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American journal of veterinary research.
Periodical
Veterinary Medicine
Publisher:
American Veterinary Medical Assn.. Schaumburg, Ill. : American Veterinary Medical Association
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Veterinary Medical Association.
Start Year:1940 -
Identifiers
| ISSN: | 0002-9645 (Print) 1943-5681 (Electronic) 0002-9645 (Linking) |
| NLM ID: | 0375011 |
| (DNLM): | A25065000(s) |
| (OCoLC): | 01480202 |
| Coden: | AJVRAH |
| LCCN: | 42050041 |
| Classification: | W1 AM53 |
Studies of the virus of equine infectious anemia.
American journal of veterinary research
April 1, 1950
Volume 11, Issue 39 157-158
REAGAN RL, LILLIE MG, HICKMAN JW, BRUECKNER AL.No abstract available Dosage of caronamide required for inhibition of renal tubular excretion of penicillin in horses.
American journal of veterinary research
April 1, 1949
Volume 10, Issue 35 154-157
DOLL ER, WALLACE ME, NEWTON AC.No abstract available The blood in equine periodic ophthalmia.
American journal of veterinary research
April 1, 1947
Volume 8, Issue 27 145-152
ROBY TO, JONES TC.No abstract available The relation of riboflavin to equine periodic ophthalmia.
American journal of veterinary research
October 1, 1946
Volume 7, Issue 25 403-416
JONES TC, ROBY TO, MAURER FD.No abstract available The tonsils of the horse.
American journal of veterinary research
July 1, 1946
Volume 7 343-349
ELIAS H.No abstract available Changes in the equine larynx associated with laryngeal hemiplegia.
American journal of veterinary research
April 1, 1946
Volume 7 69-77
COLE CR.No abstract available Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis.
American journal of veterinary research
March 3, 2007
Volume 68, Issue 3 290-296 doi: 10.2460/ajvr.68.3.290
Frisbie DD, Kawcak CE, Werpy NM, Park RD, McIlwraith CW.To assess the clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum (ACS) in the treatment of experimentally induced osteoarthritis in horses. Methods: 16 horses. Methods: Osteoarthritis was induced arthroscopically in 1 middle carpal joint of all horses. In 8 placebo- and 8 ACS-treated horses, 6 mL of PBS solution or 6 mL of ACS was injected into the osteoarthritis-affected joint on days 14, 21, 28, and 35, respectively; PBS solution was administered in the other sham-operated joints. Evaluations included clinical assessment of lamenes... Read More
89
Assessment of repeatability of a wireless, inertial sensor-based lameness evaluation system for horses.
American journal of veterinary research
September 2, 2011
Volume 72, Issue 9 1156-1163 doi: 10.2460/ajvr.72.9.1156
Keegan KG, Kramer J, Yonezawa Y, Maki H, Pai PF, Dent EV, Kellerman TE, Wilson DA, Reed SK.To determine repeatability of a wireless, inertial sensor-based lameness evaluation system in horses. Methods: 236 horses. Methods: Horses were from 2 to 29 years of age and of various breeds and lameness disposition. All horses were instrumented with a wireless, inertial sensor-based motion analysis system on the head (accelerometer), pelvis (midline croup region [accelerometer]), and right forelimb (gyroscope) before evaluation in 2 consecutive trials, approximately 5 minutes apart, as the horse was trotted in a straight line. Signal-processing algorithms generated overall trial asymmetry me... Read More
74
Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis.
American journal of veterinary research
July 3, 2008
Volume 69, Issue 7 928-937 doi: 10.2460/ajvr.69.7.928
Nixon AJ, Dahlgren LA, Haupt JL, Yeager AE, Ward DL.To assess the potential of adipose-derived nucleated cell (ADNC) fractions to improve tendon repair in horses with collagenase-induced tendinitis. Methods: 8 horses. Methods: Collagenase was used to induce tendinitis in the superficial digital flexor tendon of 1 forelimb in each horse. Four horses were treated by injection of autogenous ADNC fractions, and 4 control horses were injected with PBS solution. Healing was compared by weekly ultrasonographic evaluation. Horses were euthanatized at 6 weeks. Gross and histologic evaluation of tendon structure, fiber alignment, and collagen typing were... Read More
74
Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue.
