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Topic:Equine Health
Equine health encompasses the study and management of diseases, disorders, and overall well-being of horses. It involves understanding various physiological systems, preventive care, and treatment strategies to maintain optimal health in equine populations. Common areas of focus include nutrition, infectious diseases, orthopedic conditions, and reproductive health. Research in equine health aims to advance knowledge on diagnostic methods, therapeutic interventions, and management practices that improve horse welfare and performance. This page collects peer-reviewed research studies and scholarly articles that explore the diverse aspects of equine health, offering insights into current findings and advancements in the field.
Actions of non-steroidal anti-inflammatory drugs on equine leucocyte movement in vitro. The direct effects of four non-steroidal anti-inflammatory drugs (NSAIDs) on equine polymorphonuclear (PMN) and mononuclear (MN) leucocyte movement were investigated using two in vitro assay systems. The Boyden chamber microfilter technique measures both chemokinetic and chemotactic locomotion, and the agarose microdroplet assay measures solely chemokinesis. Zymosan-activated plasma (ZAP) and the synthetic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) were used as standard chemoattractants for PMN and MN leucocytes, respectively. The actions of six concentrations of each NSAID, indome...
Thoroughbred blood serum inorganic phosphate concentrations in relation to feeding regime and racing performance. Horses receiving a pelleted or cubed dietary supplementation with roughage, have serum inorganic phosphate (SIP) concentrations consistently below an accepted mean of 1,032 mmol l-1 or 3, 1 mg dl-1. Further, it has been reported that the best eight, two-year-old Irish Thoroughbred track performers of 51 horses tested over a 10 month period, had significantly lower SIP concentrations than the worst eight track performers. In an endeavour to assess any nutritive effect on SIP concentrations and also to assess any effect of SIP concentrations on track performance, metabolic blood profiles from 30...
The induction of equine laminitis with an aqueous extract of the heartwood of black walnut (Juglans nigra). An aqueous extract of the heartwood of black walnut (Juglans nigra) was given via stomach tube to 10 horses. Eight developed Obel grade 3 or 4 laminitis within 12 hr. Limb edema and mild sedation were the only other clinical signs observed. One horse was euthanized due to severe signs. The other 7 recovered within 6 days. Gas chromatography/mass spectrometry of aqueous extracts of heartwood, bark and nuts of black walnut identified juglone in the bark and nuts, but not in the heartwood. It was concluded that the aqueous extract of heartwood is laminogenic to horses, but the active ingredient i...
[Testing of a deworming scheme for horses]. In 1983 and 1984 the effect of a deworming scheme, in which horses were treated at turn out and 4 and 8 weeks later, on the egg output, larval differentiation, weight gain, herbage infestation and in 1984, the percentages of some serum proteins were tested. In 1983 the experiment was done with 42 mares, 54 two year old male horses and 42 male yearlings, kept in groups with permanent or rotational grazing. In 1984 only 90 male yearlings were investigated. In 1983 albendazole and ivermectin were used, 1984 ivermectin. The results of the faecal examinations showed that after ivermectin treatment ...
Pythium destruens sp. nov., an agent of equine pythiosis. The equine phycomycotic agent known commonly as Hyphomyces destruens or occasionally as Pythium gracile, is described as a new species Pythium destruens. Separation is on the basis of morphological features, temperature growth profiles, esterase/lipase activity, and carbohydrate utilization ability. P. diclinum (synonymous with P. gracile sensu Middleton) showed minor differences in vesicle, oospore and oogonium size from P. destruens. P. destruens grew at 40 degrees C on corn meal agar and hydrolysed esters of lauric and oleic acids. These abilities were not displayed by P. diclinum, but this...
Transmural coronary vasodilator reserve and flow distribution during maximal exercise in normal and splenectomized ponies. 1. Transmural distribution of myocardial blood flow was studied using 15 micron diameter radionuclide-labelled microspheres in six normal ponies and nine splenectomized ponies at rest, and during maximal exercise performed without as well as with adenosine infusion (3 microM kg-1 min-1). The splenectomized ponies were also studied during submaximal exercise performed at 75% of the workload. 2. Maximal exertion in normal ponies increased heart rate (348%), mean arterial blood pressure (40.9%), rate-pressure product (563%), arterial O2 content (43.2%), and mean pulmonary artery pressure (247%). ...
