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Frontiers in veterinary science2016; 3; 29; doi: 10.3389/fvets.2016.00029

Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma.

Abstract: Mechanisms to reduce lameness associated with osteoarthritis (OA) are vital to equine health and performance. This study was designed to quantify response to autologous, intra-articular platelet-rich plasma (PRP) in horses with OA. Kinetic gait analysis was performed on 12 horses with unilateral forelimb lameness and OA in the same limb before and after intra-articular anesthesia (IAA). Radiographs and kinetic data were obtained before and 6 and 16 weeks after PRP administration to same joint, 4 weeks after IAA. Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA. A positive response to IAA or PRP was defined as ≥5% improvement in peak vertical force, vertical impulse, or breaking impulse of the affected limb. Out of 10 horses that responded to IAA, 3 responded to PRP at both time points and 4 responded at one. Of the two horses that did not respond to IAA, one responded to PRP at both time points. Filtration increased platelet concentration significantly. The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA. Changes in kinetic variables following IAA in joints with naturally occurring OA provide a custom standard to assess intra-articular therapy. Kinetic gait changes after intra-articular PRP are variable in horses with moderate to severe forelimb OA.
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Publication Date: 2016-04-13 PubMed ID: 27148544PubMed Central: PMC4829588DOI: 10.3389/fvets.2016.00029Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a study that aimed to measure the effectiveness of platelet-rich plasma (PRP) in treating horses with osteoarthritis (OA). It uses kinetic gait analysis to determine the response to the treatment, with the findings showing a variable response to PRP in horses with OA.

Experiment Design and Methodology

  • The study involved 12 horses with OA in one of their forelimbs, which caused unilateral lameness.
  • Kinetic gait analysis was used to assess the horses before and after they received intra-articular anesthesia (IAA).
  • The horses also received PRP treatment in the same joint as the OA after four weeks of IAA.
  • Further radiographs and kinetic data were taken before and at two separate intervals (six and sixteen weeks) after the PRP treatment.

Data Analysis and Evaluation

  • The research used several statistical methods to evaluate the data. This included assessing the impact of filtration on platelet concentration, examining the relationship between changes in gait after IAA and PRP, and an analysis of the responses to both treatments.
  • A positive response to the treatments was defined as having a 5% or more improvement in kinetic variables of the affected limb: peak vertical force, vertical impulse, or breaking impulse

Findings and Outcomes

  • Of the 10 horses that responded positively to IAA, only seven showed some response to PRP: three at both intervals, and four at one interval.
  • One of the horses that did not respond to IAA showed a response to PRP at both testing points.
  • The filtration process was found to significantly increase platelet concentration.
  • No significant relationship was found between the changes in kinetic variables after IAA and PRP.
  • The response to PRP did not show any correlation with the response to IAA, platelet concentration, or the severity of OA as revealed by radiographs.

Conclusions

  • The changes in kinetic variables following IAA in joints affected by OA can be seen as a custom standard for assessing the effects of intra-articular therapy.
  • However, the effect of PRP treatments shows variable results in horses afflicted with moderate to severe OA in the forelimb.

Cite This Article

APA
Mirza MH, Bommala P, Richbourg HA, Rademacher N, Kearney MT, Lopez MJ. (2016). Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma. Front Vet Sci, 3, 29. https://doi.org/10.3389/fvets.2016.00029

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 3
Pages: 29

Researcher Affiliations

Mirza, Mustajab H
  • Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.
Bommala, Prakash
  • Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.
Richbourg, Heather A
  • Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.
Rademacher, Nathalie
  • Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.
Kearney, Michael T
  • Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.
Lopez, Mandi J
  • Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, LA , USA.

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Citations

This article has been cited 18 times.
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