookup
27. Jorch SK, Kubes P. An emerging role for neutrophil extracellular traps in noninfectious disease.. Nat Med 2017 Mar 7;23(3):279-287.
    pubmed: 28267716doi: 10.1038/nm.4294google scholar: lookup
28. Ciepiela O, Ostafin M, Demkow U. Neutrophils in asthma--a review. Respiratory Physiology & Neurobiology 2015;209:13–16.
29. . Guidelines for the diagnosis and management of asthma (EPR-3). 2007.
30. Sato E, Koyama S, Takamizawa A, Masubuchi T, Kubo K, Robbins RA, Nagai S, Izumi T. Smoke extract stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activities.. Am J Physiol 1999 Dec;277(6):L1149-57.
    pubmed: 10600885doi: 10.1152/ajplung.1999.277.6.l1149google scholar: lookup
31. Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. Journal of Immunology 1995;154(9):4719–4725.
32. Pham DL, Ban GY, Kim SH, Shin YS, Ye YM, Chwae YJ, Park HS. Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma.. Clin Exp Allergy 2017 Jan;47(1):57-70.
    pubmed: 27883241doi: 10.1111/cea.12859google scholar: lookup
33. Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, Calhoun WJ, Erzurum S, Gaston B, Israel E, Curran-Everett D, Wenzel SE. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data.. J Allergy Clin Immunol 2014 May;133(5):1280-8.
    pubmed: 24589344pmc: 4038417doi: 10.1016/j.jaci.2013.11.042google scholar: lookup
34. Moore WC. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Journal of Allergy and Clinical Immunology 2014;133(6):1557–63.e5.
35. Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.. Am J Respir Crit Care Med 2000 Apr;161(4 Pt 1):1185-90.
    pubmed: 10764310doi: 10.1164/ajrccm.161.4.9812061google scholar: lookup
36. Shaw DE, Berry MA, Hargadon B, McKenna S, Shelley MJ, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma.. Chest 2007 Dec;132(6):1871-5.
    pubmed: 17925424doi: 10.1378/chest.07-1047google scholar: lookup
37. Nabe T. Steroid-resistant asthma and neutrophils. Biological & Pharmaceutical Bulletin 2020;43(1):31–35.
38. Kianmeher M, Ghorani V, Boskabady MH. Animal Model of Asthma, Various Methods and Measured Parameters: A Methodological Review.. Iran J Allergy Asthma Immunol 2016 Dec;15(6):445-465.
    pubmed: 28129678
39. Nials AT, Uddin S. Mouse models of allergic asthma: acute and chronic allergen challenge. Disease Models & Mechanisms 2008;1(4-5):213–220.
40. Kalidhindi RSR, Ambhore NS, Bhallamudi S, Loganathan J, Sathish V. Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice.. Front Pharmacol 2019;10:1499.
    pubmed: 32116656doi: 10.3389/fphar.2019.01499google scholar: lookup
41. Vandamme TF. Use of rodents as models of human diseases. Journal of Pharmacy & Bioallied Sciences 2014;6(1):2–9.
42. Jucker M. The benefits and limitations of animal models for translational research in neurodegenerative diseases.. Nat Med 2010 Nov;16(11):1210-4.
    pubmed: 21052075doi: 10.1038/nm.2224google scholar: lookup
43. Marqués-García F, Marcos-Vadillo E. Review of Mouse Models Applied to the Study of Asthma.. Methods Mol Biol 2016;1434:213-22.
    pubmed: 27300541doi: 10.1007/978-1-4939-3652-6_15google scholar: lookup
44. Wenzel S, Holgate ST. The mouse trap: It still yields few answers in asthma.. Am J Respir Crit Care Med 2006 Dec 1;174(11):1173-6; discussion 1176-8.
    pubmed: 17110654doi: 10.1164/rccm.2609002google scholar: lookup
45. Kumar RK, Foster PS. Modeling allergic asthma in mice: pitfalls and opportunities.. Am J Respir Cell Mol Biol 2002 Sep;27(3):267-72.
    pubmed: 12204888doi: 10.1165/rcmb.f248google scholar: lookup
46. Kumar RK, Foster PS. Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?. Front Physiol 2012;3:312.
    pubmed: 23060800pmc: 3459343doi: 10.3389/fphys.2012.00312google scholar: lookup
47. Leclere M, Lavoie-Lamoureux A, Lavoie JP. Heaves, an asthma-like disease of horses.. Respirology 2011 Oct;16(7):1027-46.
    pubmed: 21824219doi: 10.1111/j.1440-1843.2011.02033.xgoogle scholar: lookup
48. Davis KU, Sheats MK. Bronchoalveolar Lavage Cytology Characteristics and Seasonal Changes in a Herd of Pastured Teaching Horses.. Front Vet Sci 2019;6:74.
    pubmed: 30923711pmc: 6426765doi: 10.3389/fvets.2019.00074google scholar: lookup
49. Ewart SL, Robinson NE. Genes and respiratory disease: a first step on a long journey.. Equine Vet J 2007 May;39(3):270-4.
    pubmed: 17520980doi: 10.2746/042516407x194296google scholar: lookup
50. McGorum BC, Dixon PM, Halliwell RE. Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens.. Equine Vet J 1993 Jul;25(4):261-7.
    pubmed: 8354208doi: 10.1111/j.2042-3306.1993.tb02960.xgoogle scholar: lookup
51. Jose-Cunilleras E, Kohn CW, Hillier A, Saville WJ, Lorch G. Intradermal testing in healthy horses and horses with chronic obstructive pulmonary disease, recurrent urticaria, or allergic dermatitis.. J Am Vet Med Assoc 2001 Oct 15;219(8):1115-21.
    pubmed: 11700711doi: 10.2460/javma.2001.219.1115google scholar: lookup
52. Gorman BK, Chu M. Racial and ethnic differences in adult asthma prevalence, problems, and medical care. Ethnicity & Health 2009;14(5):527–552.