Echocardiographic evaluation of equine aortic insufficiency. Echocardiographic evaluation of 23 horses with aortic insufficiency was performed, using M-mode (n = 23) and 2-dimensional real-time echocardiography (n = 14 of 23). Echocardiograms were evaluated for abnormalities of aortic and mitral valves and alterations in motion of these valves. Changes in left ventricular chamber size and function, as well as aortic root size, were evaluated. The presence of other cardiac disease was also evaluated. Horses with aortic insufficiency had significant increases (P less than 0.01) in mean values of left ventricular chamber size, aortic root diameter, and sho...
Mixed venous oxygen tension as an estimate of cardiac output in anesthetized horses. The relationship between mixed venous O2 tension and cardiac output was studied in six anesthetized horses breathing 100% O2. Cardiac output, O2 consumption, mean arterial pressure, heart rate, and arterial and venous blood gases were measured after administration of xylazine or dobutamine to horses in lateral, sternal, and dorsal recumbencies. After approximately 3 hours, Escherichia coli endotoxin was administered while horses were in dorsal recumbency, and all measurements were repeated. Relationships between cardiac index (CI) and PVO2, heart rate, mean arterial pressure, jugular PVO2, and...
Clinical pathologic alterations in horses during a water deprivation test. A 72-hour water deprivation test was performed in 12 horses to determine clinical pathologic changes. Reference values for electrolyte (X) clearance, expressed as a percentage of creatinine clearance (CLCR; %CLCRX), were also determined. A comparison was made between urine concentration measurement techniques. Results of %CLCRX determination in 12 horses before water deprivation were 0.034 +/- 0.095 %CLCRNa, 42.4 +/- 9.8 %CLCRK, 0.352 +/- 0.190 %CLCRCl, and 0.710 +/- 0.250 %CLCRP. During water deprivation, there was individual variation for electrolyte clearances, but Na excretion increased si...
Auditory brain stem response testing in anesthetized horses. Auditory brain stem response testing, using insert earphones, was performed in 10 healthy horses given general anesthesia. The procedure involved clicks of alternating polarity delivered at a rate of 25 clicks/s. Wave forms, including five peaks, were commonly identified. Latencies were measured in milliseconds for waves I through V for all intensities. Latencies of all waves decreased as stimulus intensity increased. For waves I through V, a least-squares regression line was determined for each horse, using all responses between 87-dB sound pressure level (SPL) and 136-dB SPL, inclusive. Slop...
The pathology of a case of biliary atresia in a foal. The pathological features of biliary atresia in a foal are described. A 4-week-old American Saddler foal was presented for autopsy following an illness characterised by clinical features indicative of hepatic failure. The significant macroscopical lesions occurred in the liver which was extremely enlarged, mottled in appearance and indurated. Bile stasis was evident. Lobular distinction was absent and on sectioning, large bile ducts were absent. A moderate ascites, hydrothorax and hydropericardium and a mild anasarca and intermuscular oedema accompanied the hepatic lesion. The diagnosis of bil...
Time-related responses of spontaneously breathing, laterally recumbent horses to prolonged anesthesia with halothane. Cardiovascular and respiratory functions were serially evaluated in ten healthy, fasting, spontaneously breathing, laterally recumbent adult horses during five hours of constant 1.06% alveolar halothane (equivalent to 1.2 times the minimum alveolar concentration for horses). Mean carotid arterial pressure was about 25% higher after one hour of constant-dose halothane than after 30 minutes of constant-dose (P less than 0.05), and remained increased throughout the study. Mean carotid arterial pressure peaked after 90 minutes, and was about 30% higher than at 30 minutes. Total peripheral vascular...
Echinococcus granulosus: occurrence of ecdysteroids in protoscoleces and hydatid cyst fluid. Both free ecdysteroids and hydrolysable polar conjugated ecdysteroids were detected in protoscoleces of Echinococcus granulosus from the equine host, and in hydatid cyst fluid from the same source. Comparisons were made of hydatid cyst fluid from E. granulosus infections of three intermediate host species: horses, sheep and humans. Ecdysone and 20-hydroxyecdysone were identified in both protoscoleces and hydatid cyst fluids by high-performance liquid chromatography monitoring fractions by radioimmunoassay, and by capillary gas chromatography/mass spectrometry (selected ion monitoring). The fre...
