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Topic:Equine Diseases

Equine diseases encompass a wide range of health conditions that can affect horses, including infectious diseases, metabolic disorders, and genetic conditions. These diseases can impact the overall health, performance, and well-being of horses. Common equine diseases include equine influenza, equine herpesvirus, laminitis, and equine metabolic syndrome. Diagnosis and management of these diseases often require a combination of clinical evaluation, laboratory testing, and appropriate treatment strategies. This page gathers peer-reviewed research studies and scholarly articles that explore the etiology, pathophysiology, diagnosis, and treatment options for various equine diseases, providing valuable insights for veterinarians and researchers in the field.
Spatial distribution, risk factors and haemato-biochemical alterations associated with Theileria equi infected equids of Punjab (India) diagnosed by indirect ELISA and nested PCR.
Acta tropica    December 30, 2015   Volume 155 104-112 doi: 10.1016/j.actatropica.2015.12.020
Sumbria D, Singla LD, Kumar S, Sharma A, Dahiya RK, Setia R.Equine piroplasmosis is a febrile, tick-borne disease of equids predominately caused by obligatory intra-erythrocytic protozoa Theileria equi in the Indian sub-continent. A cross-sectional study was carried out on 464 equids (426 horses and 38 donkeys/mules) in Punjab, India to assess the level of exposure to equine piroplasmosis by 18S rRNA gene nested polymerase chain reaction (nPCR) and equine merozoite antigen-2 (EMA2) indirect-ELISA (enzyme linked immunosorbent assay), to investigate risk factors and haemato-biochemical alterations associated with the infection. The endemicity of the dise...
Congenital diaphragmatic hernia with concurrent aplasia of the pericardium in a foal.
BMC veterinary research    December 30, 2015   Volume 11 309 doi: 10.1186/s12917-015-0623-2
Tăbăran AF, Nagy AL, Cătoi C, Morar I, Tăbăran A, Mihaiu M, Bolfa P.In veterinary medicine congenital abnormalities of the diaphragm and pericardium are rare, idiopathic malformations, being reported mainly in dogs. This report documents an unusual case of developmental defects in a foal consisting of diaphragmatic hernia concurrent with pericardial aplasia. Methods: Following a normal delivery, a full term, female Friesian stillborn foal with the placenta was presented for necropsy. External morphological examination indicated a normally developed foal. At necropsy, a large oval defect (approximately 20 × 15 cm in size) was observed in the left-dorsal si...
Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells.
Veterinary journal (London, England : 1997)    December 29, 2015   Volume 210 85-88 doi: 10.1016/j.tvjl.2015.12.008
Claessen C, De Lange V, Huang T, Ma G, Osterrieder N, Favoreel H, Van de Walle GR.Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data ind...
Development and characterization of a synthetic infectious cDNA clone of the virulent Bucyrus strain of equine arteritis virus expressing mCherry (red fluorescent protein).
Archives of virology    December 28, 2015   Volume 161, Issue 4 821-832 doi: 10.1007/s00705-015-2633-6
Mondal SP, Cook RF, Chelvarajan RL, Henney PJ, Timoney PJ, Balasuriya UB.Strains of equine arteritis virus (EAV) differ in their virulence phenotypes, causing anywhere from subclinical infections to severe disease in horses. Here, we describe the in silico design and de novo synthesis of a full-length infectious cDNA clone of the horse-adapted virulent Bucyrus strain (VBS) of EAV encoding mCherry along with in vitro characterization of the progeny virions (EAV sVBSmCherry) in terms of host-cell tropism, replicative capacity and stability of the mCherry coding sequences following sequential passage in cell culture. The relative stability of the mCherry sequence duri...
Concentrations of progesterone, a metabolite of PGF2α, prolactin, and luteinizing hormone during development of idiopathic persistent corpus luteum in mares.
