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The Veterinary clinics of North America. Equine practice2004; 20(3); 615-630; doi: 10.1016/j.cveq.2004.07.005

Clostridium difficile diarrhea: infection control in horses.

Abstract: C difficile has emerged as an important cause of diarrheic disease in horses. C difficile diarrhea is usually diagnosed in mature horses, mostly when they are treated with antimicrobials and hospitalized. It is important for clinicians at veterinary hospitals to have knowledge about the organism and the infection. To prevent C difficile diarrhea, judicious use of antimicrobials is important, as is minimizing different stress factors at the animal hospital or clinic. Infected horses must be isolated. Routine examination for C difficile and toxin A or B is recommended in horses with antibiotic-associated diarrhea. When treating foals for R equi pneumonia, it is important to avoid accidental ingestion of erythromycin by the dams. To reduce the number of environmental spores, thorough cleaning and surface disinfection of the animal hospital and clinic are important. Routine handwashing should be performed by all staff.
Publication Date: 2004-11-03 PubMed ID: 15519822DOI: 10.1016/j.cveq.2004.07.005Google Scholar: Lookup
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Summary

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The research article primarily deals with the significant effects of Clostridium difficile diarrhea in horses and its management, prevention, and control in veterinary hospitals and clinics.

Understanding Clostridium difficile Diarrhea in Horses

  • Clostridium difficile is a bacterium that causes severe diarrheic disease in horses. It usually infects mature horses that are hospitalized and undergoing antimicrobial treatment.
  • The problem of C. difficile diarrhea is emerging and increasing in importance, hence the need for veterinary clinicians to understand the organism and the infection it causes.

Prevention and Management of C. difficile Diarrhea

  • A key preventive measure is the judicious use of antimicrobials to avoid triggering C. difficile infections. Veterinary clinicians are advised to use antibiotics responsibly and only when necessary.
  • Reducing stress factors in the clinical environment is another preventive measure. High-stress environments can make horses more susceptible to C. difficile infections.

Infection Control Protocol in Veterinary Hospitals and Clinics

  • Infected horses should be isolated to prevent the spread of the bacteria to other animals.
  • Routine examination for C. difficile and its toxins (A or B) is recommended whenever horses have antibiotic-associated diarrhea. This helps in early detection and treatment.
  • Special care should be taken when treating foals for R. equi pneumonia to avoid accidental ingestion of erythromycin by the dams, as it might stimulate C. difficile infection.

Environmental Control and Staff Practices

  • The hospital or clinic environment needs to be thoroughly cleaned and disinfected to reduce the number of bacterial spores, inhibiting the spread of the infection.
  • Routine handwashing by all staff members is important to prevent cross-contamination and protect both the animals and the staff from C. difficile.

Cite This Article

APA
Båverud V. (2004). Clostridium difficile diarrhea: infection control in horses. Vet Clin North Am Equine Pract, 20(3), 615-630. https://doi.org/10.1016/j.cveq.2004.07.005

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 20
Issue: 3
Pages: 615-630

Researcher Affiliations

Båverud, Viveca
  • Department of Bacteriology, National Veterinary Institute, SE-751 89 Uppsala, Sweden. viveca.baverud@sva.se

MeSH Terms

  • Animals
  • Clostridioides difficile / isolation & purification
  • Clostridioides difficile / pathogenicity
  • Cross Infection / prevention & control
  • Cross Infection / veterinary
  • Diarrhea / microbiology
  • Diarrhea / prevention & control
  • Diarrhea / veterinary
  • Enterocolitis, Pseudomembranous / microbiology
  • Enterocolitis, Pseudomembranous / prevention & control
  • Enterocolitis, Pseudomembranous / veterinary
  • Horse Diseases / microbiology
  • Horse Diseases / prevention & control
  • Horses
  • Infection Control / methods

Citations

This article has been cited 8 times.
  1. Uchida-Fujii E, Niwa H, Senoh M, Kato H, Kinoshita Y, Mita H, Ueno T. Clostridioides difficile infection in thoroughbred horses in Japan from 2010 to 2021.. Sci Rep 2023 Aug 11;13(1):13099.
    doi: 10.1038/s41598-023-40157-xpubmed: 37567893google scholar: lookup
  2. Uzal FA, Arroyo LG, Navarro MA, Gomez DE, Asín J, Henderson E. Bacterial and viral enterocolitis in horses: a review.. J Vet Diagn Invest 2022 May;34(3):354-375.
    doi: 10.1177/10406387211057469pubmed: 34763560google scholar: lookup
  3. Lindroth KM, Dicksved J, Pelve E, Båverud V, Müller CE. Faecal bacterial composition in horses with and without free faecal liquid: a case control study.. Sci Rep 2021 Feb 26;11(1):4745.
    doi: 10.1038/s41598-021-83897-4pubmed: 33637818google scholar: lookup
  4. Kachrimanidou M, Tzika E, Filioussis G. Clostridioides (Clostridium) Difficile in Food-Producing Animals, Horses and Household Pets: A Comprehensive Review.. Microorganisms 2019 Dec 9;7(12).
    doi: 10.3390/microorganisms7120667pubmed: 31835413google scholar: lookup
  5. Olivo G, Lucas TM, Borges AS, Silva RO, Lobato FC, Siqueira AK, da Silva Leite D, Brandão PE, Gregori F, de Oliveira-Filho JP, Takai S, Ribeiro MG. Enteric Pathogens and Coinfections in Foals with and without Diarrhea.. Biomed Res Int 2016;2016:1512690.
    doi: 10.1155/2016/1512690pubmed: 28116290google scholar: lookup
  6. Keen PL, Patrick DM. Tracking Change: A Look at the Ecological Footprint of Antibiotics and Antimicrobial Resistance.. Antibiotics (Basel) 2013 Mar 27;2(2):191-205.
    doi: 10.3390/antibiotics2020191pubmed: 27029298google scholar: lookup
  7. Yan W, Shin KS, Wang SJ, Xiang H, Divers T, McDonough S, Bowman J, Rowlands A, Akey B, Mohamed H, Chang YF. Equine hyperimmune serum protects mice against Clostridium difficile spore challenge.. J Vet Sci 2014;15(2):249-58.
    doi: 10.4142/jvs.2014.15.2.249pubmed: 24136208google scholar: lookup
  8. Dubberke ER, Haslam DB, Lanzas C, Bobo LD, Burnham CA, Gröhn YT, Tarr PI. The ecology and pathobiology of Clostridium difficile infections: an interdisciplinary challenge.. Zoonoses Public Health 2011 Feb;58(1):4-20.