53. Shah R, Newcomb DC. Sex Bias in Asthma Prevalence and Pathogenesis.. Front Immunol 2018;9:2997.
    pubmed: 30619350pmc: 6305471doi: 10.3389/fimmu.2018.02997google scholar: lookup
54. Marti E, Gerber H, Essich G, Oulehla J, Lazary S. The genetic basis of equine allergic diseases. 1. Chronic hypersensitivity bronchitis.. Equine Vet J 1991 Nov;23(6):457-60.
    pubmed: 1778165doi: 10.1111/j.2042-3306.1991.tb03761.xgoogle scholar: lookup
55. Ramseyer A, Gaillard C, Burger D, Straub R, Jost U, Boog C, Marti E, Gerber V. Effects of genetic and environmental factors on chronic lower airway disease in horses.. J Vet Intern Med 2007 Jan-Feb;21(1):149-56.
    pubmed: 17338163doi: 10.1892/0891-6640(2007)21[149:eogaef]2.0.co;2google scholar: lookup
56. McPherson EA, Lawson GH, Murphy JR, Nicholson JM, Breeze RG, Pirie HM. Chronic obstructive pulmonary disease (COPD): factors influencing the occurrence.. Equine Vet J 1979 Jul;11(3):167-71.
    pubmed: 488065doi: 10.1111/j.2042-3306.1979.tb01332.xgoogle scholar: lookup
57. Lavoie JP, Maghni K, Desnoyers M, Taha R, Martin JG, Hamid QA. Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile.. Am J Respir Crit Care Med 2001 Oct 15;164(8 Pt 1):1410-3.
    pubmed: 11704587doi: 10.1164/ajrccm.164.8.2012091google scholar: lookup
58. Padoan E, Ferraresso S, Pegolo S, Castagnaro M, Barnini C, Bargelloni L. Real time RT-PCR analysis of inflammatory mediator expression in recurrent airway obstruction-affected horses.. Vet Immunol Immunopathol 2013 Dec 15;156(3-4):190-9.
    pubmed: 24176614doi: 10.1016/j.vetimm.2013.09.020google scholar: lookup
59. Ainsworth DM, Grünig G, Matychak MB, Young J, Wagner B, Erb HN, Antczak DF. Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells.. Vet Immunol Immunopathol 2003 Nov 15;96(1-2):83-91.
    pubmed: 14522137doi: 10.1016/s0165-2427(03)00142-9google scholar: lookup
60. Ainsworth DM, Wagner B, Franchini M, Grünig G, Erb HN, Tan JY. Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstruction.. Am J Vet Res 2006 Apr;67(4):669-77.
    pubmed: 16579761doi: 10.2460/ajvr.67.4.669google scholar: lookup
61. Hastie AT. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. Journal of Allergy and Clinical Immunology 2010;125(5):1028–1036.e13.
62. Durrant DM, Metzger DW. Emerging roles of T helper subsets in the pathogenesis of asthma.. Immunol Invest 2010;39(4-5):526-49.
    pubmed: 20450290pmc: 3787690doi: 10.3109/08820131003615498google scholar: lookup
63. Lange-Consiglio A, Stucchi L, Zucca E, Lavoie JP, Cremonesi F, Ferrucci F. Insights into animal models for cell-based therapies in translational studies of lung diseases: Is the horse with naturally occurring asthma the right choice?. Cytotherapy 2019 May;21(5):525-534.
    pubmed: 30929991doi: 10.1016/j.jcyt.2019.02.010google scholar: lookup
64. Venner M, Schmidbauer S, Drommer W, Deegen E. Percutaneous lung biopsy in the horse: comparison of two instruments and repeated biopsy in horses with induced acute interstitial pneumopathy.. J Vet Intern Med 2006 Jul-Aug;20(4):968-73.
    pubmed: 16955824doi: 10.1892/0891-6640(2006)20[968:plbith]2.0.co;2google scholar: lookup
65. Clements JM, Pirie RS. Respirable dust concentrations in equine stables. Part 1: validation of equipment and effect of various management systems.. Res Vet Sci 2007 Oct;83(2):256-62.
    pubmed: 17477944doi: 10.1016/j.rvsc.2006.12.002google scholar: lookup
66. Berndt A, Derksen FJ, Robinson NE. Endotoxin concentrations within the breathing zone of horses are higher in stables than on pasture. Veterinary Journal 2010;183(1):54–57.
