"Horses" is a broad topic that encompasses various aspects of equine biology, behavior, and management. This category includes studies on the anatomy, physiology, and genetics of horses, as well as their behavior, nutrition, and care. Research in this area may also cover the historical and cultural significance of horses, their roles in agriculture, sport, and therapy, and the challenges associated with their conservation and welfare. The page aggregates peer-reviewed research articles and scholarly studies that explore the multifaceted relationships between humans and horses, examining both scientific and socio-economic perspectives.
McCue PM, Wilson WD.Mastitis was diagnosed in 28 mares. Cytological evaluation of milk samples showed large numbers of neutrophils in 72 per cent and bacteria in 33 per cent. Aerobic bacteria were cultured from 71 per cent of samples. Streptococcus zooepidemicus was the most common isolate (37 per cent). Gram-negative species accounted for 42 per cent. Determination of the probability for antimicrobial susceptibility of bacterial isolates from mares with mastitis indicated that a trimethoprim-sulphonamide combination would be active against more than 75 per cent of isolates while penicillin would be active agains...
Friedman DS, Schoster JV, Pickett JP, Dubielzig RR, Czuprynski C, Knoll JS, Wolfgram LJ.The fungal organism Pseudallescheria boydii was isolated from the cornea of a Quarter Horse with ulcerative keratitis. Despite aggressive hourly medication through a subpalpebral lavage system, with drugs including miconazole and natamycin, the cornea developed a stromal abscess. Orbital exenteration was performed after 3 weeks. The fungal isolate was later determined to be resistant to all 8 antifungal drugs tested. Microscopic examination of the cornea revealed fungal hyphae throughout the corneal stroma and penetrating the Descemet membrane. Pseudallescheria boydii has not been implicated p...
Brusie RW, Sullins KE, Silverman DG, Rosenberger JL.Arteriovenous (ischaemic strangulating obstruction, ISO) and venous obstructions (haemorrhagic strangulating obstruction, HSO) were created for 70 min in the small intestine of eight anaesthetised horses, and ISO was created in four horses for 2 h and four horses for 3 h at the sternal and diaphragmatic flexures of the large colon. Five minutes following release of the occlusions, sodium fluorescein 20 per cent (0.5 mg/kg bodyweight intravenously) was administered. Serial quantitative measurements of serosal surface fluorescence of the injured segments and a control segment were made at 2, 10,...
Eustace RA, Caldwell MN.This paper describes the treatment of 10 horses suffering from acute laminitis using the heart bar shoe and a dorsal hoof wall resection technique. All cases had progressed to prolapse of the tip of the pedal bone covered by solar corium through the horny sole; in one case the exposed tip of the distal phalanx became visible. Nine cases of distal phalangeal rotation and one case of distal displacement of the distal phalanx (sinking) are described. Two animals were destroyed because of the degree of lameness, one remains slightly lame at the trot and the remaining seven have returned to their p...
Stick JA, Derksen FJ.Videoendoscopy of the larynx during treadmill exercise was used to determine the surgical treatment of upper airway obstruction in a Standardbred colt. Surgical correction of right-sided laryngeal hemiplegia, first by laryngoplasty, then subtotal arytenoidectomy, was ineffective. Videoendoscopy indicated, and upper airway flow mechanics confirmed, that the laryngeal opening was adequate at rest, but obstruction occurred during exercise. On the basis of the appearance of the larynx during high airflow rates on slow-motion playback of the videorecording, total arytenoidectomy was performed, whic...
Watson ED, Sertich PL.Embryos, endometrial biopsies, and uterine lavage fluid were collected from pregnant and non-pregnant mares 14 days after ovulation. Embryos were cultured for 20.5 h with and without endometrial tissue from pregnant mares, and endometrial tissue was cultured alone. Endometrial content of PGF tended to be higher (P = 0.06) in non-pregnant than in pregnant mares, but the amount of PGF released from tissue during culture was similar for pregnant and non-pregnant mares. Lavage fluid from non-pregnant mares also tended (P = 0.08) to contain higher concentrations of PGF. Coincubation of embryos with...
