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Topic:Disease

The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Identification of a pegivirus (GB virus-like virus) that infects horses.
Journal of virology    April 17, 2013   Volume 87, Issue 12 7185-7190 doi: 10.1128/JVI.00324-13
Kapoor A, Simmonds P, Cullen JM, Scheel TK, Medina JL, Giannitti F, Nishiuchi E, Brock KV, Burbelo PD, Rice CM, Lipkin WI.The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.
Equine grass sickness: what’s new?
The Veterinary record    April 16, 2013   Volume 172, Issue 15 393-394 doi: 10.1136/vr.f2191
Schwarz B.No abstract available
Comparison of cytological and histological examinations in different locations of the equine uterus-an in vitro study.
Theriogenology    April 16, 2013   Volume 79, Issue 9 1262-1268 doi: 10.1016/j.theriogenology.2013.02.007
Overbeck W, Jäger K, Schoon HA, Witte TS.Endometritis constitutes a major problem in managing broodmares. The histological occurrence of polymorphonuclear neutrophils (PMNs) in the stratum compactum of the endometrium is accepted as the reference standard to diagnose endometritis in mares. The objective of this study was to determine the distribution of PMNs within different sampling locations of the uterus by cytological examinations and to compare it with PMN numbers in endometrial biopsies of the corresponding location. Cytological and endometrial samples were obtained from 37 uteri within 2 ± 1 hours after slaughter through smal...
Leptospirosis in horses.
Veterinary microbiology    April 16, 2013   Volume 167, Issue 1-2 61-66 doi: 10.1016/j.vetmic.2013.04.012
Verma A, Stevenson B, Adler B.Leptospirosis in horses has been considered a relatively uncommon infection. However, recent data suggest that the infection is widespread, with the incidence and infecting serovars varying considerably in different geographical regions. The majority of infections remain asymptomatic. Clinical signs in equine leptospirosis resemble those seen in other animal species. However, leptospirosis as a cause of acute respiratory distress is becoming more frequently recognised. A particular feature of equine leptospirosis is post infection recurrent uveitis (moon blindness or periodic ophthalmia), whic...
Development of a focus-reduction neutralizing test for detecting equine herpesvirus type-1-neutralizing antibodies.
The Journal of veterinary medical science    April 16, 2013   Volume 75, Issue 9 1209-1212 doi: 10.1292/jvms.13-0043
Bannai H, Nemoto M, Tsujimura K, Yamanaka T, Kondo T, Matsumura T.Virus-neutralizing (VN) testing is essential for evaluating virus-specific immunity in equine herpesvirus type-1 (EHV-1) infection. We developed a focus-reduction neutralization test (FRNT) for EHV-1 using 96-well plates for faster large-scale testing with sufficient sensitivity. We used an overlay medium containing Avicel (FMC Biopolymer), a microcrystalline cellulose with lower viscosity than the methylcellulose. The foci were visualized by immuno-staining with anti-EHV-1 gp14 monoclonal antibody. The FRNT successfully detected seroconversion in horses experimentally infected with EHV-1 (n =...
Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis.
Reproduction (Cambridge, England)    April 13, 2013   Volume 145, Issue 3 289-296 doi: 10.1530/rep-12-0452
Woodward EM, Christoffersen M, Campos J, Betancourt A, Horohov D, Scoggin KE, Squires EL, Troedsson MH.Transient endometritis after breeding is necessary for clearance of bacteria and spermatozoa; however, in a subpopulation of mares, the inflammation fails to resolve in a timely fashion. The objective of this study was to describe the uterine inflammatory response in mares susceptible or resistant to persistent breeding-induced endometritis (PBIE) during the first 24 h after induction of uterine inflammation.Twelve mares were classified as susceptible (nZ6) or resistant (nZ6) to PBIE. Mares were inseminated over five estrous cycles and endometrial biopsies were collected at one time point per ...
Influence of seroreactivity to leptospira and reproductive failures in recipient mares of equine embryo transfer programmes.
Reproduction in domestic animals = Zuchthygiene    April 13, 2013   Volume 48, Issue 4 e55-e57 doi: 10.1111/rda.12166
Pinna A, Martins G, Souza G, Lilenbaum W.The aim of this study was to demonstrate that seroreactivity against Leptospira is significantly associated to the reproductive efficiency of recipient mares of an embryo transfer (ET) programme. A serosurvey was conducted from August 2007 to March 2009 in five herds from Rio de Janeiro, Brazil, with high rates of reproductive failure, as early embryonic death (>12%), abortion (>12%) and perinatal death. Detailed information about the losses was obtained from practitioner. A total of 338 recipient mares were tested by microscopic agglutination test, and 226 (66.9%) were seroreactive, mainly ag...