67. Wålinder R, Riihimäki M, Bohlin S, Hogstedt C, Nordquist T, Raine A, Pringle J, Elfman L. Installation of mechanical ventilation in a horse stable: effects on air quality and human and equine airways.. Environ Health Prev Med 2011 Jul;16(4):264-72.
    pubmed: 21431789doi: 10.1007/s12199-010-0195-5google scholar: lookup
68. Ivester KM, Couëtil LL, Moore GE, Zimmerman NJ, Raskin RE. Environmental exposures and airway inflammation in young thoroughbred horses.. J Vet Intern Med 2014 May-Jun;28(3):918-24.
    pubmed: 24773603pmc: 4895475doi: 10.1111/jvim.12333google scholar: lookup
69. Poole JA, Romberger DJ. Immunological and inflammatory responses to organic dust in agriculture.. Curr Opin Allergy Clin Immunol 2012 Apr;12(2):126-32.
    pubmed: 22306554pmc: 3292674doi: 10.1097/aci.0b013e3283511d0egoogle scholar: lookup
70. Pirie RS, Dixon PM, Collie DD, McGorum BC. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses.. Equine Vet J 2001 May;33(3):311-8.
    pubmed: 11352355doi: 10.2746/042516401776249732google scholar: lookup
71. Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, Pauwels R, Sergysels R. Severity of asthma is related to endotoxin in house dust.. Am J Respir Crit Care Med 1996 Dec;154(6 Pt 1):1641-6.
    pubmed: 8970348doi: 10.1164/ajrccm.154.6.8970348google scholar: lookup
72. Dauvillier J, Ter Woort F, van Erck-Westergren E. Fungi in respiratory samples of horses with inflammatory airway disease.. J Vet Intern Med 2019 Mar;33(2):968-975.
    pubmed: 30576012doi: 10.1111/jvim.15397google scholar: lookup
73. Fairs A, Agbetile J, Hargadon B, Bourne M, Monteiro WR, Brightling CE, Bradding P, Green RH, Mutalithas K, Desai D, Pavord ID, Wardlaw AJ, Pashley CH. IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma.. Am J Respir Crit Care Med 2010 Dec 1;182(11):1362-8.
    pubmed: 20639442pmc: 3029929doi: 10.1164/rccm.201001-0087ocgoogle scholar: lookup
74. Lien E, Ingalls RR. Toll-like receptors.. Crit Care Med 2002 Jan;30(1 Supp):S1-S11.
    pubmed: 11839939
75. Wyatt TA, Slager RE, Heires AJ, Devasure JM, Vonessen SG, Poole JA, Romberger DJ. Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor.. Am J Respir Cell Mol Biol 2010 Jun;42(6):706-15.
    pubmed: 19635931doi: 10.1165/rcmb.2009-0065ocgoogle scholar: lookup
76. Palmberg L, Larsson BM, Malmberg P, Larsson K. Induction of IL-8 production in human alveolar macrophages and human bronchial epithelial cells in vitro by swine dust. Thorax 1998;53(4):260–264.
77. Pirie RS, Dixon PM, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 3: Effect of fractionation of HDS.. Equine Vet J 2002 Jul;34(4):343-7.
    pubmed: 12117105doi: 10.2746/042516402776249236google scholar: lookup
78. Sundblad BM, von Scheele I, Palmberg L, Olsson M, Larsson K. Repeated exposure to organic material alters inflammatory and physiological airway responses.. Eur Respir J 2009 Jul;34(1):80-8.
    pubmed: 19213791doi: 10.1183/09031936.00105308google scholar: lookup
79. Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Fallert Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD. Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.. PLoS One 2015;10(8):e0134219.
    pubmed: 26261989pmc: 4532492doi: 10.1371/journal.pone.0134219google scholar: lookup
80. Pirie RS, Collie DD, Dixon PM, McGorum BC. Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma).. Clin Exp Allergy 2003 May;33(5):676-83.
    pubmed: 12752598doi: 10.1046/j.1365-2222.2003.01640.xgoogle scholar: lookup
81. Nocker RE, Schoonbrood DF, van de Graaf EA, Hack CE, Lutter R, Jansen HM, Out TA. Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease.. Int Arch Allergy Immunol 1996 Feb;109(2):183-91.
    pubmed: 8563494doi: 10.1159/000237218google scholar: lookup
82. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. Journal of Immunology 2002;168(10):5278–5286.
83. Singh SR, Sutcliffe A, Kaur D, Gupta S, Desai D, Saunders R, Brightling CE. CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration.. Allergy 2014 Sep;69(9):1189-97.
    pubmed: 24931417pmc: 4215601doi: 10.1111/all.12444google scholar: lookup
84. Molet S, Hamid Q, Davoine F, Nutku E, Taha R, Pagé N, Olivenstein R, Elias J, Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.. J Allergy Clin Immunol 2001 Sep;108(3):430-8.
    pubmed: 11544464doi: 10.1067/mai.2001.117929google scholar: lookup
85. Itakura E, Kishi-Itakura C, Mizushima N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.. Cell 2012 Dec 7;151(6):1256-69.
    pubmed: 23217709doi: 10.1016/j.cell.2012.11.001google scholar: lookup
86. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells.. Annu Rev Immunol 2009;27:485-517.
    pubmed: 19132915doi: 10.1146/annurev.immunol.021908.132710google scholar: lookup
87. Murcia RY, Vargas A, Lavoie JP. The Interleukin-17 Induced Activation and Increased Survival of Equine Neutrophils Is Insensitive to Glucocorticoids.. PLoS One 2016;11(5):e0154755.
    pubmed: 27138006pmc: 4854453doi: 10.1371/journal.pone.0154755google scholar: lookup
88. Debrue M, Hamilton E, Joubert P, Lajoie-Kadoch S, Lavoie JP. Chronic exacerbation of equine heaves is associated with an increased expression of interleukin-17 mRNA in bronchoalveolar lavage cells.. Vet Immunol Immunopathol 2005 May 1;105(1-2):25-31.
    pubmed: 15797472doi: 10.1016/j.vetimm.2004.12.013google scholar: lookup
89. Wolf L, Sapich S, Honecker A, Jungnickel C, Seiler F, Bischoff M, Wonnenberg B, Herr C, Schneider-Daum N, Lehr CM, Bals R, Beisswenger C. IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia.. Am J Physiol Lung Cell Mol Physiol 2016 Nov 1;311(5):L1015-L1022.
