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Topic:Clinical Findings

Clinical findings in horses encompass a range of observable signs and symptoms identified during veterinary examinations that contribute to diagnosing and managing equine health conditions. These findings can include physical observations, such as changes in behavior, posture, or gait, as well as physiological measurements like heart rate, respiratory rate, and temperature. Diagnostics may also involve laboratory tests, imaging, and other diagnostic procedures to assess organ function and detect abnormalities. Recognizing and interpreting clinical findings are essential components of veterinary practice, aiding in the identification of diseases, monitoring treatment progress, and guiding therapeutic interventions. This page brings together peer-reviewed research studies and scholarly articles that explore the methodologies, interpretations, and implications of clinical findings in the context of equine health care.
Samarium 153-labeled hydroxyapatite microspheres for radiation synovectomy in the horse: a study of the biokinetics, dosimetry, clinical, and morphologic response in normal metacarpophalangeal and metatarsophalangeal joints.
Veterinary surgery : VS    March 24, 2000   Volume 29, Issue 2 191-199 doi: 10.1111/j.1532-950x.2000.00191.x
Yarbrough TB, Lee MR, Hornof WJ, Koblik PD, Brodack J, Troup C, O'Brien TR, Pool R.To determine the effects of Samarium-153 bound to hydroxyapatite microspheres (153SmM) when injected into the metacarpophalangeal and metatarsophalangeal joints of horses. Methods: - Horses were injected with 153SmM in metacarpophalangeal and metatarsophalangeal joints with the diagonal contralateral joints used as untreated controls. Methods: Twelve adult horses without pre-existing disease involving the metacarpo/metatarsophalangeal joints. Methods: Horses were divided into three groups: high-dose Samarium-153 (12.5 to 17.0 millicurie [mCi]), intermediate dose (6.5 to 12.0 mCi), and low dose...
Reproductive parameters of miniature stallions.
Theriogenology    March 23, 2000   Volume 51, Issue 7 1343-1349 doi: 10.1016/S0093-691X(99)00078-3
Paccamonti DL, Buiten AV, Parlevliet JM, Colenbrander B.Breeding soundness evaluation (BSE) of stallions is a routine component of stud farm practice. Guidelines for assessing satisfactory breeding potential have been developed using data derived from stallions of full-size breeds. In view of the increasing popularity of miniature stallions, knowledge of normal semen parameters of these stallions is important. Therefore, testicular measurements and semen parameters from 216 sexually rested miniature stallions were obtained. Semen was collected twice, 1.5 to 3 h apart, using an artificial vagina. Values were averaged over the 2 collections because o...
Pathogenicity of a new neurotropic equine herpesvirus 9 (gazelle herpesvirus 1) in horses.
The Journal of veterinary medical science    March 17, 2000   Volume 62, Issue 2 215-218 doi: 10.1292/jvms.62.215
Taniguchi A, Fukushi H, Matsumura T, Yanai T, Masegi T, Hirai K.Pathogenicity of equine herpesvirus 9 (EHV-9), a new type of equine herpesvirus isolated from Gazella thomsoni, in horses was investigated by intranasal inoculation of EHV-9 (10(7) pfu) to two conventionally reared 8-months old half-bred weanling horses. Fever higher than 39 degrees C was recorded. Virus was recovered from nasal swabs and peripheral blood mononuclear cells. Both horses developed neutralizing antibody to EHV-9. Perivascular infiltration of mononuclear cells and glial reaction were found in the olfactory and limbic systems. The results suggested that EHV-9 has a pathogenicity in...
Theriogenology question of the month. Premature birth attributable to placental insufficiency that resulted from establishment of pregnancy in the uterine body with subsequent villous atrophy.
Journal of the American Veterinary Medical Association    March 15, 2000   Volume 216, Issue 6 833-835 
DiGrassie WA, Dascanio JJ, Ley WB, Newman SJ, Prater DA.No abstract available
Hepatic abscesses in three horses.
Journal of the American Veterinary Medical Association    March 15, 2000   Volume 216, Issue 6 882-865 doi: 10.2460/javma.2000.216.882
Sellon DC, Spaulding K, Breuhaus BA, Katz L, Mealey R.Hepatic abscesses were diagnosed in 3 adult horses. Two were < 4 years old and had evidence of concurrent immune-mediated conditions, including aseptic arthritis, immune-mediated thrombocytopenia, and immune-mediated anemia. Predisposing factors for hepatic abscess formation in these horses included prior abdominal surgery, proximal duodenitis/jejunitis, inflammatory bowel disease, and a penetrating foreign body in the large colon. Serum hepatic enzyme activities were within or slightly greater then reference limits in all 3 horses. The most pronounced and consistent abnormalities on CBC and s...