American journal of veterinary research
October 6, 2010
Volume 71, Issue 10 1237-1245 doi: 10.2460/ajvr.71.10.1237
Toupadakis CA, Wong A, Genetos DC, Cheung WK, Borjesson DL, Ferraro GL, Galuppo LD, Leach JK, Owens SD, Yellowley CE.To determine the optimal osteogenic source of equine mesenchymal stem cells (eMSCs) and optimize collection of and expansion conditions for those cells. Methods: 10 adult Quarter Horses and 8 newborn Thoroughbred foals. Methods: eMSCs were isolated from bone marrow (BM), adipose tissue, and umbilical cord blood and tissue, and the osteogenic potential of each type was assessed. Effects of anatomic site, aspiration volume, and serum type on eMSC yield from BM were investigated. Results: BM-eMSCs had the highest overall expression of the osteogenic genes Cbfa1, Osx, and Omd and staining for ALP ... Read More
59
Isolation and characterization of bone marrow-derived equine mesenchymal stem cells.
American journal of veterinary research
October 6, 2007
Volume 68, Issue 10 1095-1105 doi: 10.2460/ajvr.68.10.1095
Arnhold SJ, Goletz I, Klein H, Stumpf G, Beluche LA, Rohde C, Addicks K, Litzke LF.To isolate and characterize bone marrow-derived equine mesenchymal stem cells (MSCs) for possible future therapeutic applications in horses. Methods: Equine MSCs were isolated from bone marrow aspirates obtained from the sternum of 30 donor horses. Methods: Cells were cultured in medium (alpha-minimum essential medium) with a fetal calf serum content of 20%. Equine MSC features were analyzed to determine selfrenewing and differentiation capacity. For potential therapeutic applications, the migratory potential of equine MSCs was determined. An adenoviral vector was used to determine the transdu... Read More
48
Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses.
American journal of veterinary research
January 30, 2014
Volume 75, Issue 2 141-151 doi: 10.2460/ajvr.75.2.141
Bertone AL, Ishihara A, Zekas LJ, Wellman ML, Lewis KB, Schwarze RA, Barnaba AR, Schmall ML, Kanter PM, Genovese RL.To evaluate intra-articular autologous protein solution (APS) for the treatment of osteoarthritis in horses. Animals-40 client-owned horses with naturally occuring osteoarthritis. Methods: APS was generated from a dual-device system that concentrated plasma and WBC proteins and enriched platelet growth factors. Horses were randomly assigned to receive an intra-articular injection of 5 mL of saline (0.9% NaCl) solution (n = 20) or APS (20), exercised on a treadmill, and evaluated on the basis of lameness grades, kinetic gait analysis, joint circumference, and range of motion for 14 days. Horses... Read More
43
Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells.
American journal of veterinary research
September 15, 1998
Volume 59, Issue 9 1182-1187
Fortier LA, Nixon AJ, Williams J, Cable CS.To isolate mesenchymal stem cells from adult horses and determine specific monolayer culture conditions required to enhance biochemically and phenotypically defined chondrocytic differentiation. Methods: 2 adult horse bone marrow donors without skeletal or hematologic abnormalities. Methods: Bone marrow was aspirated from the sternebra, and mesenchymal stem cells were isolated by centrifugation and cultured in monolayers. Subcultures were established in 24-well plates on day 13. Culture medium was harvested every 2 days, and culture of 12 of the 24 wells was terminated on day 6 and of the rema... Read More
42
Risk factors for development of neurologic disease after experimental exposure to equine herpesvirus-1 in horses.
American journal of veterinary research
December 3, 2008
Volume 69, Issue 12 1595-1600 doi: 10.2460/ajvr.69.12.1595
Allen GP.To identify risk factors associated with development of clinical neurologic signs in horses exposed to equine herpesvirus-1 (EHV-1). Methods: 36 adult horses. Methods: Blood samples collected before and after challenge inoculation with nonneuropathogenic or neuropathogenic EHV-1 were analyzed for leukocyte-associated viremia, serum neutralizing antibody, and EHV-1-specific cytotoxic T-lymphocyte precursors (CTLPs). Associations between variables and neurologic disease and correlations between age category or breed and development of neurologic disease were examined. Results: 9 horses developed... Read More
41
Veterinary applications of infrared thermography.