    pubmed: 27694471doi: 10.1152/ajplung.00158.2016google scholar: lookup
90. Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, Hackney J, Kim J, Zhou M, Lai J, Modrusan Z, Sai T, Lee W, Xu M, Caplazi P, Diehl L, de Voss J, Balazs M, Gonzalez L Jr, Singh H, Ouyang W, Pappu R. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.. Nat Immunol 2011 Oct 12;12(12):1159-66.
    pubmed: 21993848doi: 10.1038/ni.2156google scholar: lookup
91. Honda K, Wada H, Nakamura M, Nakamoto K, Inui T, Sada M, Koide T, Takata S, Yokoyama T, Saraya T, Kurai D, Ishii H, Goto H, Takizawa H. IL-17A synergistically stimulates TNF-α-induced IL-8 production in human airway epithelial cells: A potential role in amplifying airway inflammation.. Exp Lung Res 2016 May;42(4):205-16.
    pubmed: 27269887doi: 10.1080/01902148.2016.1190796google scholar: lookup
92. Morishima Y. Th17-associated cytokines as a therapeutic target for steroid-insensitive asthma. Clinical & Developmental Immunology 2013;2013:609395.
93. Qiu YY, Zhou XY, Qian XF, Wu YX, Qin C, Bian T. 1,25-dihydroxyvitamin D3 reduces mouse airway inflammation of neutrophilic asthma by transcriptional modulation of interleukin-17A.. Am J Transl Res 2017;9(12):5411-5421.
    pubmed: 29312493pmc: 5752891
94. Al-Harbi NO, Nadeem A, Ahmad SF, AlThagfan SS, Alqinyah M, Alqahtani F, Ibrahim KE, Al-Harbi MM. Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma by upregulation of antioxidants and attenuation of Th17 immune responses in the airways.. Eur J Pharmacol 2019 Jul 15;855:276-284.
    pubmed: 31100413doi: 10.1016/j.ejphar.2019.05.026google scholar: lookup
95. Liang L, Hur J, Kang JY, Rhee CK, Kim YK, Lee SY. Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model.. Korean J Intern Med 2018 Nov;33(6):1210-1223.
    pubmed: 29665658pmc: 6234391doi: 10.3904/kjim.2017.207google scholar: lookup
96. Dos Santos TM, Righetti RF, Camargo LDN, Saraiva-Romanholo BM, Aristoteles LRCRB, de Souza FCR, Fukuzaki S, Alonso-Vale MIC, Cruz MM, Prado CM, Leick EA, Martins MA, Tibério IFLC. Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma.. Front Physiol 2018;9:1183.
    pubmed: 30233389pmc: 6134017doi: 10.3389/fphys.2018.01183google scholar: lookup
97. Camargo LDN, Righetti RF, Aristóteles LRCRB, Dos Santos TM, de Souza FCR, Fukuzaki S, Cruz MM, Alonso-Vale MIC, Saraiva-Romanholo BM, Prado CM, Martins MA, Leick EA, Tibério IFLC. Effects of Anti-IL-17 on Inflammation, Remodeling, and Oxidative Stress in an Experimental Model of Asthma Exacerbated by LPS.. Front Immunol 2017;8:1835.
    pubmed: 29379497doi: 10.3389/fimmu.2017.01835google scholar: lookup
98. Fei X, Zhang PY, Zhang X, Zhang GQ, Bao WP, Zhang YY, Zhang M, Zhou X. IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozonec.. Inflammation 2017 Jun;40(3):788-797.
    pubmed: 28194607pmc: 5429348doi: 10.1007/s10753-017-0523-7google scholar: lookup
99. Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, Lin SL. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma.. Am J Respir Crit Care Med 2013 Dec 1;188(11):1294-302.
    pubmed: 24200404doi: 10.1164/rccm.201212-2318ocgoogle scholar: lookup
100. O'Byrne PM, Metev H, Puu M, Richter K, Keen C, Uddin M, Larsson B, Cullberg M, Nair P. Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial.. Lancet Respir Med 2016 Oct;4(10):797-806.
     pubmed: 27574788doi: 10.1016/s2213-2600(16)30227-2google scholar: lookup
101. Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species.. Nat Rev Immunol 2013 May;13(5):349-61.
     pubmed: 23618831pmc: 4250048doi: 10.1038/nri3423google scholar: lookup
102. Nguyen GT, Green ER, Mecsas J. Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.. Front Cell Infect Microbiol 2017;7:373.
     pubmed: 28890882pmc: 5574878doi: 10.3389/fcimb.2017.00373google scholar: lookup
103. Zuo L, Zhou T, Pannell BK, Ziegler AC, Best TM. Biological and physiological role of reactive oxygen species--the good, the bad and the ugly. Acta Physiologica (Oxford, England) 2015;214(3):329–348.
104. Kleniewska P, Pawliczak R. The participation of oxidative stress in the pathogenesis of bronchial asthma. Biomedicine & Pharmacotherapy 2017;94:100–108.
105. Bishopp A, Sathyamurthy R, Manney S, Webbster C, Krishna MT, Mansur AH. Biomarkers of oxidative stress and antioxidants in severe asthma: a prospective case-control study. Annals of Allergy, Asthma & Immunology 2017;118(4):445–451.
