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Topic:Equine Diseases
Equine diseases encompass a wide range of health conditions that can affect horses, including infectious diseases, metabolic disorders, and genetic conditions. These diseases can impact the overall health, performance, and well-being of horses. Common equine diseases include equine influenza, equine herpesvirus, laminitis, and equine metabolic syndrome. Diagnosis and management of these diseases often require a combination of clinical evaluation, laboratory testing, and appropriate treatment strategies. This page gathers peer-reviewed research studies and scholarly articles that explore the etiology, pathophysiology, diagnosis, and treatment options for various equine diseases, providing valuable insights for veterinarians and researchers in the field.
Transformation of cultured equine fibroblasts with a bovine papillomavirus. Fetal equine fibroblasts exposed to bovine papillomavirus became transformed by the criteria of morphological alterations and the acquisition of an increased life span, although they failed to grow in soft agar. Papillomavirus genome persisted in the transformed fibroblasts and was apparently not integrated with the cellular genome. These findings support the notion that bovine papillomaviruses are involved in the production of equine sarcoids.
Turbidimetric measurement of IgG(T) in the serum of healthy Thoroughbreds and ponies. The turbidimetric analysis of IgG(T) in the serum of horses is described. Reference values are provided for 'worm-free' ponies (2.6 +/- 0.7 g/litre), stabled Thoroughbreds two years old and over (4.1 +/- 1.3 g/litre), grazing Thoroughbred broodmares (7.1 +/- 2.4 g/litre) and regularly wormed adult and young ponies grazing pasture contaminated with intestinal parasite eggs and larvae.
Antifungal sensitivity testing for equine keratomycosis. We evaluated 31 fungal specimens obtained from equine corneas over a 10-year period, 1973 to 1983. More than half were received in late summer and early autumn, and the number tended to increase in frequency during the 1980s. These isolates included 13 different genera and 20 different species. The prevalent genus was Aspergillus (35%). On the basis of examinations for tube-dilution minimal inhibitory concentrations and minimal fungicidal concentrations of 16 fungal isolates, the imidazole antibiotics such as miconazole and ketoconazole consistently showed the lowest geometric mean titers for ...
Evaluation of the wick catheter as used to measure intracompartmental muscle pressure in equine muscle. The use of the wick catheter to measure intracompartmental muscle pressure in equine muscle was documented. The presence of muscle compartments involving the extensor carpi radialis muscle and the long head of the triceps brachii was demonstrated by anatomic dissection and radiographic technique. The wick catheter was capable of accurately measuring pressures within both of these compartments. Furthermore, the wick catheter was sensitive to pressure changes resulting from external compression of muscle compartments. Manipulation of systemic blood pressure and PaCO2 in 1 anesthetized horse did ...
Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Weak organic acids possessing anti-inflammatory, analgesic and antipyretic properties--commonly known as aspirin-like drugs--have been used in equine medicine for almost 100 years. These non-steroidal anti-inflammatory drugs (NSAIDs) may be classified chemically into two groups; the enolic acids such as phenylbutazone and carboxylic acids like flunixin, meclofenamate and naproxen. All NSAIDs have similar and possibly identical modes of action accounting for both their therapeutic and their toxic effects. They block some part of the cyclo-oxygenase enzyme pathway and thereby suppress the synthe...
Use of guaiacol glycerine ether in clinical anaesthesia in the horse. A total of 103 anaesthetic inductions were performed in horses for a variety of elective procedures. All cases were premedicated with acepromazine maleate (0.02 to 0.05 mg/kg body weight [bwt] intramuscularly [im]). In 50 cases (Group A) anaesthesia was induced by a single intravenous (iv) bolus of thiopentone sodium (11.1 mg/kg bwt or 1 g/90 kg bwt) followed immediately by a bolus of suxamethonium chloride (0.1 mg/kg bwt). In 53 cases (Group B) anaesthesia was induced using iv guaiacol glycerine ether (GGE) (approximately 50 mg/kg bwt) followed by a bolus of thiopentone at half the usual dose...