Tulamo RM, Bramlage LR, Gabel AA.Infectious arthritis was induced experimentally in one tarsocrural joint of six horses by intra-articular injection of 1 ml Staphylococcus aureus-saline suspension with the addition of 200 mg methylprednisolone acetate. The corresponding contralateral joint was injected with 1 ml of saline with the addition of 200 mg methylprednisolone acetate, and served as a control. The purpose of the experiment was to examine the effect of corticosteroids on the acute clinical signs of infectious arthritis, and the associated changes in synovial fluid, to separate the effects of a steroid injection from th...
Hildebrand SV, Hill T, Holland M.To determine whether cholinesterase inhibition by an organophosphate would influence atracurium's neuromuscular blockade, six horses were anesthetized and paralyzed with atracurium (total of five injections per horse) on experimental Day 1, then were given trichlorfon (64 mg/kg per os) 6 days later. On Day 7, horses were anesthetized and paralyzed in the same manner as on experimental Day 1. Blood was taken to measure serum cholinesterase activity prior to anesthesia on Days 1 and 7. No significant difference was noted in atracurium's neuromuscular blocking activity between the 2 experimental ...
Kirberger RM, Gottschalk RD.The clinical, radiological and anatomical changes in a yearling foal with kyphoscoliosis are described. The lesion was due to a primary malformation of the eleventh, twelfth, fourteenth and fifteenth thoracic vertebral bodies resulting in hemivertebrae. Secondary changes occurred in the laminae, pedicles, spinous and articular processes of the affected vertebrae and the adjacent vertebrae. The possible pathogenesis and differential diagnosis are discussed.
Gilbert RO.Luteolysis with subsequent shortening of diestrus has been reported to follow equine endometrial biopsy performed early in the luteal phase of the estrous cycle, but a comprehensive study of the effect of endometrial biopsy on cycle length at different times of the cycle has not been reported. In this study, endometrial biopsies were obtained from four different pony mares on each of Days 0, 4, 8, 12, 16 and 20 after ovulation as determined by serial palpation per rectum. Compared with control cycles in the same mares, the ovulatory interval was shortened in mares from which biopsies were obta...
Kobluk CN, Ducharme NG, Lumsden JH, Pascoe PJ, Livesey MA, Hurtig M, Horney FD, Arighi M.From May 1, 1983 to April 1, 1985, 142 operations were performed on horses with signs of acute abdominal pain (colic), using a ventral midline incision. Seventy-eight horses lived for at least 15 days after surgery or had acute dehiscence and were included in the study. Seventy horses had surgery once, and 8 horses had surgery 2 or more times. Six-month follow-up evaluation was obtained for 66 horses that had 1 surgery and for 6 horses that had multiple surgeries. Incisional complications included drainage (including infection), acute dehiscence, hernia, and suture sinus formation. The effects...
Turner AS, Tucker CM.A randomised double-blind clinical trial of 28 horses was undertaken to evaluate the efficacy of isoxsuprine hydrochloride at four different doses:- 0.0 mg/kg bodyweight (bwt) (placebo), 0.6 mg/kg bwt, 1.2 mg/kg bwt and 1.8 mg/kg bwt for treatment of navicular disease. The results showed that horses treated with isoxsuprine hydrochloride (N = 22) responded significantly with respect to clinical assessment score (P less than 0.01) when compared with the control group (N = 6). Furthermore, there were no dose-related differences in the responses of the horses treated with increasing levels of iso...
Freeman DE, Ferrante PL, Kronfeld DS, Chalupa W.A D-xylose absorption test was conducted on 4 healthy mares deprived of food for 12, 36, 72, and 96 hours before the test, with a 13- to 15-day adjustment period between each test. Maximal plasma concentrations after 72 and 96 hours of food deprivation were approximately 36% lower than those obtained after the 12- and 36-hour periods (P = 0.0001). Absorption curves were flatter and the decrease in plasma concentration was slower after the 72- and 96-hour periods of food deprivation. The rate of D-xylose absorption (P = 0.0108) and the initial rate of urinary excretion (P = 0.0117) were slower ...
