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Topic:Veterinary Medicine

Veterinary medicine for horses encompasses the study and application of medical practices to diagnose, treat, and prevent diseases in equine species. This field involves a comprehensive understanding of equine anatomy, physiology, pathology, and pharmacology. Veterinary practitioners employ a range of diagnostic tools and therapeutic interventions to address health issues in horses, including lameness, gastrointestinal disorders, respiratory conditions, and infectious diseases. Preventative care, such as vaccination and deworming programs, is also a significant aspect of equine veterinary medicine. This page gathers peer-reviewed research studies and scholarly articles that explore various aspects of veterinary medicine as it pertains to horses, including advancements in diagnostic techniques, treatment protocols, and preventive health strategies.
Acute lead intoxication in a pregnant mare.
Journal of the South African Veterinary Association    August 6, 2008   Volume 79, Issue 1 50-53 doi: 10.4102/jsava.v79i1.242
Kruger K, Saulez MN, Neser JA, Solberg K.Lead (Pb) intoxication in horses is usually a chronic phenomenon with clinical signs associated with central nervous dysfunction. This report gives details of a case of acute Pb intoxication in a 9-year-old American Saddlebred mare with severe, progressive and ultimately fatal neurological deterioration. During the 4 days of hospitalisation, clinical signs progressed from intermittent headshaking and depression to severe, continuous, uncontrollable manic behaviour. At autopsy, three grey-coloured, hard metal particles were present in the gastrointestinal tract and subsequently found to contain...
Blood glucose concentrations in critically ill neonatal foals.
Journal of veterinary internal medicine    August 6, 2008   Volume 22, Issue 5 1223-1227 doi: 10.1111/j.1939-1676.2008.0174.x
Hollis AR, Furr MO, Magdesian KG, Axon JE, Ludlow V, Boston RC, Corley KT.Critical illness is associated with hyperglycemia in humans, and a greater degree and duration of hyperglycemia is associated with nonsurvival. Hypoglycemia is also seen in critically ill humans, and is associated with nonsurvival. This might also be true in the critically ill foal. Objective: To investigate the association of blood glucose concentrations with survival, sepsis, and the systemic inflammatory response syndrome (SIRS). Methods: Blood glucose concentrations at admission (515 foals) and 24 hours (159 foals), 36 hours (95), 48 hours (82), and 60 hours (45) after admission were analy...
In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis.
Equine veterinary journal    August 6, 2008   Volume 40, Issue 5 468-472 doi: 10.2746/042516408X322111
Horohov DW, Breathnach CC, Sturgill TL, Rashid C, Stiltner JL, Strong D, Nieman N, Holland RE.While immune modulators are used routinely in equine medicine, their mechanism of action is not always known. Objective: To determine the effect of a commercial preparation of inactivated parapoxvirus ovis (Orf virus; PPVO) on cytokine gene expression by equine peripheral blood mononuclear cells (PBMC) both in vitro and in vivo. Methods: PBMC were prepared from 6 mixed-breed yearlings and cultured in vitro with PPVO with or without Concanavalin A (Con A) for 24 h. Effects on the expression of IFNalpha, IFNbeta IFNgamma, TNFalpha and IL-18 were analysed by real time quantitative PCR (RT-PCR). I...
Plasma vasopressin concentrations in healthy foals from birth to 3 months of age.
Journal of veterinary internal medicine    August 6, 2008   Volume 22, Issue 5 1259-1261 doi: 10.1111/j.1939-1676.2008.0165.x
Wong DM, Vo DT, Alcott CJ, Peterson AD, Brockus CW, Hsu WH.Arginine vasopressin (AVP) has received increased attention in equine critical care but there is minimal information of AVP concentration in foals. The clinical usefulness of measuring AVP in ill foals depends on knowledge of age-related changes in AVP concentrations in healthy foals. Objective: Plasma AVP concentrations will be significantly different when measured from birth to 3 months of age in healthy foals. Methods: Thirteen healthy university-owned foals. Methods: Prospective, observational study. Blood was collected from healthy foals at birth and 3, 5, 7, 10, 14, 21, 28, 42, 56, and 8...