Variant specific opsonization of Trypanosoma evansi measured by luminol-dependent chemiluminescence. Using luminol-dependent chemiluminescence (LCL), the specificity of antibodies to variable antigen type (VAT)-populations of Trypanosoma evansi was studied in four infected ponies. Trypanosomes of each wave of parasitemia were isolated and multiplied in irradiated mice. Their opsonization by serum collected during the infection was investigated with LCL and results for isolated VAT-populations are shown in the paper. Antibodies specific to each VAT-population were first found three days after the maximum of a parasitemic wave. There was no cross reactivity between different VAT-populations. LC...
The use of an animal-baited net trap for collecting mosquitoes during western equine encephalitis investigations in Argentina. A large net trap was used to sample mosquito populations attracted to horses at three sites each in Santa Fe and Rio Negro Provinces, Argentina, during the austral summer of 1984. These provinces, as well as others in Argentina, were affected by a severe epizootic of western equine encephalitis (WEE) during 1982-83. Totals of 2,752 and 6,929 mosquitoes were collected in Santa Fe and Rio Negro Provinces during five and three trap nights, respectively. Culex mosquitoes of the subgenus Culex were predominant (45.8% of total) in the Santa Fe collections, although Aedes albifasciatus also was preva...
Natural cytotoxicity of human lymphocytes against equine target cells in vitro. Human lymphocytes displayed a frequent natural cytotoxicity (NK) in vitro against normal equine dermal fibroblasts (ED) and against equine tumour cells of a virus-containing cell line (Mc-1). Similarly, human normal sera contained antibodies that induced antibody-dependent cellular cytotoxicity (ADCC) by normal human lymphocytes against the same target cells. Both NK and ADCC varied for different donors. For individual donors, however, cytotoxicity against the two target cells was significantly correlated both in NK and ADCC. For ED there was also a significant correlation between ADCC and NK ...
Measurement of IgG in equine blood by immunoturbidimetry and latex agglutination. This paper describes the quantitative measurement of IgG concentrations in equine blood/serum by turbidimetric analysis and the qualitative assessment using latex agglutination. The concentration of IgG in foal serum measured by turbidimetry correlated well with the results obtained by radial immunodiffusion (r = 0.91) and the gamma-globulins estimated from the electrophoresis of serum on cellulose acetate (r = 0.92). The method, using antibody-coated latex beads, to detect foals with serum IgG concentrations of less than 4 g/litre (whole blood less than 2 g/litre) proved to be accurate in 96 ...
Inhibition of lipases by proteins. A kinetic study with dicaprin monolayers. We report further investigations on protein inhibition of pancreatic and microbial lipases carried out with the monolayer technique. When beta-lactoglobulin A, melittin, serum albumin, myoglobin, and a protein inhibiting lipase from soybean were preincubated with a dicaprin film at a surface pressure of 35 dynes/cm, no activity was detected with horse pancreatic or Rhizopus delemar lipases. By contrast, Rhizopus arrhizus and Geotrichum candidum lipase activities were not impaired under the same conditions. Experiments using mixed lipid-protein film transfer clearly show that the inhibition of ...
Inclusions in equine cytologic specimens. Inclusions and cellular changes were seen in cytologic specimens from 1 healthy horse, 6 horses hospitalized because of respiratory problems, and 1 horse hospitalized because of colic and hepatitis. Two bronchial aspirates contained detached ciliated cytoplasmic tufts and cytoplasmic inclusions characteristic of the specific degenerative process called ciliocytophthoria. These changes and inclusions resembled those seen in bronchial aspirates from human beings with parainfluenza virus infection. Four bronchial aspirates and 2 serous fluid specimens had nuclear inclusions resembling those seen ...
