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Topic:Clinical Pathology
Clinical pathology in horses involves the study and analysis of biological samples to diagnose and monitor diseases and health conditions. This discipline encompasses various laboratory tests and procedures that assess the physiological and biochemical status of equines. Common analyses include hematology, biochemistry, urinalysis, and cytology, each providing insights into different aspects of equine health. Hematology evaluates blood components, such as red and white blood cells and platelets, to identify conditions like anemia or infection. Biochemistry tests measure enzymes, electrolytes, and metabolites to assess organ function and metabolic status. Urinalysis examines urine samples for indicators of renal function and systemic diseases. Cytology involves the microscopic examination of cells from tissues or fluids to detect abnormalities. This page aggregates peer-reviewed research studies and scholarly articles that explore the methodologies, applications, and diagnostic value of clinical pathology in equine medicine.
Isolation and characterization of antibodies to Clostridium perfringens epsilon toxin from hyperimmune horse serum. Antibodies against epsilon toxin were isolated from hyperimmune horse serum by affinity chromatography. Purified epsilon prototoxin covalently bound to Affigel 202 was used as immunosorbent, and antibodies were eluted with 6.0 M guanidine chloride. In a single run 80 mg of antibody could be recovered from a 20 microliter column of immunosorbent. The antibody was shown to belong to the IgG(T) class of immunoglobulins.
Agammaglobulinemia in a horse. Immunologic deficiency was suspected in an 18-month-old Standardbred horse with persistent fever, multifocal bacterial infection, and neutropenia with a large number of immature neutrophils. Serum protein electrophoresis revealed marked depression of the gamma-globulin fraction (0.2 g/100 ml). Immunologic testing and histologic examination of lymphoid tissues identified the immune deficit as agammaglobulinemia. Serum concentrations of immunoglobulin (Ig)G and IgG(T) were initially low and declined with time; IgM and IgA were not detectable. The horse failed to produce antibodies when inoculate...
Peritoneal lavage in the horse. Eight horses ranging in age from 4 days to 9 years were treated for peritonitis. Escherichia coli was isolated in four cases and Nocardia sp in one case. In each case, a catheter placed in the peritoneal cavity allowed drainage of a large amount of purulent fluid. Retrograde peritoneal lavage was performed through a Foley catheter or medical tubing, using Ringer's lactate solution containing kanamycin, povidone iodine, or nitrofurazone. All except two horses responded well to repeated lavage.
Effect of pneumatic tourniquet application to the distal extremities of the horse: blood gas, serum electrolyte, osmolality, and hematologic alterations. With 120 minutes of pneumatic tourniquet application to the distal extremity in the horse, the following effects were noted in the tourniqueted limb vein (TLV): (i) local venous acidemia, (ii) increase in serum K+ concentrations, (iii) minimal changes in plasma total solids, Na+, or osmolality, and (iv) apparent reduction in hematocrit values when compared with the same measurements in the control leg. Tourniquet release after 120 minutes produced a prompt return to base line for PCV and PO2 in the TLV; however, pH, PCO2 and K+ values in the TLV required 10 to 15 minutes to reach base line (TL...
Acquired torticollis in eleven horses. Case records of 11 horses with acquired torticollis during a 15-year period were reviewed. The cause was established in seven of eight cases and included cervical intervertebral disk protrusion, skull fracture, neurogenic atrophy, and dystrophic myodegeneration. The latter condition was considered to be the most likely cause in the three horses that recovered.
[Periosteal new bone formation in the horse induced by trauma. (author’s transl)]. The radiological interpretation of periosteal new bone formation in the horse induced by trauma is described and illustrated by some casereports. The better the margins of the new bone can be defined the lesser the activity. The greater the density of the new bone, the longer the duration of time since injury.
Phenylbutazone toxicity in ponies. The oral administration of phenylbutazone at a dose rate of approximately 10 mg per kg per day for seven to 14 days resulted in the development of signs of toxicity in seven of eight ponies treated. Clinical signs included anorexia, depression and abdominal oedema. Blood biochemical determinations showed a decrease in total plasma protein and calcium concentrations with an increase in urea concentration. These changes were considered indicative of water retention. Three of the ponies died during treatment following the development of shock. Shock was considered to arise from the submucosal oed...
The pH/log PCO2 buffer curve of horse blood. Samples of jugular venous blood from six horses were equilibrated with six oxygen and carbon dioxide gas mixtures of PCO2 between 28 and 54 mm Hg. In all six samples the correlations between the pH and the log PCO2 values were linear and highly significant, with r in all six samples greater than 0.985.
It was concluded that the Astrup method for the determination of the acid-base status of the blood of horses is valid.
