Veterinary care in horses encompasses the medical and preventive measures taken to maintain and improve the health and well-being of equine patients. It includes a wide range of practices such as routine health examinations, vaccinations, dental care, parasite control, and management of injuries and diseases. Veterinary care also involves diagnostic procedures, surgical interventions, and therapeutic treatments tailored to the specific needs of horses. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of equine veterinary care, including advancements in diagnostic techniques, treatment protocols, and health management strategies to support the well-being and performance of horses.
Schellenberg LM, Regenthal R, Abraham G.The present study addresses the effect of the Rho-kinase (ROCK) inhibitor Y-27632 on the β-adrenoceptor density and β-agonist-stimulated intracellular second messenger cAMP formation in primary equine bronchial epithelial cells (EBEC). Y-27632 significantly decreased the β-adrenoceptor number (B) without markedly affecting the receptor affinity (dissociation constant, K) to the radioligand [I]-iodocyanopindolol (ICYP). In contrast, Y-27632 augmented the β-agonist-stimulated intracellular cAMP production. Herein, Y-27632 markedly increased the maximal cAMP responses (E) (isoproterenol >...
Hurley DJ, Berghaus LJ, Hurley KA, Moore JN.To evaluate effects of black walnut extract (BWE) on equine mononuclear cells and determine whether BWE has direct proinflammatory effects. Methods: Mononuclear cells separated from blood samples from 8 horses. Methods: Aqueous BWE was prepared and processed to eliminate contamination with particulates and microbes. A Limulus amoebocyte lysate assay was used to detect lipopolysaccharide (LPS) contamination in the BWE. Mononuclear cells were incubated in minimal essential medium with or without the addition of 0.6% to 10% (vol/vol) BWE. These mononuclear cells were assessed for viability, activ...
Haynes PF.The intent and extent of the respiratory tract examination relevant to purchase are dictated by numerous factors, including historical information, signs suggestive of respiratory tract abnormalities, intended use of the horse, and economic considerations. Following a thorough and systematic examination of the horse at rest, evaluation during and following exercise may be warranted. The physical examination should include evaluation of regional symmetry of the head, neck, and thorax; evaluation of nasal airflow and patency; palpation of the nasal septum, larynx, and trachea; examination for su...
Hermans H, van den Berg EMH, Slenter IJM, Vendrig DJC, de Nijs-Tjon LJL, Vernooij JCM, Brommer H, Boevé MH, Gehring R.Topical dexamethasone and prednisolone are currently the mainstay treatment for equine ophthalmic inflammatory diseases, such as equine recurrent uveitis. Comparative pharmacokinetic studies in horses are lacking and current guidelines are mainly based on empirical data and extrapolation from other species. Objective: To investigate the penetration and local concentrations of topically applied dexamethasone and prednisolone in normal equine ocular fluids and serum. Methods: Prospective randomised experimental pharmacokinetic study. Methods: Twenty-one Shetland ponies without ophthalmic disease...
van Haeringen H.Investigations for the presence of antibodies to red blood cell antigens were carried out in equine colostrum and serum. Material from 181 mares without clinical disease was tested. The object was to obtain information on the number of mares producing antibodies capable of inducing haemolytic disease in newborn foals. Of the mares 2.8% was positive for haemolysins. These mares are expected to be a risk for haemolytic disease. In addition agglutinating antibodies were identified in 39.2 per cent of the mares examined. It is not known whether or not these antibodies constitute a hazard for the f...
Clarke PN.Application of nursing theory in daily life by applying elements of Parse's paradigm allowed for a more expansive view of the dressage experience by focusing on the paradox of visible-invisible in the unique rhythmic-patterns of the horse-rider team. The study of classical nursing theory has diminished in a similar pattern as classical dressage. The importance of studying the classics in any field is emphasized along with concerns about the future of nursing and healthcare.
Marqués FJ, Hehenberger E, Dickinson R, Wojnarowicz C, Lohmann K.A 9-year-old, 1494-lb (679-kg) Quarter horse gelding in good body condition was admitted to the Veterinary Teaching Hospital, Western College of Veterinary Medicine (WCVM), University of Saskatchewan, for evaluation and treatment of acute respiratory distress. On a trail ride 26 days before presentation, the gelding had been exposed to a horse with clinical signs of an upper respiratory tract infection. The gelding performed well on the trail ride but, 4 days later, developed a mild swelling in the retropharyngeal area and a slight bilateral mucoid nasal discharge. The gelding was examined at ...
