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Topic:Veterinary Research
Veterinary research in horses encompasses the study of diseases, health management, and medical treatments specific to equine species. This field investigates various aspects of horse health, including infectious diseases, metabolic disorders, and musculoskeletal conditions. Researchers focus on understanding the pathophysiology of equine ailments, developing diagnostic tools, and evaluating therapeutic interventions. The study of horse health also involves examining preventive measures such as vaccination protocols and nutritional management to promote overall well-being. This page collects peer-reviewed research studies and scholarly articles that explore the diverse areas of veterinary science related to horses, providing insights into disease mechanisms, treatment strategies, and advancements in equine healthcare.
Identification of the lysine residue modified during the activation of acetimidylation of horse liver alcohol dehydrogenase. A single amino group in horse liver alcohol dehydrogenase was modified with methyl(14C)acetimidate by a differential labeling procedure. Lysine residues outside the active site were modified with ethyl acetimidate while a lysine residue in the active site was protected by the formation of an enzyme-NAD+-pyrazole complex. After the protecting reagents were removed, the enzyme was treated with methyl(14C)acetimidate. Enzyme activity was enhanced 13-fold as 1.1 (14C)acetimidyl group was incorporated per active site. A labeled peptide was isolated from a tryptic-chymotryptic digest of the modified...
Pregnancy failure induced by human chorionic gonadotrophin in pony mares. Ten pregnant Welsh pony mares were each treated with a series of three intravenous injections of 2000 iu human chorionic gonadotrophin (HCG) on alternate days. In four mares the first dose was given before the 39th day of gestation and conceptual loss followed treatments in all mares. The other six mares were first treated between the 40th and 97th days. No conceptual loss occurred despite five of the mares being given a fourth dose of HCG. Two mares first treated on days 36 and 38 of pregnancy subsequently produced PMSG although foetal death had occurred.
Occurrence of nervous-tissue tumors in cattle, horses, cats and dogs. From 11 North American veterinary university hospitals and clinics, 248 animals were a confirmed diagnosis of nervous-tissue tumor were identified; 7 tumors were found in cattle, 28 in horses, 14 in cats, 199 in dogs, and none in other species. Tumors were divided for analysis into three categories-glial, meningeal, and peripheral nerve. In cattle and horses, all tumors involved peripheral nerves, the risk of which, in horses, reached a plateau at 4-6 years of age and remained constant thereafter. In cats, the tumors were equally distributed among the three tumor categories whereas, in dogs, t...
Giant cell tumor of soft parts. A report of an equine and a feline case. Masses removed from the superficial fascia of the jugular groove of a 12-year-old Arabian mare and from the femoral canal of a 7 1/2-year-old female cat appeared to be counterparts of the human malignant giant cell tumor of soft parts, even recapitulating the clinical behavior of the respective subgroups. Histologically, both neoplasms contained the characteristic features of the malignant giant cell tumor of soft parts: large multinucleate giant cells, pleomorphic mononuclear giant cells, histiocytes, fibroblasts and fibrocytes that were sometimes sarcomatous, and foci of hemorrhage and necro...
Experimentally induced infection of dogs, cats, and nonhuman primates with Ehrlichia equi, etiologic agent of equine ehrlichiosis. Dogs (German Shepherd Dogs and Beagles), cates, rhesus macaques (Macaca mulatta), and baboons (Papio anubis) were inoculated with Whrlichia equi, the etiologic agent of equine ehrlichiosis. Within 3 to 7 days after inoculation, morulae were observed in the eosinophils of cats, neurtrophils of macaques and baboons, and in both neutrophils and eosinophils of dogs. The severe disease produced in horses by this agent was not a feature of E equi infection in dogs, cats, macaques, and baboons. However, a susceptible horse, inoculated with the pooled blood of 2 infected macaques, developed severe cli...
Hyperlipoproteinaemia in ponies: mechanisms and response to therapy. (I) The lipid and lipoprotein concentrations in sera of 4 healthy and 9 hyperlipaemic patients were determined. From the results of the analyses, it is suggested that three types of hyperlipoproteinaemia can be distinguished in ponies: (a) Type 1, characterised by a very pronounced increase in only the very low density lipoproteins (VLDL); (b) Type 2, in which there is a pronounced increase in the chylomicrons (Chylo) and the very low density lipoproteins (VLDL); (c) Type 3, which can be the result of fasting and is characterised by a moderate increase in the concentration of chylomicrons and ...
Conformational studies of equilibrium structures in fragments of horse heart cytochrome c. Ultraviolet absorption and circular dichroism studies have been carried out on horse heart apo-cytochrome c and heme-free peptide fragments obtained by cyanogen bromide cleavage of the native protein. It was noted that the various peptides assume predominantly an unordered conformation in water solution. Increasing ionic strength and addition of 2-chloroethanol increase the right-handed helical content. Guanidinium hydrochloride favors the coil state. It was also demonstrated that two non-interacting helical regions of different stability are present in the apo-protein in 2-chloroethanol.
Castration and other factors affecting the risk of equine laminitis. The characteristics of a series of equine laminitis cases were compared with that of other Equidae examined at the University of Missouri Veterinary Hospital and Clinic during May, 1965 through December, 1971. The model age for ponies with laminitis was 7-9 years and for all other cases the model age was 4-6 years. Also the predominant age for mares was 4-6 years and for males was 7-9 years. After controlling for age and breed differences, there were significantly fewer castrated males among the affected males than expected (P small than 0.02), indicating that hormonal factors may play a role ...
