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Home / Equine Research Bank / Vet Sci / Outlook of Adipose-Derived Stem Cells: Challenges to Their C...
Veterinary sciences2023; 10(5); 348; doi: 10.3390/vetsci10050348

Outlook of Adipose-Derived Stem Cells: Challenges to Their Clinical Application in Horses.

Abstract: Adipose tissue is recognized as the major endocrine organ, potentially acting as a source of mesenchymal stem cells for various applications in regenerative medicine. Athletic horses are often exposed to traumatic injuries, resulting in severe financial losses. The development of adipose-derived stem cells' regenerative potential depends on many factors. The extraction of stem cells from subcutaneous adipose tissue is non-invasive, non-traumatic, cheaper, and safer than other sources. Since there is a lack of unique standards for identification, the isolated cells and applied differentiation protocols are often not species-specific; therefore, the cells cannot reveal their multipotent properties, so their stemness features remain questionable. The current review discusses some aspects of the specificity of equine adipose stem cells concerning their features, immunophenotyping, secretome profile, differentiation abilities, culturing conditions, and consequent possibilities for clinical application in concrete disorders. The presented new approaches elucidate the possibility of the transition from cell-based to cell-free therapy with regenerative purposes in horses as an alternative treatment to cellular therapy. In conclusion, their clinical benefits should not be underestimated due to the higher yield and the physiological properties of adipose-derived stem cells that facilitate the healing and tissue regeneration process and the ability to amplify the effects of traditional treatments. More profound studies are necessary to apply these innovative approaches when treating traumatic disorders in racing horses.
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Publication Date: 2023-05-12 PubMed ID: 37235430PubMed Central: PMC10221601DOI: 10.3390/vetsci10050348Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the potential of adipose-derived stem cells as a treatment option for traumatic injuries in horses. It identifies various challenges related to their extraction, identification, differentiation, and application and suggests that a move towards cell-free therapy may provide potential benefits.

Adipose-Derived Stem Cells in Regenerative Medicine

  • The research focuses on adipose tissue – a major endocrine organ – as a promising source of mesenchymal stem cells for regenerative medicine.
  • Racing horses often suffer traumatic injuries which can result in substantial financial losses. Thus the potential development of stem cell-derived treatments is of keen interest.
  • The extraction of these cells is typically non-invasive, safe, and less expensive compared to other sources.

Challenges for Use in Horses

  • A significant barrier to their use is the lack of standards for cell identification. The isolated cells and applied differentiation protocols are often not species-specific.
  • The non species-specific character can prevent the reveal of cells’ multipotent properties and make their stemness features questionable.

Specific Characteristics of Equine Adipose Stem Cells

  • The article explores the specificity of equine adipose stem cells, including their features, immunophenotyping, secretome profile, differentiation abilities, and culturing conditions.
  • These factors can significantly affect the potential for clinical applications in treating various disorders.

Cell-Free Therapy Option

  • The review suggests a new approach of transitioning from cell-based to cell-free therapy for regenerative purposes in horses.
  • This alternative treatment could potentially amplify the effects of traditional treatments, promoting healing and tissue regeneration.
  • The underlying premise is that adipose-derived stem cells have a high yield and possess physiological properties that promote healing and tissue regeneration.

Future Directions

  • While there is promise, the research concludes that more detailed studies are necessary to validate the use of these innovative therapeutic approaches for treating traumatic disorders in racing horses.
  • Despite the challenges, the clinical benefits of adipose-derived stem cells should not be underestimated due to their propensity to enhance healing and regeneration processes.

Cite This Article

APA
Petrova V, Vachkova E. (2023). Outlook of Adipose-Derived Stem Cells: Challenges to Their Clinical Application in Horses. Vet Sci, 10(5), 348. https://doi.org/10.3390/vetsci10050348

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 10
Issue: 5
PII: 348

Researcher Affiliations

Petrova, Valeria
  • Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria.
Vachkova, Ekaterina
  • Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria.

Conflict of Interest Statement

The authors declare no conflict of interest.

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