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Topic:Equine Health

Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Fumonisins: their implications for human and animal health.
Natural toxins    January 1, 1995   Volume 3, Issue 4 193-221 doi: 10.1002/nt.2620030405
Marasas WF.Fusarium moniliforme is one of the predominant fungi associated with corn intended for human and animal consumption world-wide. Fumonisins, food-borne carcinogens that occur naturally in corn, were first isolated and chemically characterized in South Africa in 1988. The major metabolite, fumonisin B1 (FB1), was subsequently shown to cause leukoencephalomalacia (LEM) in horses, pulmonary edema syndrome (PES) in pigs, and liver cancer in rats. FB1 is also a cancer promoter and initiator in rat liver; hepatotoxic to horses, pigs, rats, and vervet monkeys; cytotoxic to mammalian cell cultures; and...
Diffuse alveolar damage in the horse.
Equine veterinary journal    January 1, 1995   Volume 27, Issue 1 76-78 doi: 10.1111/j.2042-3306.1995.tb03037.x
Kelly DF, Newsholme SJ, Baker JR, Ricketts SW.No abstract available
The effect of maternal age and parity on the racing performance of thoroughbred horses.
Equine veterinary journal    January 1, 1995   Volume 27, Issue 1 73-75 doi: 10.1111/j.2042-3306.1995.tb03036.x
Barron JK.No abstract available
Equine parentage testing and DNA technology–the route forward?
The British veterinary journal    January 1, 1995   Volume 151, Issue 1 1-3 doi: 10.1016/s0007-1935(05)80054-5
Knapp MR, Goelet P.No abstract available
Use of sodium monoiodoacetate to fuse the distal hock joints in horses.
Australian veterinary journal    January 1, 1995   Volume 72, Issue 1 25-28 doi: 10.1111/j.1751-0813.1995.tb03471.x
Sammut EB, Kannegieter NJ.Intra-articular injection of sodium monoiodoacetate (MIA) was investigated as an agent for chemical arthrodesis of the distal hock joints in the horse. Five horses diagnosed with either spavin (three horses), a small tarsal bone fracture or a failed surgical arthrodesis, had 150 mg of MIA injected into the tarsometatarsal (TMT) joint of the affected hock(s). Eight joints were treated in the five horses. Follow-up evaluation by clinical and radiological examination took place over 9 to 14 months. Two of the five horses were sound at the conclusion of the study and one horse, although lame after...
Spermatophagy in the stallion epididymis: a scanning and transmission electron microscopy study.
Acta anatomica    January 1, 1995   Volume 153, Issue 3 181-188 
López Alvarez ML, Bustos Obregón E.The occurrence of phagocytosis of spermatozoa in the epididymis is a controversial issue in male reproductive biology. In this paper we documented, by scanning and electron microscopy, the presence of spermatophages in the lumen of the proximal region of stallion epididymis. Sperm phagocytosis involving the principal cells that line the cauda epididymidis region was also observed. The possible meaning of this process in the removal of damaged, aged or surplus spermatozoa is discussed. These observations were made in samples obtained from random cases, during the course of research work carried...
[Differentiation between glanders and melioidosis].
Klinicheskaia laboratornaia diagnostika    January 1, 1995   Issue 1 47-48 
Dunaev GS, Lobanov AN, Larionov GM, Britanova AL.No abstract available
Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1.
Journal of virology    January 1, 1995   Volume 69, Issue 1 606-612 doi: 10.1128/JVI.69.1.606-612.1995
Allen G, Yeargan M, Costa LR, Cross R.An experimental system that permits sensitive and reproducible detection of equine herpesvirus 1 (EHV-1)-specific cytotoxic T-lymphocyte (CTL) activity in the horse was developed. Peripheral blood mononuclear cells (PBMC) collected from immune horses were restimulated in vitro by culture with live EHV-1. Cytotoxic activity against virus-infected, pokeweed mitogen-stimulated lymphoblast targets was assessed in a 4-h 51Cr release assay. The optimal conditions for in vitro stimulation of equine memory CTLs and for preparation of EHV-1-infected target cells expressing viral antigens were systemati...
Capacitation in vitro of stallion spermatozoa: comparison of progesterone-induced acrosome reactions in fertile and subfertile males.
