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Topic:Anorexia
Anorexia in horses refers to a decreased or complete lack of appetite, which can be symptomatic of various underlying health issues. This condition can arise due to numerous factors, including gastrointestinal disorders, dental problems, pain, or systemic diseases. Anorexia can lead to significant weight loss and nutritional deficiencies, affecting the overall health and performance of the horse. Monitoring and assessing anorexia involves evaluating the horse's dietary habits, physical condition, and any accompanying clinical signs. This page gathers peer-reviewed research studies and scholarly articles focusing on the causes, diagnostic approaches, and management strategies for anorexia in equine populations.
Serological response of experimental ponies orally infected with Ehrlichia risticii. Ten healthy, mature ponies were orally infected with Ehrlichia risticii using Ehrlichia-infected P388D1 mouse monocyte tissue culture cells. Seven developed signs of equine ehrlichial colitis including fever, depression, anorexia, reduced borborygmi, increased abdominal hyperresonance, and diarrhoea. Three remained clinically normal apart from early fever in one. Indirect fluorescent antibody titres were detected in the clinically affected ponies by Days 12 to 17 post infection and increased rapidly to high levels (1:640 to 1:5120) which were maintained until the end of the observation period ...
Kleingrass-associated hepatotoxicosis in horses. Chronic hepatic disease was diagnosed in 6 horses with history of anorexia and weight loss. These horses consistently had abnormally high serum gamma-glutamyltransferase activities, total and direct bilirubin and blood ammonia values, and sulfobromophthalein clearance times, whereas serum iditol dehydrogenase, aspartate transaminase, and alkaline phosphatase activities were variable. In the 6 horses, histologic examination of the liver revealed lesions of chronic hepatitis with varying degrees of fibrosis. All 6 horses had ingested kleingrass (Panicum coloratum) for variable periods. Three hea...
Diagnosis and surgical treatment of functional obstruction of the right dorsal colon in a horse. Functional obstruction of the right dorsal colon was found at surgery in a 6-year-old American Saddlebred gelding with a history of anorexia, depression, weight loss, and intermittent colic. Side-to-side anastomosis of the right dorsal colon to the small colon was done to bypass the obstruction. Histopathologic findings of the right dorsal colon and regional colonic lymph nodes were unremarkable. Surgical treatment was successful.
Disease features in horses with induced equine monocytic ehrlichiosis (Potomac horse fever). Fifty-five horses were inoculated IV and/or SC with materials containing Ehrlichia risticii, ie, infected whole blood, buffy coat cells, or cell culture, to study clinical and hematologic features of equine monocytic ehrlichiosis (Potomac horse fever). Major clinical and hematologic features of induced E risticii infection were biphasic increase in rectal temperature with peak increases of 38.9 C and 39.3 C on postinoculation days (PID) 5 and 12, respectively; depression; anorexia; decreased WBC count (maximal decrease of 47% on PID 12); and diarrhea from PID 14 to PID 18. Increased WBC count ...
Salinomycin poisoning in horses. Six cases of accidental salinomycin poisoning in horses are described. The horses were fed a contaminated ration and presented clinical signs which were extremely varied in nature and severity. However, the range of signs, including anorexia, colic, weakness and ataxia bore similarities to those described in horses poisoned with the related ionophore monensin. Other similarities became apparent in serum biochemical profiles of the clinical cases. Although ionophore toxicity is rarely reported in horses they appear to be particularly susceptible, and it should therefore be considered as a diffe...
Suppurative splenitis and peritonitis in a horse after gastric ulceration caused by larvae of Gasterophilus intestinalis. A 12-year-old Thoroughbred mare, with a history of anorexia, dramatic weight loss, fluctuating pyrexia and intermittent diarrhoea after an episode of colic, was presented for examination with depression, emaciation and ataxia. Thoracic and abdominal paracenteses yielded copious quantities of inflammatory exudate. Palpation per rectum revealed an enlarged spleen. The primary alterations in haematology included a severe leucocytosis with a left shift, and a hyperproteinaemia characterised by hypoalbuminaemia and hypergammaglobulinaemia. Post-mortem examination revealed a low grade pleurisy and p...
Equine ehrlichiosis in northern California: 49 cases (1968-1981). Case records of horses with equine ehrlichiosis (Ehrlichia equi) at the University of California Veterinary Medical Teaching Hospital and Ackerman Creek Large Animal Clinic were analyzed for evaluation of clinical signs, time of onset, hematologic values, response to treatment, and recovery. Equine ehrlichiosis was found to be seasonal in horses in the foothills of northern California, with higher incidence than reported previously. The horses developed fever, anorexia, depression, limb edema, icterus, and ataxia. Hematologic changes were leukopenia, thrombocytopenia, icterus, anemia, and incl...
Clinical features and treatment of renal tubular acidosis in two horses. Two horses were admitted separately for evaluation and treatment of profound hyperchloremic metabolic acidosis without azotemia. One, an 11-year-old Quarter Horse mare, had been depressed and ataxic for 2 days. The other, a 2-year-old Quarter Horse colt, had a 6-week history of depression, anorexia, and weight loss. Both horses responded to fluid and electrolyte therapy, but required daily oral administration of sodium bicarbonate for maintenance. In each case, the diagnosis was renal tubular acidosis.
