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Topic:Intra-Articular Injection

Intra-articular injection in horses involves the administration of therapeutic agents directly into a joint space. This technique is used to manage joint diseases, such as osteoarthritis, by delivering medications like corticosteroids, hyaluronic acid, or biologic therapies directly to the affected area. The procedure aims to reduce inflammation, alleviate pain, and improve joint function. Intra-articular injections are commonly performed under sterile conditions to minimize the risk of infection. This page compiles peer-reviewed research studies and scholarly articles that explore the methods, efficacy, and safety of intra-articular injections in equine medicine, as well as their impact on joint health and performance in horses.
Intra-articular use of corticosteroids in the horse.
Journal of the American Veterinary Medical Association    August 1, 1982   Volume 181, Issue 3 292-294 
Hackett RP.No abstract available
Therapeutic effect of intracorneal injection of immunoglobulins on corneal ulcers in horses experimentally infected with Pseudomonas aeruginosa.
Nihon juigaku zasshi. The Japanese journal of veterinary science    April 1, 1982   Volume 44, Issue 2 301-308 doi: 10.1292/jvms1939.44.301
Ueda Y, Sanai Y, Homma JY.No abstract available
Effect of intra-articular injection of orgotein and saline solution on equine synovia.
American journal of veterinary research    April 1, 1982   Volume 43, Issue 4 594-597 
Wagner AE, McIlwraith CW, Martin GS.Orgotein was injected into the right intercarpal joint of each of 8 horses; the corresponding left joint was left alone (not injected) or was given an injection of normal saline solution. Injection with orgotein caused a transient, marked inflammatory response, evidenced by clinical signs and by increased leukocytes and total protein in the synovia (synovial fluid). Leukocyte numbers and total protein concentration were increased (P less than 0.010) in the orgotein-injected joints within 24 hours. However, saline solution alone also elicited a marked inflammatory response, manifested by increa...
Preliminary trial of synovial fluid transfer for treating joint lameness in Standardbreds.
Equine veterinary journal    October 1, 1981   Volume 13, Issue 4 264-266 doi: 10.1111/j.2042-3306.1981.tb03516.x
Rülcker C, Lindholm A.No abstract available
Corticosteroid and hyaluronic acid treatments in equine degenerative joint disease. A review.
The Cornell veterinarian    October 1, 1981   Volume 71, Issue 4 355-375 
Nizolek DJ, White KK.Degenerative arthrosis is perhaps the most common debilitating disease of performance horses. Treatment should be based upon a knowledge of the anatomy and physiology of normal joints and upon an understanding of the processes of degeneration and repair. These topics are briefly reviewed. Although rest is probably, the most beneficial therapy, physical and pharmaceutical treatments are often employed in an effort to speed recovery. The effects and relative benefits of intrasynovial injections of corticosteroids, hyaluronica cid, and Arteparon are considered in detail. Although local corticoste...
Distal intertarsal and tarsometatarsal joints in the horse: communication and injection sites.
Journal of the American Veterinary Medical Association    August 15, 1981   Volume 179, Issue 4 355-359 
Sack WO, Orsini PG.One hundred three equine hocks, obtained from the postmortem room, were used to study the communication and injection of material into the distal intertarsal and tarsometatarsal joints. Excluding the hocks with fused central and 3rd tarsal bones, in 8.3% of hocks injected with low (clinical) pressure and in 23.8% injected with high pressure, the distal intertarsal and tarsometatarsal joints communicated by dissection of the material through 2 internal spaces: the tarsal canal and the space between the combined tarsal bones 1 and 2 tarsal bone 3. A "pop" sometimes felt when high pressure was us...
Effect of exogenous hyaluronic acid on joint function in experimentally induced equine osteoarthritis: dosage titration studies.