Bertone AL, VanSoest PJ, Johnson D, Ralston SL, Stashak TS.Fecal excretion of a particulate marker, ytterbium (Yb), was evaluated in 9 horses before surgery and 3 weeks, 3 months, and 6 months (4 trials) after sham-operation (group 1; n = 3) or extensive large colon resection (group 2; n = 6). Fecal excretion curves of total Yb excretion, loge Yb excretion, % Yb excretion, loge % Yb excretion, and cumulative % Yb excretion were evaluated, and kinetic analysis was performed on the loge Yb excretion curves to detect mixing pools and to calculate the fractional rate of particulate passage, turnover rate, and pool size. Calculations were performed to dete...
Adams JG, Trim CM.Five horses were anaesthetised twice with thiopentone sodium, guaifenesin and halothane. The second anaesthesia was 16 days after the first and two days following oral administration of trichlorfon. Heart rate, carotid arterial, pulmonary arterial and right atrial pressures, cardiac output and blood temperature were measured every 15 minutes for 120 minutes. Heart rate, carotid arterial pressure and cardiac output were similar on both occasions. Pulmonary arterial and right atrial pressures were highest during anaesthesia after treatment with trichlorfon when compared with values obtained befo...
Gray WL, Yalamanchili R, Raengsakulrach B, Baumann RP, Staczek J, O'Callaghan DJ.Equine herpesvirus type 1 (EHV-1) preparations enriched in defective interfering particles (DIPs) have previously been demonstrated to mediate the coestablishment of persistent infection and oncogenic transformation in primary hamster embryo fibroblasts. In this study, it was demonstrated that infection of a rabbit kidney (RK) cell line with EHV-1 DIP-enriched preparations also results in the establishment of persistent infection. Viral transcription was characterized in RK cells infected with DIP-enriched stocks and compared to viral transcription in RK cells infected with standard (STD) EHV-...
Bertone AL, Schneiter HL, Turner AS, Shoemaker RS.Two mares with multiple carpal bone fractures, malarticulation and degenerative joint disease were successfully treated with unilateral arthrodeses of the antebrachiocarpal, middle carpal, and carpometacarpal joints. Arthrodesis was achieved by removal of articular cartilage, autogenous cancellous bone graft, and double dynamic compression plating. In one horse, wedge ostectomy corrected the severe, acquired angular limb deformity. External coaptation supplemented the internal fixation. Postoperative complications were limited to cast sores that healed with treatment, although protracted in on...
Lochner F, Sangiah S, Burrows G, Shawley R, McNew R, Walker J.The effect of allopurinol pretreatment 12 hours before an intraperitoneal challenge with a sublethal dose of Escherichia coli endotoxin (50 micrograms kg-1) was evaluated in 18 horses. The horses were divided among three equal groups: 1-endotoxin alone; 2-5 mg allopurinol kg-1 bodyweight plus endotoxin; and 3-50 mg allopurinol kg-1 bodyweight plus endotoxin. A variety of evaluation parameters were used. No differences among the groups were noted in rectal temperature, heart rate, respiration rate, haematological values, blood PaO2, blood PaCO2, blood pH or blood bicarbonate. Significant (P les...
Detilleux PG, Cheville NF, Sheahan BJ.Tissues from subcutaneous lymphosarcomas and regional lymph nodes were examined by light and electron microscopy and by lectin histochemistry. Tumors were composed of two major cell types: small lymphocytes with few organelles and pleomorphic histiocytic cells with undulant surfaces, large numbers of cytoplasmic vacuoles, and many mitochondria with large crystalline inclusions. A large gram-positive coryneform bacterium was isolated from tumor nodules but was not identified morphologically in tumor tissues. Evaluation of sections of tumors with lectins as histochemical probes revealed three st...
Byars TD, Simpson JS, Divers TJ, Shiner KA, Rantanen NW.Percutaneous nephrostomy was used to provide urine output in a 3-year-old Thoroughbred filly with azotemia and obstructive ureterolithiasis. Previous left ureteral surgery had failed to provide clinical improvement, and the filly became more azotemic. Nephrostomy was performed in the standing patient, with ultrasonographic guidance and local anesthesia. Continuing IV fluid therapy and diuresis through the nephrostomy tube resulted in a decrease in clinical signs of azotemia. However, the filly developed a cecal impaction, which ruptured during surgery because of colic, and was euthanatized.
