Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Heyneman RA, Bruyninckx WJ, Vercauteren RE.Two distinct groups of acid phosphatase containing granules were characterized in neutrophils, each group displaying different multiple forms of the enzyme. The heavy granule acid phosphatase showed a lysosomal location. A second lighter group of particles contained a thermolabile, thiol-dependent acid p-nitrophenyl and alpha-naphtylphosphatase, an enzyme clearly different from lysosomal acid phosphatase. Acid phosphatase activity from eosinophil leukocytes appeared to be totally associated with the typical eosinophil granules. On mechanical disruption of these particles, an acid phosphatase w...
Ghoshal NG.The occurrence of aberrant lymph nodes, on both sides of the head of a horse, belonging to the retropharyngeal lymphocenter has been reported.
Diethelm AG, Chambers LM, Balch CM, Phillips SJ.Anti-human thymocyte cell membrane antibody prepared by hyperimmunization of the horse produced an antiserum capable of prolonging skin allografts in the rhesus monkey for an average of 26 days. Lymphocyte depletion was present in paracortical areas of mesenteric lymph nodes of these animals after 28 days of treatment; the intravenous administration was tolerated without ill effects. Immunofluorescent studies identified both broad specificity antibodies reacting with numerous human cell types as well as thymus-dependent (T) cell antibodies reactive with human thymocytes and peripheral T-cells....
Matheka HD, Coggins L, Shively JN, Norcross NL.EIA virus was purified from equine fetal kidney cell cultures by PEG-precipitation, two sucrose-gradient sedimentations (5-30 per cent) and (25 to 60 per cent) centrifugation, using the immunodiffusion test to follow the procedure. Purified EIA virus had a density (20 degrees C) of 1.162 and a sedimentation constant of S20w=656. electron microscopy revealed a particle of about 100 nm in diameter with a very flexible but usually spherical shape. The dense core may be at various locations inside the membrane bound particle.
Steel JD, Hall MC, Stewart GA.Changes that occur in the equine ECG during and after exercise have been described and compared with resting ECG's obtained from the same horses. When the speed of work equals or is greater than "three-quarter pace" (i.e. "even time" or 200 metres in 15 seconds) the high heart rates developed cause the loss of ECG waveforms that are readily discernible at rest. Although differences in the waveforms between horses with normal and abnormal resting ECG's have been observed, the more definitive useful information is the fact that abnormal horses showed significantly higher heart rates than normal ...
Vaughan JT, Montes LF, Bembibre A, Blaquier PC.A 5-year-old Thoroughbred chestnut mare was presented because of multiple lesions noticed for approximately one year over the vulva and ther perianal areas. Clinically, there were moist warts that stood out because of their whitish color which contrasted strikingly with the surrounding, normally pigmented, uninvolved skin (Fig. 1). Repeated topical applications of 20% podophyllin in 95% ethyl alcohol produced rapid involution. Histopathologically, marked acanthosis, numerous mitoses, prominently vacuolated epidermal cells and a chronic dermal inflammatory infiltrate were seen (Figs. 2, 3, and ...
Løowenstein H, Markussen B, Weeke B.Three major allergens of horse hair and dandruff have been isolated. The fractionation procedures involved various combinations, described in detail, of ethanol precipitation below --5degreesC, cation- and anion-exchange chromatography, and gel filtration. UV absorption, quantitative immunoelectrophoresis and RAST inhibition were used to monitor the separations. Protein impurities constituted less than 5% in all cases. The molecular weights of the isolated proteins were 1.9 X 10(4), 5.1 X 10(4) and 3.1 X 10(4) daltons, respectively. The pIs were determined as 4.1, 3.8 and 3.9, respectively. Th...
Genchi C, Malnati G.Strongyloides westeri larvae transmission by mare milk in foals has been studied; the results show the importance of this route for parasite penetration.
Bodurov N, Filipov Zh.Comparative clinical and experimental investigations were carried out on 18 clinically normal horses. It was found that the single transfusion of in vitro UV-treated autogenous blood, following a previously described method, was tolerated well by horses and did not lead to any deviations from the normal indices. Under the effect of the treated blood there was an increase in the hemoglobin content, rise in the erythrocyte and leukocyte count with slightly expressed hyperleukocytosis and weak neutrophilia (simple regeneration of the blood). The sedimentation of erythrocytes also showed higher ra...
Johansson HE, Rejnö S.Light and electron microscopic examination was made on equine synovial membrane from 23 healthy joints, nine joints with synovitis caused by intraarticular fracture and 10 joints with synovitis caused by osteochondrosis dissecans. Histologically as well as ultrastructurally the equine synovial membrane from healthy joints was of principally the same character as described in other species. Three types of synovial membrane — areolar, fibrous and adipose — and two types of lining cell were distinguished histologically. Ultrastructurally three types of lining cells were distinguished: A and Î...