Research in veterinary science    March 1, 1981   Volume 30, Issue 2 192-197 
Gingerich DA, Auer JA, Fackelman GE.A single intra-articular injection of 20 or 40 mg of purified hyaluronic acid of rooster comb origin resulted in restoration of normal joint function in horses with experimentally induced osteoarthritis. The functional improvement, measured by pressure sensitive force plate techniques, was detectable within one week after treatment and persisted throughout a four week experimental period despite continued use of the joints. The response was dose dependent in that injection of 0 (saline), 5 or 10 mg hyaluronic acid per joint space resulted in no significant change in joint function while dosage...
Selective intra-articular anesthesia as an aid in the diagnosis of bone spavin.
Journal of the American Veterinary Medical Association    February 1, 1981   Volume 178, Issue 3 297-300 
Lindsay WA, Taylor SD, Watters JW.No abstract available
Experimentally induced arthritis of the equine carpus: histologic and histochemical changes in the articular cartilage.
American journal of veterinary research    February 1, 1981   Volume 42, Issue 2 209-217 
McIlwraith CW, Van Sickle DC.Arthritis was experimentally induced in the intercarpal joints of a series of mature ponies by the intraarticular injections of 400 microgram of the polyene antibiotic filipin in 1 ml of dimethyl sulfoxide. Twelve consecutive weekly injections were administered and the ponies were euthanatized 4 weeks after the last injection of filipin was made. The ponies were exercised for 1 hour each day throughout the experiment. Articular cartilage specimens from 4 sites in each intercarpal joint were examined histologically and histo-chemically. For the histochemical examination, safranin O-fast green, ...
Pharmacokinetics of procaine injected into the hock joint of the horse.
Equine veterinary journal    January 1, 1981   Volume 13, Issue 1 68-69 doi: 10.1111/j.2042-3306.1981.tb03460.x
Wintzer HJ, Fitzek A, Frey HH.No abstract available
Sodium hyaluronate in equine traumatic arthritis.
Journal of the South African Veterinary Association    December 1, 1980   Volume 51, Issue 4 231-233 
Irwin DH.Thirty seven intra-articular injections, each 2 ml sodium hyaluronate were made into 21 arthritic joints in 15 racing Thoroughbreds and one part-bred polo pony. One joint failed to improve at all, 16 became sound with one injection, 4 became sound with 2 injections, and 11 joints showed various degrees of response. Eleven of 14 horses became sound for flat racing. Discussion relates to the technique of using sodium hyaluronate, some clinical and pathological aspects of traumatic arthritis, joint lubrication and a brief review of some properties of sodium hyaluronate which have a bearing on art...
The effect of joint position on juxta-articular bone marrow pressure. Relation to intra-articular pressure and joint effusion–an experimental study on horses.
Acta orthopaedica Scandinavica    December 1, 1980   Volume 51, Issue 6 893-897 doi: 10.3109/17453678008990890
Arnoldi CC, Reimann I, Mortensen S, Christensen SB, Kristoffersen J, Sønnichsen HV, Smith M.Six metacarpo-phalangeal joints of adult horses were studied. Pressure measurements were made in the joint and the metacarpal bone with simultaneous measurement of the systemic arterial blood pressure. Investigations performed to study the effect of joint position on juxta-articular bone marrow pressure showed that an increase in joint flexion was always followed by a rise in intraosseous pressure with a significant increase at flexion above 60 degrees. Increase in intra-articular pressure which was achieved by injection of saline was always followed by a slower rise in intraosseous pressure. ...
Intra-articular corticosteroid therapy in the horse.
Journal of the American Veterinary Medical Association    October 15, 1980   Volume 177, Issue 8 710-713 
Owen RR.Physiologic features of the equine diarthrodial joint and the effects of intra-articular corticosteroid therapy were investigated. It was concluded that intra-articular injection of corticosteroids may be beneficial when lesions are confined to soft tissues of the joint, excluding injuries involving joint laxity. Rest following therapy is important.
Diseases of the carpus.