Norman WM, Williams R, Dodman NH, Kraus AE.After surgery, high intramuscular pressures were measured in a horse with clinical signs of postanesthetic myopathy that developed following a 2.25-hour surgical procedure. In the postoperative period, tests for muscular and neurologic integrity were made, including measurement of intracompartmental muscle pressure.
Meagher DM, Aldrete AV.Lateral luxation of the superficial digital flexor tendon from the calcaneal tuber occurs in horses as a result of tearing or rupture of the medial retinaculum of the tendon. This report describes the repair of this condition in 2 Thoroughbred race horses, using a surgical technique in which 2 cancellous bone screws were placed in the calcaneus lateral to the tendon, along with suturing the medial retinaculum.
Venugopalan CS, Beadle RE, Seahorn TL, Holmes EP.The response of parenchymal strips from guinea-pig lungs to tracheobronchial lavage fluid (TBLF) collected from 8 normal horses and from 8 affected with summer pasture-associated obstructive pulmonary disease (SPAOPD) was determined. TBLF was collected during the summer (July) and winter (February) seasons. The serum/TBLF urea nitrogen ratio was used to standardize the mediator concentration in the TBLF. Four strips were used from each guinea-pig. The first strip did not receive any antagonist and served as the control. The second, third and fourth strips received antagonists of PGE2, LTD4 and...
Thompson JC, Ellison RS, Kirk J.Total thyroxine and total tri-iodothyronine concentrations were measured in the sera from 125 horses of mixed age, breed and sex, and varied clinical histories. While low serum thyroxine concentrations were detected in 35 horses, the majority of those horses had serum thyroxine values within the reference range when retested. Only one horse had a mildly decreased serum tri-iodothyronine concentration. Those horses in which the serum thyroxine concentration was low when retested had a normal thyrotropin releasing hormone stimulation test. Hypothyroidism was not diagnosed in any horses in this s...
During husbandry, domestic animals are exposed to many factors that can influence their circadian physiology organization leading to an increase in animals' discomfort. Thermal homeostasis is at the basis of animal wellness, the aim of the present study was to investigate the daily fluctuation of serum concentrations of 3,5,3'-triiodothyronine (T3) and thyroxine (T4) in association with the daily fluctuation of uncoupling protein 1 (UCP1) and clock gene Per2 in healthy horses housed in individual box, to improve the knowledge on this matter. Seven clinically healthy female Italian Saddle horse...
Fuller CJ, Barr AR, Dieppe PA, Sharif M.An epitope of keratan sulphate (KS) and total glycosaminoglycans (GAG) were measured in synovial fluid samples from joints of 53 horses immediately following humane destruction. Internal examination of the joints post mortem ensured that there was no gross evidence of osteoarthritis or other joint disease. Joints sampled were distal interphalangeal (DIP), proximal interphalangeal (PIP), metacarpophalangeal (MCP), metatarsophalangeal (MTP), tarsometatarsal (TMT), tarsocrural (TC), femoropatellar (FP) and antebrachiocarpal (ABC) joints. The age of each horse was assessed by examination of the te...
McDonnell SM, Kenney RM, Meckley PE, Garcia MC.Pony stallions were given sexual behavior trials in experimental "home" and "novel" environments, similar in all major features except location. In the novel environment, erection latency was increased and erection time decreased. Treatment with an anxiolytic benzodiazepine derivative (diazepam) appeared to block these effects.
Strzemienski PJ, Do D, Kenney RM.Luminal fluid from the mare uterus was used to investigate its relation to antibacterial defenses. Uterine flushings were collected at Day 3 of estrus, Day 8 postovulation and Day 15 postovulation. Uterine proteins were concentrated by ultrafiltration, dialyzed and examined for chemotactic activity to neutrophils and for antibacterial properties. Serum taken at the time of flushing was dialyzed and studied in a similar manner. Neutrophil migration in response to serum from Day 3 estrus and Day 8 postovulation was increased (P less than 0.05) above controls. Uterine protein from Day 8 postovula...
Hall-Patch PK, Orton RG, Sampson JH.A description is given of trail and endurance riding in the UK as controlled by the Endurance Horse and Pony Society. Veterinary involvement and responsibility are described and measures for their satisfactory execution discussed. Opportunities and need for research into the problems arising are mentioned.