Comparison of equine amnion and a nonadherent wound dressing material for bandaging pinch-grafted wounds in ponies.
American journal of veterinary research    March 14, 2000   Volume 61, Issue 3 326-329 doi: 10.2460/ajvr.2000.61.326
Goodrich LR, Moll HD, Crisman MV, Lessard P, Bigbie RB.To evaluate healing of pinch-grafted wounds on the distal aspect of the limbs of ponies bandaged with equine amnion or a standard nonadherent wound dressing material. Methods: 6 ponies. Methods: A 2.5x2.5-cm full-thickness section of skin was removed from the dorsal aspect of each limb at the midpoint of the metacarpus or metatarsus. Six days later, wounds were grafted with partial-thickness pinch grafts. Half the wounds were bandaged with amnion, and the other half were bandaged with a nonadherent dressing. Bandages were changed every 3 days until wound healing was complete. At each bandage c...
Polysaccharide storage myopathy in Morgan, Arabian, and Standardbred related horses and Welsh-cross ponies.
Veterinary pathology    March 14, 2000   Volume 37, Issue 2 193-196 doi: 10.1354/vp.37-2-193
Valentine BA, McDonough SP, Chang YF, Vonderchek AJ.Polysaccharide storage myopathy is an equine neuromuscular disorder characterized by accumulation of glycogen-related polysaccharide inclusions within skeletal muscle fibers. The pathologic criteria for diagnosis of this disorder are somewhat controversial; however, periodic acid-Schiff-positive, amylase-resistant inclusions are considered pathognomonic. Although these inclusions are most often found in affected horses related to the Quarter Horse, draft horse, and Warmblood breeds, this report describes these characteristic inclusions in muscle of five horses from nonrelated breeds (two Morga...
Clinical and pathologic findings in donkeys with hypothermia: 10 cases (1988-1998).
Journal of the American Veterinary Medical Association    March 9, 2000   Volume 216, Issue 5 725-729 doi: 10.2460/javma.2000.216.725
Stephen JO, Baptiste KE, Townsend HG.To describe clinical signs and clinicopathologic findings in donkeys with hypothermia. Methods: Retrospective study. Methods: 10 hypothermic donkeys. Methods: Information on signalment, history, physical examination findings, results of diagnostic tests, treatments, and necropsy findings was extracted from medical records of all donkeys with hypothermia between 1988 and 1998 and compared with information from medical records of all normothermic donkeys and hypothermic horses admitted to the hospital during the same period. Results: Donkeys were more likely to be hypothermic than horses. The me...
Clinical trial to determine the effect of omeprazole given once or twice daily on gastric ulceration.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 87-90 doi: 10.1111/j.2042-3306.1999.tb05177.x
Vatistas NJ, Nieto JE, Snyder JR, Thompson D.No abstract available
Clinical syndromes of gastric ulceration in foals and mature horses.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 30-33 doi: 10.1111/j.2042-3306.1999.tb05165.x
Andrews FM, Nadeau JA.No abstract available
Safety, acceptability and endoscopic findings in foals and yearling horses treated with a paste formulation of omeprazole for twenty-eight days.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 67-70 doi: 10.1111/j.2042-3306.1999.tb05173.x
Murray MJ, Eichorn ES, Holste JE, Cox JL, Stanier WB, Cooper WL, Cooper VA.A paste formulation of the H+,K(+)-ATPase inhibitor omeprazole was evaluated in Thoroughbred foals and yearlings for its safety and acceptability. Twenty foals age 11-16 weeks and 20 yearling horses age 15-17 months were included and gastroscopic examinations performed 1-3 days before and at the end of each trial. Lesions were scored on a scale of 0 to 3 and animals allocated based on endoscopic lesion score and sex, with 4 animals in each of 5 replicates. Dosages of 4 mg omeprazole/kg bwt or sham treatment were administered once daily for 28 days, from a syringe graduated in 50 lb (22.68 kg) ...
Treatment of gastric lesions in horses with pectin-lecithin complex.