The Veterinary clinics of North America. Large animal practice    May 1, 1980   Volume 2, Issue 1 81-99 doi: 10.1016/s0196-9846(17)30176-3
Auer J.Degenerative joint disease is the most frequently diagnosed problem of the carpus. Horses afflicted with this disease should not be injected with corticosteroids, but should be rested for several months. Swimming exercise and intra-articular injections of hyaluronic acid during this time help to restore the integrity of the involved joints. Chip fractures of the various carpal bones and the distal radius are commonly diagnosed as the cause of the lameness. Not all horses with carpal fractures are candidates for surgery. It is important that the severity of the problem be realized and that the ...
Effect of hyaluronic acid in naturally occurring and experimentally induced osteoarthritis.
American journal of veterinary research    April 1, 1980   Volume 41, Issue 4 568-574 
Auer JA, Fackelman GE, Gingerich DA, Fetter AW.Effect of intraarticular injections of hyaluronic acid was evaluated in two groups of horses, using force plates to assess quantitatively the degree of lameness observed. In six horses, chip fractures were created surgically on the dorsomedial aspects of both radial carpal bones. After the horses were trained for 30 days, 40 mg of hyaluronic acid was injected intraarticularly into the limb showing the greater degree of lameness. Horses were worked for 2 more weeks and then were evaluated. A highly significant (P less than 0.01) increase in weight bearing on the treated limb was observed. Ten h...
A technique for intra-articular injection of the equine tarsometatarsal joint.
Veterinary medicine, small animal clinician : VM, SAC    February 1, 1980   Volume 75, Issue 2 265-270 
Brown MP, Valko K.No abstract available
Orgotein in equine navicular disease: a double blind study.
Journal of the American Veterinary Medical Association    February 1, 1979   Volume 174, Issue 3 261-264 
Coffman JR, Johnson JH, Tritschler LG, Garner HE, Scrutchfield WL.Fourteen horses (7 treated with orgotein and 7 treated with a placebo) with navicular disease were studied on a double blind basis. All 14 horses had clinical and radiographic evidence of navicular disease. Orgotein and the placebo were administered by juxtabursal injection. Of the 7 orgotein-treated horses, 3 responded but none of the 7 placebo-treated horses responded. The difference was statistically significant (P less than 0.05).
The intra-articular use of sodium hyaluronate for the treatment of osteo-arthrosis in the horse.
New Zealand veterinary journal    January 1, 1979   Volume 27, Issue 1-2 5-8 doi: 10.1080/00480169.1979.34585
Rose RJ.No abstract available
Treatment of traumatic arthritis in the horse with intra-articular orgotein (palosein).
Equine veterinary journal    April 1, 1978   Volume 10, Issue 2 122-124 doi: 10.1111/j.2042-3306.1978.tb02235.x
Ahlengard S, Tufvesson G, Pettersson H, Andersson T.A total of 134 horses of various breeds were treated for aseptic arthritis of traumatic origin using Orgotein (Palosein). The drug was injected into 192 affected joints of these animals. Recovery rates of 94 per cent were recorded in cases which had shown lameness for less than 2 months before treatment commenced and 49 per cent in those lame for longer than 2 months.
Treatment of equine shoulder sweeny with intra-articular corticosteroids.
Veterinary medicine, small animal clinician : VM, SAC    June 1, 1977   Volume 72, Issue 6 1077-1079 
Miller RM, Dresher LK.No abstract available
The urinary excretion of synthetic corticosteroids by the horse.
The Veterinary record    May 21, 1977   Volume 100, Issue 21 447-450 doi: 10.1136/vr.100.21.447
Chapman DI, Whiteside J.A radioimmunoassay method has been developed that enables the administration of therapeutic doses of synthetic corticosteroids to be detected in horse urine. Fourteen proprietary preparations of these steroids have been given by intramuscular injection to ponies and thoroughbreds. The administration of some preperations could still be detected six days after a single intramuscular injection of a therapeutic dose. The route of injection of dexamethasone-21-sodium phosphate, whether intramuscular, intravenous or intra-articular, did not appear to alter the length of time over which the steroid o...