Journal of andrology    January 1, 1995   Volume 16, Issue 1 47-54 
Meyers SA, Overstreet JW, Liu IK, Drobnis EZ.Mammalian sperm that have completed capacitation are capable of undergoing the acrosome reaction in response to a number of biological and chemical stimuli. In the present report, we have investigated the ability of progesterone to stimulate acrosome reactions of stallion sperm capacitated in vitro. Motile sperm were selected by a two-layer Percoll gradient centrifugation and were incubated in TALP medium modified by the 1:1 (v/v) addition of TEST-yolk medium for 5 hours at 39 degrees C, under 5% CO2 in humidified air. Sperm incubated in vitro in TALP-TEST medium had a higher percentage of acr...
Flow-cytometric studies of the phagocytic capacities of equine neutrophils.
Acta veterinaria Scandinavica    January 1, 1995   Volume 36, Issue 4 553-562 doi: 10.1186/BF03547669
Johannisson A, Gröndahl G, Demmers S, Jensen-Waern M.Methodological aspects of flow-cytometric evaluation of the phagocytic properties of equine neutrophils were elucidated. The kinetics of attachment and ingestion were studied, and the phagocytic process was more rapidly completed when serum-opsonized yeast cells were used than with use of IgG-opsonized yeast cells. Trypan blue was successfully used to quench fluorescence of non-ingested yeast cells. There were only minor differences in the kinetics of phagocytosis between quenched and unquenched samples, indicating that attachment is rapidly followed by ingestion. Trypan blue quenching caused ...
Response of ponies to adjuvanted EHV-1 whole virus vaccine and challenge with virus of the homologous strain.
The British veterinary journal    January 1, 1995   Volume 151, Issue 1 27-37 doi: 10.1016/s0007-1935(05)80061-2
Dolby CA, Hannant D, Mumford JA.Five yearling ponies were vaccinated with inactivated Equid herpesvirus type 1 (EHV-1) in Freund's complete adjuvant as a double emulsion and revaccinated 6 weeks later with EHV-1 in Freund's incomplete adjuvant. These ponies and three age-matched controls were challenged intra-nasally after a further 6 weeks with homologous live virus and monitored clinically, biologically and serologically. After challenge, clinical signs were mild in both groups. No cell-associated viraemias were detected in vaccinated ponies. Vaccination induced high levels of complement-fixing (CF) and virus-neutralizing ...
[Military veterinary service and the formation of veterinary medicine and farriery in the 19th century].
Schweizer Archiv fur Tierheilkunde    January 1, 1995   Volume 137, Issue 1 5-10 
Krähenmann A.No abstract available
Absorption and dosage of theophylline in the horse after single and repeated administration of a microencapsulated preparation.
Equine veterinary journal    January 1, 1995   Volume 27, Issue 1 13-18 doi: 10.1111/j.2042-3306.1995.tb03026.x
Roncada P, Tomasi L, Montesissa C, Grossi G, Stracciari GL, Anfossi P.The kinetics of 2 formulations of theophylline were studied in horses. In an initial cross-over study (Phase I) serum concentration-time curves were determined for granulated and microencapsulated theophylline after a single oral administration (5 mg/kg bwt). In Phase II microencapsulated theophylline was administered at 5 mg/kg bwt/12 h for 10 days at feeding time, as in normal clinical practice. Although no significant differences between the 2 preparations were found with respect to the main kinetic parameters, the microencapsulated form was more evenly and completely absorbed from the dige...
The identification of polymorphic microsatellite loci in the horse and their use in thoroughbred parentage testing.
The British veterinary journal    January 1, 1995   Volume 151, Issue 1 9-15 doi: 10.1016/s0007-1935(05)80057-0
Binns MM, Holmes NG, Holliman A, Scott AM.Six new horse microsatellite loci were identified by sequencing M13 clones containing horse genomic inserts which gave positive signals when probed with a CA/GT repeat probe. Oligonucleotide primer pairs were synthesized for these loci and for two previously described horse microsatellites, HTG4 and HTG6. Polymerase chain reaction assays were then carried out on a panel of 20 different unrelated Thoroughbred horse DNAs. DNAs from eight cases of double covering which could not be solved by conventional blood typing were also examined. Several of the loci amplified were found to be polymorphic a...
