Infections in horses encompass a range of diseases caused by various pathogens, including bacteria, viruses, fungi, and parasites. These infections can affect different systems within the horse, such as the respiratory, gastrointestinal, and integumentary systems, leading to a variety of clinical signs depending on the pathogen and the severity of the infection. Common infectious diseases in horses include equine influenza, strangles, and equine herpesvirus. Diagnosis often involves clinical examination, laboratory testing, and sometimes imaging, to identify the causative agent and assess the extent of the disease. Treatment strategies may include antimicrobial therapy, supportive care, and preventive measures such as vaccination and biosecurity practices. This page aggregates peer-reviewed research studies and scholarly articles that explore the pathogenesis, diagnosis, treatment, and prevention of infectious diseases in equine populations.
Boulanger P, Bannister GL, Carrier SP.An agar-gel immunodiffusion test recommended for the diagnosis of equine infectious anemia was evaluated. Our preliminary observations confirmed those of Coggins concerning the mechanism of the test and the results obtained. Furthermore, emphasis was put on the difficulties encountered in the production of spleen antigens with an optimum amount of reactivity. Acetone-ether extraction procedures for the preparation of a liquid antigen extract are described. This type of antigen was reactive in the complement-fixation test in 1:8 or greater dilution and it is proposed to use the complement-fixat...
Barron AL, Caste PG, Paul B, Page LA.Postinoculation sera collected from pigeons, turkeys, guinea pigs, sheep, a calf, a rabbit, and a horse experimentally infected with various strains of Chlamydia psittaci yielded a high incidence of positive reactions when tested by double diffusion in gel. Antigen was a deoxycholate extract of SA-2 strain of C. trachomatis. Good correlation was obtained with results of complement fixation tests, whereas double diffusion in gel was less sensitive. Immunoelectrophoresis of the antigen revealed presence of two antigens in the extract.
Science (New York, N.Y.)March 3, 1972
Volume 175, Issue 4025 996-997 doi: 10.1126/science.175.4025.996
Gershon RK, Kondo K.Mice rendered tolerant to sheep red cells and then given normal thymocytes, made no antibody when immunized with these cells. When immunized with horse red blood cells, however, they made significant amounts of noncross-reacting antibody to sheep red blood cells. This suggests that antibody-making precursor cells (B cells) which are nontolerant but nonactivatable by specific antigen, may exist in tolerant hosts.
Kamphues J, Meyer H, Liebler EM, Johannsen A.Anamnesis and clinical signs of horses form five different stables after ingestion of ionophores are reported and techniques of feed examination are described. Within a few hours or days after feeding of new types or batches of concentrates horses fell ill. They showed colic-like symptoms with intense sweating and ataxia. Most of the sick animals died within a short time span. Samples of the concentrates were analysed and different types and amounts of ionophores were detected. In four cases contamination by monensin in concentrations of less than 5 mg to 679 mg/kg feed were found. One feed sa...
Eysker M, Vercruysse J.The epidemiology, chemotherapy and control of strongylus infections in the horse are discussed. The annual cycle of various species are stated. In addition the anthelmintics available for treatment and control and the occurrence of anthelmintic resistance are referred to. Finally the options for control under various management conditions (little if any grazing; extensive grazing; intensive grazing) are discussed.
Kumar R, Sethi K, Gaur DK, Goyal SK, Kumar S, Jain S, Kumar S.Serodiagnosis of surra, caused by Trypanosoma evansi, is still based on native antigens purified from bloodstream form of T. evansi grown in rodents. In order to investigate prospective diagnostic possibilities as an alternative for native antigens, we cloned, expressed 26 kDa calflagin protein containing 218 amino acids from T. evansi (Indian Strain) in Escherichia coli. The potential of recombinant calflagin (rCLF) protein as diagnostic antigen was evaluated in immunoblot and indirect ELISA using experimentally infected equine serum samples from 0 to 84 days post infection. The antibodies a...