Complications from a testicular prosthesis in a stallion. A testicular prosthesis was removed from the scrotum of a 3-year-old Quarter Horse stallion. The prosthesis had been placed in the left side of the scrotum 10 months earlier, after an unsuccessful attempt to reposition the retained left testis. Because of a persistent draining fistula on the scrotum, first noted 5 months after placement of the prosthesis, surgery was performed to remove the prosthesis. At surgery, the left testis was found in a fibrous mass surrounding the prosthesis. The left testis had descended after placement of the prosthesis, and its involvement in the fibrous tissue sur...
Rate of rise of arterial carbon dioxide tension in the halothane-anesthetized horse. The rate of rise of arterial partial pressure of carbon dioxide (PaCO2) was determined in 49 apneic halothane-anesthetized horses following controlled ventilation. Drugs given for induction of anesthesia did not affect the rapid rate of rise of PaCO2 during the first minute after controlled ventilation, the PaCO2 at 1 minute after controlled ventilation, or the PaCO2 at which spontaneous ventilation began. Horses given xylazine-ketamine for induction of anesthesia had a significantly (P less than 0.05) faster rate of rise of PaCO2 after 1 minute following controlled ventilation than did horses...
Infectious disease incidence among horses in France, Ireland and the United Kingdom during 1984. An outbreak of equine viral arteritis in the American state of Kentucky led to a temporary ban being imposed by France, Ireland and the UK on the importation of horses from the USA during 1984. Sporadic cases of influenza caused by the type 2 strain of the virus were confirmed in France throughout the year and cases of strangles in thoroughbred mares and foals were reported from all three countries. No cases of contagious equine metritis were confirmed among the thoroughbred breeding population, although a number of outbreaks of the abortion form of rhinopneumonitis occurred. A small number of...
The value of spectrofluorometry for the diagnosis of contagious equine metritis. No abstract available
Assignment of foal paternity when a mare is bred to two stallions. Accuracy of assigning foal paternity to the second serving stallion for foals whose dams had been bred to two stallions within an interval of 1 to 45 days was investigated using breeding dates from 108 equine paternity cases solved by blood typing. One hundred two of the foals were sired by the second stallion but six foals (5.5%) were excluded as being by the second sires. Thus, breeding dates are not reliable as a sole source of information to assign equine paternity accurately.
Equine congenital defects. In a 13-year survey of equine congenital defects that resulted in death or required euthanasia in central Kentucky, necropsies were performed on 608 deformed fetuses or newborn foals. The following congenital anomalies were observed: contracted foal syndrome (33.2%), miscellaneous limb contraction (20%), multiple defects (5.3%), microphthalmia (4.6%), craniofacial malformations (4.3%), cleft palate (4.0%), heart defects (3.5%), umbilical defects (3.5%), and hydrocephalus (3.0%). Eleven less frequently occurring anomalies constituted the balance of the congenital defects in fetuses and newborn ...
Axial sesamoid injuries associated with lateral condylar fractures in horses. Axial sesamoid injuries were found in 4 of 18 horses with lateral condylar fractures of the metacarpus or metatarsus. The injuries appeared as axial sesamoid fractures or progressive demineralization of the axial border of one of the sesamoids. None of the horses with axial sesamoid injuries returned to performance soundness. Axial sesamoid injury appeared to be an indication of severe fetlock trauma due to condylar fracture. Such injuries appeared to indicate a poor prognosis for return to performance soundness.
Pharmacokinetics and bioavailability of cefazolin in horses. The pharmacokinetics and bioavailability of cefazolin given (IV, IM) to horses at the dosage of 11 mg/kg were investigated. The disposition of cefazolin given by IV route was characterized by a rapid disposition phase with a half-life of 5 to 10 minutes and a subsequent slower elimination phase with a half-life of 35 to 46 minutes. The total plasma clearance of cefazolin averaged 5.51 ml/min/kg and was due mainly to renal clearance (5.39 ml/min/kg) of unchanged drug. The volume of distribution at steady-state averaged 188 ml/kg. Plasma protein binding of cefazolin at a concentration of 10 micr...