Domestic animal endocrinology    December 28, 2015   Volume 55 114-122 doi: 10.1016/j.domaniend.2015.12.004
Ginther OJ, Baldrighi JM, Castro T, Wolf CA, Santos VG.In experiment 1, daily blood samples were available from Days 0 to 20 (Day 0 = ovulation) in mares with an interovulatory interval (IOI, n = 5) and in mares that developed idiopathic persistent corpus luteum (PCL, n = 5). The PCL was confirmed by maintenance of progesterone (P4) concentration until end of the experiment (Day 20). Significant interactions of group and day revealed the novel findings that luteinizing hormone (LH) was lower (P < 0.05) in the PCL group than that in the IOI group on Days 0 to 4, and prolactin was lower (P < 0.05) on Days 1, 4, 6, and 7. In experiment 2, treat...
Heritabilities of health traits in Swiss Warmblood horses.
Equine veterinary journal    December 25, 2015   Volume 49, Issue 1 15-18 doi: 10.1111/evj.12537
Lauper M, Gerber V, Ramseyer A, Burger D, Lüth A, Koch C, Dolf G.There is a lack of evidence regarding genetic parameters of health traits in Swiss Warmblood horses. Objective: To estimate heritabilities of equine sarcoid disease, horn quality of hooves, prognathism and increased filling of talocrural joints as a possible indicator for osteochondrosis in Swiss Warmblood horses examined at the field tests for 3-year-olds between 2005 and 2013. Methods: Retrospective analysis of breed society database. Methods: Swiss Warmblood horses were examined clinically by 13 veterinarians at field tests in Switzerland between 2005 and 2013. The presence of sarcoids, hor...
Antimicrobial selection and dosing in the treatment of wounds in the United Kingdom.
Equine veterinary journal    December 25, 2015   Volume 48, Issue 6 676-680 doi: 10.1111/evj.12535
Ross SE, Duz M, Rendle DI.Antimicrobial stewardship within the veterinary profession is recognised by governing and professional bodies as being important; the attitudes and behaviour of veterinary surgeons merit investigation. Objective: To investigate levels of protected antimicrobial use and accuracy of antimicrobial dosing in a common clinical scenario in equine practice. Methods: Retrospective cohort study. Methods: Antimicrobial use was evaluated retrospectively in 113 cases subsequently referred to a single referral hospital for the treatment of limb wounds over a 20-month period. Antimicrobial classification (f...
A method for isolating and culturing placental cells from failed early equine pregnancies.
Placenta    December 24, 2015   Volume 38 107-111 doi: 10.1016/j.placenta.2015.12.014
Rose BV, Cabrera-Sharp V, Firth MJ, Barrelet FE, Bate S, Cameron IJ, Crabtree JR, Crowhurst J, McGladdery AJ, Neal H, Pynn J, Pynn OD, Smith C....Early pregnancy loss occurs in 6-10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases. Lack of viable conceptus material has inhibited investigations of many potential genetic and pathological causes. We present a method for isolating and culturing placental cells from failed early equine pregnancies. Trophoblast cells from 18/30 (60%) failed equine pregnancies of gestational ages 14-65 days were successfully cultured in three different media, with the greatest growth achieved for cells cultured in Amnio...
Equine disease events resulting from international horse movements: Systematic review and lessons learned.
Equine veterinary journal    December 23, 2015   Volume 48, Issue 5 641-653 doi: 10.1111/evj.12523
Dominguez M, Münstermann S, de Guindos I, Timoney P.An analysis of the factors leading to equine disease events was used to support the development of international recommendations for mitigating the risk of disease dissemination through sport horse movements (high health, high performance - 'HHP' horses). Objective: A review was undertaken to identify the factors resulting in equine disease events following international movement of horses to draw lessons in support of the development of international recommendations for the safe movements of a specific subpopulation of horses: the HHP sport horses. Methods: Systematic review carried out in ac...
The first reported case of equine Nocardioform placentitis in New Zealand.
New Zealand veterinary journal    December 21, 2015   Volume 64, Issue 3 198-199 doi: 10.1080/00480169.2015.1120166
Hanlon DW, McLachlan AD, Gibson I.No abstract available
The first reported Florida clade 1 virus in the Nordic countries, isolated from a Swedish outbreak of equine influenza in 2011.