American journal of veterinary research
December 29, 2015
Volume 77, Issue 1 98-107 doi: 10.2460/ajvr.77.1.98
Rekant SI, Lyons MA, Pacheco JM, Arzt J, Rodriguez LL.Abnormal body temperature is a major indicator of disease; infrared thermography (IRT) can assess changes in body surface temperature quickly and remotely. This technology can be applied to a myriad of diseases of various etiologies across a wide range of host species in veterinary medicine. It is used to monitor the physiologic status of individual animals, such as measuring feed efficiency or diagnosing pregnancy. Infrared thermography has applications in the assessment of animal welfare, and has been used to detect soring in horses and monitor stress responses. This review addresses the var... Read More
38
Comparison of a body-mounted inertial sensor system-based method with subjective evaluation for detection of lameness in horses.
American journal of veterinary research
December 29, 2012
Volume 74, Issue 1 17-24 doi: 10.2460/ajvr.74.1.17
Keegan KG, Wilson DA, Kramer J, Reed SK, Yonezawa Y, Maki H, Pai PF, Lopes MA.To compare data obtained with an inertial sensor system with results of subjective lameness examinations performed by 3 experienced equine veterinarians for evaluation of lameness in horses. Methods: 106 horses. Methods: Horses were evaluated for lameness with a body-mounted inertial sensor system during trotting in a straight line and via subjective evaluation by 3 experienced equine practitioners who performed complete lameness examinations including lunging in a circle and limb flexion tests. Agreement among evaluators regarding results of subjective evaluations and correlations and agreeme... Read More
37
Characterization of the fecal microbiota of healthy horses.
American journal of veterinary research
July 31, 2018
Volume 79, Issue 8 811-819 doi: 10.2460/ajvr.79.8.811
Stewart HL, Pitta D, Indugu N, Vecchiarelli B, Engiles JB, Southwood LL.OBJECTIVE To characterize the fecal microbiota of horses and to investigate alterations in that microbiota on the basis of sample collection site (rectum vs stall floor), sample location within the fecal ball (center vs surface), and duration of environmental exposure (collection time). ANIMALS 6 healthy adult mixed-breed mares. PROCEDURES From each horse, feces were collected from the rectum and placed on a straw-bedded stall floor. A fecal ball was selected for analysis immediately after removal from the rectum and at 0 (immediately), 2, 6, 12, and 24 hours after placement on the stall floor... Read More
37
Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.
American journal of veterinary research
January 3, 2008
Volume 69, Issue 1 122-129 doi: 10.2460/ajvr.69.1.122
Bailey SR, Habershon-Butcher JL, Ransom KJ, Elliott J, Menzies-Gow NJ.To determine the metabolic phenotype of a group of laminitis-prone ponies when at pasture in summer, compared with when at pasture in winter. Methods: 40 ponies of various breeds predisposed to recurrent pasture-associated laminitis and 40 unaffected control ponies. Methods: Body condition score and size of the crest of the neck were assessed, blood samples obtained, and blood pressure measured by use of an indirect oscillometric technique, while ponies were kept on winter pasture (last week of November or beginning of December) and again on summer pasture (June). Serum insulin concentration a... Read More
37
Determination of the prevalence and severity of metacarpophalangeal joint osteoarthritis in Thoroughbred racehorses via quantitative macroscopic evaluation.
American journal of veterinary research
November 3, 2010
Volume 71, Issue 11 1284-1293 doi: 10.2460/ajvr.71.11.1284
Neundorf RH, Lowerison MB, Cruz AM, Thomason JJ, McEwen BJ, Hurtig MB.To determine the prevalence and severity of osteoarthritis in the metacarpophalangeal joints of Thoroughbred racehorses via development and validation of a quantitative macroscopic evaluation system. Methods: Metacarpophalangeal joints from 50 Thoroughbred racehorses. Methods: Joints were collected from horses that died or were euthanized within 60 days of racing. Metacarpophalangeal joints were assessed for osteoarthritic degeneration by use of macroscopic and histologic scoring systems, polarized light microscopy, and cartilage biochemical analysis. The global macroscopic score for the entir... Read More
35
Comparison of an inertial sensor system with a stationary force plate for evaluation of horses with bilateral forelimb lameness.
American journal of veterinary research
March 1, 2012
Volume 73, Issue 3 368-374 doi: 10.2460/ajvr.73.3.368
Keegan KG, MacAllister CG, Wilson DA, Gedon CA, Kramer J, Yonezawa Y, Maki H, Pai PF.To assess the analytic sensitivity of an inertial sensor system for detection of the more severely affected forelimb in horses with bilateral lameness. Methods: 18 adult horses with forelimb lameness. Methods: Horses were fitted with inertial sensors and evaluated for lameness with a stationary force plate as they were trotted in a straight line. Inertial sensor-derived measurements for vertical head movement asymmetry (HMA) and vector sum (VS) of maximum and minimum head height differences between right and left halves of the stride were used to predict differences in mean peak vertical force... Read More
34
Associations of force plate and body-mounted inertial sensor measurements for identification of hind limb lameness in horses.