Zuffa T, Bennet ED, Parkin TDH.Endurance riding is a popular equestrian sport organised at the international level by the Fédération Équestre Internationale (FEI). The sport involves prolonged exercise at speed over significant distances, which puts a substantial load on equine athletes' musculoskeletal systems and metabolism and contributes to the risk of injuries and other veterinary problems. The FEI employs a system of in-ride veterinary inspections aimed at early detection of such problems and elimination of horses unfit to continue in the ride. To date, risk factors for elimination due to irregular gait or metaboli...
Marr K, Marsh K, Hernandez L, Cunningham FM, Lees P.Leukotrienes, products of the 5-lipoxygenase pathway of arachidonic acid metabolism, possess properties consistent with their involvement in a range of inflammatory diseases. In this study the pharmacokinetics and pharmacodynamics of the selective 5-lipoxygenase inhibitor, fenleuton, have been examined in the horse. Orally administered fenleuton (four 5 mg kg(-1) doses, given once daily) was absorbed from the gastrointestinal tract, and penetrated readily into tissue cage exudate, the ratio of the plasma:exudate AUC0-48h being 0.90+/-0.02 (n=6). Ionophore-stimulated leukotriene (LT) B4 synthes...
Gaughan EM.Skeletal origins of exercise intolerance and performance failure can reside in multiple tissues. Diagnosis of injury that results in an ability to continue to exercise, yet inefficiently do so, requires familiarity with evaluation of subtle lameness and often with the specific demands of the different equine sports. Imaging is usually vital to diagnosis development and understanding of lesion influences on locomotion. Therapy is lesion dependent. Return to competitive exercise and performance is dictated by an understanding of skeletal tissue response to injury, rational progressive treatment,...
Albanese V, Mereu M.Pelvic abscesses occur in horses of all ages and breeds. Although conservative management may be successful, surgical drainage may be necessary for larger abscesses or in case of secondary intestinal obstruction. The purpose of this report is to describe two cases of pelvic abscesses that were successfully drained using indwelling chest tubes, repeated lavages and targeted antibiotic treatment.
Lyons ET, Tolliver SC, Drudge JH, Swerczek TW, Crowe MW.A total of 89 Thoroughbreds, 14 to 333 days old (born in 1982), were examined at necropsy for certain internal parasites during a 1-year-period, Mar 1, 1982, to Feb 28, 1983. The eyes of 73 of the horses and the cranial mesenteric arteries of 71 were examined. Specific interest was on prevalence of parasites according to month of the year and age of the horses at necropsy. Parasites recovered (first month-last month infected horse found) were as follows: Thelazia lacrymalis (eyes) immature and mature (June - February); Habronema/Draschia (lungs) immature (May - September); Habronema muscae (st...
Fielding CL, Magdesian KG.To evaluate changes in electrolyte concentrations and hydration status that take place in endurance horses prior to the start of a competition and determine whether these changes would be associated with elimination. Methods: 19 horses entered in the 2016 Tevis Cup 100-Miles (160 km) One-Day Western States Trail Ride. Methods: Heparinized blood samples were collected at 5 time points: prior to transport to the ride (T0), during check-in the day before the ride (T1), 1 to 2 hours before the start of the ride (T2), at the 15-km mark (T3), and at the 55-km mark (T4). Packed cell volume and plasma...
Schofield WL, Mulville JP.The modified Forssell's procedure was performed on 10 horses in an attempt to cure oral stereotypies. Three horses were cured completely, two horses were considerably improved, and five horses continued to perform the stereotypy after periods of remission ranging from two weeks to six months. This rate of success for the modified Forssell's procedure, as in other published reports, was lower than for the original Forssell's procedure. Surgery to eliminate a stereotypical behaviour pattern may exacerbate the stress for an animal and the modified Forssell's procedure can no longer be recommended...
Kneller SK, Losonsky JM.Bilateral metacarpophalangeal radiographs of 100 Thoroughbreds were examined for visualization and location of the major nutrient foramen of the proximal phalanx. The foramina were located on the dorsal or palmar aspects of the cortex or were not visible radiographically. Of the 100 horses, 60 had the same pattern in both forefeet. In the remaining 40 horses, the left and right proximal phalangeal foramina were asymmetric. Of the 200 proximal phalangeal foramina (100 horses), 53 were on the dorsal aspect of the cortex and 101 were on the palmar aspect of the cortex; 46 were not visible radiogr...
