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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
The effect of neomycin on the kidney function of the horse. The toxic effect of neomycin on the horse kidney was studied. Twelve horses were used, and were divided at random into three groups of four. The first group was treated twice a day with 10 mg/kg I.M. for 15 days and then euthanised; kidney and liver samples were studied and no histopathological changes were observed. Group 2 was treated with neomycin sulphate as in group 1, and group 3 was used as control. Blood samples were taken at 8.00 h and 20.00 h daily from both neomycin treated and control horses. Serum creatinine, potassium, sodium and urinary creatinine remained without change. On day...
Intramuscular bioavailability of ketoprofen lysine salt in horses. Lysine salts are often used in human pharmaceuticals to increase the solubility and absorption of acidic drugs when these are administered parenterally. In this study the intramuscular bioavailability of ketoprofen administered as the lysine salt was evaluated in horses (n = 5) treated intravenously and intramuscularly (2.2 mg/kg active substance) in a cross-over study. The absorption rate of ketoprofen administered as the lysine salt was rather low: the mean residence time increased from 31.7 min after IV injection to 128.9 min (after IM injection), and the bioavailability was high (mean 92.4...
Prevalence of the virulence-associated gene of Rhodococcus equi in isolates from infected foals. The prevalence of the plasmid-encoded virulence-associated gene (vapA) of Rhodococcus equi, as determined by PCR, was found to be 98% in isolates from 154 foals with pneumonia, confirming the strong association of vapA with virulence. The vapA genes from 60 representative isolates were compared by digestion with the restriction endonuclease HinfI, and no evidence of sequence variation was detected.
Influence of type and breed of horse on serum osteocalcin concentration, and evaluation of the applicability of a bovine radioimmunoassay and a human immunoradiometric assay [corrected]. To evaluate applicability of a human osteocalcin (OC) immunoradiometric assay (IRMA) for use with equine serum and compare it with a bovine radioimmunoassay (RIA) previously proven valid for such samples, and to describe the effect of type and breed of horses on serum OC concentration. Methods: 100 healthy horses of either sex, classified as type I or II (draught or warmblood, respectively). Each type was represented by 2 breed groups, each comprising 25 horses. Methods: Blood samples were collected in the morning, and the serum was separated. Osteocalcin was measured, using commercially avail...
Effect of transportation on lower respiratory tract contamination and peripheral blood neutrophil function. To evaluate the effect of transportation on lower respiratory tract contamination and peripheral blood neutrophil function in horses and to compare results from transported horses with those obtained in earlier experiments from horses confined with heads elevated. Methods: A prospective study. Methods: Six horses were transported by road for 12 h. Clinical and haematological examination, transtracheal aspiration and cell function studies were conducted before and after transportation. Results obtained after transportation were compared to pre-transportation values. Results: After transportatio...
Prevalence of equine piroplasmosis in Central Mongolia. Antigen for the indirect fluorescent antibody test (IFAT) was routinely prepared from infected erythrocytes from horses experimentally infected with Babesia equi and Babesia caballi. With the successful establishment of in vitro cultures of B. equi and B. caballi, it is now possible to employ culture-derived antigens in this test. In this study, in vitro-propagated B. equi- and B. caballi-infected erythrocytes were used as antigen in the IFAT. Various modifications to an established protocol had to be implemented to allow repeatable results. Cultures with 3-4% parasitized erythrocytes were fou...
[Development of nutrition science in veterinary medicine as an example of the School of Veterinary Medicine Hannover]. Animal nutrition is not a main subject in veterinary medicine training, nevertheless it has been taught in the Tierärztliche Hochschule Hannover since its foundation in 1778. In the very beginning only a few lectures about feedstuffs and toxic plants for horses and feeding technique have been presented. During the 19th century animal nutrition was taught about 20 h under the general topic: Gesundheitspflege or Dlätetik. Diätetik included in that time all factors which are important for health as soil, water, climate, stable, hamess and nutrition, too. Textbooks about "Gesundheitspflege" fro...
Design complexity and fracture control in the equine hoof wall. Morphological and mechanical studies were conducted on samples of equine hoof wall to help elucidate the relationship between form and function of this complex, hierarchically organized structure. Morphological findings indicated a dependence of tubule size, shape and helical alignment of intermediate filaments (IFs) within the lamellae on the position through the wall thickness. The plane of the intertubular IFs changed from perpendicular to the tubule axis in the inner wall to almost parallel to the tubule axis in the outer wall. Morphological data predicted the existence of three crack dive...