Oestrogens in faeces as an indicator of the foeto-placental unit function in mares. Janowski T, Skolimowska A, Zdunczyk S, Baranski W.Total of 30 pregnant mares were used in this study: 17 Thoroughbred and 13 Primitive Polish Horse. The concentration of total unconjugated oestrogens was determined by radioimmunoassay in faecal samples obtained every second week after mating until delivery or interruption of pregnancy. Concentration of oestrogens in pregnant healthy mares ranged from 40 to 200 ng/g and showed typical profiles for pregnancy. In 5 of 30 mares (16.6%) of either breed abortions and cases of embryonic death occurred. Abortions were preceded by sharp or gradual decrease in oestrogen concentration, whereas prior to ...
Detection of equine herpesvirus-1 in nasal swabs of horses by quantitative real-time PCR.
Journal of veterinary internal medicine    August 6, 2008   Volume 22, Issue 5 1234-1238 doi: 10.1111/j.1939-1676.2008.0172.x
Perkins GA, Goodman LB, Dubovi EJ, Kim SG, Osterrieder N.Early identification of inhalation-transmitted equine herpesvirus type 1 (EHV-1) infections has been facilitated by the availability of a number of real-time quantitative PCR (qPCR) tests. A direct comparison between nasal swab qPCR and traditional virus isolation (VI) requires a method for normalizing the qPCR samples and controlling for PCR inhibitors present in some clinical samples. Objective: To quantify EHV-1 shedding in viral swabs using an internal control and to compare fast qPCR to VI for the detection of EHV-1 in nasal swabs from horses. Methods: Fifteen horses experimentally infect...
Glycogen synthase 1 (GYS1) mutation in diverse breeds with polysaccharide storage myopathy.
Journal of veterinary internal medicine    August 6, 2008   Volume 22, Issue 5 1228-1233 doi: 10.1111/j.1939-1676.2008.0167.x
McCue ME, Valberg SJ, Lucio M, Mickelson JR.A missense mutation in the GYS1 gene was recently described in horses with polysaccharide storage myopathy (PSSM). Objective: The first objective was to determine the prevalence of the GYS1 mutation in horses with PSSM from diverse breeds. The second objective was to determine if the prevalence of the GYS1 mutation differed between horses diagnosed with PSSM based on grade 1 (typically amylase-sensitive) or grade 2 (typically amylase-resistant) polysaccharide. Methods: Eight hundred and thirty-one PSSM horses from 36 breeds. Methods: Horses with PSSM diagnosed by histopathology of skeletal mus...
The use of electrochemically activated saline as a uterine instillation in pony mares.
Journal of the South African Veterinary Association    August 6, 2008   Volume 79, Issue 1 36-38 doi: 10.4102/jsava.v79i1.238
Annandale CH, Schulman ML, Kirkpatrick RD.Twelve pony mares were randomly assigned to either a control or a treatment group and inseminated with fresh, raw semen from a single stallion of known fertility in a cross-over trial design. Pregnancy was diagnosed by transrectal ultrasound 12-14 days post-ovulation and then terminated by administration of a luteolytic dose of cloprostenol. Treatment mares received a uterine instillation of 100 ml of electrochemically activated (ECA) saline 4-12 hours post-insemination. Control mares received no treatment post-insemination. Per cycle pregnancy rate was 58.3 % in the control group and 50 % in ...
Propylthiouracil for treatment of hyperthyroidism in a horse.
Journal of veterinary internal medicine    August 6, 2008   Volume 22, Issue 5 1253-1258 doi: 10.1111/j.1939-1676.2008.0169.x
Tan RH, Davies SE, Crisman MV, Coyle L, Daniel GB.No abstract available
Use of intralesional formalin administration for treatment of a subepiglottic cyst in a horse.
Journal of the American Veterinary Medical Association    August 5, 2008   Volume 233, Issue 3 463-465 doi: 10.2460/javma.233.3.463
Dougherty SS, Palmer JL.A 4-year-old horse was evaluated for chronic coughing, mucopurulent nasal discharge, and failure to thrive. Results: Endoscopy was performed on the larynx, pharynx, and trachea and revealed an approximately 2-cm fluctuant subepiglottic cyst. Results: The subepiglottic cyst was treated with intralesional formalin administration. Following 2 injections, 2 weeks apart, the cyst was completely resolved with no evidence of scarring or epiglottic deformity. Conclusions: Findings suggest that intralesional formalin administration for treatment of subepiglottic cysts may be a minimally invasive, econo...
Effect of dexamethasone supplementation on chondrogenesis of equine mesenchymal stem cells.
