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Topic:Disease Diagnosis
Disease diagnosis in horses involves the identification and characterization of illnesses through various diagnostic methods and tools. This process is essential for effective veterinary care and management of equine health. Techniques used in diagnosing diseases in horses include clinical examinations, laboratory tests, imaging modalities such as ultrasonography and radiography, and molecular diagnostics. Blood tests are frequently utilized to assess parameters such as complete blood count and biochemical profiles, which can indicate underlying health issues. Additionally, advancements in genetic testing and biomarker identification have enhanced the ability to detect specific diseases early. This page aggregates peer-reviewed research studies and scholarly articles that explore diagnostic methodologies, their applications, and their impact on equine health management.
Nonstrangulated colonic displacement in horses. Nonstrangulated colonic displacement was diagnosed by exploratory celiotomy in 32 horses with acute abdominal pain. Clinical signs progressed slowly and included evidence of mild to moderate abdominal pain, good cardiovascular status, reduced intestinal sounds, and normal peritoneal fluid, and resembled those of colonic impaction. In most horses, rectal palpation supported a diagnosis of colonic obstruction but not a diagnosis of colonic impaction.
Gastrointestinal complications associated with the use of atropine in horses. Atropine sulfate was given at 2 dosages (0.044 mg/kg, 0.176 mg/kg) to clinically normal ponies in order to evaluate the drug's effect on the gastrointestinal tract. Intestinal motility, as assessed by ausculation of borborygmus, was stopped 30 minutes after injection, but it gradually returned to normal within 12 hours. Signs of abdominal pain developed in 3 of 10 ponies. In 3 clinical cases of gastrointestinal disorder, prior atropine treatment was confusing to the diagnostician and resulted in delayed surgical treatment in 1 case. It was concluded that atropine should not be used for allevia...
[Contribution to the parasitic fauna of the GDR (German Democratic Republic). 7. Occurrence of Gasterophilus larvae (Diptera: Gasterophilidae) in horses]. Observations were carried out from May 1977 to May 1980 on occurrence, fauna, and seasonal dynamics of Gasterophilus spp. in 2,539 horses for butchering from all districts of the German Democratic Republic and also in 79 horses after control against gasterophilosis. 99.98% of the 13,742 second and third instar larvae of horses for butchering were Gasterophilus intestinalis, only 0.02% Gasterophilus nasalis. Out of 7,765 larvae passed after control measures Gasterophilus intestinalis dominated with more than 96%. Only in four districts of the German Democratic Republic Gasterophilus nasalis was...
Equine esophageal pressure profile. Esophageal motility was studied in 5 healthy adult horses, using a 4 side-hole catheter assembly continuously perfused with distilled water. Resting pressure and maximal pressures generated during swallowing were measured over the whole length of the esophagus (mean +/- S means = 132.7 +/- 2.31 cm). Four functionally distinct regions of the esophagus were demonstrated: cranial esophageal sphincter, caudal esophageal sphincter, and "fast" and "slow" regions in the body of the esophagus. The resting pressure of the cranial and caudal esophageal sphincters were 171.1 +/- 20.45 (x +/- S means) and...
Critical tests in equids with fenbendazole alone or combined with piperazine: particular reference to activity on benzimidazole-resistant small strongyles. Seven critical tests in equids were conducted with single doses of fenbendazole (5 mg kg-1) alone (Panacur--American Hoechst, Somerville, NJ); (2 tests with paste and 1 with suspension formulation) or in combination with piperazine (American Hoechst); (40 mg base kg-1); (4 tests with paste formulation). The main purpose of the tests was evaluation of activity against benzimidazole-resistant small strongyles (Cyathostomum catinatum, Cyathostomum coronatum, Cylicocyclus nassatus, Cylicostephanus goldi, and Cylicostephanus longibursatus). Natural infections of 2 populations of benzimidazole-resis...
The activity of closantel as an equine antiparasitic agent. Eighteen pony foals were experimentally infected with 500 third stage larvae of Strongylus vulgaris at 2 weeks, and at 2, 4, 6 and 8 months after birth. For the duration of the study, all foals were kept in the same pasture with their mothers to allow natural infection with other parasites by exposure to a contaminated environment. Twelve of the foals were utilized in groups of 3 and treated orally five times at two month intervals starting at one month of age with closantel at doses of 5, 10, 20 or 40 mg kg-1. Ten months after birth the foals were necropsied to determine the parasitic burdens...
Pathologic changes in 3-methylindole-induced equine bronchiolitis. The pathologic features of bronchiolitis were studied in horses and ponies from 30 minutes to 27 days after an oral dose of 3-methylindole (3MI). From 30 minutes to 3 hours, lesions were limited to nonciliated bronchiolar epithelial (Clara) cells, which lost apical caps and cytoplasmic granules and had dilated smooth endoplasmic reticulum (SER). At 12 hours, necrotic Clara cells were exfoliated; degeneration and necrosis were evident, in bronchiolar ciliated cells. Rare epithelial cells with hyperplastic SER appeared on the denuded basal lamina at 24 hours. Inflammatory cells, epithelia, fibro...
Equine complement activation as a mechanism for equine neutrophil migration in Onchocerca cervicalis infections. Extracts of Onchocerca cervicalis, an equine parasite, were incubated with radiolabeled equine neutrophils and neutrophil migration was assessed for factors derived from the parasite itself or for host-derived factors after incubation of these same parasite extracts with equine serum. No stimulus for cell migration was observed in saline extracts of adult worms, uterine microfilariae, or skin microfilariae at any dosage tested. However, after incubation of saline extracts with fresh normal equine sera a marked stimulus for neutrophil migration was observed. Ablation of this biologic activity w...