Low-molecular-weight displacers for high-resolution protein separations. The resolving power of displacement chromatography using low-molecular-weight displacers was investigated using a model mixture containing bovine and horse heart cytochrome c. The linear and nonlinear adsorption behavior of these two proteins was examined in cation-exchange chromatography and shown to be quite similar. Furthermore, an analysis of the dynamic affinity of these proteins indicated extremely similar affinities under displacement conditions. Despite the extreme similarities in the adsorption behavior, displacement chromatography using a protected amino acid displacer resulted in ex...
Magnetic resonance imaging of the equine metacarpophalangeal joint: three-dimensional reconstruction and anatomic analysis. Magnetic resonance imaging was used to examine the equine metacarpophalangeal joint. Thirty-two saggital images generated by partial volume imaging were transferred to a computer for three-dimensional reconstruction and analysis. All the tissues constituting the metacarpophalangeal joint were readily identified. The most significant increase finding regarded the soft tissues on the palmar aspect of the metacarpophalangeal joint and their interactions with the proximal sesamoid bones. The equine metacarpophalangeal joint has not previously been evaluated using 3-dimensional imaging software.
Components of the total kinetic moment in jumping horses. Thirty horses were filmed with a panning camera operating at 50 frames/s as they jumped over a 1.20 x 1.20 m fence. The markers of 9 joints on the horse and 7 joints on the rider were tracked in 2D with the TrackEye system. The centre of gravity and moment of inertia of each segment were calculated using a geometric algorithm and a cylindric model, respectively. The kinetic moment of each part of the horse was calculated after filtering, and resampling of data. This method showed the relative contribution of each body segment to the body overall rotation during the take-off, jump and landing p...
Kinematics and kinetics of the carpus. This study investigated the kinematics and kinetics of the carpus during the stance phase. Five Standardbred horses trotted on a treadmill at 8.9 m/s. The kinematics of the horses were filmed and hoof reaction forces (HRF) were recorded. The carpus was overextended throughout most of the stance. There were 2 periods of overextension, a more rapid period in the beginning of the stance and second directly following the first period. Maximal overextension occurred slightly before the second minimum of the braking horizontal HRF. The metacarpal and antebrachial segments rotated counter-clockwise f...
Combined hepatocellular carcinoma and cholangiocarcinoma in a mare. A hepatic malignant tumour composed of both hepatocellular and cholangiocellular elements was studied histologically, immunohistochemically and electron microscopically in an 18-year-old Thoroughbred mare. Bile canaliculi and alpha-fetoprotein were useful in identifying the hepatocellular element, and mucin and keratin were good markers of biliary differentiation. The simultaneous presence of bile canaliculi and mucin-producing cells in most of the neoplastic lesions suggested that this tumour arose from a stem cell with capacity to differentiate into hepatocytes and biliary epithelium.
Modified carotid artery transposition for repetitive arterial blood gas sampling in large animals. A modified surgical procedure for creation of a carotid loop for repeated percutaneous sampling of arterial blood gas was performed on 8 Holstein heifers and 14 horses. This approach permitted sampling of blood gas via fine-needle aspiration (one to three times daily) and/or catheterization for extended periods. It offers several advantages over previously reported techniques, including greater accessibility, absence of postoperative complications such as hematoma formation, and absence of foreign materials supporting the loop.
Kinematics in horses at the trot before and after an induced forelimb supporting lameness. The aim of this study was to analyse the biokinematic alterations caused by an induced lameness in the right forelimb of Dutch Warmblood (DWB) horses using a system of computer-aided normal videography. Five mature DWB were recorded with a videocamera (frame rate 1/25) from a lateral view before and after an induced lameness. Before videotaping, passive markers were placed on the skin, over easily identifiable anatomical references to determine the joint angles in the forelimb (always on the flexor side). Lameness was induced using special horseshoes. The lameness was evident at the trot and m...
Comparison of three methods of ulnar fixation in horses. This study compares the mechanical properties of three methods of equine ulnar fixation: dynamic compression plating, pins and wires tension band, and a prototype grip system. Methods: The mechanical properties of dynamic compression plating, pins and wires tension band, and a prototype grip system repair of equine ulnar fractures were evaluated in a cadaveric osteotomy model. Methods: Fifteen pairs of the radius and ulna from equine cadavers. Methods: The three repair techniques were evaluated to mimic the pull of the triceps brachii muscle in single cycle to failure and in cyclic fatigue loa...
