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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
What is your diagnosis? Osteochondritis dissecans (OCD).
Journal of the American Veterinary Medical Association    July 23, 1999   Volume 215, Issue 2 191-192 
Charlton A, Jann H, Henry G.No abstract available
Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Annals of the New York Academy of Sciences    July 23, 1999   Volume 878 594-597 doi: 10.1111/j.1749-6632.1999.tb07737.x
Billinghurst RC, O'Brien K, Poole AR, McIlwraith CW.No abstract available
MMP inhibition by chemically modified tetracycline-3 (CMT-3) in equine pulmonary epithelial lining fluid.
Annals of the New York Academy of Sciences    July 23, 1999   Volume 878 675-677 doi: 10.1111/j.1749-6632.1999.tb07759.x
Maisi P, Kiili M, Raulo SM, Pirilä E, Sorsa T.No abstract available
The erythrocyte cytoskeleton protein 4.2 is not demonstrable in several mammalian species.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas    July 21, 1999   Volume 32, Issue 6 683-687 doi: 10.1590/s0100-879x1999000600003
Guerra-Shinohara EM, Barretto OC.Erythrocyte membrane proteins from 44 representative mammals were studied. Protein 4.2 was not detected in guinea pigs (Cavia porcellus) (N = 14), Southern Brazilian swamp large rats (Myocastor coypus) (N = 2), cutias (Dasyprocta sp) (N = 4), and horses (Equus caballus) (N = 13). These animals also presented high ankyrin concentrations except for the horse which did not exhibit a sharp band, although minor components located between proteins 2 and 3 could account for the ankyrin family. The rodents studied did present band 6, which was not detectable in other common rodents such as white rats ...
Analysis of myosin heavy chains at the protein level in horse skeletal muscle.
Journal of muscle research and cell motility    July 21, 1999   Volume 20, Issue 2 211-221 doi: 10.1023/a:1005461214800
Rivero JL, Serrano AL, Barrey E, Valette JP, Jouglin M.Combined methodologies of enzyme-linked immunosorbent assay (ELISA), sodium dodecyl sulphate polyacrilamide gel electrophoresis (SDS-PAGE), immunoblotting, traditional myofibrillar ATPase (mATPase) histochemistry and immunocytochemistry of whole biopsied samples were used to study myosin heavy chain (MHC) isoforms in the equine gluteus medius muscle. The ELISA technique allowed the quantification of the three MHC isoforms known to be present in different horse muscles: slow (MHC-I) and two fast (termed MHC-IIA and MCH-IIX). The SDS-PAGE method resolved MHCs in three bands: MHC-I, MHC-IIX and M...
Near infrared spectroscopy in large animals: optical pathlength and influence of hair covering and epidermal pigmentation.
Veterinary journal (London, England : 1997)    July 20, 1999   Volume 158, Issue 1 48-52 doi: 10.1053/tvjl.1998.0306
Pringle J, Roberts C, Kohl M, Lekeux P.The effects of epidermal pigmentation and hair covering on the relative transparency of various animal tissues to near infrared (NIR) light were examined, and the pathlengths of NIR light through tissues at four wavelengths in the NIR range were subsequently determined. Black hair covering and black or dark-coloured hooves prevented NIR light from penetration sufficient for conduction of pathlength or NIR spectroscopy measurements. Non-pigmented hair covering of the head did not appear to be a barrier to successful NIR light transmission. Tissues sufficiently transparent to NIR light had the d...
Effects of fetuin on zona pellucida hardening and fertilizability of equine oocytes matured in vitro.
Biology of reproduction    July 20, 1999   Volume 61, Issue 2 533-540 doi: 10.1095/biolreprod61.2.533
Dell'Aquila ME, De Felici M, Massari S, Maritato F, Minoia P.In vitro fertilization (IVF) has had poor success in the horse, a situation related to low rates of sperm penetration through the zona pellucida (ZP). Zona pellucida hardening (ZPH) is seen in mouse and rat oocytes cultured in serum-free medium. The hardened ZP is refractory to sperm penetration. Fetuin, a component of fetal calf serum, inhibits ZPH and allows normal fertilization rates in oocytes cultured in the absence of serum. We evaluated whether fetuin is present in horse serum and follicular fluid (FF) and whether fetuin could inhibit ZPH in equine oocytes matured in vitro, thus increas...
A plasma membrane-associated hyaluronidase is localized to the posterior acrosomal region of stallion sperm and is associated with spermatozoal function.
