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Topic:Veterinary Medicine
Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Allergen-specific ELISA for horse IgE. An enzyme-linked immuno sorbent assay (ELISA) for measuring horse IgE specific to ovalbumin, bencylpenicilloic acid and odinitrocarboxyphenol is described. We used a sandwich type of ELISA by which horse serum was incubated in antigen-coated tubes containing one additional polystyrene ball, followed by rabbit anti horse IgE serum. The tubes were then incubated with biotinylated goat anti rabbit globulin followed by avidin coupled to phosphatase. Endpoint titrations were compared. The ELISA is highly reproducible due to the pretreatment of the polystyrene with glutaraldehyde. The increased anti...
Chronic obstructive pulmonary disease in the horse. 1: Nature of the disease. The aetiology, pathophysiological changes, pathology and clinical signs of the disease as presently understood are discussed. The condition appears to be a hypersensitivity of the respiratory system in some horses to poor quality hay and straw. Micropolyspora faeni is the chief agent identified in the northern part of the United Kingdom. In other locations, the chief agent is probably different. The principal changes are spasm of the airways and bronchiolitis of the small airways. Onset may be acute or insidious. The chief clinical signs are well known but the disease process is reversible if ...
Plasma cortisol and beta-endorphin in horses subjected to electro-acupuncture for cutaneous analgesia. Electro-acupuncture (EA) treatment of horses to induce cutaneous analgesia also increased plasma concentrations of beta-endorphin (beta-EP) and cortisol. The magnitude of these increases did not relate consistently to the degree of EA-induced analgesia. Respiration and heart rates were also markedly increased during EA treatment. Intact female horses had higher packed cell volume and plasma beta-EP as well as lower plasma total protein than castrated male horses. Plasma cortisol, heart rate, and respiration rate did not differ significantly between sexes. None of the parameters measured before...
A clinical and experimental study of tendon injury, healing and treatment in the horse. This project was carried out over a five year period (1977 to 1981 inclusive) at the University of Bristol following discussion between the British Veterinary Association and the Royal College of Veterinary Surgeons about the efficacy of, and ethical justification for, the practice of 'firing' (cautery). These discussions had been promoted by parliamentary questions but led to no firm conclusions because previously reported clinical investigations on specific treatments lacked adequate comparisons and controls and thus did not provide scientifically acceptable, statistically valid data. The pr...
The pathology of experimental Corynebacterium equi infection in foals following intragastric challenge. The intragastric inoculation of a suspension of Corynebacterium equi on five consecutive days induced severe ulcerative colitis, typhlitis, and lymphadenitis of colonic and cecal nodes in two ponies necropsied three weeks after infection. No gross lesions were observed in two ponies necropsied ten days after infection. A single inoculum of equivalent size failed to induce gross lesions in four ponies killed at ten or 20 days after infection. Microscopic lesions consistent with early C. equi infection of Peyer's patches were seen in two of the ponies killed ten days after infection. Only one sm...
Studies related to the metabolism of anabolic steroids in the horse: the metabolism of 1-dehydrotestosterone and the use of fast atom bombardment mass spectrometry in the identification of steroid conjugates. The metabolism and urinary excretion of 1,2(n)-3H-1-dehydrotestosterone were studied in cross-bred gelded horses. Approximately 40% of the dose was excreted in 24 h. The steroid metabolites were extracted by Amberlite XAD-2 resin and fractionated into glucuronides and sulphoconjugates. Unchanged 1-dehydrotestosterone was the only component identified by gas chromatography mass spectrometry after solvolysis of the sulphoconjugates. Positive and negative ion fast atom bombardment mass spectra were obtained on the purified 1-dehydrotestosterone sulphoconjugate isolated from horse urine and on the...
Warfarin: a review with emphasis on its use in the horse. Warfarin or dicoumarol prevents the production of functional clotting factors II, VII, IX and X. Navicular disease and thrombophlebitis are examples of equine thrombotic diseases in which warfarin has been used therapeutically. The initiation of anticoagulant therapy is relatively simple but attending veterinarians must be aware of the potential risks in order to minimize them. These risks include epistaxis, bleeding into the gastrointestinal tract and at the venipuncture site, and increased susceptibility to hematoma formation following local trauma. Vitamin K, especially vitamin K(1) is a sw...