Anna M, Łukasz M, Adam O, Chełmońska-Soyta A.The aim of the study was to investigate the mechanisms leading to immunization through the use of a multicomponent bacterial immunomodulator and to find out the relationship between the TLR 4 receptor with selected parameters of innate immunity and to acquire immunity. The study was conducted on 18 Polish Pony Horses foals divided into two study groups: control (n = 9) and experimental (n = 9). Foals from the experimental group received intramuscular duplicate injection of 5 ml of multi-component bacterial immunomodular at 35 and 40 days of age. RNA isolated from venous blood was use...
Becht JL, Page EH, Morter RL, Boon GD, Thacker HL.Serological evidence with or without clinical signs of neonatal isoerythrolysis was experimentally produced in 6 of 8 foals born to mares allo-immunized with washed erythrocytes from the stallion. Blood group antigens were determined in all mares, stallions and foals, and the incompatible antigenic factor(s) responsible for the disease were defined. In 5 of 8 foals born to alloimmunized mares, a single antigenic factor difference accounted for the erythrocyte incompatibility between mare and foal. The erythrocyte antigen suspected as the most responsible for isoerythrolysis observed was A1. Ag...
Atwill ER, Mohammed HO, Lopez JW, McCulloch CE, Dubovi EJ.To locate counties within New York state with a high seroprevalence among the equine population, to determine host, management, and environmental factors that were associated with seropositivity to Ehrlichia risticii, and to determine evidence for arthropod- or helminth-mediated transmission of E risticii to horses. Methods: Cross-sectional study. Methods: A random sample of 3,000 of the 39,000 equine operations in New York state was selected, and 2,587 horses from 511 operations were tested. Methods: Blood samples were collected from horses and tested for seropositivity, using the indirect fl...
Haider W, Brehm W, Keller H.An apparently unilateral cryptorchid stallion was referred to the clinic with a history of colic. In the course of laparotomy an ileus caused by strangulation of the small intestine was found and the horse was euthanized because of poor prognosis. During autopsy strictures and ectasia of the jejunum were found as well as hermaphroditism along with male phenotype. The frequency of cryptorchidism in the case of intersexuality is discussed.
Scherbarth R, Pózvári M, Heilkenbrinker T, Mumme J.From 1972 to 1991, presecretion on an average of 183 stallions per year had been examined. Facultatively pathogenic germs were ascertained in 13.5% of the samples. However, the portion showed considerable annual fluctuation, as did the percentage of the different kinds of germs. In most of the cases, only minimal growth had been observed in culture. Except for the total percentage, these results are contradictory to those we found during the examination of cervical swabs of mares. In order to ascertain the importance of the respective results and to render possible a correct interpretation, th...
Denny HR.The current trends in equine fracture treatment are reviewed. Surgical approach, method of fixation, the advantages of Association for the Study of Internal Fixation (ASIF) implants and the complications of treatment are discussed with reference to 21 fracture cases. Normal limb function was restored in four horses with fractures of the olecranon and one with a mid shaft fracture of the tibia following stabilisation of the fracture with plates. A horse with a chip fracture of the distal radius and three other animals with fractures of the lateral condyle of the third metacarpal bone were also ...
Bacon Miller C, Wilson DA, Martin DD, Pace LW, Constantinescu GM.A 3-year-old Quarter Horse gelding was treated for left guttural pouch mycosis by ligation and balloon catheterization of the left internal carotid artery. Catheter advancement was shorter (10 cm) than the normally reported distance (13-15 cm), but was observed endoscopically during placement as it coursed within the internal carotid artery through the guttural pouch. The horse developed a persistently abnormal respiratory pattern after catheter placement, failed to gain consciousness, developed pulmonary edema, and died 5.5 hours postoperatively. Postmortem examination revealed an aberrant le...
