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Topic:Dendritic Cells
Dendritic cells are a type of immune cell present in horses that function as antigen-presenting cells, playing a significant role in initiating and regulating the adaptive immune response. These cells are capable of capturing, processing, and presenting antigens to T-cells, thus facilitating the activation of the immune system. In equine immunology, dendritic cells are studied for their involvement in immune surveillance and their potential impact on vaccination efficacy and disease resistance. This page compiles peer-reviewed research studies and scholarly articles that explore the biology, function, and potential clinical applications of dendritic cells in equine health.
Blue-cone horizontal cells in the retinae of horses and other equidae. The morphology of horizontal cells chiefly of the horse, but also of asses, mules, and a zebra, has been examined by Lucifer yellow injections into lightly fixed retinae and by immunocytochemistry. In common with other mammals, equids have a B-type horizontal cell, i.e., a cell with dendrites synapsing with cones and possessing a single axon synapsing with rods. Most mammalian retinae have a further type of horizontal cell, the A-type, also synapsing with cones but without an axon. The second type of horizontal cell in equids also has no axon; otherwise, it is most unusual. Compared with other...
An immunohistological study of MHC class II expression and T lymphocytes in the endometrium of the mare. The distribution of T lymphocytes and of cells bearing MHC Class II antigens in the endometrium of the mare was studied using an avidin-biotin-peroxidase staining method. The cells within the endometrium which expressed MHC Class II were macrophages, lymphocytes, monocytes, dendritic cells, epithelial cells and endothelial cells. MHC Class II expression increased significantly (P < 0.05) in the luminal epithelium and tended (P = 0.0573) to increase in the subepithelial layers during oestrus. Numbers of T lymphocytes did not differ between oestrus and dioestrus. MHC Class II expression and T...
Langerhans’ cells in equine cutaneous papillomas and normal skin. Langerhans' cells (LC) were investigated immunohistochemically and electron microscopically in normal equine epidermis and 133 equine cutaneous papillomas experimentally induced in five 2-year-old Thoroughbred horses. Class II major histocompatibility complex antigen-positive dendritic LC were found in the normal epidermis and ultrastructurally had the characteristic Birbeck's granules. In the developing phase of the papillomas, LC were significantly decreased in number and size, indicative of a hypofunctional state. In the regressing phase of the papillomas, LC were markedly increased in numb...
The effects of thermal stimulation on the ultrastructure of the fundus and duct of the equine sweat gland. Sweating in the horse had little effect on the ultrastructure of the glandular duct, other than on the lumen which enlarged. The fundus secretory cells, which in the resting gland were packed with vesicles, gradually lost them as sweating progressed until, after 4 hours of activity, few remained. Sweat appeared to be largely the product of secretion (a) by fluid transport, probably involving a region of complex cellular interdigitations adjacent to the basement membrane and (b) by exocytosis of vesicles, although a secondary mechanism of vesicle loss by micro-apocrine secretion may occur. Howe...