Emmerich IU.In 2010, three new active pharmaceutical ingredients were released on the German market for horses and food-producing animals. These were gamithromycin (Zactran®), a new macrolide antibiotic, Monepantel (Zolvix®), a broad spectrum anthelmintic with a novel mechanism, and Pergolide (Prascend®), the first dopamine receptor agonist for animals. Two substances have been approved for additional species. The tetracycline antibiotic doxycycline is now also authorized for turkeys and the nonsteroidal anti-inflammatory drug firocoxib from the group of cyclo-oxygenase-2 (COX-2) inhibitors is now avai...
Georgiev P, Petkov PI, Georgiev Kh, Bŭrzev G.Parallel physiologic, biochemical, and hormonal investigations of racehorses were carried out within the time period of a training cycle. The changes found in the physiologic and biochemical indices were said to be in a general relationship with the amount of physical training of the animals, at the same time reflecting some seasonal variations. The changes in the level of T-4 and cortisol were found to be in direct relationship with the continuation of training.
Claessen C, De Lange V, Huang T, Ma G, Osterrieder N, Favoreel H, Van de Walle GR.Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data ind...
Bernard W, Reef VB, Clark ES, Vaala W, Ehnen SJ.Records of 6 horses with pericarditis were reviewed. Septic pericarditis was suspected in all horses, based on historic and clinical findings. In horses 1, 2, and 4, cytologic examination of the pericardial effusion revealed acute inflammation with severe neutrophil degeneration. In horses 3 and 5, cytologic examination of pericardial fluid revealed subacute inflammation with degenerated neutrophils, and in horse 6, chronic active inflammation, with well preserved neutrophils. In horses 1 and 3, bacteria were identified on cytologic examination of pericardial fluid. Results of microbiologic cu...
Oishi S.The author has already reported on the time course of blood level of sulfonamides in horses at various dose schedules3). The present paper is concerned with the tissue distri-bution of sulfadimethoxine and sulfamonomethoxine in horses. The distribution of sulfonamides has been reported by KoNDol) in experimental animals, in which the concentrations of these drugs in the kidney, liver, lung and spleen were found to be close to the blood level. Many investigators ascribed the low concen-tration of sulfonamides in the spinal fluid to the existence of a blood-brain barrier, and also observed that ...
Perryman LE, Mason PH.Monoclonal antibodies (MAbs) have been successfully used to evaluate immune responses in horses, and to target important antigens of equine infectious agents to which protective immune responses may be directed (1–5). Most of these studies are performed with murine MAb produced by fusing spleen cells from immunized mice with an appropriate myeloma cell line, as described in Chapter 3. However, there are experimental questions for which murine MAb are not adequate. These include:
1.Definition of microbial epitopes recognized by the infected host;
2.Identification of immunodominant epito...
Dyke TM, Hinchcliff KW.Ceftiohr sodium was evaluated as a therapy for respiratory
infections in horses. This cephalosporin antimicrobial was
administered intramuscularly every 24 h and at a dose of 2.2
mglkg (1.0 mgllb) of body weight. The efficacy of ceftiofur
sodium was compared with that of a positive control drug,
ampicillin sodium (recommended dose of 6.6 mg/kg [3 mg/lb],
given every 12 h). Both treatments were continued for 48 h
after clinical symptoms were no longer evident (maximum of
10 days). Fifty-five (55) horses with naturally acquired
respiratory infections were included in the study; 28 were
...
Feringer-Júnior WH, de Carvalho JRG, Moranza HG, de Almeida MLM, Lemos EGM, Soares OAB, Ribeiro G, de Camargo Ferraz G.Cost of transport (COT) and monocarboxylate transporters (MCTs) could affect the ability to perform fast actions during a jumping discipline. This study aimed to compare the COT and evaluate the MCT1, MCT4, and their auxiliary protein CD147 content in the gluteus medius and RBCs of Brazilian sport horses (BH), a breed developed for jumping competitions, with low-level (LL) or intermediate-level (IL) jumping capacities. The physiological difference between the horses was assessed by an incremental jump test (IJT), in which the cost of lactate (COT) and heart rate (COT) of running were determine...
