Topic:Adverse Effects
Adverse effects in horses refer to unintended and potentially harmful outcomes that occur as a result of medical treatment, environmental exposure, or other interventions. These effects can impact various physiological systems and may manifest as behavioral changes, organ dysfunction, or other health-related issues. Monitoring and understanding adverse effects are important for ensuring the safety and well-being of horses, particularly in the context of veterinary medicine and equine management. This page gathers peer-reviewed research studies and scholarly articles that explore the causes, mechanisms, and implications of adverse effects in horses, offering insights into their identification, management, and prevention.
Comparative trial of three heterologous anti-tetanus sera. The three heterologous anti-sera currently provided for tetanus prophylaxis have been compared with reference to the production of untoward reactions in 498 patients, and to the blood antitoxin concentrations produced in 76 patients. Equine serum, although giving rise to more reactions, was the only effective agent in terms of the levels and duration of serum antitoxin concentration produced. The local response to a test dose of any of the three sera is not a reliable guide to immediate or late general reactions.
Cross-reactivity studies of horse, goat and rabbit anti-lymphocyte globulin. In the sera of ten normal humans and twenty-eight candidates for organ transplantation, the passive haemagglutination test detected a 50% incidence of preformed antibodies of low titre directed against horse serum. Such antibodies were also found to cross react with goat or rabbit sera in most instances. Seventeen of the organ recipients were later studied after the institution of treatment with horse antihuman-lymphocyte globulin (ALG). The incidence of anti-horse-serum antibodies rose to 100%. At the same time, an increased activity against goat serum developed; cross-reactions against rabbi...
Safety of intravenous proteolytic enzymes (varizyme) in equine practice. No horse receiving combined streptokinase, streptodornase, and human plasminogen alone in either 125,000-unit or 375,000-unit doses manifested any clinical reaction. Untoward reactions occurred in 2 horses receiving both the combined streptokinase, streptodornase, and human plasminogen (125,000 units), and chlortetracycline. The reaction was transitory and subsided without treatment.
Effectiveness of ivermectin in the treatment of equine Parascaris equorum and Oxyuris equi infections. Fifteen horses harboring naturally acquired, patent Parascaris equorum and Oxyuris equi infections were equally allotted to 3 treatment groups given (1) injectable vehicle; (2) injectable ivermectin at the dose rate of 200 microgram/kg of body weight; and (3) injectable ivermectin at the rate of 300 microgram/kg. All treatments were given IM in the neck. All animals were killed 14 days after treatment and examined for the targeted nematodes. Regardless of dose rate, ivermectin proved 100% effective in the removal of adult O equi and P equorum infections. Levels of immature P equorum were decre...