Equine veterinary journal. Supplement    March 4, 2000   Issue 29 91-96 doi: 10.1111/j.2042-3306.1999.tb05178.x
Venner M, Lauffs S, Deegen E.This study compared the study of a pectin-lecithin complex (Pronutrin) on gastric ulcer healing during an 11 day period in 2 groups of 12 horses each. Twenty-four horses suffering from gastric lesions of differing severity were selected from a larger group of clinical cases on the basis of gastroscopic examination. Both gastric mucosal erosions as well as gastric ulcers were found in the 2 mucosal regions (pars nonglandularis and pars glandularis). The gastric mucosal lesions occurred predominantly in the pars nonglandularis in the vicinity of the margo plicatus. The 24 horses were divided equ...
Radiographic diagnosis: thoracic spinal fracture resulting in kyphosis in a horse. Kothstein T, Rashmir-Raven AM, Thomas MW, Brashier MK.No abstract available
Use of 99mTc-mercaptoacetyltriglycine to evaluate renal function in horses. Woods PR, Drost WT, Clarke CR, Rodebush CJ.Ten healthy horses were injected intravenously with 99mTc-MAG3 and the disappearance of radioactivity from the blood was measured. The total body clearance (Cl(B)) and elimination half-life (t1/2(beta)) were 7.9 +/- 1.5 ml/kg/minute and 32.8 +/- 4.1 minutes, respectively. The disappearance of 99mTc-MAG3 from the blood of 2 horses with compromised renal function was also measured. The data suggest that 99mTc-MAG3 is a useful and clinically applicable radiopharmaceutical for measurement of effective renal blood flow in the horse.
Intrapelvic hemangiosarcoma in a horse. Kiupel M, Frank N, Stevenson GW, Siems J, Snyder PW.No abstract available
Correlation of clinical score, intrapleural pressure, cytologic findings of bronchoalveolar fluid, and histopathologic lesions of pulmonary tissue in horses with summer pasture-associated obstructive pulmonary disease.
American journal of veterinary research    February 24, 2000   Volume 61, Issue 2 167-173 doi: 10.2460/ajvr.2000.61.167
Costa LR, Seahorn TL, Moore RM, Taylor HW, Gaunt SD, Beadle RE.To correlate clinical score, intrapleural pressure, cytologic findings of bronchoalveolar lavage fluid (BALF), and histologic lesions of pulmonary tissue in horses affected with summer pasture-associated obstructive pulmonary disease (SPAOPD). Methods: 8 adult horses affected with SPAOPD and 6 adult horses without evidence of respiratory tract disease. Methods: Clinical score, change in intrapleural pressure (deltaPpl) during tidal breathing, results of cytologic examination and bacteriologic culture of BALF, and results of histologic examination of pulmonary parenchyma were evaluated. Results...
Survey of retinal haemorrhages in neonatal thoroughbred foals.
The Veterinary record    February 22, 2000   Volume 146, Issue 4 95-101 doi: 10.1136/vr.146.4.95
Munroe G.Twenty-seven of 167 neonatal thoroughbred foals (16 per cent) were found to have retinal haemorrhages after a careful examination of the entire fundus. Experience in differentiating haemorrhages from other lesions, and the selection of foals from normal populations, were considered to have an important effect on their apparent incidence. Bilateral haemorrhages were more common and there was a significantly higher incidence in female foals. The numbers of haemorrhages ranged between one and 20; 36 per cent of eyes with retinal haemorrhages had the small punctate type and 56 per cent had the spl...
Disseminated hemangiosarcoma in the horse: 35 cases.
Journal of veterinary internal medicine    February 11, 2000   Volume 14, Issue 1 105-109 doi: 10.1892/0891-6640(2000)014<0105:dhithc>2.3.co;2
Southwood LL, Schott HC, Henry CJ, Kennedy FA, Hines MT, Geor RJ, Hassel DM.Thirty-five cases of disseminated hemangiosarcoma (21 clinical cases and 14 previously reported cases) were reviewed to describe the disease in horses. Hemangiosarcoma occurred in mature, particularly middle-aged horses, with no apparent sex predilection. Thoroughbreds seemed to be overrepresented (13 cases) but a true breed predilection could not be established. The respiratory and musculoskeletal systems were most commonly affected and presenting complaints included dyspnea (26%), subcutaneous or muscular swelling (24%), epistaxis (17%), and lameness (12%). Heart and respiratory rates were u...
Equine dental disease. Part 3: A long-term study of 400 cases: disorders of wear, traumatic damage and idiopathic fractures, tumours and miscellaneous disorders of the cheek teeth.