American journal of veterinary research    August 5, 2008   Volume 69, Issue 8 1013-1021 doi: 10.2460/ajvr.69.8.1013
Stewart AA, Byron CR, Pondenis HC, Stewart MC.To determine whether expansion of equine mesenchymal stem cells (MSCs) by use of fibroblast growth factor-2 (FGF-2) prior to supplementation with dexamethasone during the chondrogenic pellet culture phase would increase chondrocytic matrix markers without stimulating a hypertrophic chondrocytic phenotype. Methods: MSCs obtained from 5 young horses. Methods: First-passage equine monolayer MSCs were supplemented with medium containing FGF-2 (0 or 100 ng/mL). Confluent MSCs were transferred to pellet cultures and maintained in chondrogenic medium containing 0 or 10(7)M dexamethasone. Pellets were...
Cardiac output determination by use of lithium dilution during exercise in horses.
American journal of veterinary research    August 5, 2008   Volume 69, Issue 8 1054-1060 doi: 10.2460/ajvr.69.8.1054
Durando MM, Corley KT, Boston RC, Birks EK.To compare cardiac output (CO) obtained by the lithium dilution method (LiDCO) with CO calculated from the Fick principle (FickCO), in horses maximally exercising on a high-speed treadmill. Methods: 13 Thoroughbreds. Methods: In part 1 of the study, 5 horses performed a warm-up (walk, trot, and canter) and exercise test (walk, trot, canter, and gallop [90% to 100% maximum oxygen consumption [{VO(2)max}]) with measurements of LiDCO and FickCO obtained simultaneously after 60 seconds at each exercise level, for a total of 7 measurements. In part 2 of the study, 8 horses performed a warm-up (walk...
Epidemiological survey on farms with documented occurrence of equine proliferative enteropathy due to Lawsonia intracellularis.
The Veterinary record    August 5, 2008   Volume 163, Issue 5 156-158 doi: 10.1136/vr.163.5.156
Pusterla N, Higgins JC, Smith P, Mapes S, Gebhart C.No abstract available
Erythrocytosis and pleural effusion associated with a hepatoblastoma in a Thoroughbred yearling.
Australian veterinary journal    August 5, 2008   Volume 86, Issue 8 329-333 doi: 10.1111/j.1751-0813.2008.00299.x
Axon JE, Russell CM, Begg AP, Adkins AR.A 10-month-old Thoroughbred filly was presented with a 2-month history of recurrent fever and pleural effusion. Major clinical findings were pyrexia and congested mucous membranes. Clinical pathology tests revealed an erythrocytosis, hyperfibrinogenaemia and hyperglobulinaemia. Pleural fluid was seen on ultrasonographic examination of the thorax and analysis of a thoracocentesis sample indicated a lymphocytic, modified transudate. A transtracheal aspirate was normal. The erythrocytosis persisted despite IV fluid therapy. Arterial blood gas analysis and bone marrow aspirate were normal. These f...
Equine metabolic syndrome and Cushing’s disease clinical trial.
The Veterinary record    August 5, 2008   Volume 163, Issue 5 164 doi: 10.1136/vr.163.5.164-c
Eustace R.No abstract available
Cutaneous pythiosis in a nontravelled California horse.
Veterinary dermatology    August 5, 2008   Volume 19, Issue 6 391-394 doi: 10.1111/j.1365-3164.2008.00690.x
White SD, Ghoddusi M, Grooters AM, Jones K.An 18-year-old Arabian mare was examined with a large mass on the left hind pastern and fetlock. The mare was located in the Central Valley of northern California, and had never been out of the state. Routine histopathological processing and examination of biopsy samples from the mass showed several hyphal organisms that were delineated with a silver stain. Using immunohistochemistry the organism was diagnosed as Pythium insidiosum. The owner declined debulking surgery, and despite treatment with an immunotherapeutic vaccine, the horse's condition deteriorated leading to euthanasia.
Welfare standards in livery yards.
The Veterinary record    August 5, 2008   Volume 163, Issue 5 164 doi: 10.1136/vr.163.5.164
House C.No abstract available
[Genetics of recurrent airway obstruction (RAO)].
DTW. Deutsche tierarztliche Wochenschrift    August 5, 2008   Volume 115, Issue 7 271-275 
Gerber V, Swinburne JE, Blott SC, Nussbaumer P, Ramseyer A, Klukowska-Rötzler J, Dolf G, Marti E, Burger D, Leeb T.Recurrent airway obstruction (RAO) is a multifactorial and polygenic disease. Affected horses are typically 7 years of age or older and show exercise intolerance, increased breathing effort, coughing, airway neutrophilia, mucus accumulation and hyperreactivity as well as cholinergic bronchospasm. The environmental factors responsible are predominantly allergens and irritants in haydust, but the immunological mechanisms underlying RAO are still unclear. Several studies have demonstrated a familiar predisposition for RAO and it is now proven that the disease has a genetic basis. In offspring, th...
