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Topic:Disease
The study of diseases in horses encompasses a wide range of conditions affecting equine health, including infectious diseases, metabolic disorders, and genetic abnormalities. These diseases can impact various systems within the horse, such as respiratory, gastrointestinal, and musculoskeletal systems, and can lead to significant health challenges. Research in this area focuses on understanding the pathophysiology, diagnosis, prevention, and treatment of equine diseases. Common diseases studied include equine influenza, equine herpesvirus, and laminitis. This page provides access to peer-reviewed research studies and scholarly articles that explore the etiology, clinical presentation, and management strategies of diseases in horses, contributing to the advancement of equine veterinary medicine.
Copper deficiency in cattle, sheep and horses caused by excess molybdenum from fly ash: a case report. A case of copper deficiency or molybdenum toxicosis in cattle, sheep and horses after heavy pollution of a pasture with fly ash is described. If the pastures had not been grazed by cattle and sheep as well as the horses, it would have been difficult to identify the reason for the intoxication in the horses. It is argued that molybdenum intoxication, although seldom seen in non-ruminants, was the cause of the deaths of the horses. It is suggested that the bioavailability of molybdenum in fly ash is high and therefore can cause equine intoxication.
Amphotericin B treatment of Candida arthritis in two horses. Infectious arthritis caused by Candida spp was diagnosed in 2 horses. Source of infection was by direct inoculation in 1 horse and was presumed to be hematogenous in the other horse. On microbial culturing of synovial fluid and synovial membrane specimens, the organisms were isolated in both horses. In both horses, the joint infections resolved after i.v. administration of amphotericin B and joint drainage; however, 1 horse was eventually euthanatized because of signs of cervical pain and progressively worsening ataxia. Fungal organisms isolated on microbial culturing of joint specimens in hor...
[Incidence of Parascaris equorum in foals and their mares after strategic use of wide-spectrum anthelmintics for several years]. In this epidemiological survey 30 foals and their mares from seven breeding farms were investigated. Six farms used wide spectrum anthelmintics strategically at least for three years, on one farm no anthelmintic prophylaxis was practiced. Excretion of P.-equorum-eggs occurred in all breeding farms and in 80% of the foals, but in only one mare. In foals infection with roundworms was detected at the earliest 85 days post partum. Before first shedding of P.-equorum-eggs wide spectrum anthelmintics had been administered to two and to one foal(s) one and two times, respectively, to four animals thr...
Efficacy of moxidectin oral gel against Onchocerca cervicalis microfilariae. During a series of dose-titration experiments designed to evaluate the efficacy of moxidectin oral gel against equine gastrointestinal parasites, infection with Onchocerca cervicalis was diagnosed in 25 of 82 ponies prior to treatment. Microfilariae were identified in full-thickness skin biopsies taken from the ventral midline. Treatment with moxidectin in single doses of 300, 400, or 500 micrograms/kg of body weight was 100% effective in eliminating microfilariae from 20 skin biopsies taken 14 days posttreatment, whereas 5 microfilaria-positive ponies in 2 control groups remained positive fol...
Inflammation and increased numbers of bacteria in the lower respiratory tract of horses within 6 to 12 hours of confinement with the head elevated. Confinement of horses with their heads elevated for periods up to 24 hours was used to evaluate the extent and the effects of bacterial contamination of the equine lower respiratory tract. Significant (P < 0.05) increases in bacterial numbers (up to 10(9) colony forming units/mL in transtracheal aspirate derived samples) occurred within 6 or 12 hours in most horses. Pasteurella/Actinobacillus spp and Streptococcus spp were most commonly isolated. Lowering of the head for 30 minutes every 6 hours to facilitate postural drainage did not prevent multiplication of organisms to levels equivalent...
Plasmid profiles of Klebsiella pneumoniae isolated from horses. Plasmid profiles of Klebsiella pneumoniae isolated from horses were examined. Thirty-nine strains of K. pneumoniae capsular type 1 (K1) isolated from cervical swabs of mares suffering from metritis, and from semen of stallions showed similar plasmid profile patterns, and all strains possessed a 125 megadaltons (Md) plasmid. There was no difference in plasmid profiles between the heavily-encapsulated and the less heavily-encapsulated strains of K. pneumoniae K1. Non-capsulated variants derived from the strains of K1 showed the same plasmid profile pattern as the parent strains. Plasmid profiles...
Polyclonal antibody-based antigen-detection immunoassay for diagnosis of Trypanosoma evansi in buffaloes and horses. An enzyme-linked immunosorbent assay (ELISA) was employed for the detection of Trypanosoma evansi antigens in serum samples of field cases of buffaloes and horses in northern India. In 323 naturally infected/suspected buffaloes, circulating antigenaemia was detected in 180 (55.72%), whereas parasitaemia by wet blood smear examination was found in 62 (19.19%) only. The antigen-ELISA was positive in 47 of the 62 parasitologically proven cases and in 86 of the 116 cases with anti-trypanosome antibodies detected by ELISA. Of the 80 horses examined antigen-ELISA was positive in 45 (56.75%) sera. Th...