Equine veterinary journal    February 8, 2000   Volume 32, Issue 1 9-18 doi: 10.2746/042516400777612099
Dixon PM, Tremaine WH, Pickles K, Kuhns L, Hawe C, McCann J, McGorum BC, Railton DI, Brammer S.Of 400 horses referred because of dental disorders, 349 cases were diagnosed as suffering from primary disorders of their cheek teeth. Details of 104 of these cases are presented, including 44 cases with abnormalities of wear, 26 cases with traumatic damage, 24 cases with idiopathic fractures and 10 cases with miscellaneous cheek teeth disorders including oral tumours. The long-term response to treatment was excellent in most cases, even in cases with residual secondary periodontal disease.
Clinical and neuropathological features of West Nile virus equine encephalomyelitis in Italy.
Equine veterinary journal    February 8, 2000   Volume 32, Issue 1 31-35 doi: 10.2746/042516400777612080
Cantile C, Di Guardo G, Eleni C, Arispici M.West Nile (WN) virus infection is a mosquito-borne flavivirosis endemic in Africa and Asia. Clinical disease is usually rare and mild and only in a few cases the infection causes encephalomyelitis in horses, fever and meningoencephalitis in man. We report here the clinical and pathological findings in an epidemic of the disease involving 14 horses from Tuscany, Italy. All cases were observed from August to October 1998. Affected horses showed ataxia, weakness paresis of the hindlimbs and, in 6 cases, there was paraparesis progressing to tetraplegia and recumbency within 2 to 9 days. Eight anim...
Upper airway disease: does it affect lower airway mechanics and pulmonary haemodynamics?
Equine veterinary journal. Supplement    February 5, 2000   Issue 30 639 doi: 10.1111/j.2042-3306.1999.tb05302.x
Ducharme NG, Hiraga A.No abstract available
Plasma glutamine status in the equine at rest, during exercise and following viral challenge.
Equine veterinary journal. Supplement    February 5, 2000   Issue 30 612-616 doi: 10.1111/j.2042-3306.1999.tb05295.x
Routledge NB, Harris RC, Harris PA, Naylor JR, Roberts CA.The variation over 24 h of plasma glutamine concentration in nonexercising horses was studied in 3 Thoroughbreds (TB) fed at 1600 h and 0700 h. This indicated a small but regular change associated with feeding. Starting at a mean of 482 mumol/l at 1600 h the concentration increased to 522 mumol/l at 2000 h, falling to 476 mumol/l at 1600 h and increasing again to 525 mumol/l at 2000 h. 'Normal' values were established in 19 part-bred TB horses, lacking clinical signs or remarkable pathology and in light training, by sampling weekly at 1000 h over a 10 week period. The mean concentration was 49...
Sequential changes in bronchoalveolar cytology after autologous blood inoculation.
Equine veterinary journal. Supplement    February 5, 2000   Issue 30 126-130 doi: 10.1111/j.2042-3306.1999.tb05202.x
McKane SA, Slocombe RF.Six horses, free of recent exercise-induced pulmonary haemorrhage (EIPH), each had 8 bronchial segments inoculated with 40 ml of autologous blood lavaged on Days 3, 5, 7, 10, 14 and 21 after inoculation. The bronchoalveolar lavage (BAL) fluid samples were analysed, and total leucocyte counts and differential cell percentages determined. Statistical analysis of the differences between the 8 post inoculation and 1 pre-inoculation (control) lavage sites demonstrated an early neutrophilic response, rising from < 5% of alveolar leucocytes to 10% by 24-48 h post inoculation. As this response wane...
Racing performance in red blood cell hypervolaemic standardbred trotters.
Equine veterinary journal. Supplement    February 5, 2000   Issue 30 617-620 doi: 10.1111/j.2042-3306.1999.tb05296.x
Persson SG, Osterberg I.The association between red blood cell hypervolaemia (RCHV) and racing performance was examined in 116 Standardbred trotters referred to the clinic during a 5 year period with histories of impaired racing performance. Red cell hypervolaemia was the only significant abnormality detected in a thorough clinical examination, cell volumes ranging 116-178% of the predicted normal values. They were also compared with the performance traits of the contemporary Swedish Standardbred trotter population (n = 58,058). The performance traits were based on earnings per year and start, best annual racing time...
Effects of analgesia of the distal interphalangeal joint or palmar digital nerves on lameness caused by solar pain in horses.