Sebek Z, Wallner H, Sixl W, Kaaserer G, Valová M.Results are presented of a serological examination of 1,547 domestic animals (cattle, pig, sheep, horse, goat, dog, cat) from 9 Tyrolian districts (Austria), performed in order to disclose the incidence of leptospirosis. Completely significant titres were domonstrated by means of the MAL test in the serotypes icterohaemorrhagiae or copenhageni, sorex-jalna, bratislava, sejroe and saxkoebing. In addition, antibodies were confirmed against L. bataviae, L. pomona, L. tarassovi and L. bulgarica, but the titres were insignificant. Of the animals examined, 7.2% gave positive reactions in titres of 1...
Sutoh M, Saheki Y, Ishitani R, Inui S, Narita M, Hamazaki H, Yokota T.This is the first report on Eimeria leuckarti infection in foals in Japan. Seven Thoroughbred or Angloarabian foals 2 to 7 months of age raised in the Hidaka district, Hokkaido, were infected with E. leuckarti. They died of severe alterations caused by the larval migration of Strongylus vulgaris, and were examined over a period from 1970 to 1973. Protozoa of this species were observed in the small intestine in all the foals. They were found mostly in vacuoles of the cytoplasm of monoclear cells in the lamina propria at or near the tip of villi. Various stages of gametocytes, oocysts, and micro...
Kooistra LH, Ginther OJ.At day 24 of gestation, pregnant mares were allotted to 1 of 5 treatment groups (3 to 5 mares/group): group A--nontreated controls; group B--intraembryonic injection of 4 mg of colchicine on day 24; group C--removal of embryo on day 24; group D--subcutaneous injection of 1.25 mg of prostaglandin F2alpha (PGF2alpha) on day 32; and group E--removal of embryo on day 24 and subcutaneous injection of PGF2alpha on day 32. In all mares treated with colchicine (group B), the fetal bulge was absent within 2 days. The interval from injection of colchicine to onset of estrus was very short (mean, 4 days)...
Anwer MS, Chapman TE, Gronwall R.Variables of glucose metabolism determined by the use of [U-14C]glucose were compared in fed and fasted ponies. Relative recycling of glucose carbon with respect to tritium in fed animals was negligible for 6-T and 3-T and 16% for 2-T studies; in fasted animals relative recycling was 12 and 14% for 6-T and 3-T studies, respectively. Minimal mass of total-body glucose decreased significantly in the fasted ponies. Based on relative recycling of carbon to tritium, a negligible fraction of plasma glucose was produced via the Cori cycle or from glycerol in fed ponies; recycled tricarbon units contr...
Houpt KA.Knowledge of animal behavior is an important asset for the veterinarian; therefore a course in veterinary animal behavior is offered at the New York State College of Veterinary Medicine as an elective. The course emphasizes the behavior of those species of most interest to the practicing veterinarian: cats, dogs, horses, cows, pigs and sheep. Dominance heirarchies, animal communication, aggressive behavior, sexual behavior and maternal behavior are discussed. Play, learning, diurnal cycles of activity and sleep, and controls of ingestive behavior are also considered. Exotic and zoo animal beha...
O'Neill HJ, Gershbein LL.The lipids of human and equine smegma pools were saponified and the total fatty acids submitted to temperature programmed gas chromatography (GC) analysis. In contrast to the human products, the horse smegma fatty acids contained very low odd saturated as well as olefinic branched chain acid contents. The cyclopropane fatty acid, 9,10-methyleneoctadecanoic acid, occurred in smegma sampled from men over 35 years of age but could not be detected in the pool from persons of 17-20 years of age nor in any of the equine mixtures. The alcoholic fraction from horse smegma contained about 85% sterol, t...
Simić V, Ilić A.The caecum in man as a part of the large colon (intestinum crassum) differs morphologically and topographically from the caecum of domestic mammals. The caecum in domestic mammals differs not only from the human caecum but also comparatively morphologically and topographically among the domestic mammals. The appendix vermiformis does not exist in domestic mammals, which represents the main difference between the human caecum and that of domestic mammals. There are certainly some differences in the physiological function of the caecum in man and the caecum in domestic mammals, which are carnivo...
