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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
A chronic wasting syndrome in a horse associated with granulomatous enteritis. A case of granulomatous enteritis in a 2 year-old Thoroughbred colt is reported. Clinically the horse showed chronic wasting and subcutaneous oedema of the ventral parts of the body and legs. Grossly the wall of the jejunum and ileum was uniformly thickened. Microscopically the lamina propria, submucosa and the tunica muscalaris of the small intestine were infiltrated with lymphocytes, plasma cells, epithelioid cells and occasional multinucleated giant cells. The granulomatous reaction was most marked in the muscular layers of the gut wall.
Glyceryl guaiacolate in equine anaesthesia. GG is a useful sedative and anaesthetic agent in horses. Used
alone, or in conjunction with barbiturates, it produces a un-
iformly smooth recovery from anaesthesia.
The need to infuse large volumes to obtain the desired effect is
a disadvantage ofthis agent. Few critical studies have been made
on the short and long term effects of administration of GG to
horses. Its pharmacology and clinical use are described and
indicate that it is a safe and useful drug.
A study of the specificity of Bandeiraea simplicifolia lectin I by competitive-binding assay with blood-group substances and with blood-group A and B active and other oligosaccharides. The specificity of Bandeiraea simplicifolia lectin I (BS I) has been studied by competitive-binding assays (CBA) using tritium-labeled human B and hog A substances. Blood-group B substances isolated from horse gastric mucosae and from human ovarian-cyst fluids were much better inhibitors of binding of tritiated blood-group B substance to insoluble BS I-Sepharose 2B than were human blood-group A substances from saliva and ovarian-cyst fluid. A and B active blood-group substances showed the same range of potency in inhibiting binding of tritium-labeled hog A substance to BS I-Sepharose 2B. CBA w...
Observations on thyroid hormones in the blood of thoroughbreds. During an investigation of a group of clinically well thoroughbreds housed in the same stable, it was noted that seven of the 14 had no detectable thyroxine in the plasma (less than 5 nmol/litre). An investigation of thoroughbreds in this stable over a five month period suggested that the thyroids were functioning normally and that the thyroxine was excreted in the urine. Thyroxine binding studies on the blood of these horses suggested that the major part of the circulating thyroxine was bound to albumin. The thyroxine had been displaced resulting in an apparent absence of plasma thyroxine sin...
Surgical correction of deviated nasal septum and premaxilla in a colt. A 6-month-old Appaloosa colt had a deviation of the premaxilla and nasal septum as well as a dorsal hump of the nasal bone and maxillomandibular malocclusion. Two surgical procedures were performed 12 weeks apart to correct these anomalies. An intraoral approach and autogenous rib graft were used to correct the malocclusion and deviation of the premaxilla. Osteotomy of the nasal bone and removal of the nasal septum were performed to help correct the deviation and to facilitate free air passage through the nares.
An evaluation of the efficacy of oxfendazole against the common nematode parasites of the horse. In a controlled trial in naturally-infected young ponies, oxfendazole administered orally at dose-rates of 10 mg per kg and 50 mg per kg resulted in complete elimination of Trichostrongylus axei, Parascaris equorum, Oxyuris equi and adult Strongylus vulgaris. Also, all migrating Strongylus edentatus larvae recovered from the subperitoneal tissues of the flank were found to be dead. Minimum efficiencies of 99.8 per cent and 99.1 per cent were obtained against adult small strongyles (Trichonema spp) and 97.6 per cent and 100 per cent of developing small strongyle larvae at dose-rates of 10 mg pe...
Pharmacological studies on the pulmonary vein of the horse. I. Effects of selected spasmogens. Horses suffer from a respiratory condition, similar to human allergic asthma, that is characterized by severe dyspnea, wheezing, coughing, and mucus production. Mediator substances released during the allergic reaction may contract airways and pulmonary vasculature. Nothing is known of the effects of autacoids and other vasoactive substances on equine pulmonary vessels. Therefore, spiral strips of equine pulmonary vein were prepared in vitro and the effects of histamine (H), 5-hydroxytryptamine (5HT), bradykinin (BK), carbachol (Carb), and phenylephrine (phen) were studied. The order of contra...
An investigation of the action and haemolytic effect of glyceryl guaiacolate in the horse. Glyceryl guaiacolate (GGE) was found to be a useful and safe casting agent when given by rapid intravenous infusion. It was administered to premedicated horses under controlled conditions at various concentrations from 10 to 20 per cent GGE solution. The onset and degree of relaxation was dependent only on the speed of infusion. For casting adult horses 350 to 450 ml of 15 per cent solution must be given within 30 to 60 seconds. A slight transient hypoxaemia occurred which seemed to be related to the animal being in lateral recumbency rather than the depressive action of GGE on respiratory fun...
The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse. The effect of morphine, Tinct. opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and Tinct. opii, and hastened by atropine. The liquid marker was slowed by Tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the faecal sodium excretion. This drug also decreased faecal water and weight; it appeared worthy of clinical trial in diarrhoea. Tinct. opii decreased by morp...
Heart rate during a defined exercise test in horses with heart and lung diseases. During a gradually increasing exercise test heart rates were determined in healthy animals and in 2 groups of sick horse. These included 31 animals with a chronic pulmonary disorder and 5 with chronic heart disease. The alteration in heart rate was correlated with the clinical signs exhibited. In the horses with lung disease there was a close correlation between the stage of the diseases and the heart rate during the exercise test. In 3 animals with heart valve disease there was no apparent difference in heart rate compared with healthy horses. On the other hand the exercising heart rate of ho...