American journal of veterinary research
March 31, 2016
Volume 77, Issue 4 337-345 doi: 10.2460/ajvr.77.4.337
Bell RP, Reed SK, Schoonover MJ, Whitfield CT, Yonezawa Y, Maki H, Pai PF, Keegan KG.To investigate associations between inertial sensor and stationary force plate measurements of hind limb lameness in horses. Methods: 21 adult horses with no lameness or with mild hind limb lameness. Methods: Horses were instrumented with inertial sensors and evaluated for lameness with a stationary force plate while trotting in a straight line. Inertial sensor-derived measurements of maximum and minimum pelvic height differences between right and left halves of the stride were compared with vertical and horizontal ground reaction forces (GRFs). Stepwise linear regression was performed to inve... Read More
34
In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.
American journal of veterinary research
November 13, 2001
Volume 62, Issue 11 1755-1760 doi: 10.2460/ajvr.2001.62.1755
Brideau C, Van Staden C, Chan CC.To determine potency and selectivity of nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase- (COX-) specific inhibitors in whole blood from horses, dogs, and cats. Methods: Blood samples from 30 healthy horses, 48 healthy dogs, and 9 healthy cats. Methods: Activities of COX-1 and COX-2 were determined by measuring coagulation-induced thromboxane and lipopolysaccharide-induced prostaglandin E2 concentrations, respectively, in whole blood with and without the addition of various concentrations of phenylbutazone, flunixin meglumine, ketoprofen, diclofenac, indomethacin, meloxicam, car... Read More
34
Diagnosis of equine infectious anemia by immunodiffusion test.
American journal of veterinary research
January 1, 1972
Volume 33, Issue 1 11-18
Coggins L, Norcross NL, Nusbaum SR.No abstract available Read More
33
Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease.
American journal of veterinary research
May 1, 2001
Volume 62, Issue 4 538-546 doi: 10.2460/ajvr.2001.62.538
Couëtil LL, Rosenthal FS, DeNicola DB, Chilcoat CD.To evaluate the association among clinical signs, results of cytologic evaluation of bronchoalveolar lavage (BAL) fluid, and measures of pulmonary function in horses with inflammatory respiratory disease. Methods: 9 healthy horses, 5 horses with inflammatory airway disease (IAD), and 9 horses with chronic obstructive pulmonary disease (COPD). Methods: Clinical examination, lung function tests, and BAL were performed on each horse. Results: Standard lung mechanics of horses with exacerbated COPD differed significantly from those of healthy horses; however, there were few differences among horse... Read More
33
Evaluation of the osteogenic and chondrogenic differentiation capacities of equine adipose tissue-derived mesenchymal stem cells.
American journal of veterinary research
October 6, 2010
Volume 71, Issue 10 1228-1236 doi: 10.2460/ajvr.71.10.1228
Braun J, Hack A, Weis-Klemm M, Conrad S, Treml S, Kohler K, Walliser U, Skutella T, Aicher WK.To evaluate the proliferative behavior, telomere length, immunophenotype, and differentiation capacity of equine adipose tissue-derived mesenchymal stem cells (AT-MSCs). Methods: 6 adult racing horses treated for articular Injury but otherwise healthy. Methods: AT-MSCs were Isolated from horses and expanded In Dulbecco modified Eagle medium enriched with fetal bovine serum and antimicrobials. Expression of cell surface antigens and telomere length were Investigated via flow cytometry Differentiation of MSCs Into chondrocytes, osteoblasts, and adipocytes was Induced In vitro by specific stimuli... Read More
33
Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses.
American journal of veterinary research
September 8, 2000
Volume 61, Issue 9 1099-1105 doi: 10.2460/ajvr.2000.61.1099
Sheoran AS, Timoney JF, Holmes MA, Karzenski SS, Crisman MV.To determine concentrations of IgA and IgG subclasses in serum, colostrum, milk, and nasal wash samples of adult horses and foals. Methods: Seven 2-year-old Welsh ponies, 27 adult mixed-breed horses, and 5 Quarter Horse mares and their foals. Methods: Serum was obtained from ponies and adult horses. Colostrum and milk were obtained from mares and serum and nasal wash samples from their foals immediately after parturition and on days 1, 7, 14, 28, 42, and 63. Nasal wash samples were also obtained from 23 adult horses. Concentrations of immunoglobulins were determined by use of inhibition ELISA.... Read More
32
Rotavirus infection in foals.