Krpan MK.Transtracheal aspiration is used to obtain samples for culture and cytologic examination of respiratory tract secretions and exudates. A 15-cm-long area of the ventral midcervical region is surgically prepared, a small site infiltrated SC with 2-3 ml lidocaine, and a stab incision made in the skin. A trocar with cannula is inserted through the incision and annular ligament into the trachea and the trocar removed. An 8-Fr polypropylene catheter is inserted about 35-40 cm down the trachea and attached to a 30-ml syringe, containing 20 ml sterile saline, with a 3-way stopcock . The saline is rapi...
Wright L, Puchalski SM, Kristoffersen M, Lindegaard C.To develop arthroscopic approaches to the atlanto-occipital (A-O) and describe associated arthroscopic anatomy. Methods: Experimental ex vivo study and clinical case report. Methods: Ten equine cadaver joints and 1 clinical case. Methods: CT arthrograms of 8 A-O joints were performed to determine the placement of an arthroscopic portal. Arthroscopy was performed via dorsal and/or ventral approaches (dorsal or ventral to the longissimus capitis tendon) in 10 cadaveric A-O joints and the A-O joint of a 2-week-old foal with septic arthritis. Accessible cartilage was debrided in 3 cadaver joints. ...
Doyle AJ, Saab ME, Lewis KM, McClure JT.An alcohol-based rub has been confirmed effective at reducing bacterial counts on equine skin. Skin sites with expected high bacterial burden have not been tested or has a comparison to a common protocol been performed. Objective: To determine if ethanol-based antisepsis reduces bacterial counts on the equine distal limb comparable to a current chlorhexidine scrub method and determine the most effective application technique for the product. Methods: Randomised trial. Methods: Forty-one horses were used in the study. By horse, each limb was randomly assigned to a treatment group: 5min scrub us...
Meier HP.In 1828, the Society of Swiss Veterinarians (GST) raised a prize question in regard to the symptoms, etiology and prophylaxis of polyarthritis in the foal. The treatise of Matthias Anker on this subject was treated with distinction and published in 1830. His statements answered both the questions to the clinical aspects and referred also to epidemiological, pathological, economical and ethical issues as well as husbandry and relations with the breeders. The comprehensive article of Anker in a lucid language and obliging views still finds great interest today, as the septicemia is one of the bi...
Materniak-Kornas M, Rożek W, Rola J, Osiński Z, Löchelt M, Kuźmak J.Equine foamy virus (EFVeca) is a foamy virus of non-primate origin and among the least-studied members of this retroviral subfamily. By sequence comparison, EFVeca shows the highest similarity to bovine foamy virus. In contrast to simian, bovine or feline foamy viruses, knowledge about the epidemiology of EFVeca is still limited. Since preliminary studies suggested EFVeca infections among horses in Poland, we aimed to expand the diagnostics of EFVeca infections by developing specific diagnostic tools and apply them to investigate its prevalence. An ELISA test based on recombinant EFVeca Gag pr...
Steuer AE, Scoggin K, Stewart JC, Barker VD, Adams AA, Loynachan AT, Nielsen MK.This study aimed to collect information on local and systemic inflammatory responses, and goblet cell-associated components, following anthelmintic treatment with moxidectin and ivermectin in horses naturally infected with cyathostomin parasites. Thirty-six horses aged 2-5 years of age were randomly allocated to three groups. Group 1 received ivermectin/praziquantel (0.2 mg/kg), Group 2 received moxidectin/praziquantel (0.4 mg/kg) and Group 3 were untreated controls. Tissue samples from the Cecum, Dorsal and Ventral Colons were used for histopathological evaluation and preserved for RNA is...
Odenkirchen S, Huskamp B.Casuistics of 200 patients with acute diarrhea (72 horses with salmonellosis, 55 horses with typhlocolitis, 73 horses with unspecific diarrhea) have been analyzed. It was shown, that horses with salmonellosis have been fallen ill with a primary disease for a longer period of time before the beginning of diarrhea than those with typhlocolitis and that in cases of salmonellosis antibiotics very often were used during the preliminary treatment. Frequently a primary illness of the colon was seen with typhlocolitis. Besides the frequent use of butylscopolamin during the pretreatment was noticed. Th...