A collaborative assay of mycoplasma reference antisera. A total of 29 Mycoplasma and Acholeplasma antiserum reagents produced in mules and horses by the Baltimore Biological Laboratory and by Huntingdon Research Centre, under the auspices of National Institutes of Health, Bethesda, USA, were tested for potency and specificity, by a great variety of serological techniques, at the FAO/WHO Collaborating centre for Animal Mycoplasmas, University of Aarhus, Denmark. Subsequently, the antisera were subjected to a collaborative assay in which 20 workers from 15 different laboratories participated under the auspices of the International Research Programme ...
Radioimmunological measurement of beta-endorphin in equine plasma. Radioimmunoassay procedures were developed and validated for the quantification of beta-endorphin (beta-EP)-like immunoreactivity in equine plasma. beta-EP could be quantitatively extracted from plasma with silicic acid powder and subsequently assayed, however, valid estimates of this hormone could also be obtained on unextracted plasma. Although beta-lipotropin (beta-LPH) cross-reacted in the assay, it was not necessary to correct for beta-LPH activity when assaying unextracted plasma because chromatographic analyses showed that 92% of the immunoreactivity in plasma extracts was similar in mo...
Evaluation of quantitative bacterial counts as an aid in the treatment of wounds in the horse. Bacterial quantification was evaluated in 15 cases as a means of wound assessment. This study suggests that bacterial quantification may be used as an aid in the evaluation of treatment procedures and wound preparation in veterinary surgery.
Contagious equine metritis: distribution of organisms in experimental infection of mares. After contagious equine metritis bacteria were inoculated into the uterus of mares, genital tract tissues were examined for presence of the organism by bacteriologic cultural technique and an indirect immunofluorescent staining technique. Up to 14 days after mares were inoculated, the organism was frequently in the lumen of the uterus and in the cervix and, less frequently, in the vagina, vestibule, clitoral fossa, clitoral sinus, and uterine tubes. After 21 to 116 days, the organism was occasionally found on the ovarian surface, in the uterine tubes, uterus, cervix, and vagina and more freque...
Attempts at surgical correction of unusual colonic fistulae in the horse. Two incidents of penetrating wounds into the abdominal cavity of horses are presented. In both events these had resulted in penetraton of the intestinal tract. Both animals had received only minimal veterinary attention in the acute stage and had survived with the formation of intestinal fistulae.Attempts at surgical repair resulted in failure in one animal and in closure of the fistula in the second with some subsequent cosmetic defect.
Traumatic patella fractures in the horse. Six cases of patella fractures are reported. Three horses presented an avulsion fracture of the medial patellar angle. For a precise diagnosis of this fracture a radiographic skyline view was indispensable; lateral views were not diagnostic. One of these horses recovered after three months' rest but radiographically the fracture remained visible. One horse with a comminuted fracture recovered after five months' rest. A case with a contaminated longitudinal patella fracture was destroyed. The sixth horse had a chip fracture of the dorsomedial part of the patella. The outcome of this case is unk...
Attempted reconstitution of a foal with primary severe combined immunodeficiency. A foal with primary severe combined immunodeficiency, diagnosed within the first two weeks of life, was maintained with its dam in semi-isolation. The foal received continuous prophylactic antibiotic therapy, plasma from a sibling hyperimmunised with equine adenovirus vaccine, and intensive general nursing care. A full sibling female was selected as a bone marrow donor on the basis of red blood cell cross-matching and mixed lymphocyte reactions. Cyclophosphamide was given before two bone marrow transfusions at 35 and 73 days of age. To prevent graft versus host disease graft versus host diseas...
The effects of stanozolol and boldenone undecylenate on scrotal width, testis weight, and sperm production in pony stallions. Fifty mature pony stallions were randomly assigned to one of five treatment groups: Group 1- controls (no treatment), Group 2 - 0.55 mg/kg stanozolol weekly for 13 treatments, Group 3 - 1.1 mg/kg stanozolol every 3 weeks for 5 treatments, Group 4 - 1.1 mg/kg boldenone undecylenate every 3 weeks for 5 treatments, and Group 5 - 0.55 mg/kg boldenone undecylenate weekly for 13 treatments. Scrotal widths (SW), combined testis weights (CTW), and daily sperm productions (DSP) were not different between Groups 1 and 2. Ponies in Group 5 had smaller SW (P<0.01), smaller CTW and decreased DSP compare...