In vitro assessment of two species of nematophagous fungi (Arthrobotrys oligospora and Arthrobotrys flagrans) to control the development of infective cyathostome larvae from naturally infected horses.
Veterinary parasitology    January 1, 1995   Volume 56, Issue 1-3 181-187 doi: 10.1016/0304-4017(94)00663-w
Bird J, Herd RP.The ability of two species of nematophagous fungi, Arthrobotrys oligospora and Arthrobotrys flagrans (syn. Trichothecium flagrans, Duddingtonia flagrans), to control the development of infective larvae in feces from naturally infected horses was assessed in vitro. The horses were from a farm where it had been previously established that cyathostomes accounted for 100% of the strongyle egg output. The feces from these naturally infected horses were mixed with spores of each fungal species at four concentrations: 0 (control), 1, 10, and 100 spores per egg. Five replicates for each group were inc...
Genotyping of isolates of Taylorella equigenitalis from thoroughbred brood mares in Japan.
Veterinary research communications    January 1, 1995   Volume 19, Issue 4 265-271 doi: 10.1007/BF01839309
Miyazawa T, Matsuda M, Isayama Y, Samata T, Ishida Y, Ogawa S, Takei K, Honda M, Kamada M.Profiles of the genomic DNA of 104 strains of T. equigenitalis isolated from brood mares with contagious equine metritis in Hokkaido during the breeding seasons from 1980 to 1993, as well as those of five strains (SS28, EQ56, EQ59, EQ70 and HH139) previously isolated in Japan were examined after restriction digestion and crossed-field gel electrophoresis. These profiles were essentially identical to each other and the various isolates and strains appeared to have a common genotype, designated 'genotype J', with respect to two restriction enzymes, ApaI and NotI. These results suggest a common s...
Stress failure of pulmonary capillaries as a limiting factor for maximal exercise.
European journal of applied physiology and occupational physiology    January 1, 1995   Volume 70, Issue 2 99-108 doi: 10.1007/BF00361536
West JB, Mathieu-Costello O.The pulmonary blood-gas barrier has a basic physiological dilemma. On the one hand it needs to be extremely thin for efficient gas exchange. On the other hand it also needs to be immensely strong because the stresses on the pulmonary capillary wall become extremely high when the capillary pressure rises on exercise. Maximal hydrostatic pressures in human pulmonary capillaries during exercise are not accurately known but must exceed 30 mmHg. In some animals, for example thoroughbred horses, the capillary pressure rises to about 100 mmHg. These pressures cause stresses in the capillary wall of 5...
Endothelial lipopigment as an indicator of alpha-tocopherol deficiency in two equine neurodegenerative diseases.
Acta neuropathologica    January 1, 1995   Volume 90, Issue 3 266-272 doi: 10.1007/BF00296510
Cummings JF, de Lahunta A, Mohammed HO, Divers TJ, Summers BA, Valentine BA, Jackson CA.Two spontaneous neurodegenerative diseases of the horse, equine motor neuron disease (EMND) and equine degenerative myeloencephalopathy (EDM), have been associated with alpha-tocopherol deficiency, and both were characterized by prominent accumulations of endothelial lipopigment in the small vessels of the spinal cord. These endothelial pigment deposits appear to be reversible. In EMND horses pasture-supplemented for 9 months or more after the progression of weakness and wasting had arrested, there was very little endothelial lipopigment. The origin and the potential effects of these endotheli...
Mammalian sperm DNA susceptibility to in situ denaturation associated with the presence of DNA strand breaks as measured by the terminal deoxynucleotidyl transferase assay.
Journal of andrology    January 1, 1995   Volume 16, Issue 1 80-87 
Sailer BL, Jost LK, Evenson DP.Sperm from four mammalian species were analyzed by the sperm chromatin structure assay (SCSA) and the terminal deoxynucleotidyl transferase assay (TdTA) using flow cytometry. The SCSA quantitates the susceptibility of sperm nuclear DNA to in situ acid denaturation, while the TdTA quantitates the presence of endogenous DNA strand breaks in sperm nuclear chromatin. Correlations were seen between the percentage of sperm cells showing susceptibility to in situ acid denaturation and the percentage of cells showing the presence of DNA strand breaks for humans (r = 0.56, P = 0.004), rams (r = 0.84, P...
