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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Subclinical lumbar polyradiculopathy in multiple aged mammalian species. Lumbar polyradiculopathy, characterized by ballooning myelin sheaths was diagnosed in multiple aged mammalian species including two horses, a cow, a squirrel, a woodchuck, a rabbit, a guinea pig, a hamster, and a mouse. The lesion was subclinical, and considered an incidental, age-related finding.
Comparison of early conceptus mobility between mares and jennies. The caracteristics of early intrauterine mobility of the conceptus were compared between ponies (n = 9) and donkeys (n = 9). The extensive mobility of the early conceptus, previously reported for ponies and horses, was found in donkeys as well. There were no significant differences between donkeys and ponies in the characteristics or patterns of mobility. However, the mean day of fixation was approximately one day later (P<0.05) in donkeys (Day 15.6 +/- 0.3) than in ponies (Day 14.7 +/- 0.2).
The site of focal osteomyelitis lesions in foals. The long bone ends of foals with infectious disease were sawn into sagittal slabs, washed and inspected. Tissue suspected to be abnormal on the basis of change of colour and consistency was radiographed, and then decalcified and examined histologically. The exact site of 140 focal osteomyelitis lesions from 18 foals was determined. There were more lesions in the epiphysis than the metaphysis. Epiphyseal lesions were in specific sites within a given epiphysis, and in most epiphyses the lesions were at the site of thickest cartilage. Metaphyseal lesions in the metacarpal, metatarsal and distal r...
[Karyotypes of cattle (Bos taurus) and horses (Equus caballus) on the basis of synaptonemal complexes]. The cytogenetic study performed has shown that karyotyping of meiotic cells can be based on the synaptonemal complexes (SC) of spreading pachytene spermatocytes of bull and of horse. The horse SC karyotype has not been previously described. A comparison of the relative length of SC with metaphase chromosomes of bull and horse somatic cells has revealed the correspondence of the chromosome length in pachytene of meiosis and metaphase, which is in agreement with the data on house mouse and Chinese hamster. The method of spreading pachytene cells may be of great practical importance in studies of...
Establishment of equine T-lymphocyte cultures dependent on recombinant human interleukin-2. Long-term equine lymphocyte cultures were initiated and maintained in continuous culture with medium containing recombinant human interleukin-2. Cultures were successfully maintained with lectin activation signals and recombinant human interleukin-2 or with recombinant human interleukin-2 alone. All cell cultures that were characterized had a T-lymphocyte phenotype and had lectin-dependent or -independent cytotoxicity directed to various cell types. These findings demonstrate that long-term equine T-lymphocytes cultures can be initiated and maintained easily.
Recognition and management of disseminated intravascular coagulation in horses. This article reviews normal hemostasis in order to provide the reader with the basis for understanding the pathogenesis and manifestations (both clinical and laboratory) of disseminated intravascular coagulation (DIC) in horses. DIC is subsequently discussed. The diagnosis and treatment of DIC in horses are also described.
Examination of the horse with colic. The purpose of this detailed description of the clinical examination of the colic patient is to arrive at a specific diagnosis. However, this is hardly ever possible, but the practitioner should be in the position to establish the suspicion of an intestinal obstruction or to rule out its presence during the course of the development. Single clinical findings should not be interpreted in isolation but in relation to one another, so that a false diagnosis is not made. All clinical findings should be documented, so that when repeated examinations are carried out, findings can be compared with one...
Hemodynamic and respiratory responses in halothane-anesthetized horses exposed to positive end-expiratory pressure alone and with dobutamine. The influence of positive end-expiratory pressure (PEEP) on the alveolar-arterial O2 tension difference [P(A-a)O2], physiologic right-to-left shunt fraction, physiologic dead space-to-tidal volume ratio, and hemodynamic variables was studied in halothane-anesthetized horses maintained in dorsal recumbency during controlled ventilation. Dobutamine was used to minimize the adverse cardiovascular consequences of PEEP. Six adult horses were anesthetized, using xylazine (2.2 mg/kg of body weight, IM), guaifenesin (50 mg/kg, IV), thiamylal Na (4.4 mg/kg, IV), and halothane (1.5 to 2% inspired) in 10...
Hematologic and blood chemical characteristics of feral horses from three management areas. Blood was collected from 486 feral horses of mixed sex and age classes captured from three wild horse management areas in Nevada and Oregon from December 1985 to February 1986. Males were significantly outnumbered by females in the Flanigan area, but both sexes were represented in approximately equal numbers in the Wassuk and Beaty's Butte areas. Hematology and chemistry values averaged 16.4 +/- 0.11, 46.3 +/- 0.28, 9.9 +/- 0.07, 6.9 +/- 0.10, 47.1 +/- 0.24, 16.6 +/- 0.09, 35.2 +/- 0.09, 10.4 +/- 0.14 and 23.4 +/- 0.25 for hemoglobin (HGB), hematocrit (HCT), red blood cells (RBC), white blood ...
Pyrrolizidine alkaloid-induced liver disease in horses: an early diagnosis. Nine adult horses were fed alfalfa hay cubes containing approximately 10% Senecio vulgaris until all horses had consumed approximately the same amount of toxic components of S vulgaris, pyrrolizidine alkaloids (PA). The amount of PA consumed was determined by the amount that induced clinical signs of PA toxicosis in 3 horses. The 6 other horses were given similar amounts per kilogram of body weight. An initial decrease of feed intake was observed when horses' diets were changed from alfalfa cubes to alfalfa/Senecio cubes, and feed intake was decreased further over 89 to 98 days. From 50 to 159...