Spier SJ, Meagher DM.Rational perioperative management improves the success rate of abdominal surgery. Important aspects of management are discussed, including principles of fluid therapy, nutrition, intravenous catheterization, antimicrobial prophylaxis, and the use of nonsteroidal anti-inflammatory medication. Current advances in the area of immunotherapy are mentioned.
Milnes E, Delnatte P, Dutton CJ, Brouwer E, Cai HY, Smith DA, Peregrine AS.A 23-yr-old captive-born Przewalski's horse mare ( Equus przewalskii) was euthanized at a Canadian zoo because of severe colic resulting from rupture of a jejunal pseudodiverticulum. An incidental finding of an encysted larval cestode within a hepatic granuloma was diagnosed on histopathology. Gel-based polymerase chain reaction (PCR) on liver tissue was positive for Echinococcus granulosus sensu lato, and deoxyribonucleic acid sequencing of the PCR product was 100% homologous with Echinococcus equinus. This appears to be the first molecular confirmation of E. equinus in North America, and the...
Thurston CC, Stefanovski D, MacKinnon MC, Chapman HS, Richardson DW, Levine DG.The objective of this study was to determine the diagnostic ability of serum amyloid A (SAA) and fibrinogen for early detection of surgical site infection (SSI) after equine internal fixation. Horses undergoing internal fixation for fracture, arthrodesis, or osteotomy with internal fixation for limb deformity were included in the study. SAA and fibrinogen were measured on blood samples preoperatively and on days 1, 3, 5, 7, 10, and 14 postoperatively. Statistical analysis included use of Spearman's rank correlation, logistic regression, and calculating the area under the receiver operating cha...
Steiner N, Lindner A.By means of a survey, the reproductive rate of mares and the foal losses in ten Thoroughbred, Saddlebred and Pony studs in Germany, mainly from North-Rhine-Westfalia, were collected and evaluated. Data for the survey were recorded for 1985-1990. The study also examined the hygienic management in the surveyed studs, and the morbidity rate of suckling foals was obtained for 1990. In addition to the survey questionnaire each stud was visited once. Two studs of each horse group were visited several times every week from March to August in order to evaluate as exactly as possible the husbandry and ...
Do Carmo GM, Da Silva AS, Klauck V, Pazinato R, Moura AB, Duarte T, Duarte MM, Bochi GV, Moresco RN, Stefani LM.Toxoplasmosis is an important parasitic disease affecting several species of mammals, but little is known about this disease in horses. This study aimed to investigate the levels of several immunological variables and markers of cell damage in the serum of seropositive horses for Toxoplasma gondii. Sera samples of adult horses from the Santa Catarina State, Brazil used on a previous study were divided into groups according to their antibody levels for T. gondii determined by immunofluorescence assay, i.e. 20 samples from seronegative horses (Group A - control), 20 samples from horses with tite...
Platt H.From a perinatal survey carried out on Thoroughbred studs, information was obtained on the incidence, mortality and long-term effects of joint-ill and other bacterial infections. Many of these infections occurred in foals with a history of other perinatal abnormalities, and in foals in which receipt of colostrum was delayed. There was no direct relationship between the incidence of infection and maternal age, but prenatal lactation and loss of colostrum were more frequent in older mares. There was a significant reduction in the incidence of infections in foals given neomycin and framomycin dur...