The pathogenesis of equine laryngeal hemiplegia–a review. Recent research on the muscular and nervous changes which occur in idiopathic equine laryngeal hemiplegia has indicated that many of the traditional concepts of the aetiology of this disease are erroneous. In light of the new knowledge gained, the various predispositions and possible causes of laryngeal hemiplegia are discussed, and it is suggested that the underlying mechanism of axonal damage in this neuropathy of horses may be related to abnormal energy metabolism in the axon.
The host preferences of Culiseta inornata in southwestern Manitoba. The capillary tube precipitin test was used to determine the host utilization patterns of Culiseta inornata in southwestern Manitoba. Ruminant blood was identified in 83.3% and equine blood in 15.8% of 1,036 positively reacting blood-meals. Human, swine and avian blood accounted for 0.9% of these blood-meals and mixed blood-meals accounted for 1.5% of the total. Culiseta inornata preferentially fed on large mammals, and selection between cattle and horses reflected the relative abundance of these two hosts rather than a specific preference for either one.
Skeletal muscle perfusion during prolonged 2.03% end-tidal isoflurane-O2 anesthesia in isocapnic ponies. Effects of 1.55 minimum alveolar concentration isoflurane O2 anesthesia (2.03% end-tidal isoflurane) on blood flow in the up-(nondependent) and down-(dependent) positioned skeletal muscles were studied at 60, 120, and 180 minutes in 6 healthy isocapnic ponies in right lateral recumbency on a nonpadded hardwood floor. Measurements were made, using 15-micron diameter radionuclide-labeled microspheres injected into the left ventricle, and comparisons were made with data obtained from ponies in the conscious state. Isoflurane administration caused a sharp reduction in cardiac output and systemic p...
Functional genes for cellobiose utilization in natural isolates of Escherichia coli. The genes for utilization of cellobiose are normally cryptic in both laboratory strains and natural isolates of Escherichia coli. A survey of natural isolates of E. coli reveals that functional genes for cellobiose utilization, while rare, are present. The fraction of E. coli that utilized cellobiose ranged from less than 0.01% in human fecal samples to 7% in fecal samples obtained from horses. Samples obtained from sheep, cows, dogs, and pigs contained 0.1 to 0.5% cellobiose-positive E. coli. Neither the previously identified cel genes nor the bgl genes from E. coli K-12 were expressed during...
The pathology of a case of biliary atresia in a foal. The pathological features of biliary atresia in a foal are described. A 4-week-old American Saddler foal was presented for autopsy following an illness characterised by clinical features indicative of hepatic failure. The significant macroscopical lesions occurred in the liver which was extremely enlarged, mottled in appearance and indurated. Bile stasis was evident. Lobular distinction was absent and on sectioning, large bile ducts were absent. A moderate ascites, hydrothorax and hydropericardium and a mild anasarca and intermuscular oedema accompanied the hepatic lesion. The diagnosis of bil...
Gonadotropin-releasing hormone treatment induces follicular growth and ovulation in seasonally anestrous mares. A study was conducted to evaluate the effectiveness of gonadotropin-releasing hormone (GnRH) pulse infusion to stimulate follicular development and induce ovulation in seasonally anestrous standardbred mares. Seventeen mares were selected for use in this experiment, on the basis of a previous normal reproductive history, and were housed under a photoperiod of 8L:16D beginning one week prior to the start of the experiment (second week in January). Mares were infused with 20 micrograms (n = 7) or 2 micrograms (n = 6) GnRH/h, or were subjected to photoperiod treatment only (controls, n = 4). Seru...
Biological and immunological properties of zebra pituitary gonadotropins: comparison with horse and donkey gonadotropins. Previous studies from this laboratory have described the properties of purified luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from horse and donkey anterior pituitary glands. The present study afforded the opportunity to further characterize these previously purified hormone preparations and to compare them with enriched gonadotropin fractions from zebra pituitary glands. Although a single LH and FSH fraction was usually obtained for each pool of pituitaries, two separate zebra LH and two donkey FSH preparations were generated. Purified hormone preparations from the horse wer...