American journal of veterinary research
October 1, 1980
Volume 41, Issue 10 1699-1703
Conner ME, Darlington RW.Fecal samples from 86 foals with diarrhea were examined by electron microscopy during a 2.5 year period. Of these, 26 (30%) were positive for rotavirus. All of the cases were found in epizootic areas. The disease was produced in an experimental foal by inoculation via stomach tube of a bacteria-free fecal filtrate containing rotavirus. Examination of postmortem tissues from the duodenum and jejunum of 2 naturally infected foals and an experimentally infected foal revealed replicating virus in the intestinal epithelial cells. A limited survey of complement-fixing antibody to rotavirus in horses... Read More
32
Effect of fibroblast growth factor-2 on equine mesenchymal stem cell monolayer expansion and chondrogenesis.
American journal of veterinary research
September 4, 2007
Volume 68, Issue 9 941-945 doi: 10.2460/ajvr.68.9.941
Stewart AA, Byron CR, Pondenis H, Stewart MC.To determine whether fibroblast growth factor-2 (FGF-2) treatment of equine mesenchymal stem cells (MSCs) during monolayer expansion enhances subsequent chondrogenesis in a 3-dimensional culture system. Methods: 6 healthy horses, 6 months to 5 years of age. Methods: Bone marrow-derived MSCs were obtained from 6 horses. First-passage MSCs were seeded as monolayers at 10,000 cells/cm(2) and in medium containing 0, 1, 10, or 100 ng of FGF-2/mL. After 6 days, MSCs were transferred to pellet cultures (200,000 cells/pellet) and maintained in chondrogenic medium. Pellets were collected after 15 days.... Read More
32
Characterization and osteogenic potential of equine muscle tissue- and periosteal tissue-derived mesenchymal stem cells in comparison with bone marrow- and adipose tissue-derived mesenchymal stem cells.
American journal of veterinary research
May 1, 2013
Volume 74, Issue 5 790-800 doi: 10.2460/ajvr.74.5.790
Radtke CL, Nino-Fong R, Esparza Gonzalez BP, Stryhn H, McD￮ LA.To characterize equine muscle tissue- and periosteal tissue-derived cells as mesenchymal stem cells (MSCs) and assess their proliferation capacity and osteogenic potential in comparison with bone marrow- and adipose tissue-derived MSCs. Methods: Tissues from 10 equine cadavers. Methods: Cells were isolated from left semitendinosus muscle tissue, periosteal tissue from the distomedial aspect of the right tibia, bone marrow aspirates from the fourth and fifth sternebrae, and adipose tissue from the left subcutaneous region. Mesenchymal stem cells were characterized on the basis of morphology, ad... Read More
32
Effects of interleukin-1beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytes.
American journal of veterinary research
June 13, 2000
Volume 61, Issue 6 624-630 doi: 10.2460/ajvr.2000.61.624
Richardson DW, Dodge GR.To determine the effects of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) on expression and regulation of several matrix-related genes by equine articular chondrocytes. Methods: Articular cartilage harvested from grossly normal joints of 8 foals, 6 yearling horses, and 8 adult horses. Methods: Chondrocytes maintained in suspension cultures were treated with various doses of human recombinant IL-1beta or TNF-alpha. Northern blots of total RNA from untreated and treated chondrocytes were probed with equine complementary DNA (cDNA) probes for cartilage matrix-related ge... Read More
32
Effect of transforming growth factor beta1 on chondrogenic differentiation of cultured equine mesenchymal stem cells.
American journal of veterinary research
September 8, 2000
Volume 61, Issue 9 1003-1010 doi: 10.2460/ajvr.2000.61.1003
Worster AA, Nixon AJ, Brower-Toland BD, Williams J.To determine the morphologic and phenotypic effects of transforming growth factor beta1 (TGFbeta1) on cultured equine mesenchymal stem cells (MSC) and articular chondrocytes. Methods: Bone marrow aspirates and articular cartilage samples from a 2-year-old and two 8-month-old horses. Methods: After initial isolation and culture, MSC and chondrocytes were cultured in Ham's F-12 medium supplemented with TGF-beta1 at a concentration of 0, 1, 5, or 10 ng/ml. Medium was exchanged on day 2, and cells were harvested on day 4. Medium was assayed for proteoglycan (PG) content. Total RNA was isolated fro... Read More
31
Effect of trotting speed and circle radius on movement symmetry in horses during lunging on a soft surface.
