Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Tarsal osteomyelitis in foals. Nine foals with haematogenous osteomyelitis of the tarsal bones were studied clinically, radiologically and pathologically. Clinical examination, including aspiration of articular or periarticular effusions in the tarsal area, and radiological study provide definitive diagnosis in most cases.
Endoscopic examination of the equine thorax. PLEUROSCOPY is a diagnostic technique in which a flexible
or rigid endoscope is used to examine the pleural space.
Although pleuroscopy is a relatively new technique in equine
medicine, it has been used for some time in human medicine
(Jacobaeus 1910, 1925; Lloyd 1953). It is most often used in
human patients to explore the thoracic cavity of persons with
undiagnosed pleural effusions when more conservative
methods, such as percutaneous lung or pleural biopsy, have
been unsuccessful in providing a diagnosis (Hatch and
Decamp 1966; Decamp, Mosely, Scott and Hatch 1973;
Gwin et a1 1975...
Fascial compartments of the equine crus. The deep fascia of the equine crus was dissected grossly and separated into 2 layers, the superficial and deep laminae of the deep fascia. Attachments of these fascial laminae to the tibia and fibula formed 5 separate osteofascial compartments: cranial, lateral, caudal deep, caudal intermediate, and caudal superficial. Cranial tibial vessels and the deep peroneal nerve entered the cranial compartment through separate fascial hiatuses; this may predispose the equine crus to the occurrence of compartmental syndromes with clinically recognizable neural deficits.
Laboratory evaluation of aqueous humor in the healthy dog, cat, horse, and cow. Using routinely available clinical laboratory methods, aqueous humor samples were evaluated from 12 healthy dogs, 15 healthy cats, 7 healthy horses, and 6 healthy cows. Aqueous humor was almost acellular; cells that were present had degenerated beyond recognition. Protein concentration was low; only albumin was detectable on electrophoresis. Creatine phosphokinase and lactate dehydrogenase isoenzymes were not detected. Artifacts induced by sampling were insignificant compared with alterations in aqueous humor composition that occur with ocular diseases.
Antifungal sensitivity testing for equine keratomycosis. We evaluated 31 fungal specimens obtained from equine corneas over a 10-year period, 1973 to 1983. More than half were received in late summer and early autumn, and the number tended to increase in frequency during the 1980s. These isolates included 13 different genera and 20 different species. The prevalent genus was Aspergillus (35%). On the basis of examinations for tube-dilution minimal inhibitory concentrations and minimal fungicidal concentrations of 16 fungal isolates, the imidazole antibiotics such as miconazole and ketoconazole consistently showed the lowest geometric mean titers for ...
Evaluation of the wick catheter as used to measure intracompartmental muscle pressure in equine muscle. The use of the wick catheter to measure intracompartmental muscle pressure in equine muscle was documented. The presence of muscle compartments involving the extensor carpi radialis muscle and the long head of the triceps brachii was demonstrated by anatomic dissection and radiographic technique. The wick catheter was capable of accurately measuring pressures within both of these compartments. Furthermore, the wick catheter was sensitive to pressure changes resulting from external compression of muscle compartments. Manipulation of systemic blood pressure and PaCO2 in 1 anesthetized horse did ...
Direct current stimulation of bone production in the pony: observations with a diaphyseal osteotomy model. Electrically induced osteogenesis exhibits a dose response curve and can induce bone formation in the absence of trauma and in nonunions. Electrically induced osteogenesis, using direct electric current (DC) in a third metacarpal diaphyseal osteotomy model, in conjunction with internal fixation and postoperative loading, was investigated. Twelve young adult ponies of mixed sex were divided into 2 treatment groups (A and B) of 3 stimulated and 3 controls each and evaluated, using a specifically designed procedure. Stimulated ponies in both groups were given 20 microA of DC via an implanted bone...
Direct current stimulation of bone production in the horse: preliminary study with a “gap healing” model. The effect of a 20-microA direct-current implantable bone growth stimulator (BGS) on bone production with a "gap healing" model in the horse was evaluated. The right and left 4th metatarsal bones (Mt-4) were used in 7 adult horses to create the "gap healing" model. A 4-mm section of the Mt-4 bone was resected bilaterally in each horse. The BGS was surgically placed into the 7 left Mt-4 defects. The 7 right Mt-4 defects served as controls. Six horses survived the 16-week experimental period. Signs of pain, decreased range of limb motion, or lameness was not observed in any animal during the 16 ...
Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Weak organic acids possessing anti-inflammatory, analgesic and antipyretic properties--commonly known as aspirin-like drugs--have been used in equine medicine for almost 100 years. These non-steroidal anti-inflammatory drugs (NSAIDs) may be classified chemically into two groups; the enolic acids such as phenylbutazone and carboxylic acids like flunixin, meclofenamate and naproxen. All NSAIDs have similar and possibly identical modes of action accounting for both their therapeutic and their toxic effects. They block some part of the cyclo-oxygenase enzyme pathway and thereby suppress the synthe...
Use of guaiacol glycerine ether in clinical anaesthesia in the horse. A total of 103 anaesthetic inductions were performed in horses for a variety of elective procedures. All cases were premedicated with acepromazine maleate (0.02 to 0.05 mg/kg body weight [bwt] intramuscularly [im]). In 50 cases (Group A) anaesthesia was induced by a single intravenous (iv) bolus of thiopentone sodium (11.1 mg/kg bwt or 1 g/90 kg bwt) followed immediately by a bolus of suxamethonium chloride (0.1 mg/kg bwt). In 53 cases (Group B) anaesthesia was induced using iv guaiacol glycerine ether (GGE) (approximately 50 mg/kg bwt) followed by a bolus of thiopentone at half the usual dose...
Pharmacokinetic studies of theophylline in horses. The pharmacokinetics of theophylline were determined in Standardbred trotters after single intravenous and oral administration. A bi-exponential equation was fitted to the intravenous data and a tri-exponential equation to the oral data. The biological half-life of theophylline was found to be 14.8 h, the volume of distribution 1.02 l/kg and the total plasma clearance 0.86 ml/kg/min. The oral absorption of the drug was complete (bioavailability 108%) and rapid (absorption half-life 0.4 h).
Sixteen fractures of the shoulder region in the horse. The clinical and radiological features of fractures of the shoulder region in 16 horses are described. High quality radiographic views were essential for an accurate diagnosis. This sometimes necessitated general anaesthesia. The limitations of radiography are discussed. Nine horses had articular fractures of the supraglenoid tuberosity and eight of these were destroyed because of persistent lameness. The possibility of surgical removal of the fracture fragment(s) is discussed and the importance of early diagnosis emphasised. Seven other fractures of the shoulder region are described. The clin...
Arterial to end-tidal CO2 tension and alveolar dead space in halothane- or isoflurane-anesthetized ponies. The correlation between end-tidal partial pressure of CO2 (PETCO2) and arterial (PaCO2) was determined for spontaneously breathing ponies under halothane or isoflurane anesthesia. The PETCO2 was useful as a trend indicator of PaCO2 during the first 60 minutes of halothane or isoflurane anesthesia when PaCO2 values were less than 60 to 70 mm of Hg. Halothane anesthesia lasting greater than 90 minutes was associated with PaCO2 values in excess of 60 to 70 mm of Hg, a large arterial- to end-tidal PCO2 difference (PaCO2-PETCO2) and a significant increase in alveolar dead space. These effects were ...
A retrospective study of head fractures in 21 horses. The clinical features of 21 horses which sustained head fractures are reviewed. There was a higher incidence of fractures in males and Standardbred horses. Surgical treatment was practical and successful in most cases when the fractures involved the bones of the jaws and the face. Fractures which involved the cranial cavity or the cranial nerves were difficult to treat and usually held a poor prognosis.
Capacitively coupled electrical stimulation of bone healing in the horse: in vivo study with a Salter type IV osteotomy model with stainless steel surface electrodes. The use of capacitively coupled low-voltage signals for stimulation of osteogenesis has been reported in a variety of animal models. Electrically induced osteogenesis was investigated with a capacitively coupled electric field on a radius (distal-lateral orientation) osteotomy model, in conjunction with internal fixation and postoperative loading. Twelve adult horses of either sex were allotted to 2 groups of 6; 1 group was given electrical stimulation and the other served as controls. A low-voltage high-frequency capacitively coupled electrical signal was locally and continuously applied to t...