Klossiella equi induced tubular nephrosis and interstitial nephritis in a pony. Heavy renal infection in a pony with Klosiella equi resulted in moderate diffuse tubular nephrosis and tubular rupture. Multifocal non-suppurative interstitial nephritis was associated with ruptured tubules. Ultrastructural examination of sporoblasts demonstrated both the presence of a bilaminated membrane encasing organisms and nuclear budding. Endogenous corticosteroid production probably led to the development of an immune-compromized state and subsequent extensive parasitic replication.
Equine Culicoides hypersensitivity in Florida: biting midges collected in light traps near horses. Twenty-three species of Culicoides were trapped near pruritic horses during a 2-year survey in Florida. Nearly 99% of the biting midges collected were represented by Culicoides insignis Lutz, C. edeni Wirth and Blandon, C. stellifer (Coquillett), C. niger Root and Hoffman, C. haematopotus Malloch and C. venustus Hoffman. The relative contribution to the total catch by each of these species varied among collection sites. Seasonally, different species attain their largest population sizes at different times. Association of species collected in light traps with the seasonality of lesion developme...
Effect of butorphanol, pentazocine, meperidine, or metoclopramide on intestinal motility in female ponies. Effect of butorphanol, pentazocine, meperidine, and metoclopramide on jejunal and pelvic flexure myoelectric and mechanical activity in 4 female ponies was investigated. The agent to be tested or saline solution was administered IV at the start of a 6-hour recording trial. In the jejunum, duration between activity fronts of regular spiking activity, defined as the length of the migrating myoelectric complex (MMC), was measured. The average duration of the MMC during control trials was 150 +/- 46 minutes. The average duration of the MMC after meperidine, butorphanol, pentazocine, and metoclopra...
Comparative pharmacokinetics of yohimbine in steers, horses and dogs. In steers, horses and dogs, the comparative pharmacokinetics of yohimbine were determined using model-independent analysis. The intravenous dose of yohimbine was 0.25 mg/kg of body weight in steers, 0.075 or 0.15 mg/kg in horses, and 0.4 mg/kg in dogs. The mean residence time (+/- SD) of yohimbine was 86.7 +/- 46.2 min in steers, 106.2 +/- 72.1 to 118.7 +/- 35.0 min in horses, and 163.6 +/- 49.7 min in dogs. The mean apparent volume of distribution of yohimbine at steady state was 4.9 +/- 1.4 L/kg for steers, 2.7 +/- 1.0 to 4.6 +/- 1.9 L/kg for horses, and 4.5 +/- 1.8 L/kg for dogs. The total ...
Epidermal cell renewal in the horse. Epidermal cell labeling index and cell renewal time were estimated in 8 adult horses, using autoradiography after [3H]thymidine was given intradermally. The mean labeling index was 1.45 +/- 0.47%, and the mean cell renewal time of the viable epidermis was approximately 17 days.
Conformational restrictions of the sheep testicular receptor discriminates pituitary lutropin and placental gonadotropins. A membrane preparation from the testis of maturing Dorset-Leicester-Suffolk sheep, capable of discriminating pituitary LH (lutropin) from placental gonadotropins human choriogonadotropin (hCG) and equine choriogonadotropin is described. Maximum binding of 125I-oLH (ovine lutropin) to the testicular receptors occurred at 4 degrees C in a rapid manner, attaining equilibrium in 12-16 h. Under such optimal conditions, only unlabeled ovine LH or the structurally identical bovine LH effectively competed for receptor occupation. Other highly purified pituitary LH preparations from rat and human pitui...
Dose-dependent plasma elimination of subcutaneously administered calcium heparin in horses. Pharmacokinetic parameters for subcutaneous low dose heparin in horses have been determined. Four groups of five and one group of eleven mature, healthy horses of various breeds were given single subcutaneous injections of 60, 80, 100, 125, and 150 units of calcium heparin/kg of body weight (U/kg) in the pectoral region. Jugular blood samples were collected prior to, and at hourly intervals for 12 h after injection. Heparin plasma concentrations were measured using a commercially available amidolytic assay. Peak concentrations 4 h after administration were 0.021 +/- 0.016 (mean +/- SD) units o...
Chromosome anomalies and infertility in the mare. Nine reproductively normal mares, 25 infertile mares and one set of heterosexual twins were examined cytogenetically using conventional giemsa staining, C-banding and G-banding. It was concluded that G-banding was necessary to identify even gross anomalies. Three (12 per cent) of the infertile mares, but none of the controls, had a chromosomal anomaly. One was 63,XO, one a 63,XO/64,XX mixoploid and one a 64,XY sex reversed male. It is argued that a cytogenetic examination is a useful diagnostic technique but that routine screening of the whole population would be uneconomic.
Effect of beta-tricalcium phosphate in surgically created subchondral bone defects in male horses. beta-Tricalcium phosphate (TCP) was evaluated as a synthetic bone grafting material in horses. Sixteen horses were randomly assigned to 4 groups of 4 horses. In each horse, an 11-mm by 10-mm circular defect with a smooth margin was created surgically in the weight-bearing surface of both third metacarpal bones (McIII) and the left third metatarsal bone. The defect in the left McIII was filled with TCP, the defect in the right McIII was filled with a mixture of 50% autogenous cancellous bone (ACB) and 50% TCP, and the defect in the left third metatarsal bone was not filled to serve as a control...
