Zentralblatt für Veterinärmedizin. Reihe A.
Discontinued
Publisher:
Verlag Paul Parey.. Berlin : Verlag Paul Parey
Frequency: Ten no. a year
Country: Germany
Language: ger
Start Year:1963 - 1999
Identifiers
| ISSN: | 0514-7158 (Print) 0514-7158 (Linking) |
| NLM ID: | 0331323 |
| (OCoLC): | 01770613 |
| (DNLM): | Z07400000(s) |
| Coden: | ZVRAAX |
| Classification: | W1 ZE799B |
Bioavailability of bromhexine in the horse. Bromhexine was administered orally (2 mg./kg.) and intravenously (i. v.) (1 mg./kg.) in 3 horses. Plasma levels were measured and the pharmacokinetic behaviour and bioavailability were estimated. The half-life of elimination after i. v. administration ranged from 3.1 to 4.4 hours. The mean values of the apparent volume of distribution and the volume of distribution of the central compartment amounted to 16.2 and 3.3 1./kg., respectively. A very high plasma clearance, ranging from 49.8 to 59 ml./kg./min., was found.
One hour after oral administration, a mean peak plasma level of about 14 ng....