Birks EK, Hultgren BD.A primary pericardial haemangiosarcoma with metastasis to the parietal pleura and left adrenal gland is described in a 22-year-old Clydesdale x Percheron gelding. Although haemangiosarcomas have been reported in horses, the pericardium has not hitherto been described as the primary site of origin.
Eberly VE, Tyler WS, Gillespie JR.EBERLY, V. E., W. S. TYLER, AND J. R. GILLESPIE. Cardio-vascular parameters in emphysematous and control horses. J. Appl. Physiol. 2 1 (3) : 883-889. I 966.—Horses with clinical signs of chronic pulmonary emphysema were demonstrated to have heart rates, total peripheral vascular resistance, pulmonary vascular resistance, and mean pulmonary artery blood pres-sure highly significantly greater than normal. They also had a highly significant decrease in central blood volume, stroke volume, stroke index, and left ventricular work. Cardiac out-put was significantly lower than in control (normal) h...
Hu J, Brooks M, Fuller AL, Armstrong P, McDougald LR.Cultured Histomonas meleagridis cells were readily agglutinated in vitro by horse serum at concentrations as low as 5%, although clumping was more rapid and prominent at 15% or higher. For observation of clumping, the cultured organisms were washed twice in Hanks balanced solution (HBSS) by centrifugation (1,000 x g for 15 min) and filtered through glass wool. The test sera were added and the mixture incubated in a Petri plate or 24-well culture plates at r.t. for 15-30 min. Formation of clumps was time- and concentration-dependent. Gentle agitation hindered agglutination at low serum concentr...
Labonville M, Higgins R, Lavoie JP.The aim of the study was to assess the relation between the direct smear observations and bacteriological results carried out on equine tracheal secretions. A total of 304 cases comprising both the direct smear (Gram stain) and the bacteriological culture, over a period of 8 years, were submitted to this retrospective study. Most of the specimens (78%) were obtained using tracheal washings while the rest (22%) originated from tracheal brushings. A total of 96 specimens (32%) were negative for both direct smear and culture. The positive predictive value of direct smears appeared high (81-96%) w...
Tallmadge RL, Antczak DF, Felippe MJB.Host defenses against infection by viruses, bacteria, fungi, and parasites are critical to survival. It has been estimated that upwards of 7% of the coding genes of mammals function in immunity and inflammation. This high level of genomic investment in defense has resulted in an immune system characterized by extraordinary complexity and many levels of redundancy. Because so many genes are involved with immunity, there are many opportunities for mutations to arise that have negative effects. However, redundancy in the mammalian defense system and the adaptive nature of key immune mechanisms bu...
Dabernat HJ, Tainturier D, Delmas C, Ferney J, Lareng MB.The cultural, biochemical, antigenic and antibiotic susceptibility characteristics of 17 strains of Haemophilus equigenitalis, the causative organism of contagious equine metritis (CEM), were studied. Biochemical characteristics were investigated using both conventional method and the API ZYM system of enzyme detection. The biochemical profile of the H. equigenitalis strains was unique and differed from the other bacterial species studied under the same experimental conditions (H. influenzae and H. parainfluenzae, B. abortus and B. melitensis, P. multocida, A. calcoaceticus). The required X an...
Acland HM, Mann PC, Robertson JL, Divers TJ, Lichtensteiger CA, Whitlock RH.Six foals of three different breeds, born to healthy mares, appeared normal at birth, and died at two to five days of age with icterus, ataxia, head pressing, and terminal hepatic coma. Their livers were less than one-half normal weight. Most of the liver was dark red-brown and slightly rubbery. Histologically, these areas were characterized by severe bile ductule proliferation, mild portal tract fibrosis, and massive hepatocellular necrosis and lobular collapse. A small proportion of the liver, usually on the peripheral part of the lobes, was grossly light brown and slightly raised. Histologi...
Colbern GT, Moore JN.A patellar fracture was identified radiographically in the right stifle of a mature Tennessee Walking Horse stallion. The horse was markedly lame (grade IV/V) on the right hindlimb. Due to the articular nature and small size of the fragment, surgical removal via arthrotomy was selected. A dorsomedial approach to the femoropatellar joint was used. The horse recovered well and has returned to training as a show horse by 8 months following surgery.