Localization of a protective epitope on a Venezuelan equine encephalomyelitis (VEE) virus peptide that protects mice from both epizootic and enzootic VEE virus challenge and is immunogenic in horses. In order to define more precisely the protective epitope encoded within the first 25 amino acids (aa) of the E2 glycoprotein of the Trinidad donkey strain of Venezuelan equine encephalomyelitis (VEE) virus, we examined the immunogenicity of smaller peptides within the first 19 aa. pep1-9 and pep3-10 elicited virus-reactive antibody, but failed to protect mice from virus challenge. Additionally, pep3-10 was identified by a competitive binding assay using overlapping peptide octamers as the putative binding site of the antipeptide monoclonal antibody (mAb) 1A2B-10. Since the E2 amino-terminal se...
Electrostatics of hemoglobins from measurements of the electric dichroism and computer simulations. Hemoglobins from normal human cells, from sickle cells, and from horse were investigated by electrooptical methods in their oxy and deoxy forms. The reduced linear dichroism measured as a function of the electric field strength demonstrates the existence of permanent dipole moments in the range of 250-400 Debye units. The reduced limiting dichroism is relatively small (< or = 0.1); it is negative for hemoglobin from sickle cells and positive for the hemoglobins from normal human cells and from horse. The dichroism decay time constants are in the range from about 55 to 90 ns. Calculations of th...
[American Quarter Horses and HYPP]. Hyperkalaemic periodic paralysis is a genetic disease that affects the American Quarter Horse population and is caused by a mutation. As a result of this mutation in a gene which codes for the sodium channel in muscle cells, severe muscle weakness can appear. Reliable DNA-tests can establish whether a horse is homozygous negative, heterozygous, or homozygous positive for this mutation. Therapy and prevention are discussed.
A pulmonary granular cell tumour with associated hypertrophic osteopathy in a horse. Abstract Extract A 15-year-old pony mare developed firm irregular bony swellings on all four legs. These were most severe around the carpal and fetlock joints of the forelegs, restricting both flexion and extension. Over about 6 months the horse had periodic bouts of coughing. She showed moderate weight loss and a depressed demeanour.
Seroanalysis of Tyzzer’s disease in horses: implications that multiple strains can infect Equidae. A monoclonal antibody based competitive inhibition assay was used to detect antibodies in horse sera to purified flagellar antigens from distinct Clostridium piliforme isolates. Sequential absorption of hyperimmune rat serum to C. piliforme isolate E (horse-origin isolate), a positive C. piliforme-immune horse serum, and other suspected immune horse sera with unrelated bacteria or C. piliforme isolates E or isolate R1 (rat-origin isolate) alone demonstrated the specificity of this assay for C. piliforme. This specificity was associated with the inhibition of monoclonal antibody binding to C. p...
Rhodococcal abortion and pneumonia in an equine fetus. No abstract available
Skin lesions in dogs, horses and calves caused by the stable fly Stomoxys calcitrans (L.) (Diptera: Muscidae). Specific skin lesions caused by Stomoxys calcitrans on the feeding sites of different species are described. Skin lesions appeared on dogs, horses and calves following bites of stable flies. Necrotic dermatitis was observed in 32 dogs of various breeds at the tip of the ears. Exudative dermatitis appeared on the legs of 45 adult horses and dermatitis was diagnosed in the "hair whirlpools" on the backs of 18 white calves.
Dermatophytes and other keratinophilic fungi causing ringworm of horses. From 60 horses showing skin lesions, 42% were positive for fungal infection. Horses less than 2-year old were more susceptible to this infection. Fourteen species belonging to nine genera of keratinophilic and cycloheximide-resistant fungi were recovered from collected specimens. Trichophyton was the dominant genus of which T. equinum was the most common. This species proved to be the main causative agent of ringworm in horses. In addition to dermatophytes, many species of the isolated fungi were keratinophilic. The presence of such fungi on hairs and skin of horses may create an opportunity f...
Immunisation of mares to control endometritis caused by Streptococcus zooepidemicus. Normal mares were immunised by the intramuscular and intrauterine administration of an antigen with adjuvant and they and unimmunised control mares were later challenged by the intrauterine instillation of pathogenic Streptococcus zooepidemicus; the response of all the mares was monitored clinically and bacteriologically for seven days. Significantly fewer S zooepidemicus were present in cervical swabs taken from the immunised mares than from the control mares (P < 0.01) and the degree of inflammation in the genital tract of the immunised mares was also significantly less (P < 0.001). Th...
Continuing prevalence of African horse sickness in Nigeria. Equine sera collected from 10 widely separated regions throughout Nigeria were tested for antibodies against African horse sickness viruses (AHSV) using a competitive enzyme-linked immunosorbent assay (ELISA). The animals sampled included imported, exotic horses, indigenous and locally cross-bred (local) horses and African donkeys. A high percentage of the sera (79.8%) were positive, confirming the continued prevalence of AHSV antibodies in Nigerian horses and donkeys.