106. Erzurum SC. New Insights in Oxidant Biology in Asthma.. Ann Am Thorac Soc 2016 Mar;13 Suppl 1(Suppl 1):S35-9.
     pubmed: 27027950pmc: 5015728doi: 10.1513/annalsats.201506-385mggoogle scholar: lookup
107. Robinson JM. Reactive oxygen species in phagocytic leukocytes.. Histochem Cell Biol 2008 Aug;130(2):281-97.
     pubmed: 18597105pmc: 2491708doi: 10.1007/s00418-008-0461-4google scholar: lookup
108. Fukunaga M, Gon Y, Nunomura S, Inoue T, Yoshioka M, Hashimoto S, Ra C. Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils.. Int Arch Allergy Immunol 2011;155 Suppl 1:104-9.
     pubmed: 21646804doi: 10.1159/000327492google scholar: lookup
109. Natarajan K, Gottipati KR, Berhane K, Samten B, Pendurthi U, Boggaram V. Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells.. Respir Res 2016 Oct 22;17(1):137.
     pubmed: 27770804pmc: 5075176doi: 10.1186/s12931-016-0455-zgoogle scholar: lookup
110. To M, Kono Y, Ogura N, Mikami S, Honda N, Hitani A, Kano I, Haruki K, To Y. Obesity-related systemic oxidative stress: An important factor of poor asthma control.. Allergol Int 2018 Jan;67(1):147-149.
     pubmed: 28648979doi: 10.1016/j.alit.2017.06.002google scholar: lookup
111. Suzuki S, Matsukura S, Takeuchi H, Kawaguchi M, Ieki K, Odaka M, Watanabe S, Homma T, Dohi K, Aruga T, Sato M, Kurokawa M, Kokubu F, Adachi M. Increase in reactive oxygen metabolite level in acute exacerbations of asthma.. Int Arch Allergy Immunol 2008;146 Suppl 1:67-72.
     pubmed: 18504410doi: 10.1159/000126064google scholar: lookup
112. Nakamoto K, Watanabe M, Sada M, Inui T, Nakamura M, Honda K, Wada H, Mikami Y, Matsuzaki H, Horie M, Noguchi S, Yamauchi Y, Koyama H, Kogane T, Kohyama T, Takizawa H. Serum Reactive Oxygen Metabolite Levels Predict Severe Exacerbations of Asthma.. PLoS One 2016;11(10):e0164948.
     pubmed: 27776186pmc: 5077110doi: 10.1371/journal.pone.0164948google scholar: lookup
113. Kelly C, Ward C, Stenton CS, Bird G, Hendrick DJ, Walters EH. Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness.. Thorax 1988 Sep;43(9):684-92.
     pubmed: 3194874pmc: 461456doi: 10.1136/thx.43.9.684google scholar: lookup
114. Vachier I, Chanez P, Le Doucen C, Damon M, Descomps B, Godard P. Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients.. Eur Respir J 1994 Sep;7(9):1585-92.
     pubmed: 7995385doi: 10.1183/09031936.94.07091585google scholar: lookup
115. Lacy P, Latif DA, Steward M, Musat-Marcu S, Man SFP, Moqbel R. Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects. Journal of Immunology 2003;170(5):2670–2679.
116. Bucchieri F, Puddicombe SM, Lordan JL, Richter A, Buchanan D, Wilson SJ, Ward J, Zummo G, Howarth PH, Djukanović R, Holgate ST, Davies DE. Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.. Am J Respir Cell Mol Biol 2002 Aug;27(2):179-85.
     pubmed: 12151309doi: 10.1165/ajrcmb.27.2.4699google scholar: lookup
117. Zeng H, Wang Y, Gu Y, Wang J, Zhang H, Gao H, Jin Q, Zhao L. Polydatin attenuates reactive oxygen species-induced airway remodeling by promoting Nrf2-mediated antioxidant signaling in asthma mouse model.. Life Sci 2019 Feb 1;218:25-30.
     pubmed: 30092299doi: 10.1016/j.lfs.2018.08.013google scholar: lookup
118. Ravasi S, Citro S, Viviani B, Capra V, Rovati GE. CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.. Respir Res 2006 Mar 22;7(1):42.
     pubmed: 16553950pmc: 1488842doi: 10.1186/1465-9921-7-42google scholar: lookup
119. Tuo QR, Ma YF, Chen W, Luo XJ, Shen J, Guo D, Zheng YM, Wang YX, Ji G, Liu QH. Reactive oxygen species induce a Ca(2+)-spark increase in sensitized murine airway smooth muscle cells.. Biochem Biophys Res Commun 2013 May 10;434(3):498-502.
     pubmed: 23583396doi: 10.1016/j.bbrc.2013.03.102google scholar: lookup
120. Qu J, Li Y, Zhong W, Gao P, Hu C. Recent developments in the role of reactive oxygen species in allergic asthma.. J Thorac Dis 2017 Jan;9(1):E32-E43.
     pubmed: 28203435pmc: 5303105doi: 10.21037/jtd.2017.01.05google scholar: lookup
121. Jesenak M, Zelieskova M, Babusikova E. Oxidative Stress and Bronchial Asthma in Children-Causes or Consequences?. Front Pediatr 2017;5:162.
     pubmed: 28791280pmc: 5523023doi: 10.3389/fped.2017.00162google scholar: lookup
122. Venugopal C, Mariappan N, Holmes E, Kearney M, Beadle R. Effect of potential therapeutic agents in reducing oxidative stress in pulmonary tissues of recurrent airway obstruction-affected and clinically healthy horses.. Equine Vet J 2013 Jan;45(1):80-4.