Indirect measurement of mean blood pressure in the normotensive and hypotensive horse. Indirect mean arterial pressure was obtained from the tails of 78 anaesthetised and unanaesthetised normotensive and hypotensive horses. Data were obtained to determine the optimum cuff width in relation to tail circumference. A cuff that is too wide under-estimates and a cuff that is too narrow over-estimates blood pressure. With the optimum cuff width, which is slightly in excess of about one-fifth of the tail circumference, indirect mean blood pressure was obtained consistently in normotensive and hypotensive animals with mean blood pressures of 40 mmHg and frequently in animals with pressu...
Sound spectography in the diagnosis of equine respiratory disorders: a preliminary report. One problem in the diagnosis of subclinical roarers is that abnormal auditory signals occur only during a fast gait, and these fade quickly. This paper offers a novel technique to assist this problem. Sound recordings were obtained from five horses following exercise; two roarers, two non-roarers, and one suspected roarer. These signals were converted into spectrograms by Rayspan processing. All frequencies in the 0 to 2.25 kHz range during both inspiration and expiration, as well as occasional noises in the 2–4 kHz band, characterised roarers. Signals from non-roarers consisted of frequenci...
Adrenal-testis interaction in the stallion. The authors describe the short and long term effects of synthetic adrenocorticotrophin and of cortisol on peripheral plasma testosterone concentrations in 2 stallions. A single injection of either hormone temporarily raised plasma testosterone concentrations but repeated injection (twice daily for 5 days) depressed plasma testosterone concentrations. Cessation of treatment was followed by a rise in plasma testosterone to concentrations higher than those in the pretreatment period. These findings are briefly discussed.
The Fourth Sir Frederick Hobday Memorial Lecture. Back problems in the horse–a look at past, present and future progress. The horse is predisposed to back injury by virtue of the type of work and intensity of competition
to which it is subjected nowadays. This paper reviews some of the inherent difficulties in establishing meaningful criteria for the diagnosis and treatment of these injuries. It highlights some
of the large gaps in knowledge, particularly in relation to the causative factors involved and the
biomechanics of the equine spine. One controversial area in diagnosis and treatment concerns
the possible subluxation of vertebral dorsal spinous processes and their subsequent reposition by
means of man...
Phonocardiography in the horse: 2. The relationship of the external phonocardiogram to intracardiac pressure and sound. The paper describes observations during individual cardiac cycles on the changing pressures and sounds recorded from the various chambers of the heart and aorta, related to phonocardiograms from an external microphone hand-held over the cardiac area. The majority of the first sound appears to arise from the left side of the heart after the AV valves have closed and the second sound is a consequence of sudden deceleration of blood against already closed semilunar valves. Systolic murmurs at the aortic root may be benign from increased flow and turbulence at the peak of ejection but these may no...
An equine fetal monster dicephalus tetrapus dibrachius. Double monsters are structurally related to monozygotic twins and the reported frequency of these abnormalities in the equine species is low. Symmetrical, double development in both the cephalic region and caudal trunk was demonstrated along with a common undeveloped cervical mass. Anomalies found in the separate genito-urinary systems added another variant to this case.
A preliminary report on the use of warfarin in the treatment of navicular disease. Twenty horses suffering from navicular disease were treated with warfarin given orally. The dosage was to effect, to give a 2 to 4 second prolongation of the one stage prothrombin time (OSPT). Dosage was initially at a rate of 0.018 mg/kg, changing the dose by amounts of 20 per cent until the required dose was achieved. Final dose rates varied from 0.012 mg/kg to 0.75 mg/kg. All the cases treated received warfarin daily throughout the trial. Seventeen of the animals became sound and the remaining 3 showed a marked improvement in their gait. The mean of the ages of the horses was 7.5 years, the...
Studies on experimental enteric salmonellosis in ponies. Clinical, bacteriological, serological and haematological observations were made on 13 adult ponies orally inoculated with Salmonella typhimurium. The results were compared to two control ponies and four others infected by accidental transmission. The clinical responses in inoculated ponies included pyrexia lasting four days and neutropaenia during the first five days after inoculation followed by a neutrophilia. Pyrexia and neutropaenia was associated with maximal shedding of organisms in the rectal faeces. Changes in the character of the faeces occurred between one and two days after inocula...
Improved measurements of shear modulus and pleural membrane tension of the lung. The continuum solution for the deformation of an elastic half space covered by a membrane is used to interpret measurements of the indentation of lung lobes under a column of fluid. The shear modulus mu of the underlying parenchyma is found to be approximately 0.7 times transpulmonary pressure, independent of species size. The tension in the pleural membrane T increases rapidly with increasing membrane area. For dog lungs, the value of T is 10(3) to 10(4) dyn/cm. For the larger species tested, pigs and horses, T is larger. The continuum solution shows that a concentrated force applied to the p...
