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Home / Equine Research Bank / Vaccines (Basel) / A Systematic Review of Recent Advances in Equine Influenza V...
Vaccines2014; 2(4); 797-831; doi: 10.3390/vaccines2040797

A Systematic Review of Recent Advances in Equine Influenza Vaccination.

Abstract: Equine influenza (EI) is a major respiratory disease of horses, which is still causing substantial outbreaks worldwide despite several decades of surveillance and prevention. Alongside quarantine procedures, vaccination is widely used to prevent or limit spread of the disease. The panel of EI vaccines commercially available is probably one of the most varied, including whole inactivated virus vaccines, Immuno-Stimulating Complex adjuvanted vaccines (ISCOM and ISCOM-Matrix), a live attenuated equine influenza virus (EIV) vaccine and a recombinant poxvirus-vectored vaccine. Several other strategies of vaccination are also evaluated. This systematic review reports the advances of EI vaccines during the last few years as well as some of the mechanisms behind the inefficient or sub-optimal response of horses to vaccination.
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Publication Date: 2014-11-14 PubMed ID: 26344892PubMed Central: PMC4494246DOI: 10.3390/vaccines2040797Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article sweeps over the latest advancements in equine influenza (EI) vaccines, a major respiratory disease in horses. It reviews various vaccines, their effectiveness, and the less than optimal response from horses, despite decades of prevention measures.

Equine Influenza: A Persistent Problem

  • This paper introduces equine influenza, a significant respiratory disease in horses that continues to cause outbreaks globally. This is despite decades-long efforts to prevent its spread through vaccination and surveillance.
  • The authors emphasize that equine influenza is a burden on horse populations worldwide, not effectively limited by existing preventative measures in use for several decades.
  • The persistent spread of the disease suggests that the current tactics employed to control it, even though extensive, are not entirely successful.

Variety in EI Vaccines

  • A range of EI vaccines are available in the marketplace, underscoring the many approaches taken to curb the disease’s spread.
  • These include whole inactivated virus vaccines, Immuno-Stimulating Complex adjuvanted vaccines (ISCOM and ISCOM-Matrix), a live attenuated equine influenza virus (EIV) vaccine, and a recombinant poxvirus-vectored vaccine.
  • While there’s an abundance of options, there’s also a wide variety in the efficacy of these vaccines, indicating the complexity of producing an effective EI vaccine.

Non-Optimal Response to Vaccination

  • Interestingly, a key point made in this article is that horses often have an inefficient or sub-optimal response to vaccination.
  • This could suggest a lack of vaccine efficacy or possible issues with how vaccines are administered and their subsequent interaction with the horse’s immune system.
  • The researchers aim to shed light on why this may be the case, looking at mechanisms behind this insufficient response. Understanding this could help direct future efforts towards improving vaccine design, administration, and outcome.

A Systematic Review of Current Research

  • This review’s overall purpose is to summarize and synthesize the findings of recent research into vaccination against equine influenza.
  • By doing so, the authors hope to pinpoint recent advancements and areas needing additional research or different strategies.
  • This systematic review presents a comprehensive look at where EI prevention stands today, helping guide future studies and informing professional practice across the vet sector.

Cite This Article

APA
Paillot R. (2014). A Systematic Review of Recent Advances in Equine Influenza Vaccination. Vaccines (Basel), 2(4), 797-831. https://doi.org/10.3390/vaccines2040797

Publication

Vaccines
ISSN: 2076-393X
NlmUniqueID: 101629355
Country: Switzerland
Language: English
Volume: 2
Issue: 4
Pages: 797-831

Researcher Affiliations

Paillot, Romain
  • Animal Health Trust, Centre for Preventive Medicine, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK. romain.paillot@aht.org.uk.

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