     pubmed: 22506732doi: 10.1111/j.2042-3306.2012.00566.xgoogle scholar: lookup
123. Marr KA, Foster AP, Lees P, Cunningham FM, Page CP. Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease.. Res Vet Sci 1997 May-Jun;62(3):253-60.
     pubmed: 9300544doi: 10.1016/s0034-5288(97)90200-9google scholar: lookup
124. Bowler RP. Oxidative stress in the pathogenesis of asthma.. Curr Allergy Asthma Rep 2004 Mar;4(2):116-22.
     pubmed: 14769260doi: 10.1007/s11882-004-0056-7google scholar: lookup
125. Psarras S, Caramori G, Contoli M, Papadopoulos N, Papi A. Oxidants in asthma and in chronic obstructive pulmonary disease (COPD).. Curr Pharm Des 2005;11(16):2053-62.
     pubmed: 15974958doi: 10.2174/1381612054065774google scholar: lookup
126. Liao MF, Chen CC, Hsu MH. Evaluation of the serum antioxidant status in asthmatic children.. Acta Paediatr Taiwan 2004 Jul-Aug;45(4):213-7.
     pubmed: 15624367
127. Sagdic A, Sener O, Bulucu F, Karadurmus N, Özel HE, Yamanel L, Tasci C, Naharci I, Ocal R, Aydin A. Oxidative stress status and plasma trace elements in patients with asthma or allergic rhinitis. Allergol Immunopathol (Madr) 2011;39(4):200–205.
128. Niedzwiedz A, Borowicz H, Januszewska L, Markiewicz-Gorka I, Jaworski Z. Serum 8-hydroxy-2-deoxyguanosine as a marker of DNA oxidative damage in horses with recurrent airway obstruction.. Acta Vet Scand 2016 Jun 7;58(1):38.
     pubmed: 27267076pmc: 4895991doi: 10.1186/s13028-016-0215-6google scholar: lookup
129. Deaton CM, Marlin DJ, Smith NC, Roberts CA, Harris PA, Schroter RC, Kelly FJ. Antioxidant and inflammatory responses of healthy horses and horses affected by recurrent airway obstruction to inhaled ozone.. Equine Vet J 2005 May;37(3):243-9.
     pubmed: 15892234doi: 10.2746/0425164054530605google scholar: lookup
130. Deaton CM, Marlin DJ, Deaton L, Smith NC, Harris PA, Schroter RC, Kelly FJ. Comparison of the antioxidant status in tracheal and bronchoalveolar epithelial lining fluids in recurrent airway obstruction.. Equine Vet J 2006 Sep;38(5):417-22.
     pubmed: 16986601doi: 10.2746/042516406778400556google scholar: lookup
131. Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respiratory Medicine 2007;101(8):1770–1778.
132. Burbank AJ. Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. Journal of Allergy and Clinical Immunology 2018;141(4):1231–1238.e1.
133. Perez B, Henriquez C, Sarmiento J, Morales N, Folch H, Galesio JS, Uberti B, Morán G. Tamoxifen as a new therapeutic tool for neutrophilic lung inflammation.. Respirology 2016 Jan;21(1):112-8.
     pubmed: 26510482doi: 10.1111/resp.12664google scholar: lookup
134. Borlone C, Morales N, Henriquez C, Folch H, Olave C, Sarmiento J, Uberti B, Moran G. In Vitro effects of tamoxifen on equine neutrophils.. Res Vet Sci 2017 Feb;110:60-64.
     pubmed: 28159238doi: 10.1016/j.rvsc.2016.11.003google scholar: lookup
135. Olave C, Alvarez P, Uberti B, Morales N, Henriquez C, Folch H, Sarmiento J, Moran G. Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors.. J Vet Pharmacol Ther 2019 Mar;42(2):248-254.
     pubmed: 30345523doi: 10.1111/jvp.12728google scholar: lookup
136. Twaddell SH, Baines KJ, Grainge C, Gibson PG. The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease.. Chest 2019 Oct;156(4):774-782.
     pubmed: 31265835doi: 10.1016/j.chest.2019.06.012google scholar: lookup
137. Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J, Preissner KT. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones.. PLoS One 2012;7(2):e32366.
     pubmed: 22389696pmc: 3289648doi: 10.1371/journal.pone.0032366google scholar: lookup
138. Narasaraju T, Yang E, Samy RP, Ng HH, Poh WP, Liew AA, Phoon MC, van Rooijen N, Chow VT. Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis.. Am J Pathol 2011 Jul;179(1):199-210.
     pubmed: 21703402pmc: 3123873doi: 10.1016/j.ajpath.2011.03.013google scholar: lookup
139. Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. Journal of Immunology 2012;189(6):2689–2695.
140. Wright TK, Gibson PG, Simpson JL, McDonald VM, Wood LG, Baines KJ. Neutrophil extracellular traps are associated with inflammation in chronic airway disease.. Respirology 2016 Apr;21(3):467-75.
     pubmed: 26804470doi: 10.1111/resp.12730google scholar: lookup
141. Dworski R, Simon HU, Hoskins A, Yousefi S. Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways.. J Allergy Clin Immunol 2011 May;127(5):1260-6.
     pubmed: 21315435pmc: 3085562doi: 10.1016/j.jaci.2010.12.1103google scholar: lookup
142. Vargas A, Boivin R, Cano P, Murcia Y, Bazin I, Lavoie JP. Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma.. Respir Res 2017 Dec 12;18(1):207.
     pubmed: 29233147pmc: 5727947doi: 10.1186/s12931-017-0689-4google scholar: lookup
143. Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Bartlett NW, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SL. Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.. Nat Med 2017 Jun;23(6):681-691.
     pubmed: 28459437pmc: 5821220doi: 10.1038/nm.4332google scholar: lookup
144. Lapponi MJ, Carestia A, Landoni VI, Rivadeneyra L, Etulain J, Negrotto S, Pozner RG, Schattner M. Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs.. J Pharmacol Exp Ther 2013 Jun;345(3):430-7.
     pubmed: 23536315doi: 10.1124/jpet.112.202879google scholar: lookup
145. Geng X, Wang X, Luo M, Xing M, Wu Y, Li W, Chen Z, Shen H, Ying S. Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation. Aging (Albany NY) 2018;10(6):1415–1423.