Induction of oestrus and ovulation by means of prostaglandin and gonadoliberin (GnRH) treatment in an old mare barren for two breeding seasons. A 17-year-old Nooitgedacht mare was presented in mid-summer after failing to conceive during the previous 2 breeding seasons. The mare conceived to service during a PG-induced oestrus when synthetic GnRH was used to induce ovulation.
Comparison of rectal mucosal cultures and fecal cultures in detecting Salmonella infection in horses and cattle. Bacteriologic cultures of 65 rectal mucosal samples and 335 fecal samples from 53 horses and 5 cattle shedding Salmonella were performed. Salmonella spp were isolated from 34 (52%) rectal mucosal samples, 21 (32%) concurrent fecal samples, and 150 (45%) total fecal samples. The use of rectal mucosal samples when compared with concurrently obtained fecal samples significantly (P less than 0.025) improved the ability to isolate Salmonella spp. Concurrent bacteriologic culture of rectal mucosal samples and fecal samples resulted in 39 (60%) isolations. Compared with a series of fecal samples, Sal...
Measurement of IgG in equine blood by immunoturbidimetry and latex agglutination. This paper describes the quantitative measurement of IgG concentrations in equine blood/serum by turbidimetric analysis and the qualitative assessment using latex agglutination. The concentration of IgG in foal serum measured by turbidimetry correlated well with the results obtained by radial immunodiffusion (r = 0.91) and the gamma-globulins estimated from the electrophoresis of serum on cellulose acetate (r = 0.92). The method, using antibody-coated latex beads, to detect foals with serum IgG concentrations of less than 4 g/litre (whole blood less than 2 g/litre) proved to be accurate in 96 ...
Chronic intestinal intussusception in two horses. In 2 cases of chronic intestinal intussusception in horses, one involved jejunum and the other, ileum. The only clinical signs observed were intermittent colic. Surgery was performed on both horses, with successful outcomes.
Psychogenic colic in a horse. A 4-year-old mixed-breed gelding was presented with colic-type behavior of 5 days' duration that included pawing, looking at the flank area, and kicking and biting at the abdomen and flank when it was eating hay or grain. Medical evaluation did not reveal the cause of the "colic." During its stay in the hospital, the horse improved as regarded the colic-type behavior while eating, but resumed this behavior when it was able to see hay that it was not allowed to eat. It was determined that the persistent colic-type behavior developed as a result of the horse having been repeatedly displaced from...
Rate of rise of arterial carbon dioxide tension in the halothane-anesthetized horse. The rate of rise of arterial partial pressure of carbon dioxide (PaCO2) was determined in 49 apneic halothane-anesthetized horses following controlled ventilation. Drugs given for induction of anesthesia did not affect the rapid rate of rise of PaCO2 during the first minute after controlled ventilation, the PaCO2 at 1 minute after controlled ventilation, or the PaCO2 at which spontaneous ventilation began. Horses given xylazine-ketamine for induction of anesthesia had a significantly (P less than 0.05) faster rate of rise of PaCO2 after 1 minute following controlled ventilation than did horses...
Paraphimosis in seven debilitated horses. This paper reports seven cases of penile paraphimosis which occurred in both entire and castrated horses in association with general debility. Two cases were discharged after treatment while still suffering from partial paralysis; one was discharged at the owner's request with complete paralysis; three were destroyed and one died during treatment. Identified causes of debility were malnutrition, severe parasitism, glucose malabsorption and salmonellosis.
Effects of phenylbutazone and anabolic steroids on adrenal and thyroid gland function tests in healthy horses. Adrenal and/or thyroid gland function tests were evaluated in horses at various times during short-term therapy with phenylbutazone, stanozolol, and boldenone undecylenate. There were no significant treatment or time effects on mean basal plasma cortisol concentrations in horses during treatment with the following: phenylbutazone, given twice daily (4 to 5 mg/kg, IV) for 5 days; stanozolol, given twice weekly (0.55 mg/kg, IM) for 12 days; boldenone undecylenate, given twice weekly (1.1 mg/kg, IM) for 12 days; or nothing. There was no significant effect of phenylbutazone treatment on the change...