Isolation of a compound from Eupatorium adenophorum (Spreng.) [Ageratina adenophora (Spreng.)] causing hepatotoxicity in mice.
Natural toxins    January 1, 1995   Volume 3, Issue 5 350-354 doi: 10.1002/nt.2620030505
Oelrichs PB, Calanasan CA, MacLeod JK, Seawright AA, Ng JC.Regular ingestion of Eupatorium adenophorum [Ageratina adenophora (Spreng.)] or Crofton weed causes chronic pulmonary disease in horses mainly in Australia, New Zealand, and the Himalayas. The disease is characterized by pulmonary interstitial fibrosis, emphysema, alveolar epithelisation and reduced tolerance to exercise. Horses apparently are the only animals affected and there are numerous reports of farms losing all their horses. The disorder was produced experimentally in horse feeding trials, and it was shown that characteristic lesions occurred in the lungs. In studies with laboratory an...
The prevalence and epidemiology of Anoplocephala perfoliata infection in Norway.
Veterinary research communications    January 1, 1995   Volume 19, Issue 6 487-494 doi: 10.1007/BF01839337
Ihler CF, Rootwelt V, Heyeraas A, Dolvik NJ.The caecum and the adjacent 30 cm lengths of ileum and large colon of 201 horses from two different regions of Norway (Ostlandet and Trøndelag) were examined for the presence of Anoplocephala perfoliata. In all, 20% of the horses were infested with the cestode (27% in Ostlandet and 7% in Trøndelag). The mean number of worms in infected horses from the two regions was 18 and 6, respectively. Information was obtained on the age, sex, breed, type of pasture and anthelmintic treatment after the grazing season for 183 of the 20 horses. The degree of infestation with A. perfoliata was not influenc...
Activity of praziquantel (0.5 mg kg-1) against Anoplocephala perfoliata (Cestoda) in equids.
Veterinary parasitology    January 1, 1995   Volume 56, Issue 1-3 255-257 doi: 10.1016/0304-4017(94)00661-u
Lyons ET, Tolliver SC, Stamper S, Drudge JH, Granstrom DE, Collins SS.Praziquantel injectable formulation was administered at 0.5 mg k-1 per os to 24 equids naturally infected with 1-183 (average 40) Anoplocephala perfoliata. Drug activity was evaluated by a modified critical test method with necropsy 24 h after treatment. There was variable efficacy of 0-100% (aggregate average 85%); for 18 equids, 93-100%, for three equids, 70-85%, and for three equids, 0-20%.
Voltage-gated ion channelopathies: inherited disorders caused by abnormal sodium, chloride, and calcium regulation in skeletal muscle.
Annual review of medicine    January 1, 1995   Volume 46 431-441 doi: 10.1146/annurev.med.46.1.431
Hoffman EP.The pathological genetic defects in the inherited myotonias and periodic paralyses were recently elucidated using molecular genetic studies. These disorders are usually transmitted as a dominant trait from an affected parent to a child. The many clinical symptoms include cold-induced uncontrollable contraction of muscle, potassium-induced contraction and paralysis, myotonia with dramatic muscular hypertrophy, muscle stiffness, and insulin-induced paralysis (in males). Horses afflicted with the disorder can suddenly collapse, despite an impressive physique. In the past three years, these clinic...
Diagnosis of equine gammaherpesvirus 2 and 5 infections by polymerase chain reaction.
Archives of virology    January 1, 1995   Volume 140, Issue 6 1049-1060 doi: 10.1007/BF01315414
Reubel GH, Crabb BS, Studdert MJ.Nested polymerase chain reaction (PCR) assays were developed for the detection of equine herpesvirus 2 (EHV2) and equine herpesvirus 5 (EHV5) using the nucleotide sequences from the glycoprotein B (gB) gene of EHV2 and the thymidine kinase (TK) gene of EHV5. The simultaneous use of EHV2 specific and EHV5 specific primers in one nested amplification assay (multiplex PCR) enabled a rapid, specific and sensitive diagnosis for each virus. PCR was found to be 10(3) times more sensitive than virus isolation by cell culture for EHV2 and 10(6) for EHV5. In separate PCR assays, the routine detection li...
Crystalline composition of equine urinary sabulous deposits.
