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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
A light and electron microscopic study of the neuropathy of equine idiopathic laryngeal hemiplegia. A study has been made of the pathological changes in the recurrent laryngeal nerves from horses with clinical and sub-clinical idiopathic laryngeal hemiplegia. Qualitative and quantitative studies showed in clinical cases there was a progressive distal loss of large myelinated fibres in the left recurrent nerve. Regenerating clusters and onion bulbs were frequently seen in affected nerves both at proximal and distal levels. Degenerating axons were characterized by collections of organelles, and denervated bands of Bungner were common. Similar but less severe changes were seen in the left recur...
A study of the normal range of strain, strain rate, and stiffness of tendon. This paper describes the result of an investigation of strains and strain rates which normally occur in the tendons of the equine foreleg and presents stress-strain curves and moduli for the tendons at these rates. It has previously been demonstrated that resistance to flexion of the joints of the distal part of the equine foreleg is provided by a passive system of tendons and ligaments. It is therefore possible, using a large displacement, high-rate testing machine, to duplicate in the laboratory the strain rates and forces which are normally produced in the tendons of the foreleg of the runn...
Radioimmunoassay of oxfendazole in bovine, equine, or canine plasma or serum. A simple radioimmunoassay was developed for the determination of oxfendazole in plasma. Oxfendazole N-1(3)-valerate was coupled to polylysine via a carbodiimide reaction, and antiserum was developed in rabbits after inoculation with oxfendazole--polylysine conjugate. The assay was developed so that oxfendazole could be measured directly in a 0.1-ml aliquot of diluted or undiluted plasma. With the developed procedure, 200 pg of oxfendazole/ml of plasma can be determined quantitatively. Cross-reactivity was determined for closely related compounds and metabolites. The method was used to determin...
Contagious equine metritis: the present situation reviewed and a revised code of practice for its control. This report contains details of the code of practice for the control of contagious equine metritis (CEM) during the 1979 breeding season. It was prepared under the guidance of a scientific committee established by the Horserace Betting Levy Board under the chairmanship of Sir David Evans, FRS. The code is similar to the one introduced for the 1978 breeding season but takes into account the experience gained during the past 12 months. Following discussions with colleagues in Ireland it has been agreed that a similar code of practice will be introduced in the United Kingdom and Ireland so as to ...
Site of initiation of the plasma cell reaction in the rabbit lymph node. Ultrastructural evidence for two distinct antibody forming cell precursors. Two times sublethal total body-X-irradiation with weekly local thymus irradiation established a T-cell deprived experimental model in rabbits. Humoral immunity reactions in draining lymph nodes have been analyzed histologically and at the submicroscopical level after challenge with Salmonella Java vaccine, horse spleen ferritin, horse-gamma-globulin, a chemical sensitizer oxazolone (2 phenyl-4-ethoxymethylene-5-oxazolone) and after skin allografting respectively. The time sequence studies in these animals with an 'isolated B-cell system' are compared with similar experiments in normal non-irra...
An evaluation of the efficacy of oxfendazole against the common nematode parasites of the horse. In a controlled trial in naturally-infected young ponies, oxfendazole administered orally at dose-rates of 10 mg per kg and 50 mg per kg resulted in complete elimination of Trichostrongylus axei, Parascaris equorum, Oxyuris equi and adult Strongylus vulgaris. Also, all migrating Strongylus edentatus larvae recovered from the subperitoneal tissues of the flank were found to be dead. Minimum efficiencies of 99.8 per cent and 99.1 per cent were obtained against adult small strongyles (Trichonema spp) and 97.6 per cent and 100 per cent of developing small strongyle larvae at dose-rates of 10 mg pe...
An investigation of the action and haemolytic effect of glyceryl guaiacolate in the horse. Glyceryl guaiacolate (GGE) was found to be a useful and safe casting agent when given by rapid intravenous infusion. It was administered to premedicated horses under controlled conditions at various concentrations from 10 to 20 per cent GGE solution. The onset and degree of relaxation was dependent only on the speed of infusion. For casting adult horses 350 to 450 ml of 15 per cent solution must be given within 30 to 60 seconds. A slight transient hypoxaemia occurred which seemed to be related to the animal being in lateral recumbency rather than the depressive action of GGE on respiratory fun...
A histological study of macroscopically normal equine digital flexor tendons. The normal appearance of the superficial (SFT) and deep (DFT) digital flexor tendons was described and the difference between their histological structures was emphasised. Further differences were recognised between different sites from the same tendon and between tendons in the fore and hind limbs of the same animal. Both of the tendons underwent changes with age but although a number of alterations in the histological appearance were described, a particular change, involving a patchy loss of stainable nuclei, was found at the common site of SFT injuries. While this appearance has been seen i...
Heart rate during a defined exercise test in horses with heart and lung diseases. During a gradually increasing exercise test heart rates were determined in healthy animals and in 2 groups of sick horse. These included 31 animals with a chronic pulmonary disorder and 5 with chronic heart disease. The alteration in heart rate was correlated with the clinical signs exhibited. In the horses with lung disease there was a close correlation between the stage of the diseases and the heart rate during the exercise test. In 3 animals with heart valve disease there was no apparent difference in heart rate compared with healthy horses. On the other hand the exercising heart rate of ho...