Onset and duration of corticosteroid effect after injection of Betasone for treating equine arthropathies. Results of laboratory and clinical studies.
Veterinary medicine, small animal clinician : VM, SAC    February 1, 1977   Volume 72, Issue 2 241-244 
Vernimb GD, Van Hoose LM, Hennessey PW.No abstract available
A review of the pharmacology, pharmacokinetics and behavioral effects of procaine in thoroughbred horses.
British journal of sports medicine    October 1, 1976   Volume 10, Issue 3 109-116 doi: 10.1136/bjsm.10.3.109
Tobin T, Blake JW.Since procaine has both local anaesthetic and central stimulant actions its presence in the blood or urine of racing horses is forbidden. After rapid intravenous injection of procaine HC1 (2.5 mg/Kg) in thoroughbred mares plasma levels of this drug fell rapidly (t 1/2 alpha = 5 min) and then more slowly (t 1/2 beta = 50.2 min). These kinetics were well fitted by a two compartment open model (Model I). This model gave an apparent Vdbeta for procaine in the horse of about 3,500 litres. Since procaine was about 45% bound to equine plasma protein this gives a true Vdbeta for procaine of about 6,50...
Clinical use of Osteum in the horse.
Veterinary medicine, small animal clinician : VM, SAC    September 1, 1976   Volume 71, Issue 9 1181-1189 
Wisner AB.No abstract available
Observations on the intraarticular use of corticosteroids in the racing thoroughbred.
Journal of the American Veterinary Medical Association    June 1, 1976   Volume 168, Issue 11 1039-1041 
McKay AG, Milne FJ.A project to determine if intraarticular corticosteroid therapy was deleterious to the racing Thoroughbred was carried out in the 1971, 1972, and 1973 racing seasons. Of 22 horses available for follow-up examination, 6 had radiographic evidence of deterioration; 1 of these was destroyed because of probable corticosteroid-induced arthropathy. The remaining 16 horses did not have any evidence of deterioration. One of the 16, a stakes winner, had been given 12 injections into the left front fetlock during the 3-year period. It was concluded that if proper and careful aftercare is adhered to, intr...
Letter: Injecting large animals.
The Veterinary record    May 22, 1976   Volume 98, Issue 21 432-435 
No abstract available
Intra-articular treatment of arthritis in race-horses with sodium hyaluronate.
Acta veterinaria Scandinavica    January 1, 1976   Volume 17, Issue 4 379-394 doi: 10.1186/BF03547893
Asheim A, Lindblad G.Forty-five race-horses with arthritis of non-in-fectious type in 54 joints were treated with sodium hyaluronate intra-articularly. All joints had previously been treated without lasting success by conventional methods, such as firing, blistering or intraarticular injection of cortisone. In most cases only 1 injection of 2 ml (20 mg) sodium hyaluronate was needed. To avoid subjective evaluation, the effects of the treatment were based on the joint’s capacity of withstanding extreme stress, which means that the horse should be able to train and race again. The treatment was concentrated on the...
Local administration of orgotein in horses.
Modern veterinary practice    October 1, 1974   Volume 55, Issue 10 773-774 
Decker WE, Edmondson AH, Hill HE, Holmes RA, Padmore CL, Warren HH, Wood WC.No abstract available
Intra-articular injection of flumethasone suspension in normal joints of horses.
Equine veterinary journal    October 1, 1973   Volume 5, Issue 4 162-170 doi: 10.1111/j.2042-3306.1973.tb03218.x
Van Pelt RW.No abstract available
Effects of intraarticular flumethasone suspension on synovial effusion enzyme activity of arthritic horses.
Journal of the American Veterinary Medical Association    January 15, 1972   Volume 160, Issue 2 186-190 
Van Pelt RW, Tillotson PJ, Gertsen KE, Gallagher KF.No abstract available