Heinze W, Ptak W.The metacrylate and latex corrosion techniques were used to establish that the vascular system of testes is based on one coherent principle in common domestic mammals. The cone-shaped Plexus pampiniformis consists of numerous venous rami, between 0.25 mm and 1.0 mm in thickness and forming a dense vascular network, which practically encase the spiral-shaped A. spermatica interna (cooling coil principle). The testicular veins and arteries in the Tunica albuginea constitute a somewhat voluminous layer of vessels for dissipation of heat, with rami branching off radially into the testicular parenc...
Hall WC, Nielsen SW, McEntee K.Tumours of the male genital tract, excluding the testes, are relatively rare in the six major domestic animals. The most important tumours are prostate carcinoma and transmissible venereal tumour of the penis in dogs, fibropapilloma of the penis in bulls, squamous papilloma and squamous cell carcinoma in horses, and squamous papilloma in pigs. Four histological types of canine prostate carcinoma exist: alveolar papillary, acinar, organoid, and poorly differentiated. The biological behaviour of prostate carcinomas is similar to that in man, with frequent metastasis to the regional pelvic nodes,...
Pavelka M, Ronge HR, Stockinger G.Tracheal epithelia of ten different mammals were investigated with the light and the electron microscope. Characteristic differences were found concerning the thickness of the epithelia, the length of the cilia, the density of the cells in the epithelia, the numerical distribution of the different cells and their ultrastructure. Special attention was paid to the morphology of the kinetosomes. Brush cells and chromaffin cells, which are sparsely distributed in the different tracheal epithelia, were discussed.
Hall MC, Steel JD, Stewart GA.Data on resting heart rates, pre-exercise heart rates, the anticipatory rises before exercise, the influence of speed of work and recovery heart rates have been presented. Some observations on differences in the heart rate response on slow and fast working days are also recorded. In conformity with other workers, a linear relationship between heart rate and working speed within the range of 400-800 metre/min was observed. When the speed of work was between 400-800 metre/min, horses with resting ECG's classed as abnormal had significantly higher heart rates than those regarded as normal. It was...
Giguère S, Prescott JF.The remarkable ability of the horse and other animals to prevent infection by most bacterial pathogens encountered is the result of a complex set of distinct but overlapping defense mechanisms. This article summarizes the current state of knowledge on innate and adaptive immunity to bacterial pathogens and reviews various ways in which some bacteria have evolved in order to evade components of the host response.
Hodgson DR, Rose RJ, Allen JR.For determination of 3 muscle fiber types in equine skeletal muscle, a comparison of 2 preincubation buffers, each followed by myosin adenosine triphosphatase staining, was made. Serial sections of the muscle samples (n = 75) were preincubated in an acid buffer (pH 4.6) or a formaldehyde-glycine buffer (pH 7.25) and then were stained for myosin adenosine triphosphatase. Differentiation of muscle fibers into type I, IIA, and IIB was identical with both techniques; however, in the samples prepared at pH 4.6, type I fibers were black; type IIA, light gray; and type IIB, dark gray. In the samples ...
Maylin GA, Bache CA, Lisk DJ.Effluents from a number of industries which are typically treated in municipal sewage plants result in cadmium-containing sludge. Disposal of such sewage sludge by application to agricultural land can result in uptake of cadmium by crops. In this study, oats were grown on soils which had been amended with sewage sludge from Syracuse, New York. The cadmium concentration in the sludge-grown oats was 1.79 ppm dry weight. Horses were fed the sludge-grown oats for 6 weeks during which time blood samples were taken for the determination of cadmium. No significant differences (p greater than 0.05) we...
McDonell WN, Pascoe PJ, Lindsay WA, Burgess ML.The use of the wick catheter to measure intracompartmental muscle pressure in equine muscle was documented. The presence of muscle compartments involving the extensor carpi radialis muscle and the long head of the triceps brachii was demonstrated by anatomic dissection and radiographic technique. The wick catheter was capable of accurately measuring pressures within both of these compartments. Furthermore, the wick catheter was sensitive to pressure changes resulting from external compression of muscle compartments. Manipulation of systemic blood pressure and PaCO2 in 1 anesthetized horse did ...
Mugg PA, Hill A.The failure of N. gonorrhoeae to grow on isolation media was found to be due to inhibitory substances present in commercially available horse sera. Subsequent investigations indicated that the inhibitory action of the horse serum may have been due to antibodies to N. gonorrhoeae, H. influenzae, H. parainfluenzae and beta hemolytic streptococci. This experience highlights the need for media quality control programmes in laboratories which prepare microbiological culture media.
van der Mey GJ.Horse-breeding in the Netherlands is briefly reviewed. Particular attention is paid to the number of foals of various breeds. Some effects of inbreeding in Friesian horses are discussed. As regards methods selection, attention is mainly paid to saddle horses. The role of veterinarians (from the point of view of selection for soundness) is described. Selection is based on the results of studies in the Faculty of Veterinary Medicine in Utrecht. A number of these results are reviewed.