146. Tian BP, Xia LX, Bao ZQ, Zhang H, Xu ZW, Mao YY, Cao C, Che LQ, Liu JK, Li W, Chen ZH, Ying S, Shen HH. Bcl-2 inhibitors reduce steroid-insensitive airway inflammation.. J Allergy Clin Immunol 2017 Aug;140(2):418-430.
     pubmed: 28043871doi: 10.1016/j.jaci.2016.11.027google scholar: lookup
147. Lee NR, Baek SY, Gu A, Kim DH, Kim SY, Lee JS, Kim IS. House dust mite allergen suppresses neutrophil apoptosis by cytokine release via PAR2 in normal and allergic lymphocytes.. Immunol Res 2016 Feb;64(1):123-32.
     pubmed: 26666432doi: 10.1007/s12026-015-8730-5google scholar: lookup
148. Breuer J, Müller U, Locher L, Spallek A, Recknagel S, Uhlig A, Schusser GF. Differentiation of viable, apoptotic and necrotic cells in bronchoalveolar lavage fluid of normal horses and horses with recurrent airway obstruction.. Berl Munch Tierarztl Wochenschr 2011 Mar-Apr;124(3-4):154-60.
     pubmed: 21462865
149. Niedzwiedz A, Jaworski Z, Tykalowski B, Smialek M. Neutrophil and macrophage apoptosis in bronchoalveolar lavage fluid from healthy horses and horses with recurrent airway obstruction (RAO).. BMC Vet Res 2014 Jan 24;10:29.
     pubmed: 24460911pmc: 3903020doi: 10.1186/1746-6148-10-29google scholar: lookup
150. Olave C, Morales N, Uberti B, Henriquez C, Sarmiento J, Ortloff A, Folch H, Moran G. Tamoxifen induces apoptotic neutrophil efferocytosis in horses.. Vet Res Commun 2018 Mar;42(1):57-63.
     pubmed: 29297134doi: 10.1007/s11259-017-9709-6google scholar: lookup
151. Lawrence SM, Corriden R, Nizet V. The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis. Microbiology and Molecular Biology Reviews 2018;82(1).
152. Pillay J, den Braber I, Vrisekoop N, Kwast LM, de Boer RJ, Borghans JA, Tesselaar K, Koenderman L. In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days.. Blood 2010 Jul 29;116(4):625-7.
     pubmed: 20410504doi: 10.1182/blood-2010-01-259028google scholar: lookup
153. Tak T, Tesselaar K, Pillay J, Borghans JA, Koenderman L. What's your age again? Determination of human neutrophil half-lives revisited.. J Leukoc Biol 2013 Oct;94(4):595-601.
     pubmed: 23625199doi: 10.1189/jlb.1112571google scholar: lookup
154. Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic modulation of the hematopoietic niche through neutrophil clearance.. Cell 2013 May 23;153(5):1025-35.
     pubmed: 23706740pmc: 4128329doi: 10.1016/j.cell.2013.04.040google scholar: lookup
155. Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A. A Neutrophil Timer Coordinates Immune Defense and Vascular Protection.. Immunity 2019 Nov 19;51(5):966-967.
     pubmed: 31747583doi: 10.1016/j.immuni.2019.11.001google scholar: lookup
156. Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang JE, Scheiermann C, Merad M, Frenette PS. Neutrophil ageing is regulated by the microbiome.. Nature 2015 Sep 24;525(7570):528-32.
     pubmed: 26374999pmc: 4712631doi: 10.1038/nature15367google scholar: lookup
157. Becher B, Schlitzer A, Chen J, Mair F, Sumatoh HR, Teng KW, Low D, Ruedl C, Riccardi-Castagnoli P, Poidinger M, Greter M, Ginhoux F, Newell EW. High-dimensional analysis of the murine myeloid cell system.. Nat Immunol 2014 Dec;15(12):1181-9.
     pubmed: 25306126doi: 10.1038/ni.3006google scholar: lookup
158. Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils.. Nat Rev Immunol 2019 Apr;19(4):255-265.
     pubmed: 30816340doi: 10.1038/s41577-019-0141-8google scholar: lookup
159. Ji JJ, Fan J. Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing.. Mil Med Res 2019 Oct 25;6(1):33.
     pubmed: 31651369pmc: 6814050doi: 10.1186/s40779-019-0222-9google scholar: lookup
160. Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the function and fate of neutrophils in sterile injury and repair.. Science 2017 Oct 6;358(6359):111-116.
     pubmed: 28983053doi: 10.1126/science.aam9690google scholar: lookup
161. Buckley CD, Ross EA, McGettrick HM, Osborne CE, Haworth O, Schmutz C, Stone PC, Salmon M, Matharu NM, Vohra RK, Nash GB, Rainger GE. Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration.. J Leukoc Biol 2006 Feb;79(2):303-11.
     pubmed: 16330528doi: 10.1189/jlb.0905496google scholar: lookup
162. Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M, Sandy AR, McCune WJ, Kaplan MJ. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. Journal of Immunology 2010;184(6):3284–3297.