Veterinary microbiology    December 21, 2015   Volume 184 1-6 doi: 10.1016/j.vetmic.2015.12.010
Back H, Berndtsson LT, Gröndahl G, Ståhl K, Pringle J, Zohari S.Equine Influenza Virus (EIV) is a major cause of respiratory disease in horses and the virus constantly undergoes antigenic drift. Here we characterize and describe the HA1 and the NA genes of H3N8 within samples obtained from outbreaks in Sweden during November-December 2011. Both clade 1 and clade 2 viruses of the Florida sublineage were identified. The index case of clade 2 was transported to Sweden from Spain through the Netherlands, whereas the clade 1 had its origin from a Swedish stud farm. The clade 1 virus was efficiently spread between training yards by unvaccinated young horses, but...
What Is Your Diagnosis? Osteochondrotic lesions.
Journal of the American Veterinary Medical Association    December 20, 2015   Volume 248, Issue 1 55-57 doi: 10.2460/javma.248.1.55
Wong DM, Gilmour L, Alcott C, Yaeger M, Wiechert S.No abstract available
Detection of hypoglycin A in the seeds of sycamore (Acer pseudoplatanus) and box elder (A. negundo) in New Zealand; the toxin associated with cases of equine atypical myopathy.
New Zealand veterinary journal    December 20, 2015   Volume 64, Issue 3 182-187 doi: 10.1080/00480169.2015.1123123
McKenzie RK, Hill FI, Habyarimana JA, Boemer F, Votion DM.During April and May 2014 four horses aged between 5 months and 9 years, located in the Canterbury, Marlborough and Southland regions, presented with a variety of clinical signs including recumbency, stiffness, lethargy, dehydration, depression, and myoglobinuria suggestive of acute muscle damage. Two horses were subjected to euthanasia and two recovered. In all cases seeds of sycamore maple (Acer pseudoplatanus) or box elder (A. negundo) were present in the area where the horse had been grazing. Unassigned: The samaras (seeds) of some Acer spp. may contain hypoglycin A, that has been associat...
Using natriuretic peptides to detect cardiac diseases in horses.
The Veterinary record    December 19, 2015   Volume 177, Issue 24 622-623 doi: 10.1136/vr.h6887
Leroux AA.No abstract available
Tissues from equine cadaver ligaments up to 72 hours of post-mortem: a promising reservoir of stem cells.
Stem cell research & therapy    December 18, 2015   Volume 6 253 doi: 10.1186/s13287-015-0250-7
Shikh Alsook MK, Gabriel A, Piret J, Waroux O, Tonus C, Connan D, Baise E, Antoine N.Mesenchymal stem cells (MSCs) harvested from cadaveric tissues represent a promising approach for regenerative medicine. To date, no study has investigated whether viable MSCs could survive in cadaveric tissues from tendon or ligament up to 72 hours of post-mortem. The purpose of the present work was to find out if viable MSCs could survive in cadaveric tissues from adult equine ligaments up to 72 hours of post-mortem, and to assess their ability (i) to remain in an undifferentiated state and (ii) to divide and proliferate in the absence of any specific stimulus. Methods: MSCs were isolated ...
Towards the elimination of excessive cobalt supplementation in racing horses: A pharmacological review.
Research in veterinary science    December 17, 2015   Volume 104 106-112 doi: 10.1016/j.rvsc.2015.12.007
Kinobe RT.Cobalt is an essential trace element for many vital physiological functions. Cobalt is also known to stabilise hypoxia-inducible transcription factors leading to increased expression of erythropoietin which activates production of red blood cells. This implies that cobalt can be used to enhance aerobic performance in racing horses. If this becomes a pervasive practice, the welfare of racing animals would be at risk because cobalt is associated with cardiovascular, haematological, thyroid gland and reproductive toxicity as observed in laboratory animals and humans. It is expected that similar e...
Methods for the cultivation of ciliated protozoa from the large intestine of horses.
FEMS microbiology letters    December 17, 2015   Volume 363, Issue 2 fnv233 doi: 10.1093/femsle/fnv233
Bełżecki G, Miltko R, Michałowski T, McEwan NR.This paper describes cultivation methods for ciliates from the digestive tract of horses. Members of three different genera were successfully grown in vitro for short periods of time. However, only cells belonging to the genus Blepharocorys, which resides in the horse's large intestine, were maintained for longer periods. This Blepharocorys culture was successfully grown in vitro after inoculation of freshly excreted horse faeces in culture medium containing a population of bacteria. The ciliates survived for over six months, and the density of their population varied between 1.7 × 10(3) and ...