Staphylococcus hyicus in skin lesions of horses. Staphylococcus hyicus (subspecies hyicus) was isolated as the only pathogenic organism from two independent cases of dermatitis of the lower parts of the limbs (grease heel) in horses. The organism was recovered together with other pathogenic staphylococci from similar conditions in two other horses of different origins. These conditions were characterised by epidermolysis, alopecia and crust formation. They responded quickly to antibiotic treatment. The organism was also isolated from a long standing case of "summer eczema" which healed without antibiotic treatment, and from a horse with derm...
Apical fractures of the proximal sesamoid bones in 109 Standardbred horses. One-hundred and nine apical fractures of the proximal sesamoid bones were diagnosed in Standardbred racehorses at the Ohio State University Veterinary Hospital during a 5-year period ending December 1978. Lateral sesamoids of the hindlimbs accounted for 61 of the 109 fractures, which was a significantly (P less than 0.05) greater proportion than that for fractures in all other sesamoid bones. Two- and three-year-old horses accounted for 73 of the 109 apical sesamoid fractures. The remaining 36 apical sesamoid fractures were in horses 4 to 9 years old. The apical fragment was removed in 80 of t...
Chemical restraint of wild horses: effects on reproduction and social structure. Twenty-three (9 male, 14 female) wild horses (Equus caballus) in the Great Basin Desert were immobilized by ground techniques with succinylcholine chloride during 1,950 person-hr. Induction (means = 2.09 +/- 0.59 min) and recovery (means = 12.4 +/- 5.0 min) were rapid and most animals were returned in less than 10 min to original bands. Dosages ranged from 0.66-0.77 mg/kg body weight and neither abortions nor band changes in group membership resulted. However, a few concerted efforts up to 24 hr were needed to return some animals to original bands and three non-drug related mortalities occurre...
Chronic obstructive pulmonary disease in the horse. 2: Therapy. The therapy of equine chronic obstructive pulmonary disease (COPD) essentially entails minimising the horse's exposure to the aetiological antigens which are predominantly thermophilic actinomycetes and moulds occurring in hay and straw. This can be achieved, for example, by keeping affected horses permanently out of doors, or when stabled, using shredded paper, wood shavings or peat moss as bedding and feeding a complete cubed diet. There should be no supplementary hay feeding apart from dust-free vacuum-packed hay. Applying such measures generally allows horses to become asymptomatic in seve...
Copper and zinc levels in the blood of thoroughbreds in training in the United Kingdom. The concentration of copper and zinc in the blood and sera of over 300 Thoroughbreds in training was determined by atomic absorption between February 1979 and July 1981. The mean (+/- sd) concentration of copper in the serum of stabled Thoroughbreds (79 +/- 16 micrograms/dl) was significantly (P less than 0.0001) lower than that of those at grass (101 +/- 26 micrograms/dl), whereas the mean serum zinc concentration of stabled Thoroughbreds (170 +/- 54 micrograms/dl) was higher than that of those at grass (111 +/- 45 micrograms/dl). No such differences were observed in whole blood. There were m...
Successful bacterin therapy in a case of chronic equine staphylococcal infection. A Staphylococcus aureus infection in a mature horse, resulting from trauma, is described, which proved refractory to antibiotic therapy directed by the results of antibiotic sensitivity testing. After a prolonged course, rapid resolution of the infection was achieved with the administration of an autogenous formalized bacterin.
Sweet itch: responses of clinically normal and affected horses to intradermal challenge with extracts of biting insects. In a study of the skin reactivity of horses with lesions of sweet itch, six clinically normal horses and seven affected horses were challenged intradermally with extracts of Culicoides, Stomoxys, Tabanidae and Culex species. All the affected horses and three of the normal horses responded strongly to the culicoides extract. The skin reactions in the affected horses reached their maxima within 4 h in the majority of animals. Skin reactivity to culicoides was transferred to normal horses with serum from affected animals confirming that the reaction was an immediate hypersensitivity reaction. Thr...