Repair of fractured dens of the axis in a foal. Quadriplegia of 4 days' duration in a 3-week-old foal was caused by displacement of the dens of the axis due to a fracture at the dens growth plate. The displacement was reduced and was immobilized surgically. Two months after surgery, the foal was able to rise, walk, and trot without apparent neurologic deficiencies. Three years later, the only defect was a mild gait disturbance in the left hindlimb seen at a canter and a gallop.
Haemodynamics in the horse: 3. Duration of the phases of the cardiac cycle. The paper reports observations on the duration of various phases of the cardiac cycle using a bipole ECG record as a time base from which to measure the timing of pressure changes in the chambers of the heart and great vessels. From the findings the likely sequence of mechanical events during the cardiac cycle in the atria and ventricles is described.
Reference values for clinical chemistry using the Coulter Chemistry System. Reference (normal) ranges were established for clinical chemistry results obtained from the Coulter Chemistry instrument on specimens from dogs, cats, horses, and cattle. These results, in general, are very similar to those reported in the current veterinary literature. The specimens obtained from horses and cows were subdivided according to age and lactation status, respectively. Significant differences were noted between the subgroups in the results of certain tests.
Hyperlipaemia in ponies. The case histories and clinical findings of 15 ponies with hyperlipaemia are presented. The disease was characterised by hyperlipidaemia with inappetance, progressing somnolence, muscle fasciculation, diarrhoea, and ventral oedema as the predominant clinical findings. Post mortem examinations of 12 ponies showed extensive lipidosis and vascular thrombosis with widespread secondary changes. Most cases occurred in late pregnant and early lactating mares in the summer months and it is postulated that the disease was initiated in this group by a falling nutritional plane in the face of high nutrie...
[Studying the faeces for the presence of parasites in horses and ponies (author’s transl)]. In 3,791 horses and ponies submitted to the Department of Internal Disease of Farm Animals of the Faculty of Veterinary Medicine, Utrecht, the faeces were studied for the presence of parasites. The results were classified by age groups and months of arrival. Eggs of the Strongylus type were found to be present in 57.3 per cent of the faecal samples, eggs of Parascaris equorum were present in 6.1 per cent, eggs of Oxyuris equi in 1.2 per cent, eggs or larvae of Dictyocaulus arnfieldi in 0.2 per cent, eggs of Anoplocephala in 2.5 per cent and oocysts of Eimeria leuckarti in 0.3 per cent. Eggs of...
Increased plasma bromide concentration in the horse after halothane anesthesia. A long-lasting increase of the plasma bromide concentration was found in 25 horses after clinical halothane anesthesia. The plasma bromide concentration was significantly (P less than 0.005) increased at the end of anesthesia. In 18 horses, peak values were reached between 48 and 72 hours after anesthesia. Eighteen days after horses had been anesthetized, the plasma bromide concentration remained significantly (P less than 0.005) increased. Significant correlation was not found between the total dose of halothane and the plasma bromide concentration. In 1 horse reanesthetized with halothane 4 ...
A report on clinical aspects and histopathology of sweet itch. Sweet itch is an intensely pruritic dermatitis of horses recurring annually in Ireland from April to November. The tissue changes of sweet itch have similarities to immediate-type hypersensitivity reactions which occur in skin sensitised to the saliva of bloodsucking insects. There was subepidermal oedema, and marked eosinophilia; the blood vessels were tortuous and enlarged. Microfilaria were not found in serial sections of lesions of 5 affected horses. The histopathology of the immediate dermal remal reaction to the intradermal injection of Culicoides extract shows dermal vasodilation and eo...
Glucose transport by horse kidney brush borders. I.–Transport properties of brush border membrane closed vesicles. Brush border membranes isolated from horse kidney cortex as closed right-side out vesicles show selective permeability when analyzed on sucrose and dextran gradients. These vesicles can actively accumulate D-glucose. The preservation of the glucose transport system is demonstrated by the following features: (a) the uptake and release rates of D-glucose are higher in the presence of a sodium gradient, showing that D-glucose transport is a sodium-dependent process; (b) this transport, specific for the D-isomer, is inhibited by phlorizin; (c) the D-glucose transport system is saturable; (d) no in...
A complement fixation test for antibody to the contagious equine metritis organism. A complement fixation test (CFT) based on that used for brucellosis (Brinley Morgan and others 1971) has been developed for use on the sera of horses exposed to the contagious equine metritis (CEM) organism. None of 50 single samples from horses thought to be unexposed to the CEM organism was positive to the test, although five showed inconclusive reactions. Samples were examined from 41 mares either proved to be infected or from an infected stud. Of these 21 were positive, 11 were inconclusive and nine were negative. The relationship of the CFT to reactions in the other tests used in this con...
Serum folate levels in horses, with particular reference to the English thoroughbred. The assay of serum folate has been used to investigate the folate status of thoroughbreds in training to race, in-foal thoroughbred mares at stud and crossbred ponies kept permanently at grass. Throughbreds in training, with no obvious haematological or clinical abnormalities, had lower serum folate levels (mean 3.3, range 1.5 to 6.1 microgram per litre) compared with thoroughbred mares at stud (mean 10.6, range 6.4 to 15.8 microgram per litre) and crossbred ponies at grass (mean 10.9, range 7.4 to 16.6 microgram per litre. Intensive exercise, over a period of six months, significantly decreas...