Baker SJ, Gerring EL.The gastric emptying of different forms of ingesta occurs by a variety of mechanisms and dysfunction may selectively affect different components of the gastric contents. A technique for assessing gastric emptying of solid, indigestible, radiopaque markers was developed. Emptying of these markers in four ponies was variable in both pattern and rate (half emptying time ranged from less than one hour to more than 24 hours). However, whereas in man physically similar markers appear to empty relatively rapidly when fasting but are delayed by a meal, no such delay was evident in these ponies. The ho...
Hope E, Johnston SD, Hegstad RL, Geor RJ, Murphy MJ.A commercially available radioimmunoassay kit for measurement of human osteocalcin was validated for use in horses. For accurate measurement of equine serum osteocalcin, blood samples may be collected at a temperature between 20 and 25 C, then centrifuged within 90 minutes; serum may be stored at -20 C in plastic tubes for up to 26 weeks. Serum may be thawed and refrozen up to 5 times without significant change in measured equine serum osteocalcin concentration. Assay sensitivity was 0.16 ng/ml. Recovery of bovine osteocalcin standard added to equine serum was linear. Intra-assay coefficient o...
Pardoe CH, Wilson AM.Hoof wall cracks need mechanical stabilisation to allow healing. Common techniques are fixation with screws, wires and plates or bonding of a patch across the crack. An in vitro system to determine the shear properties of equine hoof crack repairs is described. The force and displacement at yield, stiffness and ultimate force were determined for 4 repair techniques based on an acrylic material, polyurethane patch attached with cyanoacrylate adhesive, steel plate attached with screws and a transverse metal bar cut into the hoof wall. The cyanoacrylate bonded patch repair had lower values for al...
Jedruch J, Gajewski Z, Kuussaari J.The effect of detomidine on the electrical activity of the uterus was studied during the last trimester of pregnancy in 6 mares. The effect was observed in 3-5 min after the i.m. injection and it lasted for 50-70 min. 20 and 40 micrograms/kg b.w. doses of detomidine decreased the myometrial electrical activity, whereas 60 micrograms/kg dose did not have any effect on the activity. The results suggested that 20, 40 and 60 micrograms/kg b.w. doses of detomidine can be administered to mares during the last trimester of pregnancy without the risk of abortion induced by increased uterine electrical...
Delgado MA, Monreal L, Armengou L, Segura D, RÃos J.Peritoneal D-Dimer concentration can be determined to assess peritoneal fibrinolysis activity in horses with gastrointestinal disorders. However, blood contamination of peritoneal fluid may occur during collection and could alter peritoneal D-Dimer concentration. Objective: Blood contamination in peritoneal fluid does not affect interpretation of peritoneal D-Dimer concentration in horses with colic. Methods: Thirty-four horses with colic and 4 healthy horses. Methods: Peritoneal fluid and blood samples were simultaneously collected upon admission. Then, peritoneal fluid was serially contamina...
Fadok VA.Papules and nodules are common lesions on horses and have a variety of underlying causes. This article addresses inflammatory and congenital nodules primarily, including urticaria, erythema multiforme, those nodules caused by infectious agents, epidermoid and dermoid cysts, and the uniquely equine skin tumor, the sarcoid. The eosinophilic nodules and other tumors are covered elsewhere in this issue. Diagnostic and therapeutic approaches to each of the diseases are emphasized.
Cannon JK, Ellis KL.Striations are present on ultrasonography of the intermediate (middle) patellar ligament in the transverse plane, which can be confused with tears. Comparison to the contralateral limb is often performed to help differentiate anatomic variation from pathologic change. The purposes of this prospective, observational study were to describe the striation patterns in Warmbloods and Quarter Horses, determine if these patterns are bilaterally symmetrical, and compare striation characteristics between Warmbloods and Quarter Horses. The intermediate patellar ligaments of six Warmblood horses and six Q...
Schreeg ME, Radkin M, Haugland J, Murphy BG, Rushton S, Linder KE.Ameloblastic carcinoma is a malignant odontogenic neoplasm that has been reported only rarely in veterinary species. A 16-y-old Arabian crossbred mare was presented for evaluation of a hard mass on the body of the mandible, with evidence of osteolysis on radiographs. Incisional biopsies revealed an invasive neoplasm comprised of spindloid epithelial cells with a high mitotic count and partial dual cytokeratin-vimentin immunoreactivity. The horse was euthanized because of rapid tumor progression 3 mo after presentation. Postmortem evaluation revealed partial obliteration of the mandible by a ...