Veterinary surgery : VS    February 1, 2000   Volume 29, Issue 1 54-58 doi: 10.1111/j.1532-950x.2000.00054.x
Schumacher J, Steiger R, Schumacher J, de Graves F, Schramme M, Smith R, Coker M.To determine if pain of the dorsal margin of the sole in horses can be attenuated by anesthesia of either the distal interphalangeal (DIP) joint or the palmar digital (PD) nerves. Methods: A unilateral forelimb lameness was induced by creating solar pain. Response to administration of local anesthetic or saline solution into the DIP joint and to administration of local anesthetic around the PD nerves was evaluated. Methods: Six horses. Methods: Lameness was induced by creating pressure on the dorsal margin of the sole by screwing set-screws into a nut welded to the inside of each branch of a s...
Spinal cord compression secondary to hemangiosarcoma in a saddlebred stallion.
The Canadian veterinary journal = La revue veterinaire canadienne    January 26, 2000   Volume 40, Issue 12 886-887 
Berry S.Hemangiosarcoma in the spinal canal was diagnosed in a 25-year-old stallion showing progressive and symmetrical 4-limb ataxia, proprioceptive deficits, and weakness. On necropsy, an extradural mass consisting of spindle-shaped cells and numerous free erythrocytes was found at the level of C7-T1. Immunohistochemical staining confirmed a neoplasm of endothelial origin.
Dietary carbohydrates and fat influence radiographic bone mineral content of growing foals.
Journal of animal science    January 21, 2000   Volume 77, Issue 12 3330-3338 doi: 10.2527/1999.77123330x
Hoffman RM, Lawrence LA, Kronfeld DS, Cooper WL, Sklan DJ, Dascanio JJ, Harris PA.Hydrolyzable carbohydrate intake in horse diets may become excessive when rapidly growing pastures are supplemented with grain-based concentrates. The substitution of fat and fiber for hydrolyzable carbohydrate in concentrates has been explored in exercising horses but not in young, growing horses. Our objective was to compare bone development in foals that were fed pasture and concentrates rich in sugar and starch (corn, molasses) or fat and fiber (corn oil, beet pulp, soybean hulls, oat straw). Forty foals were examined, 20 each in 1994 and 1995. In each year, 10 mares and their foals were f...
Gangrene in the distal extremity of all 4 limbs of a 2-week-old foal.
The Canadian veterinary journal = La revue veterinaire canadienne    January 11, 2000   Volume 41, Issue 11 861-863 
Steinman A, Orgad U, Sutton GA.Wet gangrene developed in all 4 limbs following repair of a rupture in the lower urinary tract in a 2-week-old foal. Dehydration and hypoxemia are suspected as the inciting causes of the necrosis.
Effect of long-term administration of an injectable enrofloxacin solution on physical and musculoskeletal variables in adult horses.
Journal of the American Veterinary Medical Association    January 11, 2000   Volume 217, Issue 10 1514-1521 doi: 10.2460/javma.2000.217.1514
Bertone AL, Tremaine WH, Macoris DG, Simmons EJ, Ewert KM, Herr LG, Weisbrode SE.To evaluate clinical safety of administration of injectable enrofloxacin. Methods: Randomized controlled clinical trial. Methods: 24 adult horses. Methods: Healthy horses were randomly allocated into 4 equal groups that received placebo injections (control) or IV administration of enrofloxacin (5 mg/kg [2.3 mg/lb], 15 mg/kg [6.8 mg/lb], or 25 mg/kg [11.4 mg/lb] of body weight, q 24 h) for 21 days. Joint angles, cross-sectional area of superficial and deep digital flexor and calcaneal tendons, carpal or tarsal osteophytes or lucency, and midcarpal and tarsocrural articular cartilage lesions wer...
Oxytocin administration prolongs luteal function in cyclic mares.
Journal of reproduction and fertility    January 1, 2000   Volume 116, Issue 2 315-320 doi: 10.1530/jrf.0.1160315
Stout TA, Lamming GE, Allen WR.Recent evidence indicates that, in mares, as in the domestic ruminants, oxytocin and its endometrial receptor play important roles in stimulating the pulsatile releases of prostaglandin F2 alpha from the endometrium that effect luteolysis. In the present experiment, continuous administration of oxytocin by subcutaneous minipump to five mares during days 8-20 after ovulation abolished luteolysis in four of them, while all four of the control mares infused similarly with saline underwent luteolysis at the expected time. When oxytocin administration began on day 10, instead of on day 8, after ovu...