Seek and ye shall find: cardiac arrhythmias in the horse.
Equine veterinary journal    April 10, 2013   Volume 45, Issue 3 270-272 doi: 10.1111/evj.12054
Physick-Sheard PW.No abstract available
Reply to Andy Durham.
Equine veterinary journal    April 10, 2013   Volume 45, Issue 3 388-389 doi: 10.1111/evj.12073
Suthers J, Proudman C, Pinchbeck G, Archer D.No abstract available
Replication and immunogenicity of swine, equine, and avian h3 subtype influenza viruses in mice and ferrets.
Journal of virology    April 10, 2013   Volume 87, Issue 12 6901-6910 doi: 10.1128/JVI.03520-12
Baz M, Paskel M, Matsuoka Y, Zengel J, Cheng X, Jin H, Subbarao K.Since it is difficult to predict which influenza virus subtype will cause an influenza pandemic, it is important to prepare influenza virus vaccines against different subtypes and evaluate the safety and immunogenicity of candidate vaccines in preclinical and clinical studies prior to a pandemic. In addition to infecting humans, H3 influenza viruses commonly infect pigs, horses, and avian species. We selected 11 swine, equine, and avian H3 influenza viruses and evaluated their kinetics of replication and ability to induce a broadly cross-reactive antibody response in mice and ferrets. The swin...
Genetics of anti-EHV antibody responses in a horse population.
Research in veterinary science    April 10, 2013   Volume 95, Issue 1 137-142 doi: 10.1016/j.rvsc.2013.03.011
Rusek J, Klumplerova M, Molinkova D, Sedlinska M, Dusek L, Muzik J, Putnova L, Vrtkova I, Celer V, Horin P.Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to diffe...
Getting a feel for equine colic.
The Veterinary record    April 9, 2013   Volume 172, Issue 14 354 doi: 10.1136/vr.f2119
No abstract available
Epidemiology of intoxication of domestic animals by plants in Europe.
Veterinary journal (London, England : 1997)    April 6, 2013   Volume 197, Issue 2 163-168 doi: 10.1016/j.tvjl.2013.03.007
Cortinovis C, Caloni F.This review focuses on some of the most important poisonous plants in Europe and provides an overview of the poisoning episodes that have occurred in European countries. Poisoning of livestock and companion animals by plants is a relatively common occurrence. In Europe livestock and horses are commonly poisoned by Datura stramonium (Jimson weed), Senecio spp. (ragworts and groundsels), Quercus spp. (oak), Taxus baccata (European yew), Nerium oleander (oleander), Pteridium aquilinum (bracken fern), Robinia pseudoacacia (black locust) and Rhododendron spp. (rhododendrons and azaleas). Poisoning ...
Dynamic ventrorostral displacement of the dorsal laryngeal mucosa in horses.
The Veterinary record    April 4, 2013   Volume 172, Issue 19 501 doi: 10.1136/vr.101319
Pollock PJ, Kelly PG, Reardon RJ, Kelly GM.The objectives of this report were to describe the occurrence and features of dynamic ventrorostral displacement of the dorsal laryngeal mucosa (VRDDLM) in a group of Thoroughbred horses presented for investigation of poor performance and/or abnormal respiratory noise. Records from 600, dynamic, endoscopic examinations of the upper respiratory tract of horses were reviewed. Horses with VRDDLM were identified as those in which the dorsal laryngeal mucosa progressively obscured the interarytenoid notch and dorsoaxial portion of the corniculate processes of the arytenoid cartilages during high-sp...
Development of osteochondrosis in Lusitano foals: a radiographic study.
The Canadian veterinary journal = La revue veterinaire canadienne    April 2, 2013   Volume 53, Issue 10 1079-1084 
Baccarin RY, Pereira MA, Roncati NV, Bergamaschi RR, Hagen SC.This study aimed to detect, by radiographic examination, the evolution of osteochondral lesions in the tarsocrural and femoropatellar joints of Lusitano foals. Within 1 month of age, 76.08% of foals had radiographic signs of osteochondrosis, but only 16.20% had lesions at 18 months. The radiographic signs resolved by 5 mo of age in most foals, but some cases that involved either joint, were not resolved until 12 mo of age. It is thought that the "age of no return" is 5 mo for the tarsocrural and 8 mo for the femoropatellar joint but this study demonstrated regression of osteochondral lesions i...
Prevalence and genetic diversity of piroplasm species in horses and ticks from Tunisia. Ros-García A, M'ghirbi Y, Hurtado A, Bouattour A.The genetic diversity and prevalence of Babesia and Theileria species in the equine population of Tunisia were studied using reverse line blot (RLB) hybridization on blood samples and unfed adult ticks collected from apparently healthy horses from three bioclimatic zones in Tunisia. Piroplasms were identified in 13 of 104 of the horse blood samples analyzed (12.5%) and five genotype groups were identified: Theileria equi group A (nine animals, 8.7%), group C (one animal, 1.0%) and group D (three animals, 2.9%), and Babesia caballi groups A and B (one animal each). All horses from the semi-arid...