Biology of reproduction    July 20, 1999   Volume 61, Issue 2 444-451 doi: 10.1095/biolreprod61.2.444
Meyers SA, Rosenberger AE.Sperm hyaluronidase has been implicated in sperm penetration of the extracellular matrix of the cumulus oophorus and may play a crucial role in gamete interaction and fertility in mammals. The objectives of this study were to characterize the enzyme activity of equine sperm hyaluronidase and to investigate its cellular distribution. Zymography of stallion sperm plasma membrane extracts was used to identify hyaluronidase activity in protein bands. Affinity-purified polyclonal IgG raised against equine sperm hyaluronidase was used to label fresh and capacitated stallion sperm, followed by indire...
Techniques for evaluation of right ventricular relaxation rate in horses and effects of inhalant anesthetics with and without intravenous administration of calcium gluconate.
American journal of veterinary research    July 17, 1999   Volume 60, Issue 7 872-879 
Grubb TL, Constable PD, Benson GJ, Foreman JH, Olson WO, Thurmon JC, Tranquilli WJ, Davis LE.To determine the most repeatable method for evaluating right ventricular relaxation rate in horses and to determine and compare effects of isoflurane or halothane with and without the added influence of intravenously administered calcium gluconate on right ventricular relaxation rates in horses. Methods: 6 Thoroughbred horses from 2 to 4 years old. Methods: 6 models (2 for monoexponential decay with zero asymptote, 3 for monoexponential decay with variable asymptote, and 1 for biexponential decay) for determining right ventricular relaxation rate were assessed in conscious and anesthetized hor...
Adrenergic, cholinergic, and nonadrenergic-noncholinergic intrinsic innervation of the jejunum in horses.
American journal of veterinary research    July 17, 1999   Volume 60, Issue 7 898-904 
Malone ED, Kannan MS, Brown DR, Turner TA, Trent AM.To determine the major neurotransmitters that regulate contractile activity in the jejunum of horses. Methods: Jejunal specimens from 65 horses without gastrointestinal tract lesions. Methods: Jejunal smooth muscle strips, oriented in the plane of the circular or longitudinal muscular layer, were suspended isometrically in muscle baths. Neurotransmitter release was induced by electrical field stimulation (EFS) delivered at 30 and 70 V intensities and at various frequencies on muscle strips maintained at low or high muscle tone. To detect residual nonadrenergic-noncholinergic neurotransmission,...
Pharmacokinetics and therapeutic efficacy of rimantadine in horses experimentally infected with influenza virus A2.
American journal of veterinary research    July 17, 1999   Volume 60, Issue 7 888-894 
Rees WA, Harkins JD, Lu M, Holland RE, Lehner AF, Tobin T, Chambers TM.To determine pharmacokinetics of single and multiple doses of rimantadine hydrochloride in horses and to evaluate prophylactic efficacy of rimantadine in influenza virus-infected horses. Methods: 5 clinically normal horses and 8 horses seronegative to influenza A. Methods: Horses were given rimantadine (7 mg/kg of body weight, i.v., once; 15 mg/kg, p.o., once; 30 mg/kg, p.o., once; and 30 mg/kg, p.o., q 12 h for 4 days) to determine disposition kinetics. Efficacy in induced infections was determined in horses seronegative to influenza virus A2. Rimantadine was administered (30 mg/kg, p.o., q 1...
In vitro allergen-induced degranulation of pulmonary mast cells from horses with recurrent airway obstruction (heaves).
American journal of veterinary research    July 17, 1999   Volume 60, Issue 7 841-847 
Hare JE, Viel L, Conlon PD, Marshall JS.To determine the capacity of pulmonary mast cells (PMC) to degranulate in response to various potential allergens and other secretagogues in horses with recurrent airway obstruction (heaves) and clinically normal horses before and after exposure to moldy hay. Methods: 5 horses with heaves and 5 clinically normal horses. Methods: Heaves was characterized as an increased clinical respiratory score and maximum change in transpulmonary pressure of > 20 cm H2O after exposure. Bronchoalveolar lavage was performed during each period. Washed and resuspended cells were exposed for 20 minutes at 37 C wi...
Myeloperoxidase activity of the large intestine in an equine model of acute colitis.
American journal of veterinary research    July 17, 1999   Volume 60, Issue 7 807-813 
McConnico RS, Weinstock D, Poston ME, Roberts MC.To determine whether quantification of myeloperoxidase (MPO) activity could be a useful laboratory technique to detect granulocyte infiltration in equine intestinal tissues. Methods: Intestinal tissue (inflamed or healthy) collected from 16 age- and sex-matched Shetland Ponies. Methods: Intestinal tissue MPO activity was determined, and histologic assessment of adjacent specimens from healthy and inflamed intestine was done. Results: Intestinal tissue MPO activity and histopathologic score increased with time after castor oil challenge and peaked at 16 hours in an equine diarrhea model in whic...