American journal of veterinary research
November 28, 2012
Volume 73, Issue 12 1890-1899 doi: 10.2460/ajvr.73.12.1890
Pfau T, Stubbs NC, Kaiser LJ, Brown LE, Clayton HM.To determine whether body lean angle could be predicted from circle radius and speed in horses during lunging and whether an increase in that angle would decrease the degree of movement symmetry (MS). Methods: 11 medium- to high-level dressage horses in competition training. Methods: Body lean angle, head MS, and trunk MS were quantified during trotting while horses were instrumented with a 5-sensor global positioning system-enhanced inertial sensor system and lunged on a soft surface. Speed and circle radius were varied and used to calculate predicted body lean angle. Agreement between observ... Read More
31
Diarrhea associated with enterotoxigenic Bacteroides fragilis in foals.
American journal of veterinary research
November 1, 1987
Volume 48, Issue 11 1565-1567
Myers LL, Shoop DS, Byars TD.Enterotoxigenic Bacteroides fragilis (ETBF) was isolated from the feces of 10 of 40 Thoroughbred foals with naturally acquired diarrhea. Of the 10 foals positive for ETBF, 6 were less than or equal to 7 days old. Fecal specimens from 4 of the 10 foals also were positive for rotavirus, and one fecal specimen was positive for Salmonella enteritidis. Clinical or hematologic differences were not evident between foals infected with ETBF only and those infected with ETBF and another recognized enteric pathogen. Only 1 of 10 foals infected with ETBF died. Of 25 adult rabbits with ligated ceca, 23 dev... Read More
30
Concentrations of serum amyloid A in serum and synovial fluid from healthy horses and horses with joint disease.
American journal of veterinary research
October 4, 2006
Volume 67, Issue 10 1738-1742 doi: 10.2460/ajvr.67.10.1738
Jacobsen S, Thomsen MH, Nanni S.To determine serum amyloid A (SAA) concentrations in serum and synovial fluid from healthy horses and horses with joint disease and assess the effect of repeated arthrocentesis on SAA concentrations in synovial fluid. Animals-10 healthy horses and 21 horses with various types of joint disease. Methods: Serum and synovial fluid samples were obtained from each horse. In 5 of the 10 healthy horses, arthrocentesis was repeated 9 times. Concentrations of SAA were determined via immunoturbidometry. Results: Serum and synovial fluid SAA concentrations were less than the assay detection limit in healt... Read More
30
Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint.
American journal of veterinary research
November 30, 2004
Volume 65, Issue 11 1533-1541 doi: 10.2460/ajvr.2004.65.1533
Toutain PL, Cester CC.To determine pharmacokinetic-pharmacodynamic (PK-PD) relationships and dose effects for meloxicam in horses and to propose a suitable dosage for use in clinical studies. Methods: 6 adult horses. Methods: The study was conducted by use of a randomized, Latin-square design. Arthritis was induced in the right carpal joint of each horse by administration of Freund's complete adjuvant. Various dosages of meloxicam (0, 0.25, 0.5, 1.0, and 2.0 mg/kg, IV) were then administered. Validated endpoints including stride length and overall clinical lameness score (scale of 0 to 20) were used to assess the e... Read More
29
Generation of reactive oxygen species by equine spermatozoa.
American journal of veterinary research
May 1, 2001
Volume 62, Issue 4 508-515 doi: 10.2460/ajvr.2001.62.508
Ball BA, Vo AT, Baumber J.To characterize generation of reactive oxygen species (ROS) by equine spermatozoa. Methods: Multiple semen samples collected from 9 stallions. Methods: Equine spermatozoa were separated from seminal plasma on a discontinuous polyvinylpyrrolidone (PVP)-coated silica gradient and resuspended in a modified Tyrode albumin-lactate-pyruvate medium. Amount of hydrogen peroxide (H2O2) generated was assayed by use of a 1-step fluorometric assay, using 10-acetyl-3,7-dihydroxyphenoxazine as a probe for detection of H2O2 in a microplate assay format. Concentration of H2O2 was determined by use of a fluore... Read More
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