Awareness raised at equine infectious diseases seminar.
The Veterinary record    March 26, 2013   Volume 172, Issue 12 306 doi: 10.1136/vr.f1276
No abstract available
Epidemiological survey of equine influenza in horses in India.
Revue scientifique et technique (International Office of Epizootics)    March 26, 2013   Volume 31, Issue 3 871-875 doi: 10.20506/rst.31.3.2164
Mavadiya SV, Raval SK, Mehta SA, Kanani AN, Vagh AA, Tank PH, Patel PR.A highly contagious virus infection in horses, influenza is the single most important equine respiratory disease in the world. This paper presents details of a one-year study (1 June 2008 to 31 May 2009) to determine the prevalence of equine influenza in the horses of Gujarat State in India. The prevalence of equine influenza A/equi-2 was 12.02%, but none of the samples were positive for equine influenza A/equi-1. The prevalence of equine influenza (A/equi-2) was 15.38%, 11.94%, 10.18%, and 9.09% in horses of the Kathiyawari breed, a non-descript breed, the Marwari breed and the Indian Thoroug...
Repertoire of Theileria equi immunodominant antigens bound by equine antibody.
Molecular and biochemical parasitology    March 26, 2013   Volume 188, Issue 2 109-115 doi: 10.1016/j.molbiopara.2013.03.002
Silva MG, Graça T, Suarez CE, Knowles DP.Theileriosis in horses and cattle is caused by tick-borne Apicomplexa parasites and results in death or life-long infection in their respective hosts. Transmission risk associated with persistent infection severely limits movement of horses and cattle resulting in economic losses. The recent reemergence of Theileria equi infection in U.S. horses demonstrates the continual threat Apicomplexa parasites represent to global animal health. A paucity of data concerning equine immune responses to T. equi, including antigens recognized by antibodies in clinically asymptomatic, persistently infected ho...
Bacteria isolated from field cases of equine amnionitis and fetal loss.
Australian veterinary journal    March 26, 2013   Volume 91, Issue 4 138-142 doi: 10.1111/avj.12022
Todhunter KH, Muscatello G, Blishen AJ, Chicken C, Perkins NR, Gilkerson JR, Begg AP.A series of unusual abortions occurred in Thoroughbred and Quarterhorse mares in the Hunter Valley region of New South Wales from mid-March to November 2004. The initial link between early cases was the microbiological culture of atypical environmental coryneforms from the stomach contents and/or lungs of fetuses aborted on different properties. Methods: The unique pathologic lesions were described with a case definition and the term 'equine amnionitis and fetal loss' (EAFL) was established. Results: The causal factor was the ingestion of the processionary caterpillar (Ochrogaster lunifer). Ba...
Metabolic and endocrine profiles in sick neonatal foals are related to survival.
Journal of veterinary internal medicine    March 25, 2013   Volume 27, Issue 3 567-575 doi: 10.1111/jvim.12064
Armengou L, Jose-Cunilleras E, Ríos J, Cesarini C, Viu J, Monreal L.Sick neonatal foals suffer from a variety of endocrine and metabolic derangements that may be related to outcome. There are several hepatic and lipid metabolism blood markers that have never been assessed in neonatal foals. Objective: Assess panel of endocrine and metabolic variables in group of sick and healthy neonatal foals in order to describe their relationship with diagnosis and survival. Methods: All neonatal foals referred to Unitat Equina-Fundació Hospital Clínic Veterinari during 3 consecutive foaling seasons and a group of healthy foals. Methods: Observational prospective study. B...
What is your diagnosis? Vegetative valvular endocarditis of the mitral valve.
Journal of the American Veterinary Medical Association    March 23, 2013   Volume 242, Issue 7 921-923 doi: 10.2460/javma.242.7.921
Bowser JE, Woodington MK, Boggs JJ.No abstract available
Uterine bacterial isolates from mares and their resistance to antimicrobials: 8,296 cases (2003-2008).
Journal of the American Veterinary Medical Association    March 23, 2013   Volume 242, Issue 7 977-983 doi: 10.2460/javma.242.7.977
Davis HA, Stanton MB, Thungrat K, Boothe DM.To describe bacteria isolated from reproductive tracts of mares and to examine the extent and patterns of resistance to antimicrobials commonly used for treatment of endometritis. Methods: Retrospective case series. Methods: 8,296 uterine swab, lavage, or biopsy samples obtained between January 2003 and December 2008 from 7,665 horses in central Florida. Methods: Results of bacterial culture and antimicrobial susceptibility testing were obtained for uterine swab, lavage, and biopsy samples collected from mares undergoing a routine breeding examination or examined because of a reproductive diso...