Diagnosis and effects of urine contamination in cooled-extended stallion semen.
Theriogenology    December 17, 2015   Volume 85, Issue 7 1219-1224 doi: 10.1016/j.theriogenology.2015.12.002
Ellerbrock R, Canisso I, Feijo L, Lima F, Shipley C, Kline K.Urospermia is known to affect semen quality in many mammals, including stallions. Determinations of semen pH and creatinine and urea concentrations have been used to diagnose urine contamination in raw stallion semen. Unfortunately, practitioners suspecting urine contamination in cooled-shipped samples have no proven means to confirm the presence of urine. Therefore, the objectives of this study were (1) to assess the effects of urine contamination on sperm motility of extended fresh and cooled-stored stallion semen, (2) to evaluate the usefulness of semen color, odor, pH, and creatinine and u...
Characterisation of lubricin in synovial fluid from horses with osteoarthritis.
Equine veterinary journal    December 16, 2015   Volume 49, Issue 1 116-123 doi: 10.1111/evj.12521
Svala E, Jin C, Rüetschi U, Ekman S, Lindahl A, Karlsson NG, Skiöldebrand E.The glycoprotein lubricin contributes to the boundary lubrication of the articular cartilage surface. The early events of osteoarthritis involve the superficial layer where lubricin is synthesised. Objective: To characterise the glycosylation profile of lubricin in synovial fluid from horses with osteoarthritis and study secretion and degradation of lubricin in an in vitro inflammation cartilage model. Methods: In vitro study. Methods: Synovial fluid samples collected from horses with joints with normal articular cartilage and structural osteoarthritic lesions; with and without osteochondral f...
Multiple specificities of immunoglobulin M in equine fetuses infected with Leptospira interrogans indicate a competent immune response.
Equine veterinary journal    December 16, 2015   Volume 48, Issue 6 704-709 doi: 10.1111/evj.12527
Velineni S, Timoney JF, Artiushin SC, Donahue JM, Steinman M.Foals of mares infected with Leptospira interrogans serovar Pomona type kennewicki (Lk) may be aborted/stillborn or delivered as healthy foals. Is fetal survival explained in part by the immune response of the fetus to Leptospira antigens? Objective: To describe an outbreak of Leptospira abortion in which infected mares delivered dead/sick or normal foals and determine specificities of antibody in a collection of 54 fetuses from similar outbreaks. Methods: Outbreak investigation in combination with a case-control study of a larger set of samples from aborted fetuses. Methods: Serology and poly...
Science in brief: Highlights from the applied physiology, muscle and genetics abstracts at the International Conference on Equine Exercise Physiology.
Equine veterinary journal    December 15, 2015   Volume 48, Issue 1 9-12 doi: 10.1111/evj.12484
Verdegaal EJ, Franklin SH.No abstract available
Science in brief: Report on the Havemeyer Foundation workshop on subchondral bone problems in the equine athlete.
Equine veterinary journal    December 15, 2015   Volume 48, Issue 1 6-8 doi: 10.1111/evj.12518
Smith MR, Kawcak CE, McIlwraith CW.No abstract available
Peer review: What’s expected and who benefits?
Equine veterinary journal    December 15, 2015   Volume 48, Issue 1 5 doi: 10.1111/evj.12538
Marr CM, Southwood L, Barnett T.No abstract available
Letter to the Editor. Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy.
Equine veterinary journal    December 15, 2015   Volume 48, Issue 1 130 doi: 10.1111/evj.12489
Josephson E.No abstract available
Sialolithiasis in horses: A retrospective study of 25 cases (2002-2013).
The Canadian veterinary journal = La revue veterinaire canadienne    December 15, 2015   Volume 56, Issue 12 1239-1244 
Carlson N, Eastman T, Winfield L.This study evaluated outcomes of surgical treatment of equine sialolithiasis, highlighting cases involving the proximal parotid salivary duct. Sialoliths in the proximal parotid duct were difficult to identify radiographically and more frequently associated with draining tracts and sialadenitis compared with sialoliths in the distal parotid duct. Ultrasonography confirmed the diagnosis of sialolithiasis in all cases in which there was no radiographic evidence of a sialolith. All cases of proximal parotid duct sialolithiasis required transcutaneous removal. A longer duration of illness was obse...