Galloping to the defence of other species. Burgener L.No abstract available
Equine arteritis virus derived from an infectious cDNA clone is attenuated and genetically stable in infected stallions.
Virology    July 16, 1999   Volume 260, Issue 1 201-208 doi: 10.1006/viro.1999.9817
Balasuriya UB, Snijder EJ, van Dinten LC, Heidner HW, Wilson WD, Hedges JF, Hullinger PJ, MacLachlan NJ.Virus derived from an infectious cDNA clone of equine arteritis virus (EAV030H) was intranasally inoculated into two stallions, neither of which subsequently developed clinical manifestations of equine viral arteritis (EVA). Virus was isolated from nasal swabs and mononuclear cells collected from both stallions
Malignant rhabdoid tumour in the orbit of a horse.
Journal of comparative pathology    July 16, 1999   Volume 121, Issue 2 197-201 doi: 10.1053/jcpa.1999.0311
Hong CB, Van Meter PW, Latimer CL.A malignant rhabdoid tumour was diagnosed in the orbit of a 2-year-old Thoroughbred filly. The neoplasm, which was very aggressive, was present in nearly every part of the ocular and periocular structures and had spread to the lymph nodes of the head and neck, the salivary glands and the subcutaneous tissues around the eye. The neoplasm was composed of polygonal cells with abundant eosinophilic cytoplasm. Many cells had a large, vesiculate, indented nucleus and contained a paranuclear globular inclusion. Ultrastructurally, the inclusions were seen to consist of whorls of intermediate filaments...
Diagnosis of larval cyathostominosis in horses in Belgium.
The Veterinary record    July 15, 1999   Volume 144, Issue 24 665-668 doi: 10.1136/vr.144.24.665
Smets K, Shaw DJ, Deprez P, Vercruysse J.Between October 1996 and May 1997, 94 horses which were suspected of being infected with strongyles were examined clinically, and samples of faeces were examined for strongyle eggs and cyathostome larvae (L4) and adults. Blood samples were monitored for total protein, albumin and beta-globulins. In 28 of the horses (30 per cent) cyathostome L4 and adults were detected in the faeces, and were significantly associated with the horses' condition, the occurrence of diarrhoea, with lower concentrations of total protein and albumin, and with higher percentages of beta-globulin. Thirty-four of the ho...
Pilot study to investigate the efficacy of a 1 per cent selenium sulphide shampoo in the treatment of equine chorioptic mange.
The Veterinary record    July 15, 1999   Volume 144, Issue 24 674-675 doi: 10.1136/vr.144.24.674
Curtis CF.No abstract available
Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene.
Vaccine    July 14, 1999   Volume 17, Issue 18 2245-2258 doi: 10.1016/s0264-410x(98)00496-4
Lunn DP, Soboll G, Schram BR, Quass J, McGregor MW, Drape RJ, Macklin MD, McCabe DE, Swain WF, Olsen CW.Equine influenza virus infection remains one of the most important infectious diseases of the horse, yet current vaccines offer only limited protection. The equine immune response to natural influenza virus infection results in long-term protective immunity, and is characterized by mucosal IgA and serum IgGa and IgGb antibody responses. DNA vaccination offers a radical alternative to conventional vaccines, with the potential to generate the same protective immune responses seen following viral infection. Antigen-specific antibody isotype responses in serum and mucosal secretions were studied i...
Serum cortisol concentrations in response to incremental doses of inhaled beclomethasone dipropionate.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 258-261 doi: 10.1111/j.2042-3306.1999.tb03183.x
Rush BR, Trevino IC, Matson CJ, Hakala JE.No abstract available
Ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon in horses.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 186-191 doi: 10.1111/j.2042-3306.1999.tb03170.x
Denoix JM, Busoni V.The ultrasonographic anatomy of the accessory ligament of the superficial digital flexor tendon (AL-SDFT) in the horse is presented. Comparison between anatomical sections of isolated limbs and ultrasound scans of the distal antebrachium in sound horses enabled the authors to establish the normal reference ultrasonographic images of this structure. The AL-SDFT inserts 7-14 cm above the antebrachiocarpal joint on the palmaromedial aspect of the radius. Ultrasonographically it appears as an uniformly echogenic structure located deep to the median artery. The knowledge of ultrasonographic anatomy...
Results of screw fixation combined with cortical drilling for treatment of dorsal cortical stress fractures of the third metacarpal bone in 56 Thoroughbred racehorses.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 252-257 
Dallap BL, Bramlage LR, Embertson RM.The purpose of this study was to evaluate screw fixation with cortical drilling as a surgical treatment for dorsal cortical stress fractures of MCIII in the Thoroughbred racehorse. Details of age, sex, limb affected, fracture assessment, and post operative recommendations were obtained from medical records and radiographs. Fracture healing was assessed radiographically at the time of screw removal. Performance evaluation was determined from race records obtained from The Jockey Club Information System, Lexington, Kentucky. Fifty-six Thoroughbred racehorses were treated surgically for stress fr...