163. Hacbarth E, Kajdacsy-Balla A. Low density neutrophils in patients with systemic lupus erythematosus, rheumatoid arthritis, and acute rheumatic fever.. Arthritis Rheum 1986 Nov;29(11):1334-42.
     pubmed: 2430586doi: 10.1002/art.1780291105google scholar: lookup
164. Marini O, Spina C, Mimiola E, Cassaro A, Malerba G, Todeschini G, Perbellini O, Scupoli M, Carli G, Facchinelli D, Cassatella M, Scapini P, Tecchio C. Identification of granulocytic myeloid-derived suppressor cells (G-MDSCs) in the peripheral blood of Hodgkin and non-Hodgkin lymphoma patients.. Oncotarget 2016 May 10;7(19):27676-88.
     pubmed: 27050283pmc: 5053680doi: 10.18632/oncotarget.8507google scholar: lookup
165. Sagiv JY, Michaeli J, Assi S, Mishalian I, Kisos H, Levy L, Damti P, Lumbroso D, Polyansky L, Sionov RV, Ariel A, Hovav AH, Henke E, Fridlender ZG, Granot Z. Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.. Cell Rep 2015 Feb 3;10(4):562-73.
     pubmed: 25620698doi: 10.1016/j.celrep.2014.12.039google scholar: lookup
166. Cloke T, Munder M, Taylor G, Müller I, Kropf P. Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection.. PLoS One 2012;7(11):e48939.
     pubmed: 23152825pmc: 3496742doi: 10.1371/journal.pone.0048939google scholar: lookup
167. Abdel-Salam BK, Ebaid H. Expression of CD11b and CD18 on polymorphonuclear neutrophils stimulated with interleukin-2.. Cent Eur J Immunol 2014;39(2):209-15.
     pubmed: 26155126pmc: 4440019doi: 10.5114/ceji.2014.43725google scholar: lookup
168. Fortunati E, Kazemier KM, Grutters JC, Koenderman L, Van den Bosch vJ. Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease.. Clin Exp Immunol 2009 Mar;155(3):559-66.
     pubmed: 19077082pmc: 2669533doi: 10.1111/j.1365-2249.2008.03791.xgoogle scholar: lookup
169. Fu J, Tobin MC, Thomas LL. Neutrophil-like low-density granulocytes are elevated in patients with moderate to severe persistent asthma. Annals of Allergy Asthma Immunology 2014;113(6):635–640.e2.
170. Herteman N, Vargas A, Lavoie JP. Characterization of Circulating Low-Density Neutrophils Intrinsic Properties in Healthy and Asthmatic Horses.. Sci Rep 2017 Aug 10;7(1):7743.
     pubmed: 28798364pmc: 5552858doi: 10.1038/s41598-017-08089-5google scholar: lookup
171. Nair P, Gaga M, Zervas E, Alagha K, Hargreave FE, O'Byrne PM, Stryszak P, Gann L, Sadeh J, Chanez P. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial.. Clin Exp Allergy 2012 Jul;42(7):1097-103.
     pubmed: 22702508doi: 10.1111/j.1365-2222.2012.04014.xgoogle scholar: lookup

Citations

1. Woodrow JS, Sheats MK, Cooper B, Bayless R. Asthma: The Use of Animal Models and Their Translational Utility.. Cells 2023 Apr 5;12(7).
   doi: 10.3390/cells12071091pubmed: 37048164google scholar: lookup
2. Eller MCN, Pierantozzi Vergani K, Saraiva-Romanholo BM, de Souza Xavier Costa N, de Brito JM, Antonangelo L, Faria CS, Rodrigues JC, Mauad T. Bronchial eosinophils, neutrophils, and CD8 + T cells influence asthma control and lung function in schoolchildren and adolescents with severe treatment-resistant asthma.. Respir Res 2022 Dec 9;23(1):335.
   doi: 10.1186/s12931-022-02259-4pubmed: 36494835google scholar: lookup
3. Bayless RL, Sheats MK, Jones SL. Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis.. Front Vet Sci 2022;9:900453.
   doi: 10.3389/fvets.2022.900453pubmed: 35782542google scholar: lookup
4. Morán G, Uberti B, Quiroga J. Role of Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases.. Front Immunol 2022;13:850416.
   doi: 10.3389/fimmu.2022.850416pubmed: 35493475google scholar: lookup
5. da Paz ER, de Lima CMF, Felix SN, Schaeffer B, Galvão CES, Correia AT, Righetti RF, de Arruda Martins M, de Fátima Lopes Calvo Tibério I, Saraiva-Romanholo BM. Airway inflammatory profile among cleaning workers from different workplaces.. BMC Pulm Med 2022 Apr 29;22(1):170.
   doi: 10.1186/s12890-022-01949-5pubmed: 35488256google scholar: lookup
6. Simões J, Batista M, Tilley P. The Immune Mechanisms of Severe Equine Asthma-Current Understanding and What Is Missing.. Animals (Basel) 2022 Mar 16;12(6).
   doi: 10.3390/ani12060744pubmed: 35327141google scholar: lookup
7. Cañas JA, Rodrigo-Muñoz JM, Gil-Martínez M, Sastre B, del Pozo V. Exosomes: A Key Piece in Asthmatic Inflammation.. Int J Mol Sci 2021 Jan 19;22(2).
   doi: 10.3390/ijms22020963pubmed: 33478047google scholar: lookup