Lotstra RJ, van den Broek J, Power T, Marr CM, Wijnberg ID.Atrial fibrillation is a common equine arrhythmia. Quinidine alone, or with digoxin are common treatments. Studies on outcome in Warmblood populations in which duration of the AF is often unknown are limited. Objective: To identify the factors that are associated with the success of full treatment cardioversion with oral medication, and establish whether there are differences in these factors between institutions. Methods: Retrospective case series using patient records of Equine University Clinic of Utrecht University and Rossdales Equine Hospital, Newmarket. Methods: Forty-nine horses treate...
Flota-Burgos GJ, Rosado-Aguilar JA, Rojas-Becerril R, Rodríguez-Vivas RI, Trinidad-Martínez I.Gastrointestinal nematodes (GIN) are a major impediment to breeding and exploitation of horses. Traditional control of GIN has generated resistance to main anthelmintics, including ivermectin. An analysis of five ranches with a history of IVM use was done to determine the efficacy and resistance of GIN to IVM treatment in horses from the Mexican southeast. Predesigned questionnaires were applied to collect information on previous treatment protocols. The fecal egg count reduction test (FECRT) was applied to determine resistance. Before IVM application, a McMaster test was used to diagnose GIN ...
Divers TJ, Warner A, Vaala WE, Whitlock RH, Acland HA, Mansmann RA, Palmer JE.Eight foals, 2 to 5 days of age, with similar clinical signs and laboratory and pathologic findings, died from hepatic failure. The predominant clinical signs were depression and icterus. Abnormally high values were found for plasma ammonia content, aromatic-to-branch-chain amino acid ratio, total serum bilirubin content, gamma glutamyl transferase activity, alkaline phosphatase activity, and PCV; partial thromboplastin time and prothrombin time were prolonged. Some foals had high sorbitol dehydrogenase activity. These laboratory findings were suggestive of subacute hepatic disease and failure...
Wong DM, Vo DT, Alcott CJ, Peterson AD, Brockus CW, Hsu WH.Arginine vasopressin (AVP) has received increased attention in equine critical care but there is minimal information of AVP concentration in foals. The clinical usefulness of measuring AVP in ill foals depends on knowledge of age-related changes in AVP concentrations in healthy foals. Objective: Plasma AVP concentrations will be significantly different when measured from birth to 3 months of age in healthy foals. Methods: Thirteen healthy university-owned foals. Methods: Prospective, observational study. Blood was collected from healthy foals at birth and 3, 5, 7, 10, 14, 21, 28, 42, 56, and 8...
Huricha , Kawai M, Ninomiya S.In this study, we investigated suckling behavior and the distance between a foal and its mare as indicators of foal growth in Hokkaido native horses (HKD) during the first 40 days of life. Direct observations were made of 22 mare and foal pairs from two consecutive days 1 and 2, 5 and 6, 10 and 11, 20 and 21, 30 and 31, and 40 and 41 after birth by focal animal sampling for 3 h per day. Suckling behavior was continuously recorded, along with the terminator. The distance between the foal and its mare was determined using the instantaneous sampling method (1 min), and the percentage was calc...
Guimarães T, Miranda C, Pinto M, Silva E, Damásio L, Costa AL, Correia MJ, Duarte JC, Cosinha C, Lopes G, Thompson G, Rocha A.A possible role of breeding activities in the composition of the microbial population in stallions' external genitalia (EG) and the relationship between micro-organisms colonizing the skin of the abdomen and the ones colonizing the EG have not been studied. In experiment 1, EG microbiological samples were collected from 41 stallions used for both natural cover and semen collection (BST) and from 18 non-breeding stallions (NBST). A higher (p < 0.05) frequency of isolation of potentially pathogenic species was found for BST. Age did not influence number of micro-organism species isolated both in...
Harris P, Geor RJ.The feeding of "low carbohydrate" or "low glycemic" diets has been recommended for management of horses with metabolic and endocrine disorders in which insulin resistance is a component. A "low carbohydrate" diet is a misnomer, however, because horses require that a significant proportion of their daily ration comprises structural carbohydrates (fiber/forage) to maintain gut health and mental wellbeing. This article provides a detailed description of the different carbohydrates in equine feeds. It also reviews the terminology used to describe glucose and insulin responses to the ingestion of c...
Rauws AG, van Schothorst M, Frik JF.The protein binding, the plasma half-life and the residue depletion of sulfamonomethoxine (SMM) after intramuscular administration were investigated in pigs, horses and cattle. Protein binding was weakly concentration-dependent. The bound fraction in plasma in the therapeutic range amounted to approximately 45, 40 and 50% for pigs, horses and cattle respectively, and the plasma half-lives were approximately 5.1, 5.7 and 3.1 hours respectively. SMM levels were less than 1 mug/g in muscle tissue after 36, 20 and 12 hours in pigs, horses and cattle respectively. In the kidney SMM levels were not ...