The role of prostanoids and nitric oxide in endotoxin-induced hyporesponsiveness of equine digital blood vessels.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 212-218 doi: 10.1111/j.2042-3306.1999.tb03175.x
Bailey SR, Elliott J.Endotoxin has been implicated in the pathophysiology of acute laminitis. The aim of this study was to examine the direct effects of endotoxin on isolated equine digital blood vessels. Equine digital veins (EDV), incubated in Krebs-Henseleit solution containing lipopolysaccharide (LPS) (1 microg/ml) became hyporesponsive to 5-HT after 16 h. Cycloheximide and ibuprofen blocked this effect of LPS and increased the maximum response obtained to 5-HT when compared to control vessels. L-nitroarginine methyl ester (L-NAME) reversed the hyporesponsiveness caused by LPS. Vessels maintained in culture me...
Endoscopic examination of the tarsal sheath of the lateral digital flexor tendon in horses.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 219-227 doi: 10.1111/j.2042-3306.1999.tb03176.x
Cauvin ER, Tapprest J, Munroe GA, May SA, Schramme MC.This study was designed to develop a reliable technique for endoscopic examination of the tarsal sheath of the lateral digital flexor tendon of horses. The anatomy of the tendon sheath and associated structures was studied in detail in cadavers before determining portals for the insertion of an arthroscope into the sheath. Approaches into the sheath through the proximal pouch and through the flexor retinaculum, at the level of the sustentaculum tali, were performed and compared in cadavers. The proximal pouch portal permitted visualisation only of the proximal half of the sheath, while the app...
Assessment of bilateral infra-orbital nerve blockade and bilateral infra-orbital neurectomy in the investigation and treatment of idiopathic headshaking.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 262-264 doi: 10.1111/j.2042-3306.1999.tb03184.x
Mair TS.No abstract available
Distribution of substance P binding sites in equine airways.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 238-242 doi: 10.1111/j.2042-3306.1999.tb03179.x
Sonea IM, Bowker RM, Robinson NE.Autoradiography with [125I]-Bolton Hunter substance P ([I]-BHSP) was used to detect substance P binding sites in the equine lung. Specific [I]-BHSP binding sites were very dense over small bronchial vessels, tracheobronchial glands and airway epithelium in large and small airways. The density of [I]-BHSP binding sites over airway smooth muscle was much lower than in the preceding tissues. Competition with an excess of either a specific neurokinin 1 receptor agonist, or a specific neurokinin 2 receptor agonist indicated that most specific [I]-BHSP binding sites in the equine lung represent neur...
The science and art of angular limb deformity correction.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 182-183 doi: 10.1111/j.2042-3306.1999.tb03168.x
Bramlage LR.No abstract available
Prediction of first season stallion fertility of 3-year-old Dutch Warmbloods with prebreeding assessment of percentage of morphologically normal live sperm.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 248-251 doi: 10.1111/j.2042-3306.1999.tb03181.x
Parlevliet JM, Colenbrander B.In the selection procedure to acquire a breeding licence, 3-year-old Dutch Warmblood stallions have to undergo a breeding soundness test It is questioned whether this evaluation is predictive of the stallion's fertility results in the first breeding season. Therefore, semen parameters at the beginning of their first breeding season were evaluated and correlated to nonreturn at first cycle and foaling rate of mares bred by stallions (n = 13). The total number of mares inseminated with chilled semen from those stallions was 1055. Semen parameters were recorded on 2 ejaculates, collected 1 h apar...
A method for determination of equine hoof strain patterns using photoelasticity: an in vitro study.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 232-237 doi: 10.1111/j.2042-3306.1999.tb03178.x
Dejardin LM, Arnoczky SP, Cloud GL.During impact, equine hooves undergo viscoelastic deformations which may result in potentially harmful strains. Previous hoof strain studies using strain gauges have been inconclusive due to arbitrary gauge placement. Photoelastic stress analysis (PSA) is a full-field technique which visually displays strains over entire loaded surfaces. This in vitro study identifies normal hoof strain patterns using PSA. Custom-made photoelastic plastic sheets were applied to the hoof surface. The hooves were axially loaded (225 kg) under level and varus/valgus conditions. Strain patterns were video-recorded...
Dystocia and caesarean sections: the importance of duration and good judgement.
Equine veterinary journal    July 13, 1999   Volume 31, Issue 3 179-180 doi: 10.1111/j.2042-3306.1999.tb03167.x
Embertson RM.No abstract available