Efficacy of a single-formula acupuncture treatment for horses with palmar heel pain.
The Canadian veterinary journal = La revue veterinaire canadienne    December 15, 2015   Volume 56, Issue 12 1257-1260 
Robinson KA, Manning ST.Acupuncture is used without strong scientific evidence to treat many diseases of the horse, including palmar heel pain. Research is needed to provide evidence for the application of these treatments. Within the confines of our study, acupuncture did not reliably modulate palmar heel pain in horses. Efficacité d’un traitement d’acupuncture à formule simple pour les chevaux souffrant de douleur du talon palmaire. L’acupuncture est utilisée, en l’absence de solides preuves scientifiques, pour traiter plusieurs affections des chevaux, y compris la douleur du talon palmaire. De la recher...
Historical cases of anthrax in Sweden 1916-1961.
Transboundary and emerging diseases    December 15, 2015   Volume 64, Issue 3 892-898 doi: 10.1111/tbed.12456
Elvander M, Persson B, Sternberg Lewerin S.As in most European countries, anthrax was common in Swedish livestock during the centuries leading up to the mid-twentieth century. After 1957, the disease was regarded as practically extinct. However, in the past 7 years, three outbreaks have caused public alarm because of the risk of environmental contamination. Properly buried carcasses should present little risk of spore contamination, and instructions were in place to ensure this since the 1890s. However, as has been demonstrated in recent outbreaks, carcasses were not always adequately buried and viable spores may remain in some sites....
Infundibula of equine maxillary cheek teeth: Part 2: Morphological variations and pathological changes.
Veterinary journal (London, England : 1997)    December 14, 2015   Volume 209 66-73 doi: 10.1016/j.tvjl.2015.11.023
Suske A, Pöschke A, Müller P, Wöber S, Staszyk C.Incomplete cemental filling of the infundibula of equine maxillary cheek teeth (CT) is a common feature. Depending on the extent of the defect, three stages of infundibular decay have been suggested. However, histomorphological criteria to identify non-pathological abnormalities and destructive changes have not been defined. Six hundred and eighty eight CT with no evidence of dental diseases and 55 diseased permanent, fully erupted maxillary CT were evaluated on a macroscopic level by assessing the occlusal surface and horizontal sections, including porphyrin assays to detect residual blood wi...
Intravenous administration of a polyionic solution containing 84 mEq/l of lactate resolves experimentally induced hyperchloraemic acidosis in horses.
Equine veterinary journal    December 10, 2015   Volume 49, Issue 1 87-93 doi: 10.1111/evj.12525
Romão FT, Pereira PF, Flaiban KK, Dearo AC, Fernandes TM, Lisbôa JA.Treatment of metabolic acidosis using sodium bicarbonate solutions is safe when blood gas analysis is available. The evidence that solutions containing metabolisable buffers can be used as an alternative for treatment of metabolic acidosis in horses is of practical interest. Objective: To investigate the safety and efficacy of a polyionic solution containing 84 mEq/l of lactate (L84) for the correction of induced hyperchloraemic metabolic acidosis. Methods: Non-randomised crossover design. Methods: Five healthy, adult, crossbred horses were used. A solution containing 100 mmol/l of HCl was inf...
In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy.
Journal of visualized experiments : JoVE    December 9, 2015   Issue 106 e52748 doi: 10.3791/52748
Dudhia J, Becerra P, Valdés MA, Neves F, Hartman NG, Smith RK.Recent advances in the application of bone marrow mesenchymal stem cells (BMMSC) for the treatment of tendon and ligament injuries in the horse suggest improved outcome measures in both experimental and clinical studies. Although the BMMSC are implanted into the tendon lesion in large numbers (usually 10 - 20 million cells), only a relatively small number survive (<10%) although these can persist for up to 5 months after implantation. This appears to be a common observation in other species where BMMSC have been implanted into other tissues and it is important to understand when this loss o...