Hassanpour A, Moghaddam S.Early detection of Rhodococcus equi pneumonia in foals is essential for horse health and for veterinarians. Objective: This study aimed to demonstrate the usefulness of assessing the serum concentration of acute-phase proteins (APPs) in the early diagnosis of pneumonia. Methods: The study evaluated APPs in 19 Arabian foals with R. equi pneumonia and compared them with 18 normal Arabian foals in equestrian clubs in Tabriz, Iran. Affected foals were identified through history, clinical findings and bacterial culture of tracheal washing. Biochemical methods and polymerase chain reaction tests wer...
Hasslinger MA, el-Seify MA.The investigation of 156 donkeys in the area of the veterinary faculty of the Tanta University in Kafr el-Sheikh showed that 49 animals (31.41%) were infected with trematodes, 34 donkeys (21.80%) served as hosts for Gastrodiscus aegyptiacus, 22 (14.10%) were infected with Fasciola gigantica und 7 (4.49%) with both trematodes. 6 of 40 examined horses (15.0%) showed monoinfections with G. aegyptiacus only. Because of the fragmentary knowledge on these paramphistomides of equids, some aspects concerning the morphology, pathology and clinical symptoms, differential diagnosis, occurrence, host spec...
Cohen ND, Carey VJ, Donahue JG, Seahorn JL, Harrison LR.Epidemiological and pathological findings of 433 late-term abortions associated with the mare reproductive loss syndrome (MRLS) in central Kentucky were identified by reviewing the records of the University of Kentucky Livestock Diseases Diagnostic Center. The distribution of dates of abortion was clustered during a brief period of time, presumably from a simultaneous environmental exposure. The most common pathological findings were microscopic pulmonary lesions consisting of squamous epithelial cells present in alveoli with or without concurrent infiltration of inflammatory cells (neutrophil...
Aceto H, Miller SA, Smith G.To determine time to first detection of Salmonella organisms in feces of animals after experimental infection PO and times to onset of diarrhea and pyrexia to evaluate a common method for identifying nosocomial infections on the basis of time of admission and onset of clinical signs (ie, the 3-day criterion). Methods: Meta-analysis. Methods: Cattle, horses, goats, and sheep experimentally infected PO with Salmonella enterica subsp enterica. Methods: Online databases were searched for published reports describing results of experimental infection of cattle, horses, goats, and sheep PO with salm...
Potter K, Anez D.A 17-year-old Quarter Horse mare was examined to determine the cause of a vulvar mass. Differential diagnoses for the swollen, ulcerated tissue included hypersensitivity reaction to insect stings or bites and cutaneous neoplasia. During the next 4 months, the mass enlarged involving the skin of the perineum and ventral aspect of the abdomen with secondary dependent edema of both hind limbs. Histologic examination of biopsy and necropsy specimens revealed changes consistent with a diagnosis of mycosis fungoides (cutaneous T-cell lymphoma). Diagnostic features included invasion of neoplastic lym...
Jensen K.Examination of nasopharyngeal secretion and organ material from clinical cases of respiratory diseases in horses, using inoculation of embryonated hen eggs and rabbit and horse kidney cell cultures, resulted in the isolation of influenza virus and herpes virus. In 2 cases, both viruses were present in the same specimen. On the basis of the physio-chemical, cytological and serological criteria, the viruses were found to be identical with influenza virus type A equi 2 and herpes virus equi type 1. The methods for serological diagnosis and characterization of the influenza and herpes viruses are ...
González F, Rodríguez C, De Lucas JJ, Waxman S, San Andrés MD, Serres C, Nieto J, San Andrés MI.Six donkeys each received 2 mg/kg marbofloxacin as a 10 per cent aqueous solution administered intravenously. Principal pharmacokinetic parameters were determined and two efficacy indices were computed by using pharmacokinetic parameters and selected mic90 values of marbofloxacin against pathogenic equine strains to predict the efficacy of the drug at this dose. The pharmacokinetics of marbofloxacin in donkeys was characterised by a large mean volume of distribution at a steady state (1.15 [0.09] l/kg) and a long mean (sd) elimination half-life of 9.24 (1.96) hours. It was also characterised b...