Thermography in veterinary medicine. Thermography in veterinary medicine has hitherto been proven to be a method of great value in the detection of orthopaedic lesions in racehorses. Lesions of the musculo-skeletal system affecting tendons, joints, bones and skeletal muscle can be demonstrated and documented at an early stage thereby preventing the development of more serious lesions.
Angiographic appearance of the normal equine foot and alterations in chronic laminitis. The angiographic appearance of the normal equine foot was compared with the appearance of equine feet affected with chronic laminitis. The normal foot was characterized by complete filling of the terminal arch, 8 to 10 main branches between 0.1 and 0.2 cm in diameter, a symmetrical netlike vascular pattern in the corium of the hoof, and numerous fine vessels in the corium of the coronary band. The feet affected with chronic laminitis were characterized by poor filling of the terminal arch, larger and less numerous primary branches, an irregular vascular pattern in the corium of the hoof, areas...
Studies on the dynamics of Strongyloides egg release under stud conditions. The eggs of Strongyloides westeri were found in the faeces of the foals from the 16th day of their life, with a peak in their numbers between the 30th and 40th day of life. Egg release ceased in all foals irrespective of their date of birth in the months July-August. Parallel examinations of the mares were negative. Recommendations for the control of strongyloidosis in foals are given.
Double diffusion in gel tests with Paul-Bunnell antibodies of infectious mononucleosis sera. Double diffusion tests in gel were employed for studies of reactions between infectious mononucleosis sera and extracts of bovine, sheep and equine erythrocyte stromata. The extracts were obtained by ultrasonication of stromata prepared from trypsin-digested erythrocytes. The reaction with bovine stroma extract was composed, in many instances, of two lines. A single line was observed in reactions with sheep and equine stroma extracts. This line merged into a reaction of partial or complete identy with one of the lines formed with bovine stroma extract. Evidence was obtained that some infectioo...
Equine anti-hapten antibody. IX. IgM anti-lactose antibodies. The immune response to a bacterial vaccine of Streptococcus faecalis (strain N) was characterized in all of the seven horses studied by the sustained production of about 90% IgM anti-lactose antibody over a period of 44 weeks with maximum values of the total antibody ranging from 4 mg/ml of serum to 12 mg/ml of serum. With respect to the binding of a lactose-containing ligand the association constants of the antibodies purified from sera obtained between 5 and 44 weeks fell in the range of 1 times 10-5 M-1 to 2 times 10-5 M-1. Not only was there no significant indication of maturation of a-fin...
Arteria intercarotica caudalis and its homologue in the domestic animals. The arteria intercarotica caudalis was observed to be present in the dog, horse and cat but was reticulated in the case of cattle, sheep, goat, and pig. The latter structure was a homologue of the former and represented an important intercarotid communication present in most of vertebrate.
[Contribution to the antigenic study of influenza viruses in animals. II.–Antibodies, antineuraminidase in horse: conditions of apparition and importance (author’s transl)]. In the first part of this paper the conditions for a specific titration of antibodies against the neuraminidase (N) of each of the two horse virus subtypes are defined. The antigens used are: the H72Neq 1 recombining agent to measure the anti Neq1 antibodies and the A/Duck/Ukraine/63 strain for the anti Neq2 antibodies. The immunity response to neuraminidase appears after the natural disease; this response is studied in two foci, one due to a virus belonging to the A equi I subtype (Loire 73 strain), the other to a virus of the A equi 2 subtype (SHN 73 strain). The kinetics of apparition of an...
Abnormal flexion of the corono-pedal joint or “contracted tendons” in unweaned foals. A condition frequently misnamed "contracted tendons" is described in unweaned foals. Various theories regarding its aetiology are examined. Overfeeding and lack of exercise are suggested as being the most likely causes, leading to excessive growth of the long bones. An effective method of treatment is described. "Contracted tendons" in yearlings are also discussed.
Molecular properties of multiple forms of acid phosphatase from horse liver. 1. Horse liver acid phosphatase was separated into two partially purified fractions differing in molecular weight (enzyme I about 100 00, enzyme II about 25 000). 2. Enzyme I was separated into several subfractions by DEAE-cellulose chromatography and isoelectric focusing. 3. Molecular weight, sedimentation coefficient and effective molecular radii were determined for acid phosphatases I and II by gel filtration and density-gradient centrifugation.
Spongy degeneration in the central nervous system of domestic animals. Part III: Occurrence and pathogenesis hepatocerebral disease caused by hyperammonaemia. Severe spongy degeneration of the central nervous system (CNS) was seen in 11 cattle, 19 sheep, 4 pigs and 1 goat, associated with a variety of hepatic diseases, particularly those caused by hepatotoxic pyrrolizidine alkaloids. It was also seen in a milder form in 2 of 8 horses examined, 1 dog of 5 dogs examined, and in 1 rabbit only of a large number of laboratory animals examined. This paper reports results of experiments which confirmed initially that the CNS disease cold be caused by pyrrolizidine alkaloid intoxication. This was done by poisoning lambs with lasiocarpine. As the disease was...
Cobalt metabolism in horse. Serum level and biosynthesis of vitamin B12. The levels of serum vitamin B were determined on 16 mature partly warm-blooded, partly Finnish rural-race horses by the radioisotopic competitive inhibition assay method. The mean value from three samplings carried out in dupli- or triplicate was 1.54 ± 0.16 ng/ml. The utilization of serum inorganic cobalt for cyanocobalamin synthesis was studied on two geldings, which received a dose of 200 µCi CoGl i.v. A Sephadex G-100 gel filtration was carried out with the serum proteins from serial blood samplings at different time intervals 15 min. to 48 hrs. after administration. The gel filtration s...