Lawsonia intracellularis infection in horses: 2005-2007.
Journal of veterinary internal medicine    August 4, 2008   Volume 22, Issue 5 1243-1248 doi: 10.1111/j.1939-1676.2008.0160.x
Frazer ML.Lawsonia intracellularis is an emerging equine pathogen that is a cause of equine proliferative enteropathy (EPE). Objective: To describe the signalment, month of presentation, common clinical signs, clinicopathologic values, diagnostic tests used, antimicrobial use, and survival status in horses affected with EPE; to evaluate how affected horses sold at public auction as yearlings; and to determine results of fecal polymerase chain reaction (PCR) and serum immunoperoxidase monolayer assay (IPMA) results in age matched, clinically normal herdmates. Methods: The study group was 57 horses treate...
Brainstem auditory-evoked responses in horses with temporohyoid osteoarthropathy.
Journal of veterinary internal medicine    August 4, 2008   Volume 22, Issue 5 1196-1202 doi: 10.1111/j.1939-1676.2008.0158.x
Aleman M, Puchalski SM, Williams DC, Kass PH, Holliday TA.Facial and vestibulocochlear nerve dysfunction occurs commonly in horses with temporohyoid osteoarthropathy (THO); however, auditory dysfunction has not been thoroughly assessed. Objective: To determine if auditory abnormalities occur in horses with THO. Methods: Eleven diseased and 8 control horses. Methods: This is a prospective study in which brainstem auditory-evoked responses (BAER) were recorded in 11 horses diagnosed with THO through neurologic, endoscopic, radiographic, or computed tomographic examinations. BAER findings were compared with those recorded from 8 adult control horses. Re...
Plasma levels of zinc, copper, copper/zinc ratio, and activity of carbonic anhydrase in equine piroplasmosis.
Biological trace element research    August 3, 2008   Volume 125, Issue 1 41-45 doi: 10.1007/s12011-008-8136-5
Dede S, Değer Y, Değer S, Tanritanir P.We have determined the plasma concentrations of copper, zinc, copper/zinc ratio, and carbonic anhydrase activity in horses infected with Babesia equi. The study was conducted in 14 horses with the disease and 10 healthy animals that served as controls. The infection was confirmed by the clinical manifestations of the disease and by Giemsa staining of thin blood smears showing the parasites inside red blood cells. The horses with piroplasmosis had lower plasma levels of zinc, elevated copper, and increased activity of carbonic anhydrase. Consequently, the copper/zinc ratio was also higher than ...
Evaluation of the pathogenicity of African Horsesickness (AHS) isolates in vaccinated animals.
Vaccine    August 3, 2008   Volume 26, Issue 39 5014-5021 doi: 10.1016/j.vaccine.2008.07.037
von Teichman BF, Smit TK.The polyvalent African Horsesickness (AHS) attenuated live vaccine (ALV) produced by Onderstepoort Biological Products (OBP) Ltd., South Africa, has been associated with some safety concerns and alleged cases of vaccine failure or vaccine-induced disease. The risk of reassortment and reversion to virulence is a common concern associated with the use of ALVs, and a phenomenon reported for viruses with segmented RNA genomes. The purpose of this study was to determine whether or not reassortment of AHS vaccine strains could result in reassortants and reversion to virulence and therefore cause AHS...
Equine herpesvirus infections in yearlings in South-East Queensland.
Archives of virology    August 3, 2008   Volume 153, Issue 9 1643-1649 doi: 10.1007/s00705-008-0158-y
Diallo IS, Hewitson GR, de Jong A, Kelly MA, Wright DJ, Corney BG, Rodwell BJ.Twelve nasal swabs were collected from yearling horses with respiratory distress and tested for equid herpesvirus 1 (EHV-1) and equid herpesvirus 4 (EHV-4) by real-time PCR targeting the glycoprotein B gene. All samples were negative for EHV-1; however, 3 were positive for EHV-4. When these samples were tested for EHV-2 and EHV-5 by PCR, all samples were negative for EHV-2 and 11 were positive for EHV-5. All three samples that were positive for EHV-4 were also positive for EHV-5. These three samples gave a limited CPE in ED cells reminiscent of EHV-4 CPE. EHV-4 CPE was obvious after 3 days and...
