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Topic:Clinical Pathology
Clinical pathology in horses involves the study and analysis of biological samples to diagnose and monitor diseases and health conditions. This discipline encompasses various laboratory tests and procedures that assess the physiological and biochemical status of equines. Common analyses include hematology, biochemistry, urinalysis, and cytology, each providing insights into different aspects of equine health. Hematology evaluates blood components, such as red and white blood cells and platelets, to identify conditions like anemia or infection. Biochemistry tests measure enzymes, electrolytes, and metabolites to assess organ function and metabolic status. Urinalysis examines urine samples for indicators of renal function and systemic diseases. Cytology involves the microscopic examination of cells from tissues or fluids to detect abnormalities. This page aggregates peer-reviewed research studies and scholarly articles that explore the methodologies, applications, and diagnostic value of clinical pathology in equine medicine.
Brainstem auditory evoked response in the diagnosis of inner ear injury in the horse. Brainstem auditory evoked response (BAER) testing was done to evaluate inner ear/VIIIth cranial nerve (CN8) function in the horse. The BAER test consisted of stimulating the auditory system with clicks and recording far-field responses of the brainstem auditory components via cutaneous electrodes and a signal averaging system. The normal response was shown to be a series of waves occurring within the first 10 msec after the stimulus click. Functional loss of the auditory receptor organ (cochlea) or CN8 results in loss of the entire response on the side of the injury. Because of the anatomic re...
Torsion of the spermatic cord in a horse. A 360-degree torsion of the left spermatic cord was diagnosed in a 2 1/2-year-old Quarter Horse colt. Clinical signs included abdominal discomfort, with slight elevations in heart and respiratory rates. The scrotum on the left side was moist and edematous. The left testicle was enlarged, firm, and retracted slightly toward the abdominal cavity. The colt resented palpation of the testicle. On rectal palpation, the left vaginal ring and the structures passing through the ring were edematous and painful to pressure. Surgical correction was achieved by emasculation. The tail of the epididymis and ...
Radiographic detection and characterization of palmar lesions in the equine fetlock joint. Subchondral lesions were identified in the distal palmar region of the third metacarpus in 21 fetlock joints of 15 Thoroughbred horses. The lesions were more commonly identified on the lateromedial and flexed lateral projection, with the flexed lateral projection permitting optimal visualization of the lesion. Lesions appeared as poorly marginated, radiolucent defects and were located at the level of the base of the proximal sesamoid bones. The shape and distribution of the radiolucent defects were: crescent, 4; flattened, 4; shallow concavity, 5; deep concavity, 3; oval, 3; and circular, 2. S...
Metabolic abnormalities associated with rupture of the urinary bladder in neonatal foals. Rupture of the urinary bladder was diagnosed in 4 neonatal male foals. Marked hyponatremia, hypochloremia, and hyperkalemia developed in all 4 cases, and the electrolyte abnormalities were considered to be of potential diagnostic value. Blood urea nitrogen concentration was normal or only slightly higher than normal in 3 of 4 cases and therefore was not a reliable diagnostic test.
Experimentally induced arthritis of the equine carpus: histologic and histochemical changes in the articular cartilage. Arthritis was experimentally induced in the intercarpal joints of a series of mature ponies by the intraarticular injections of 400 microgram of the polyene antibiotic filipin in 1 ml of dimethyl sulfoxide. Twelve consecutive weekly injections were administered and the ponies were euthanatized 4 weeks after the last injection of filipin was made. The ponies were exercised for 1 hour each day throughout the experiment. Articular cartilage specimens from 4 sites in each intercarpal joint were examined histologically and histo-chemically. For the histochemical examination, safranin O-fast green, ...
Evaluation of an intravenous catheter for use in the horse. A commercially available polyvinyl chloride intravenous catheter was studied in 9 horses for 3 to 10 days to evaluate the catheter's suitability for use in the horse, to develop a new insertion technique, and to establish a protocol for catheter care. Seven of the animals were clinically normal horses receiving parenteral nutrition; one was a horse with hypocalcemia receiving frequent intravenous injections of calcium gluconate, and one was a clinically normal horse receiving no infusions. The catheter dressings were changed every 48 hours, and an aspirate from the catheter and the catheter ti...
Isolation of antibiotic-resistant Salmonella krefeld from clinical veterinary materials. Six isolations of Salmonella krefeld were made from clinical veterinary specimens. These isolates were multiply resistant to several antimicrobial agents commonly used to treat salmonellosis.
Effects of different anticoagulants on determination of erythrocyte glutathione peroxidase. Glutathione peroxidase (GSH-Px) was determined in whole blood from cows, goats and horses using cumenehydroperoxide as substrate. Heparin was found to be the most suitable anticoagulant. The highest activities of GSH-Px were found with high concentrations of heparin in the blood samples (1000 and 1250 IU/ml of blood). Sodium fluoride and especially EDTA and sodium citrate gave lower activities of the enzyme. Storage of the blood samples at room temperature (~20°C) or in a refrigerator (~5°C) for 3 days resulted in significantly lower activities of the enzyme, especially in horse blood. Gluta...
Equine congenital cutaneous papillomatosis: a report of 5 cases. Four cases of equine congenital cutaneous papillomatosis were found during a review of 555 cutaneous tumours received at the pathology department, Ontario Veterinary College, during a 10-year period. A fifth case received after that period was also included. Two of the tumours were found in Thoroughbreds, one in a Standardbred, one in an Arabian and in one case the breed was not specified. The anatomical locations were the rib cage, head, hind leg and 2 on the forehead.
[Variations in plasma components in lactating mares at late pregnancy-early lactation (author’s transl)]. In an experiment comparing pregnant then lactating mares with dry non-pregnant mares, the changes in plasma components were studied as indicators of the metabolic utilization of energy (glucose, non-esterified fatty acids, beta-hydroxybutyrate), nitrogen (urea, proteins) or minerals (calcium, phosphorus, magnesium). The mares were fed daily 2 kg concentrate and hay ad libitum. Beta-hydroxybutyrate, magnesium and to a lesser extent glucose were the only constituents whose levels were affected within the period starting one month before and ending one month after foaling. The increase in food in...
Propagation of equine infectious anemia virus in horse cell cultures. The Wyoming strain of equine infectious anemia virus was adapted to cell cultures by 7 passages in horse leukocytes and 14 passages in fetal equine dermal and kidney cells. The virus was made evident by electron microscopy and immunodiffusion tests with antigens prepared from culture fluids.
