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Equine degenerative myeloencephalopathy.

Abstract: Five horses of mixed breeding and 1 zebra with symmetric tetraparesis and ataxia were studied. There were 2 females and 4 males. Signs of illness were first noticed from birth to 12 months of age. Clinical and pathologic studies were performed when the animals were 4 to 24 months old. Two of the horses were related. All of the subjects had diffuse degenerative myeloencephalopathy. The degeneration was most pronounced in thoracic segments of the spinal cord. Ventral and dorsolateral funiculi were most severely affected. Axonal swelling and abnormal neuronal cell bodies were seen in the gray matter of the spinal cord and in some brain-stem nuclei. These changes were most prominent in the nuclei of the dorsal spinocerebellar tract. The cause was not determined.
Publication Date: 1977-01-15 PubMed ID: 833044
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  • Journal Article

Summary

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The research article examines equine degenerative myeloencephalopathy, a disease impacting horses, by reviewing its historical context, identifying its symptoms, understanding diagnostic strategies and investigating its pathology, causes and development, and discussing potential treatments and preventative measures.

History and Signalment

In this section, the article explores the history of equine degenerative myeloencephalopathy, tracing its recognition as a disease and the various reports and studies related to it. The signalment, or the specific characteristics of horses affected by this disease, is also outlined.

  • The article might discuss breed and age predisposition, sex bias, and other specifics regarding the affected population.

Clinical Signs

Here, the study delves into the signs a horse may have equine degenerative myeloencephalopathy. These can range from physical symptoms to changes in behaviour.

  • These signs could include difficulties in coordination or balance, muscle weakness, or other neurological symptoms.

Differential Diagnosis

This part of the research sheds light on the differential diagnosis, aiming to differentiate equine degenerative myeloencephalopathy from other conditions with similar symptoms.

  • This might be achieved through various diagnostic tests or procedures, and could involve ruling out diseases like equine protozoal myeloencephalitis or wobbler syndrome.

Pathology

The pathology section examines changes in tissues and organs that result from equine degenerative myeloencephalopathy.

  • It may scrutinize macroscopic changes, visible to the naked eye, and microscopic changes that require a microscope to observe.
  • The section might also discuss how the disease affects the horse’s spinal cord or brain tissue.

Etiology and Pathogenesis

In this part, the authors attempt to trace the cause (etiology) of equine degenerative myeloencephalopathy and explain how the disease develops over time (pathogenesis).

  • This could involve an exploration of genetic factors, environmental influences, or dietary considerations.

Treatment and Prevention

Finally, the article talks about strategies to manage and prevent equine degenerative myeloencephalopathy. This could involve healthcare interventions, genetic counselling and selection, changes in diet, or physical therapy.

  • The discussion here might cover the efficacy of these strategies, ongoing research into new treatments, and best practices in the prevention of the disease.

Cite This Article

APA
Mayhew IG, deLahunta A, Whitlock RH, Geary JC. (1977). Equine degenerative myeloencephalopathy. J Am Vet Med Assoc, 170(2), 195-201.

Publication

ISSN: 0003-1488
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 170
Issue: 2
Pages: 195-201

Researcher Affiliations

Mayhew, I G
    deLahunta, A
      Whitlock, R H
        Geary, J C

          MeSH Terms

          • Animals
          • Ataxia / veterinary
          • Brain Stem / pathology
          • Central Nervous System Diseases / diagnostic imaging
          • Central Nervous System Diseases / pathology
          • Central Nervous System Diseases / veterinary
          • Female
          • Horse Diseases / diagnostic imaging
          • Horse Diseases / pathology
          • Horses
          • Male
          • Perissodactyla
          • Radiography
          • Spinal Cord / pathology