Feeding behavior. Problems related to feeding behavior in horses fall into three main categories: underconsumption, overconsumption, and abnormal consumption. Anorexia may be caused by a variety of diseases and overcome by removing the underlying causes (pain, fever), and physical or chemical stimulation of appetite. "Hypophagia" may be caused by poor dentition, disease, or stress. Again, removal of the cause or stimulation by physical or chemical means may improve intakes. Acute and chronic overconsumption of feeds are reflections of the normal controls (or lack thereof) of feeding in the horse. The only relia...
Splenic hematoma and abscess as a cause of chronic weight loss in a horse. An 8-year-old gelding with a 3-month history of anorexia and weight loss was found to have a massive subcapsular splenic hematoma. At flank laparotomy, 36 L of fluid was removed from the hematoma. The horse's condition improved after drainage. Fifteen months later, the horse became depressed and febrile. A splenic abscess containing Bacteroides ruminicola and Clostridium sporogenes was found at necropsy.
Bilateral renal hypoplasia in four young horses. Three horses less than or equal to 3 years old were evaluated because of stunted growth, weight loss, anorexia, depression, and lethargy of at least 1 month's duration. A neonatal foal was examined after its death. In each case, gross and microscopic renal lesions were compatible with bilateral renal hypoplasia (ie, cortical hypoplasia with severe medullary hypoplasia). In young horses with renal failure, bilateral renal hypoplasia should be considered in the differential diagnosis, and may represent a congenital lesion.
Enterocolitis caused by Ehrlichia sp. in the horse (Potomac horse fever). Potomac horse fever was reproduced in 15 ponies by transfusion of whole blood originally from two natural cases and subsequently from ponies infected by the transfusions. Incubation periods varied from 9 to 15 days. Affected ponies developed varying degrees of fever, diarrhea, anorexia, depression, and leukopenia. Eleven affected ponies were killed, three died in the acute phase of the disease, and one did not show clinical signs. The most consistent post-mortem findings were fluid contents in the cecum and large colon, and areas of hyperemia (of inconstant degree and distribution) in mucosae ...
Chronic granulomatous bowel disease in three sibling horses. Chronic granulomatous bowel disease was diagnosed in 3 sibling Standardbred horses. Clinical signs included weight loss, loose feces, and decreased appetite in the terminal stage of the disease. Abnormal laboratory findings included hypoproteinemia and low xylose absorption. Necropsy revealed granulomatous inflammation of the intestines, mesenteric lymph nodes, and liver. Eosinophilic infiltration of the granulomatous lesions was a prominent finding in one horse. A causative agent was not detected by special histochemical staining or bacteriologic culturing.
Primary gastric impaction in a pony. Primary gastric impaction developed in a pony as a result of the ingestion of persimmon seeds and mesquite beans. Clinical signs included mild abdominal pain, prolonged recumbency, anorexia, and lethargy. When medical therapy was unsuccessful, an exploratory laparotomy was performed. Previously, gastric impaction has been associated with signs of severe abdominal pain. Gastric impaction should be considered in cases of abdominal crisis of long duration and mild pain.
Ultrastructural study of ehrlichial organisms in the large colons of ponies infected with Potomac horse fever. Potomac horse fever is characterized by fever, anorexia, leukopenia, profuse watery diarrhea, dehydration, and high mortality. An ultrastructural investigation was made to search for any unusual microorganisms in the digestive system, lymphatic organs, and blood cells of ponies that had developed clinical signs after transfusion with whole blood from horses naturally infected with Potomac horse fever. A consistent finding was the presence of rickettsial organisms in the wall of the intestinal tract of these ponies. The organisms were found mostly in the wall of the large colon, but fewer organ...
Experimentally induced phenylbutazone toxicosis in ponies: description of the syndrome and its prevention with synthetic prostaglandin E2. Phenylbutazone (PBZ) toxicosis was induced in 9 ponies to further define the clinical and pathologic changes occurring with this syndrome. Six additional ponies were treated with PBZ and a synthetic prostaglandin E2 to determine the role of prostaglandins in the pathogenesis of PBZ toxicosis. Ponies given only PBZ exhibited CNS depression, anorexia, weight loss, diarrhea, cyanotic mucous membranes, and oral ulcers. Total serum protein concentration gradually decreased during the 10-day treatment period. Marked mucosal atrophy, focal erosions, and ulcers characterized the lesions in the aliment...
Choledocholithotripsy in a mare. Obstructive choledocholithiasis in a 12-year-old mare was corrected surgically by choledocholithotripsy. The mare had a history of chronic weight loss, intermittent fever, partial anorexia, jaundice, recurrent abdominal pain, and an abdominal mass palpable per rectum. Values for alkaline phosphatase, bilirubin, gamma-glutamyl transferase, sorbitol dehydrogenase, and bromsulpthalein half-life were increased and bilirubinuria was evident before surgery. Two liver biopsies revealed periportal and portal fibrosis, bile duct proliferation, cholestasis, and variable amounts of hepatocellular necrosi...