Marker characteristics of Venezuelan encephalitis virus strains isolated before and after epidemics and equine epizootics in Middle America. Ninety-four strains of Venezuelan encephalitis (VE) virus isolated from sentinel hamsters exposed in the Middle American countries of Mexico, Guatemala, Belize, and Honduras were examined for the presence of virions with marker characteristics of strains that cause large epidemics and equine epizootics. Thirty-four strains came from before and 60 strains came from after the Middle American epidemics and equine epizootics of 1966 and 1969-1972. Twenty-three virion clones that resembled epizootic strains by hydroxylapatite chromatography and Vero monkey kidney cell plaque size determinations wer...
Pathogenic bacteria and fungi associated with extraocular disease in the horse. In 123 cases of external ocular disease in the horse, pathogenic microorganisms isolated with greatest frequency were Streptococcus sp (43.9%), Staphylococcus sp (24.2%), and Pseudomonas sp (13.8%). Fungi were isolated in 4.8% of the cases. In vitro testing showed that most of the Streptococcus sp isolants were sensitive to ampicillin, cephalothin, and carbenicillin. Most of the Staphylococcus sp isolants were sensitive to gentamicin, cephalothin, and bacitracin. Most of the Pseudomonas sp isolants were sensitive to polymyxin B and gentamicin.
Fine structure of Babesia equi Laveran, 1901 within lymphocytes and erythrocytes of horses: an in vivo and in vitro study. The development of Babesia equi (Piroplasmia) in the vertebrate host was studied by electron microscopy. The tick-borne sporozoites initiated an exoerythrocytic schizogony in lymphocytes in vivo and in vitro. In lymphocyte cultures the schizonts of B. equi lay as fissured bodies directly within the host cell forming numerous cytomeres. These cytomeres were bordered by a single membrane and contained polymorphous nuclei. Merozoite differentiation was initiated at several places by protrusions appearing at the periphery of the cytomeres. The cytoplasm of the schizont merged progressively into th...
Further study of the chemical structure of the equine erythrocyte hematoside containing O-acetyl ester. The chemical structure of an equine hematoside, which contained an ester group and comprised 72% of the total erythrocyte gangliosides, was determined by means of nondestructive and destructive procedures. A 400-MHz nuclear magnetic resonance spectrum of the ganglioside in perdeuterodimethyl sulfoxide demonstrated three protons due to a methyl group of an acetyl moiety, as well as amide and anomeric protons which were compatible with those of the ordinary hematoside. The spin decoupling difference spectroscopy of the ganglioside revealed the presence of the following structures. [formula: see ...
Investigations into the biology of three ‘phycomycotic’ agents pathogenic for horses in Australia. Although 'phycomycosis' is a common disease of horses in northern Australia little is known about the causative fungi. In this paper the laboratory methods for diagnosis are described. These revealed 38 cases caused by Pythium sp. (Hyphomyces destruens), 6 cases caused by Basidiobolus haptosporus and 2 caused by Conidiobolus coronatus. Laboratory studies on the chemotatic behaviour of zoospores of Pythium sp. showed that they were strongly attracted to both animal hairs and plant tissue. Because of this behaviour a simple baiting method using human hair was used to trap the fungus from water s...
[A pony with “false” colic]. Report on the case of a pony with colic submitted a to the department of internal medicine. However, the animal was found to be affected with dilatation of the oesophagus which had given rise to acute pleurisy resulting from rupture of the wall of the oesophagus. The diagnosis was established after death.
Effects of common radioiodination procedures on the binding of glycoproteins to immobilized lectins. Representative glycoproteins including fetuin, protein A, ovalbumin, alpha 1 acid glycoprotein, and the major glycoprotein of equine infectious anemia virus were labelled with 125I by the chloramine-T or Bolton-Hunter procedure and their binding to immobilized Con A or lentil lectin compared to untreated samples of each glycoprotein. Glycoprotein modification was no greater than one substituted residue per protein molecule. Yet the radioiodinated glycoproteins typically displayed only 0-50% of the lectin binding observed with untreated samples. These results indicate that lectin glycoprotein b...
Diagnostic value of intestinal alkaline phosphatase in horse serum. Antiserum directed against equine intestinal Alkaline Phosphatase (ALP) was produced in rabbits and used to develop a sensitive and quantitative assay for the detection of intestinal ALP in equine serum. This assay was then used to measure the half-life of intravenously injected intestinal ALP and to determine if the intestinal ALP was present in normal horse sera, sera from horses presented for lesions not involving the gastrointestinal tract and sera from horses presented with lesions involving the gastrointestinal tract. The results suggest that intestinal ALP is not likely to appear in equ...
Relapsing idiopathic thrombocytopenia in a horse. TEIROMBOCYTOPENIA can be caused by failure of production or increased destruction of platelets, resulting in a bleeding diathesis, characterised by mucosal petechiac and haemorrhage into various organs. In humans, some drugs (cg, phenylbutazone and chloramphenicol) cause idiosyncratic marrow suppression and subsequent thrombocytopenia. Bone marrow suppression is also well documented in humans and small animals receiving cytotoxic drugs (Calabresi 1979; MacEwen 1980). Decreased megakaryocytic proliferation is rarely recognised in large animals. The most prevalent causes of thrombocytopenia are ...