Evaluation of arginine-glycine-aspartate-containing peptides as inhibitors of equine platelet function. To determine whether synthetic peptides containing the arginine-glycine-aspartate (RGD) sequence inhibit equine platelet function. Methods: For in vitro studies of blood, 3 healthy Thoroughbreds; for in vivo and ex vivo studies of administration of RGD-containing peptides, 4 young adult pony mares. Methods: Blood was incubated with and without addition of aspirin or RGD-containing peptides (RGDS, RPR 110885) and platelet aggregation responses and platelet adhesion to subendothelial collagen were determined. RPR 110885 was administered IV, and platelet function was evaluated. Platelet aggregati...
A unique metabolite of nimesulide. Nimesulide is a nonsteroidal anti-inflammatory drug recently detected in equine blood and urine samples taken at the race track. The detection of the drug in a blood sample led to the identification of an unknown thin-layer chromatographic (TLC) spot in track urine samples as a metabolite of nimesulide. Characterization of the unknown TLC spot and comparison with the synthesized compound shows that the unknown TLC spot is a previously unreported equine metabolite of nimesulide. The metabolite was identified as resulting from the reduction of the nitro group on nimesulide to an amino group. Thi...
Noninvasive photoelastic method to show distribution of strain in the hoof wall of a living horse. A photoelastic method used for materials testing in industry was adapted to show the distribution of strain through the hoof wall in the living horse. Strain was a change in length per unit length in the material of the loaded hoof wall compared with the unloaded condition. Coloured fringes appeared in the photoelastic plastic where there were differences in strain between adjacent sites (strain gradients) in the hoof. Strain distribution was observed in the shod and unshod hoof wall of the front hooves of 6 sound horses with hooves that appeared 'good' to visual inspection, and one unsound ho...
Sperm head morphometry analysis of ejaculate and dismount stallion semen samples. The evaluation of seminal characteristics is important in the clinical detection of stallion subfertility. Conventional semen evaluation includes subjective determination of sperm concentration, motility, and gross morphology. Due to the subjectivity and variability of the manual morphology assessment, computer automated sperm morphology analyses has been developed. Computer automated sperm morphology analysis was applied in the current study to determine if the morphometric measurements of sperm heads from collected and dismount samples of the same ejaculate were similar. If the post-ejaculat...
A light microscopic and ultrastructural examination of calcified dental tissues of horses: 1. The occlusal surface and enamel thickness. Gross and microscopic examinations were undertaken on 46 cheek (molar and premolar) and 4 incisor equine teeth that were fractured, or sectioned either with a lathe or diamond saw. Specimens were examined without treatment, after decalcification or acid etching, utilising light, and scanning and transmission electron microscopy. In some horses, the occlusal surface of the teeth were covered with an organic pellicle. The occlusal surface of the underlying equine enamel contained different wear patterns, including polished areas, local fractures, wedge-shaped pits, striations and depressions. Oc...
Cardio-histopathological observations on aborted equine fetuses infected with equid herpesvirus 1 (EHV-1). Twenty-five aborted equine fetuses infected with equid herpesvirus 1 (EHV-1) were examined cardio-histopathologically. The main changes in the heart consisted of interstitial myocarditis and intramyocardial vascular lesions accompanied by degeneration and necrosis of the cardiac myocytes. Vascular pathology of intramyocardial small arteries and arterioles was characterized by endothelial cell necrosis and fibrinoid changes in the media. Eosinophilic intranuclear inclusion bodies characteristic of herpesvirus infection were detected in the myocardial cells and macrophages within and around the ...
Cloning of equine type II procollagen and the modulation of its expression in cultured equine articular chondrocytes. The complete nucleotide sequence of equine type II procollagen has not been previously reported, and equine-specific probes have not been available. We report the complete sequence and discuss the molecular characteristics of equine type II procollagen mRNA which was cloned from a cDNA library prepared from mRNA isolated from equine articular chondrocytes. The coding sequence (4257 bp) was 92.4% homologous to the cDNA of the human sequence, and the propeptide was 97% identical to the human sequence. We demonstrated that when equine chondrocytes are grown in phenotypically-maintained cultures, ...
Functional characterization of equine neutrophils in response to calcium ionophore A23187 and phorbol myristate acetate ex vivo. Equine neutrophils (PMN) play a critical role in inflammatory processes in horses. The objective of this study was to characterize equine PMN function ex vivo following stimulation with calcium ionophore A23187 (A23187) and phorbol myristate acetate (PMA). These stimulants trigger different branches of the PMN activation process that occurs in vivo. Equine PMN were isolated from the whole blood of six clinically normal geldings using a one-step discontinuous Percoll gradient technique. Neutrophil aggregation, degranulation, and superoxide anion production were evaluated in assay systems which ...