Isolation, experimental transmission, and characterization of causative agent of Potomac horse fever. Potomac horse fever, a disease characterized by fever, anorexia, leukopenia, and occasional diarrhea, is fatal in approximately 30 percent of affected animals. The seasonal occurrence of the disease (June to October) and evidence of antibodies to the rickettsia Ehrlichia sennetsu in the serum of convalescing horses suggested that a related rickettsia might be the causative agent. Such an agent was isolated in cultured blood monocytes from an experimentally infected pony. This intracytoplasmic organism was adapted to growth in primary cultures of canine blood monocytes. A healthy pony inoculate...
Experimental cantharidiasis in the horse. Crystalline cantharidin in an alfalfa cake or in aqueous suspension was given to 8 horses at a dosage level of 450 to 489 micrograms/kg of body weight (group 1) and 2 horses at a dosage level of 720 micrograms/kg (group 2) via nasogastric tube. Both group 2 horses and 1 group 1 horse died. Horses were evaluated at 6-hour intervals for 36 hours and then again at postcantharidin hours 48. Data evaluation consisted of a comparison of the nonsurvival and survival data to one another and their respective base-line values at each sampling period, irrespective of the route of administration and dosag...
Standardization of an experimental disease model of Streptococcus zooepidemicus in the equine. A reproducible experimental disease model in horses using Streptococcus zooepidemicus was developed. An intravenous challenge dose of 1 X 10(10) colony-forming units (CFU), followed 24 h later with another challenge of 1 X 10(8) CFU of Strep. zooepidemicus produced the desired disease model. The disease was characterized by depression, pyrexia, anorexia, abnormal lung sounds, inflammation of joints, moderate to severe lameness, gradual loss of condition and emaciation. The effects of the disease on hematology, serum chemical profile and different protein fractions were studied. The disease sta...
The toxicity of Datura stramonium (thorn apple) to horses. Meal contaminated by Datura stramonium seeds at the rate of 0.5% by weight was fed to two horses. Both horses showed clinical signs of depression, anorexia, weight loss, rapid heart and respiration rates, mydriasis, polyuria, polydipsia and diarrhoea. Both recovered with treatment. Maize screenings contaminated by the seeds had been used in the manufacture of the meal.
Phenylbutazone toxicosis in the horse: a clinical study. In a retrospective study of 269 horses that had been treated with phenylbutazone, horses receiving less than or equal to 8.8 mg/kg of body weight/day for less than or equal to 4 days or 2 to 4 mg/kg of body weight/day for up to 50 days remained clinically normal. Anorexia, depression, colic, hypoproteinemia, diarrhea, melena, weight loss, ventral edema, petechial hemorrhages of mucous membranes, oral and gastrointestinal tract erosions and ulcers, renal papillary necrosis, and death were among the complications seen in horses that had received greater than 8.8 mg/kg of body weight/day. In 2 ca...
The toxicity of Datura stramonium (thorn apple) to horses. Meal contaminated by Datura stramonium seeds at the rate of 0.5% by weight was fed to two horses. Both horses showed clinical signs of depression, anorexia, weight loss, rapi heart and respiration rates, mydriasis, polyuria, polydipsia and diarrhoea. Both recovered with treatment. Maize screenings contaminated by the seeds had been used in the manufacture of the meal.
The elimination of equine strongyles and hematological and pathological consequences following larvicidal doses of thiabendazole. Twelve horses were divided into three groups and given various doses of a mixed species strongyle inoculum, representing light, moderate, and heavy infections. Three weeks after the larval inoculations, three animals from each group were given larvicidal doses of thiabendazole (TBZ) (440 mg kg-1 on two consecutive days); one animal from each group served as a non-medicated control. Treatment was repeated three weeks later. One treated animal from each group was designated for long-term study; others were necropsied to study adult and larval parasite loads. Six of the twelve animals with strong...
Effects of toxic doses of phenylbutazone in ponies. Toxic doses of phenylbutazone (10 mg/kg of body weight) were administered to 10 ponies once daily for 14 days. Clinical signs of toxicosis similar to those seen in other species included CNS depression, anorexia, oral ulcers, and soft feces. Six ponies died in 7 to 20 days; 1 pony was euthanatized during an acute abdominal crisis; and 3 ponies survived the study. At necropsy, the major lesions were oral and gastrointestinal ulcerations and renal changes.
Acute vitamin D3 toxicosis in horses: case reports and experimental studies of the comparative toxicity of vitamins D2 and D3. Acute vitamin D toxicosis was diagnosed in 2 horses fed a grain ration containing 1,102,311 IU of cholecalciferol (vitamin D3)/kg (500,000 IU/lb) for about 30 days. Horse 1 died acutely with extensive mineralization of cardiovascular and other soft tissues. Horse 2, which had severe clinical signs and clinicopathologic changes of toxicosis, was treated with nonsteroidal antiinflammatory drugs and recovered in about 6 months. In an experimental study, the toxicity of ergocalciferol (vitamin D2) and cholecalciferol was compared in 2 horses (No. 3 and 4) given the respective vitamins at a daily d...