Scanning microscopy    January 1, 1995   Volume 9, Issue 4 1071-1079 
Diaz-Espineira M, Escolar E, Bellanato J, Medina JA.The composition and crystal morphology of 141 equine sabulous deposits were determined by infrared spectroscopy (IR), scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). The IR analysis revealed that all investigated deposits contained calcium carbonates (calcite, CaCO3, and/or vaterite, CaCO3) as major constituents; 42 samples were composed of calcite and vaterite, 33 of calcite, 18 of calcite/vaterite and calcium oxalate, and 17 of vaterite. The remaining specimens contained calcite/vaterite and other compounds (calcium phosphates, sulphate and/or oxalates and/or s...
A note on the concurrent isolation, from horses and ponies, of influenza A/EQ-1 and A/EQ-2 viruses from an epidemic of equine influenza in India.
Comparative immunology, microbiology and infectious diseases    January 1, 1995   Volume 18, Issue 1 73-74 doi: 10.1016/0147-9571(94)00015-m
Singh G.A/eq-1 and A/eq-2 influenza viruses were isolated simultaneously from an epidemic of equine influenza in north India. Evidently, both types of equine influenza viruses circulated in the equine population at the same time.
[Case report: polycythemia in a horse].
Schweizer Archiv fur Tierheilkunde    January 1, 1995   Volume 137, Issue 7 306-311 
Steiger R, Feige K.A 13 year old Thoroughbred gelding was presented with a history of a single episode of collapse during mild exercise. Clinical examination revealed a high packed cell volume (PCV) of 72%, a haemoglobin concentration of 24.9 g/l and 15.2 millions erythrocytes/microliters. Despite continuous intravenous infusion therapy with large volumes, the PCV never decreased to a physiological level. The animal showed a normal appetite and no signs of discomfort or syncope. Arterial blood gas values were in the normal range as well as the concentration of erythropoietin (measured by radioimmunoassay, RIA). ...
Fetal and maternal plasma lipids in chronically catheterized mares in late gestation: effects of different nutritional states.
Reproduction, fertility, and development    January 1, 1995   Volume 7, Issue 5 1275-1284 doi: 10.1071/rd9951275
Stammers JP, Hull D, Silver M, Fowden AL.The effects of different nutritional states on plasma lipid concentrations have been examined in pregnant mares and their fetuses. Maternal and fetal arterial catheters were inserted into 12 pony mares between 244-303 days' gestation (term 320-360 days) and observations made from 5 days following the insertion of catheters. After recovery from surgery maternal and fetal arterial samples were withdrawn from 7 mares with normal feeding patterns (Group IA), from four of these mares at the end of a 30 h fast and 3 h later following refeeding (Group IB) and six mares who failed to re-establish norm...
Stimulation of KCl co-transport in equine erythrocytes by hydrostatic pressure: effects of kinase/phosphatase inhibition.
Pflugers Archiv : European journal of physiology    January 1, 1995   Volume 429, Issue 3 446-448 doi: 10.1007/BF00374163
Gibson JS, Hall AC.The effects of hydrostatic pressure on the KCl co-transporter of equine erythrocytes were studied to determine factors involved in its regulation. Pressure (0.1-40MPa) increased Cl-dependent K+ transport; in the presence of the putative kinase inhibitor N-ethylmaleimide (NEM) which stimulates the transporter, or the phosphatase inhibitor calyculin A, pressure had no significant effect. The sequential application of NEM and calyculin A clamped the transporter at about 30% of maximal flux compared to NEM alone; pressure also had no further effect. These results suggest that pressure acts on the ...
Outbreak of larval cyathostomiasis among a group of yearling and two-year-old horses.
The Veterinary record    December 17, 1994   Volume 135, Issue 25 598-600 
Mair TS.Larval cyathostomiasis was diagnosed as the cause of an outbreak of illness in a group of five young horses. One had the typical clinical signs of larval cyathostomiasis--sudden onset diarrhoea, weight loss, ventral abdominal oedema and pyrexia, but the other four suddenly started to lose weight rapidly and had limb and ventral abdominal oedema and pyrexia, in the absence of diarrhoea. Large numbers of cyathostome larvae were found in the faeces. Four of the five horses recovered after being treated with anthelmintics and steroids.