Nguyen JS, Tran Y, Su SW, Nguyen HT.This paper is concerned with the design and development of a semi-autonomous wheelchair system using cameras in a system configuration modeled on the vision system of a horse. This new camera configuration utilizes stereoscopic vision for 3-Dimensional (3D) depth perception and mapping ahead of the wheelchair, combined with a spherical camera system for 360-degrees of monocular vision. This unique combination allows for static components of an unknown environment to be mapped and any surrounding dynamic obstacles to be detected, during real-time autonomous navigation, minimizing blind-spots an...
Murray MJ, Ball MM, Parker GA.A 3-month-old foal with a history of persistent fever and leukocytosis was found to have pneumonia, ulceration of the squamous portion of the stomach, and dilatation of the distal portion of the esophagus. The foal was euthanatized and necropsied. The distal portion of the esophagus was severely dilated, and there was severe ulceration and mural thickening of the stomach at the cardia. Because of the severe gastric ulceration and mural thickening, the gastroesophageal junction was fixed in an open position, permitting gastroesophageal reflux. The megaesophagus and pneumonia were considered to ...
Knox DA, Ravis WR, Pedersoli WM, Spano JS, Nostrandt AC, Krista LM, Schumacher J.Six healthy mature horses were orally administered a single dose of phenobarbital (26 mg/kg of body weight), then multiple doses (13 mg/kg) orally for 42 consecutive days. Seventeen venous blood samples were collected from each horse after the single dose study and again after the last dose on day 42. Plasma phenobarbital concentration was determined by use of a fluorescence assay validated for horses. Additional blood samples (n = 11) were collected on days 8 and 25 to determine peak and trough concentrations, as well as total body clearance. Phenobarbital disposition followed a one-compartme...
Espino-Solis GP, Calderon-Amador J, Calderon-Aranda ES, Licea AF, Donis-Maturano L, Flores-Romo L, Possani LD.A three-dimensional model of the alphaX I-domain of the horse integrin CD11c from dendritic cells provided information for selecting two segments of the primary structure for peptide synthesis. Peptide 1 contains 20 amino acids and peptide 2 has 17 amino acid residues. The first spans from position Thr229 to Arg248 of an alpha-helix segment of the structure, whereas peptide 2 goes from Asp158 to Phe174 and corresponds to an exposed segment of the loop considered to be the metal ion-dependent adhesion site. Murine polyclonal antisera against both peptides were generated and assayed in periphera...
Elbourne M, Cawley A, Stanley S, Bowen C, Fu S.Equine urine analysis has evolved over time to detect thousands of urinary compounds for doping control in the horse racing industry. The longitudinal assessment of 3-methoxytyramine to tyramine ratio (3-MT/T) values in equine urine by GC-MS profiling was investigated to support the Racing NSW Equine Biological Passport (EBP) for detection of dopaminergic manipulation in racehorses. This involved comparison of routine urine samples to administration studies of Sinemet, a common Parkinson's disease medication containing levodopa. Using an endogenous reference compound (ERC) in a urinary ratio e...
Schott HC, Bohart GV, Eberhart SW.Efflux of potassium (K+) and lactate (lac-) from active skeletal muscle during high intensity exercise leads to increased plasma [K+] and [lac-] in venous and arterial blood. The exercise-induced increases in these ions in human athletes is ameliorated, in part, by uptake by noncontracting tissue, reflected by an increase in the arteriovenous difference across these tissues from rest to exercise. To test the hypothesis that these ions are taken up by noncontracting tissue in strenuously exercising horses, plasma [K+] and [lac-] were measured in blood samples collected simultaneously from the c...
Kenny DE, Dugan SJ, Knightly F, Baier J.A 11.5-yr-old female Przewalski's wild horse (Equus caballus przewalskii) presented for unilateral blepharitis and drainage from the left eye. The left cornea was not ulcerated, and intraocular evaluation was hampered by severe corneal edema. The left eye appeared to respond positively to treatment with anti-inflammatories and a topical mydriatic agent. During the ensuing 2 yr, there were minor episodes of epiphora from the left eye. The discharge then increased, and a luxated lens was noted during an examination by a veterinary ophthalmologist as part of the preshipment examination. Initially...