Denatured virion protein 1 of equine rhinitis B virus 1 contains authentic B-cell epitopes recognised in an enzyme-linked immunosorbent assay–short communication.
Acta veterinaria Hungarica    August 2, 2008   Volume 56, Issue 2 265-270 doi: 10.1556/AVet.56.2008.2.14
Kriegshäuser G, Cullinane A, Kuechler E, Skern T.Equine rhinitis B virus 1 (ERBV1), genus Erbovirus, family Picornaviridae, is a pathogen of horses which causes clinical and subclinical infection of the upper respiratory tract in horses. The virus is widespread in European horse populations and the current standard method for the detection of antibody against ERBV1 is by virus neutralisation (VN). VN tests, however, are labour-intensive and time-consuming, require tissue culture facilities, and generally do not provide same-day results. In this study, a protocol for the high-level expression and purification of recombinant virion protein 1 (...
Characterisation of pulses of 13,14-dihydro-15-keto-PGF2alpha (PGFM) and relationships between PGFM pulses and luteal blood flow before, during, and after luteolysis in mares.
Reproduction, fertility, and development    August 2, 2008   Volume 20, Issue 6 684-693 doi: 10.1071/rd08077
Ginther OJ, Rodrigues BL, Ferreira JC, Araujo RR, Beg MA.Blood collections for characterising 13,14-dihydro-15-keto-PGF2alpha (PGFM) pulses in mares and colour-Doppler examinations for estimating percentage of corpus luteum with blood-flow signals were done hourly for a 24-h session on Day 15 (ovulation = Day 0; n = 13 mares) or during 12-h sessions from Days 12 to 16 (n= 10 mares). Luteolysis was defined as extending from the beginning of a precipitous decrease in progesterone until progesterone was <2 ng mL(-1). Comparisons were made among preluteolysis, luteolysis, and postluteolysis. Greater prostaglandin F2alpha activity (mean PGFM concentra...
Building on the achievements of clinical research.
Equine veterinary journal    August 2, 2008   Volume 40, Issue 4 299-300 doi: 10.2746/042516408X302519
Pinchbeck GL, Proudman CJ.No abstract available
Complications and survival associated with surgical compared with medical management of horses with duodenitis-proximal jejunitis.
Equine veterinary journal    August 2, 2008   Volume 40, Issue 4 373-378 doi: 10.2746/042516408X302492
Underwood C, Southwood LL, McKeown LP, Knight D.Based on clinical observation, it is hypothesised that horses with duodenitis-proximal jejunitis (DPJ) that are treated surgically have a shorter duration, smaller volume, and slower rate of nasogastric reflux (NGR) compared to horses treated medically, are more likely to develop diarrhoea than medically managed cases, and have a higher incisional infection rate than a sample population of horses undergoing abdominal exploration for gastrointestinal disease other than DPJ. Objective: To compare: 1) duration, volume and rate of NGR and the percentage of horses with diarrhoea between medically a...
Klebsiella oxytoca as a cause of equine abortion–short communication.
Acta veterinaria Hungarica    August 2, 2008   Volume 56, Issue 2 215-220 doi: 10.1556/AVet.56.2008.2.9
Szeredi L, Jánosi S, Tenk M.Klebsiella (K.) oxytoca infection induced the abortion of a female equine fetus in the 10th month of pregnancy. Bacteria were cultured from the liver, lung and stomach content. They were labelled with an anti-Mycobacterium bovis antibody in the thymus, liver and lungs and were stained with Giemsa and Brown-Brenn staining in the thymus and lung. The diffusely consolidated lungs contained numerous grey-whitish foci 2-4 mm in diameter, which corresponded to severe pyogranulomatous pneumonia characterised by numerous intraalveolar neutrophils and macrophages and multinucleated Langhans' giant cell...
Post operative ileus: to be or not to be?
Equine veterinary journal    August 2, 2008   Volume 40, Issue 4 295-296 doi: 10.2746/042516408X302537
Merritt AM, Blikslager AT.No abstract available
Post operative ileus (POI): another perspective.
Equine veterinary journal    August 2, 2008   Volume 40, Issue 4 297-298 doi: 10.2746/042516408X302528
Freeman DE.No abstract available