[Equine Cushing’s disease; an update].
Tijdschrift voor diergeneeskunde    March 22, 2013   Volume 138, Issue 3 162-165 
Smiet E.Lately there has been a tendency to discuss Equine Cushing's disease and its related phenomena, due to the amount of recently acquired research data. The author has composed a brief overview of the present situation emphasizing relevance for practitioners.
[Stem cell therapy in horses].
Tijdschrift voor diergeneeskunde    March 22, 2013   Volume 138, Issue 3 183 
Brommer H, Smeenk LA, van Weeren PR.No abstract available
Antibody responses to natural rattlesnake envenomation and a rattlesnake toxoid vaccine in horses.
Clinical and vaccine immunology : CVI    March 20, 2013   Volume 20, Issue 5 732-737 doi: 10.1128/CVI.00004-13
Gilliam LL, Carmichael RC, Holbrook TC, Taylor JM, Ownby CL, McFarlane D, Payton ME.Antivenom antibody titers following administration of rattlesnake venom for antivenom production in horses are well documented; however, antivenom antibody titers following natural rattlesnake envenomation in horses are not. Antibody titers produced in response to the commercially available rattlesnake venom vaccine are also not published. Our study objectives were to measure antivenom antibody titers in rattlesnake-bitten horses and compare them to titers in horses vaccinated with the rattlesnake venom vaccine. Additionally, titers were compared in pregnant versus nonpregnant horses to assess...
Cloning and expression of candidate allergens from Culicoides obsoletus for diagnosis of insect bite hypersensitivity in horses.
Veterinary immunology and immunopathology    March 19, 2013   Volume 153, Issue 3-4 227-239 doi: 10.1016/j.vetimm.2013.03.005
van der Meide NM, Roders N, Sloet van Oldruitenborgh-Oosterbaan MM, Schaap PJ, van Oers MM, Leibold W, Savelkoul HF, Tijhaar E.Insect bite hypersensitivity (IBH) is an IgE-mediated (Type I) hypersensitivity reaction induced by allergens from biting midges of the Culicoides spp. The aim of the present study was to identify, clone and express recombinant allergens from C. obsoletus, the main species found feeding on horses in the Netherlands, by sequence homology searches on the C. obsoletus specific RNA database, with previously described allergens from C. nubeculosus and C. sonorensis. BLAST searches with these described allergens resulted in similarity hits with 7 genes coding for C. obsoletus allergens. These allerg...
Imaging diagnosis-aortic aneurysm and ureteral obstruction secondary to umbilical artery abscessation in a 5-week-old foal. Nogradi N, Magdesian KG, Whitcomb MB, Church M, Spriet M.A 5-week-old foal was evaluated for fever and hematuria of 3 days duration. Cystoscopy localized the blood to be originating from the left ureter. Abdominal ultrasonography revealed left hydronephrosis, hydroureter, and omphaloarteritis of the left umbilical artery with abscess formation that communicated with an arterial structure. Computed tomography (CT) revealed a large aortic aneurysm within the center of the abscess. An exploratory celiotomy was performed and the infection was nonresectable. The prognosis for life was grave; therefore the colt was euthanized. Necropsy findings confirmed ...
Prevalence and risk factors for Equine Infectious Anemia in Poconé municipality, northern Brazilian Pantanal.
Research in veterinary science    March 18, 2013   Volume 95, Issue 1 76-81 doi: 10.1016/j.rvsc.2013.02.011
Borges AM, Silva LG, Nogueira MF, Oliveira AC, Segri NJ, Ferreira F, Witter R, Aguiar DM.Serum samples collected from 547 equids in the Pantanal region of Brazil were evaluated for antibodies to Equine Infectious Anemia Virus (EIAV) by the agar gel immunodiffusion test. Risk factors associated with EIAV seropositivity were evaluated and spatial dependence investigated using a Spatial Lag Model. EIAV prevalence on farms in the Pantanal was 52.0% (13/25) with adjusted prevalence between equids of 31.5% (17.4-48.8% 95% CI). Intra-herd prevalence ranged from 5.0 to 77.0%. Statistical analysis demonstrated that farms and animals in regularly flooded areas had respectively 60 and 146 fo...
Foal immunodeficiency syndrome: carrier testing has markedly reduced disease incidence.
The Veterinary record    March 13, 2013   Volume 172, Issue 15 398 doi: 10.1136/vr.101451
Carter SD, Fox-Clipsham LY, Christley R, Swinburne J.No abstract available